Paulina Strzyz
@paulinastrzyz.bsky.social
Deputy Editor at Advanced Science
Reposted by Paulina Strzyz
Phospho-eIF2B-epsilon links stress response-driven translation to amyloidogenesis in Alzheimer's disease https://www.biorxiv.org/content/10.1101/2025.11.03.686297v1
November 4, 2025 at 2:16 PM
Phospho-eIF2B-epsilon links stress response-driven translation to amyloidogenesis in Alzheimer's disease https://www.biorxiv.org/content/10.1101/2025.11.03.686297v1
Reposted by Paulina Strzyz
Happy to start at Bluesky with a post on our recent manuscript at @nature.com:
www.nature.com/articles/s41...
Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.
www.nature.com/articles/s41...
Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.
Multiple oestradiol functions inhibit ferroptosis and acute kidney injury - Nature
17β-oestradiol establishes an anti-ferroptotic state in female kidney tubules.
www.nature.com
August 19, 2025 at 8:57 AM
Happy to start at Bluesky with a post on our recent manuscript at @nature.com:
www.nature.com/articles/s41...
Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.
www.nature.com/articles/s41...
Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.
🧬 Just published in Advanced Science: New work from @linkermannlab.bsky.social showing that secondary necrosis can occur without Gasdermin E. A clear step forward in decoding regulated necrosis. #CellDeath #SecondaryNecrosis #GSDME #CaspaseInhibition #AdvancedScience #EditorPick shorturl.at/ITJe6
Secondary Necrosis Following Caspase‐Activation can Occur Independently of Gasdermin E
Secondary necrosis follows apoptosis, but its mechanism is unclear. This study shows that although gasdermin E is cleaved during this process, it is not required for membrane rupture. Across multiple...
advanced.onlinelibrary.wiley.com
November 4, 2025 at 3:02 PM
🧬 Just published in Advanced Science: New work from @linkermannlab.bsky.social showing that secondary necrosis can occur without Gasdermin E. A clear step forward in decoding regulated necrosis. #CellDeath #SecondaryNecrosis #GSDME #CaspaseInhibition #AdvancedScience #EditorPick shorturl.at/ITJe6
New in Advanced Science: Cells regulate membraneless organelles using a shared proteostasis network. HSP70 chaperones act broadly, while co-chaperones provide organelle-specific control.
Vendruscolo-Morimoto labs collaboration
🔗 shorturl.at/v0TeH
#Proteostasis #MembranelessOrganelles
Vendruscolo-Morimoto labs collaboration
🔗 shorturl.at/v0TeH
#Proteostasis #MembranelessOrganelles
Organization of the Proteostasis Network of Membraneless Organelles
A comprehensive mapping of the proteostasis network (PN) across membraneless organelles (MLOs) reveals how central PN components coordinate MLO regulation. The analysis uncovers principles of specifi...
shorturl.at
June 19, 2025 at 10:16 AM
New in Advanced Science: Cells regulate membraneless organelles using a shared proteostasis network. HSP70 chaperones act broadly, while co-chaperones provide organelle-specific control.
Vendruscolo-Morimoto labs collaboration
🔗 shorturl.at/v0TeH
#Proteostasis #MembranelessOrganelles
Vendruscolo-Morimoto labs collaboration
🔗 shorturl.at/v0TeH
#Proteostasis #MembranelessOrganelles
New in Advanced Science: Apoptotic vesicles from mesenchymal stem cells selectively induce CD8⁺ T cell apoptosis via calcium overload—offering a novel strategy to treat type IV hypersensitivity
#Immunotherapy #ExtracellularVesicles #Nanomedicine #CD8Tcells #Hypersensitivity
🔗 doi.org/10.1002/advs...
#Immunotherapy #ExtracellularVesicles #Nanomedicine #CD8Tcells #Hypersensitivity
🔗 doi.org/10.1002/advs...
Apoptotic Vesicles Derived from Mesenchymal Stem Cells Ameliorate Hypersensitivity Responses via Inducing CD8+ T Cells Apoptosis with Calcium Overload and Mitochondrial Dysfunction
The therapeutic potential of ApoVs derived from stem cells from human exfoliated deciduous teeth (SHED-ApoVs) in the treatment of CD8+ T cell-mediated hypersensitivity reactions is noteworthy. SHED-A...
doi.org
June 19, 2025 at 10:10 AM
New in Advanced Science: Apoptotic vesicles from mesenchymal stem cells selectively induce CD8⁺ T cell apoptosis via calcium overload—offering a novel strategy to treat type IV hypersensitivity
#Immunotherapy #ExtracellularVesicles #Nanomedicine #CD8Tcells #Hypersensitivity
🔗 doi.org/10.1002/advs...
#Immunotherapy #ExtracellularVesicles #Nanomedicine #CD8Tcells #Hypersensitivity
🔗 doi.org/10.1002/advs...
Don't miss this fantastic #Review! I still feel partly responsible, having commissioned it ;) ❤️nrmcb!
🕒🕔 #CircadianClock communication during homeostasis and #ageing.
📰 New #review out in @natrevmcb.bsky.social
✍️ Thomas Mortimer, Jacob Smith, Pura Muñoz-Cánoves & Salvador Aznar
➡️ go.nature.com/3W013D1
📌 https://s.mtrbio.com/goojeyblhr
#AgeingResearch #AgingResearch 🧪
📰 New #review out in @natrevmcb.bsky.social
✍️ Thomas Mortimer, Jacob Smith, Pura Muñoz-Cánoves & Salvador Aznar
➡️ go.nature.com/3W013D1
📌 https://s.mtrbio.com/goojeyblhr
#AgeingResearch #AgingResearch 🧪
January 8, 2025 at 11:25 AM
Don't miss this fantastic #Review! I still feel partly responsible, having commissioned it ;) ❤️nrmcb!
Reposted by Paulina Strzyz
Exciting work by Martin Beck’s group @mpibp.bsky.social providing further evidence for nuclear pores responding to mechanical stress. The work includes some nice modeling estimating the fluid flow across nuclear pores as a function of (osmotic) pressure.
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Nuclear pore permeability and fluid flow are modulated by its dilation state
Hoffmann et al. describe within cells how the Dictyostelium discoideum nuclear pore complex structure constricts and dilates as a consequence of osmotic stress. Based on their experimental findings, they propose a hydrodynamics model and quantify fluid flow across nuclear pore complexes under conditions when nuclei change their volume rapidly.
www.cell.com
December 29, 2024 at 8:50 AM
Exciting work by Martin Beck’s group @mpibp.bsky.social providing further evidence for nuclear pores responding to mechanical stress. The work includes some nice modeling estimating the fluid flow across nuclear pores as a function of (osmotic) pressure.
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Reposted by Paulina Strzyz
Stoked to share TWO preprints on mitochondrial pearling! 🎉
We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024...), and
@gavsturm.bsky.social
et al. dissect the biophysics behind it (doi.org/10.1101/2024...). Details below! 🔬🧵🧪
We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024...), and
@gavsturm.bsky.social
et al. dissect the biophysics behind it (doi.org/10.1101/2024...). Details below! 🔬🧵🧪
December 23, 2024 at 4:37 PM
Stoked to share TWO preprints on mitochondrial pearling! 🎉
We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024...), and
@gavsturm.bsky.social
et al. dissect the biophysics behind it (doi.org/10.1101/2024...). Details below! 🔬🧵🧪
We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024...), and
@gavsturm.bsky.social
et al. dissect the biophysics behind it (doi.org/10.1101/2024...). Details below! 🔬🧵🧪
Reposted by Paulina Strzyz
Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint, @gavsturm.bsky.social investigates how mitochondria transiently adopt a beads-on-a-string morphology
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 23, 2024 at 5:49 PM
Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint, @gavsturm.bsky.social investigates how mitochondria transiently adopt a beads-on-a-string morphology
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Amazing initiative for peer-reviewing and curating preprints: noteforms.com/forms/dsdc-p.... Currently trialling in cancer and immunology.
Discovery Stack Pilot Participant Signups
noteforms.com
December 22, 2024 at 1:56 PM
Amazing initiative for peer-reviewing and curating preprints: noteforms.com/forms/dsdc-p.... Currently trialling in cancer and immunology.
Congrats @marija-matejcic.bsky.social for a killer talk at the ASCB #CellBio2024 👏 #Mechanobiology 4eva
December 18, 2024 at 7:28 PM
Congrats @marija-matejcic.bsky.social for a killer talk at the ASCB #CellBio2024 👏 #Mechanobiology 4eva