Pam Brigleb
@pambrigleb.bsky.social
NIAID F32 Postdoctoral Fellow Schultz-Cherry lab @stjude |Metabolism, Influenza, NK cells, Innate Immunity| PhD in Dermody Lab at UPitt
Reposted by Pam Brigleb
Online now: A metabolic atlas of mouse aging
A metabolic atlas of mouse aging
Pilley et al. describe how metabolite levels change in 12 organs from male and female mice across five ages, spanning adolescence to old age. They reveal that organs show distinct age- and sex-specific changes in metabolism. They also develop metabolic clocks that predict putative metabolic drivers of aging, including hydroxyproline.
dlvr.it
November 25, 2025 at 4:42 PM
Online now: A metabolic atlas of mouse aging
Reposted by Pam Brigleb
Up to 30% of commercial pasteurized milk in US is PCR +Ve. Pasteurization inactivates virus, but HA protein preserved. In mice, repeated oral exposure to inactivated virus did not alter mortality or worsen disease after H5N1 virus challenge.
👉 www.science.org/doi/10.1126/...
👉 www.science.org/doi/10.1126/...
October 14, 2025 at 1:48 AM
Up to 30% of commercial pasteurized milk in US is PCR +Ve. Pasteurization inactivates virus, but HA protein preserved. In mice, repeated oral exposure to inactivated virus did not alter mortality or worsen disease after H5N1 virus challenge.
👉 www.science.org/doi/10.1126/...
👉 www.science.org/doi/10.1126/...
Reposted by Pam Brigleb
St. Jude Children’s Research Hospital has been ranked among the top 10
pediatric cancer hospitals by U.S. News & World Report for the 18th year in a row.
Read more: ow.ly/HNLN50X7PsR
pediatric cancer hospitals by U.S. News & World Report for the 18th year in a row.
Read more: ow.ly/HNLN50X7PsR
October 7, 2025 at 2:57 PM
St. Jude Children’s Research Hospital has been ranked among the top 10
pediatric cancer hospitals by U.S. News & World Report for the 18th year in a row.
Read more: ow.ly/HNLN50X7PsR
pediatric cancer hospitals by U.S. News & World Report for the 18th year in a row.
Read more: ow.ly/HNLN50X7PsR
Reposted by Pam Brigleb
#H5N1 #OneHealth #Influenza #Zoonoses
References
Brigleb et al., 2025. doi.org/10.1126/scia...
Clessin et al., 2025. doi.org/10.1038/s414...
Dhakal et al., 2025. doi.org/10.1016/j.jf...
Kim et al., 2025. doi.org/10.1126/scia...
Palma, 2025. doi.org/10.3390/biol...
10/10
References
Brigleb et al., 2025. doi.org/10.1126/scia...
Clessin et al., 2025. doi.org/10.1038/s414...
Dhakal et al., 2025. doi.org/10.1016/j.jf...
Kim et al., 2025. doi.org/10.1126/scia...
Palma, 2025. doi.org/10.3390/biol...
10/10
Repeated oral exposure to H5N1 influenza virus in pasteurized milk does not cause adverse responses to subsequent influenza infection
H5N1 influenza virus in pasteurized milk does not alter immunity in mice, suggesting limited health risks from consumption.
doi.org
October 2, 2025 at 1:38 PM
#H5N1 #OneHealth #Influenza #Zoonoses
References
Brigleb et al., 2025. doi.org/10.1126/scia...
Clessin et al., 2025. doi.org/10.1038/s414...
Dhakal et al., 2025. doi.org/10.1016/j.jf...
Kim et al., 2025. doi.org/10.1126/scia...
Palma, 2025. doi.org/10.3390/biol...
10/10
References
Brigleb et al., 2025. doi.org/10.1126/scia...
Clessin et al., 2025. doi.org/10.1038/s414...
Dhakal et al., 2025. doi.org/10.1016/j.jf...
Kim et al., 2025. doi.org/10.1126/scia...
Palma, 2025. doi.org/10.3390/biol...
10/10
Super excited that our paper @ssclabquips.bsky.social is out in #ScienceAdvances (@science.org)! --> Repeated oral exposure to H5N1 influenza virus in pasteurized milk does not cause adverse responses to subsequent influenza infection | Science Advances www.science.org/doi/full/10....
Repeated oral exposure to H5N1 influenza virus in pasteurized milk does not cause adverse responses to subsequent influenza infection
H5N1 influenza virus in pasteurized milk does not alter immunity in mice, suggesting limited health risks from consumption.
www.science.org
September 29, 2025 at 2:51 PM
Super excited that our paper @ssclabquips.bsky.social is out in #ScienceAdvances (@science.org)! --> Repeated oral exposure to H5N1 influenza virus in pasteurized milk does not cause adverse responses to subsequent influenza infection | Science Advances www.science.org/doi/full/10....
Reposted by Pam Brigleb
Pasteurized milk containing inactive H5N1 viral components poses minimal health risk and does not alter influenza immunity, while unpasteurized milk remains a significant health concern. doi.org/g94636
Inactive H5N1 influenza virus in pasteurized milk poses minimal health risks
Proteins and genetic material from H5N1 influenza viruses have been found in pasteurized milk in the United States, but a study from St. Jude Children's Research Hospital shows those inactive viral pieces represent little to no health risk.
medicalxpress.com
September 27, 2025 at 11:57 AM
Pasteurized milk containing inactive H5N1 viral components poses minimal health risk and does not alter influenza immunity, while unpasteurized milk remains a significant health concern. doi.org/g94636
Super excited to see our study out in #ScienceAdvances today, summarized nicely by @stjuderesearch.bsky.social !
New study reveals pasteurized milk containing H5N1 influenza viral components poses minimal health risks and doesn’t alter influenza immunity. Regularly drinking contaminated pasteurized milk doesn’t increase flu susceptibility in model systems. ow.ly/stPC50X32eB
September 26, 2025 at 6:43 PM
Super excited to see our study out in #ScienceAdvances today, summarized nicely by @stjuderesearch.bsky.social !
Reposted by Pam Brigleb
AFD Blog `CDC Report & Risk Assessment On Potential Influenza Infection Via GI Tract' #H5N1 afludiary.blogspot.com/2025/09/cdc-...
CDC Report & Risk Assessment On Potential Influenza Infection Via GI Tract
#18,865 One of the topics we've touched on repeatedly over the past twenty years has been the - as yet, unquantified - risks of preparing, ...
afludiary.blogspot.com
September 9, 2025 at 10:46 AM
AFD Blog `CDC Report & Risk Assessment On Potential Influenza Infection Via GI Tract' #H5N1 afludiary.blogspot.com/2025/09/cdc-...
Reposted by Pam Brigleb
Do not normalize children dying from measles. Measles was previously eliminated in the US, thanks to vaccines.
When children die from measles, it means that adults have catastrophically failed to protect them because they have rejected basic science.
When children die from measles, it means that adults have catastrophically failed to protect them because they have rejected basic science.
April 7, 2025 at 5:47 PM
Do not normalize children dying from measles. Measles was previously eliminated in the US, thanks to vaccines.
When children die from measles, it means that adults have catastrophically failed to protect them because they have rejected basic science.
When children die from measles, it means that adults have catastrophically failed to protect them because they have rejected basic science.
Reposted by Pam Brigleb
New review on antiviral approaches targeting lipids, written by one of our society members.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
March 10, 2025 at 12:19 AM
New review on antiviral approaches targeting lipids, written by one of our society members.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Pam Brigleb
In Vivo Imaging and Tracking of VRE-Microbiota Interactions via Anaerobic Fluorescent Reporters in Extremely Drug-Resistant Bacteria https://www.biorxiv.org/content/10.1101/2025.02.08.637206v1
February 10, 2025 at 3:17 AM
In Vivo Imaging and Tracking of VRE-Microbiota Interactions via Anaerobic Fluorescent Reporters in Extremely Drug-Resistant Bacteria https://www.biorxiv.org/content/10.1101/2025.02.08.637206v1
Reposted by Pam Brigleb
Reposted by Pam Brigleb
NIH cuts indirect rates on grants to 15%.
This will be the end of American excellence in science.
Universities will struggle and many (likely most) will terminate their research programs.
Independent research institutions will not be able to survive this.
grants.nih.gov/grants/guide...
This will be the end of American excellence in science.
Universities will struggle and many (likely most) will terminate their research programs.
Independent research institutions will not be able to survive this.
grants.nih.gov/grants/guide...
NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD
grants.nih.gov
February 7, 2025 at 11:53 PM
NIH cuts indirect rates on grants to 15%.
This will be the end of American excellence in science.
Universities will struggle and many (likely most) will terminate their research programs.
Independent research institutions will not be able to survive this.
grants.nih.gov/grants/guide...
This will be the end of American excellence in science.
Universities will struggle and many (likely most) will terminate their research programs.
Independent research institutions will not be able to survive this.
grants.nih.gov/grants/guide...
Reposted by Pam Brigleb
In a new study by Simonson, @joanneflynn19.bsky.social et al., antibody depletion of select lymphocytes in rhesus macaques demonstrates key roles for CD4+ T cells and CD8α+ lymphocytes in conferring sterilizing immunity against #tuberculosis following i.v. BCG vaccination. https://buff.ly/4gxWbfR
February 6, 2025 at 5:15 PM
In a new study by Simonson, @joanneflynn19.bsky.social et al., antibody depletion of select lymphocytes in rhesus macaques demonstrates key roles for CD4+ T cells and CD8α+ lymphocytes in conferring sterilizing immunity against #tuberculosis following i.v. BCG vaccination. https://buff.ly/4gxWbfR
Check out the newest preprint from the Schultz-Cherry lab on susceptibility of primary cells to H5N1 clade 2.3.4.4b viruses! -->
Susceptibility of bovine respiratory and mammary epithelial cells to avian and mammalian derived clade 2.3.4.4b H5N1 highly pathogenic avian influenza viruses https://www.biorxiv.org/content/10.1101/2025.01.09.632235v1
January 11, 2025 at 5:38 PM
Check out the newest preprint from the Schultz-Cherry lab on susceptibility of primary cells to H5N1 clade 2.3.4.4b viruses! -->
Reposted by Pam Brigleb
Susceptibility of bovine respiratory and mammary epithelial cells to avian and mammalian derived clade 2.3.4.4b H5N1 highly pathogenic avian influenza viruses https://www.biorxiv.org/content/10.1101/2025.01.09.632235v1
January 10, 2025 at 9:20 AM
Susceptibility of bovine respiratory and mammary epithelial cells to avian and mammalian derived clade 2.3.4.4b H5N1 highly pathogenic avian influenza viruses https://www.biorxiv.org/content/10.1101/2025.01.09.632235v1
Reposted by Pam Brigleb
Very preliminary starter pack
Only about 25-30 on there so far
Only about 25-30 on there so far
December 6, 2024 at 2:34 AM
Very preliminary starter pack
Only about 25-30 on there so far
Only about 25-30 on there so far
Reposted by Pam Brigleb
go.bsky.app/7zMmwNY
Hi all, so nice to cross over to the light. Here is a starter pack for all things Mucosal Immunology! Exciting to create a MI community here. Let me know if you would like to join 👍
Hi all, so nice to cross over to the light. Here is a starter pack for all things Mucosal Immunology! Exciting to create a MI community here. Let me know if you would like to join 👍
November 20, 2024 at 9:51 AM
go.bsky.app/7zMmwNY
Hi all, so nice to cross over to the light. Here is a starter pack for all things Mucosal Immunology! Exciting to create a MI community here. Let me know if you would like to join 👍
Hi all, so nice to cross over to the light. Here is a starter pack for all things Mucosal Immunology! Exciting to create a MI community here. Let me know if you would like to join 👍
Reposted by Pam Brigleb
Sign of the times, no more bluebird on the biorxiv engagement tab..
November 24, 2024 at 9:59 AM
Sign of the times, no more bluebird on the biorxiv engagement tab..
Reposted by Pam Brigleb
Here Malcolm Sim and Eric Long discuss peptide sensitivity of the HLA/KIR interaction. For anyone interested in this evolving subject (i.e. immune mediated disease), this review explains the difficult concepts really nicely and introduces a couple of models. #immunology
www.cell.com/trends/immun...
www.cell.com/trends/immun...
The peptide selectivity model: Interpreting NK cell KIR-HLA-I binding interactions and their associations to human diseases
Combinations of the highly polymorphic KIR and HLA-I genes are associated with numerous
human diseases. Interpreting these associations requires a molecular understanding
of the multiple killer-cell i...
www.cell.com
November 22, 2024 at 2:39 PM
Here Malcolm Sim and Eric Long discuss peptide sensitivity of the HLA/KIR interaction. For anyone interested in this evolving subject (i.e. immune mediated disease), this review explains the difficult concepts really nicely and introduces a couple of models. #immunology
www.cell.com/trends/immun...
www.cell.com/trends/immun...
Reposted by Pam Brigleb
Adipose tissue retains an epigenetic memory of obesity after weight loss @vonmeyennlab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Adipose tissue retains an epigenetic memory of obesity after weight loss - Nature
Stable epigenetic changes indicate the existence of an obesogenic memory in mouse adipocytes that primes cells for pathological responses in an obesogenic environment and potentially contributes to th...
www.nature.com
November 19, 2024 at 1:07 AM
Adipose tissue retains an epigenetic memory of obesity after weight loss @vonmeyennlab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Pam Brigleb
Can colleagues amplify this appeal to journals and journal editors to open accounts on Bluesky, please? @MicrobioSoc @TrendsMicrobiol @CellCellPress @JBacteriology @jbiolchem @Nature @ScienceMagazine @PNASNews @MolMicroEditors @NAR_Open @NatureMicrobiol @NatureComms @ASMicrobiology 🙏
🦠🧪🧫🧬
🦠🧪🧫🧬
November 10, 2024 at 1:13 PM
Can colleagues amplify this appeal to journals and journal editors to open accounts on Bluesky, please? @MicrobioSoc @TrendsMicrobiol @CellCellPress @JBacteriology @jbiolchem @Nature @ScienceMagazine @PNASNews @MolMicroEditors @NAR_Open @NatureMicrobiol @NatureComms @ASMicrobiology 🙏
🦠🧪🧫🧬
🦠🧪🧫🧬
Reposted by Pam Brigleb
A starter pack for scientists working on NK cells or ILCs. Happy to add more names as more people join.
go.bsky.app/AjNpW2h
November 17, 2024 at 4:10 AM
A starter pack for scientists working on NK cells or ILCs. Happy to add more names as more people join.
go.bsky.app/AjNpW2h
Reposted by Pam Brigleb
The H5N1 sequence found in the hospitalized teenager shows two important mutations that improve the virus's ability to bind to human α2,6 sialic acid receptors.
This adaptation is crucial for the virus's potential to spread between humans.
The virus is evolving.
#H5N1
This adaptation is crucial for the virus's potential to spread between humans.
The virus is evolving.
#H5N1
November 16, 2024 at 6:39 PM
The H5N1 sequence found in the hospitalized teenager shows two important mutations that improve the virus's ability to bind to human α2,6 sialic acid receptors.
This adaptation is crucial for the virus's potential to spread between humans.
The virus is evolving.
#H5N1
This adaptation is crucial for the virus's potential to spread between humans.
The virus is evolving.
#H5N1
Reposted by Pam Brigleb
Tell me again how the H5N1 cattle outbreak is on its way to being contained.
An increased wastewater signal usually doesn’t suggest fewer cases.
An increased wastewater signal usually doesn’t suggest fewer cases.
Last wastewater readings found H5 bird flu in Lompoc, Los Angeles, Napa, San Francisco, Ontario, Paso Robles, Redwood City, Riverside, Sacramento, San Jose, Sunnyvale and Turlock.
November 16, 2024 at 6:40 PM
Tell me again how the H5N1 cattle outbreak is on its way to being contained.
An increased wastewater signal usually doesn’t suggest fewer cases.
An increased wastewater signal usually doesn’t suggest fewer cases.