Otoniel Rodriguez
@otonielrj.bsky.social
Immunology researcher at #UAEM Mor, Mex. Studying #Newborn #Immunology #SystemsImmunology #Omics #Immunoinformatics #Immunometabolism
Algunos de mis alumnos (as) durante el Congreso Nacional de Inmunología, en Chihuahua. @sminmunologia.bsky.social
October 2, 2025 at 8:27 PM
Algunos de mis alumnos (as) durante el Congreso Nacional de Inmunología, en Chihuahua. @sminmunologia.bsky.social
Mañana comenzamos!!
📢 ¿Listo para llevar tu conocimiento al siguiente nivel? 🔬💻📝🌱
💡 Explora, actualízate y vive la experiencia de los Cursos Pre-Congreso.
📅 27 de septiembre | Modalidad presencial
🎟 ¡Cupo limitado!
🔗 Más detalles en: sociedadmexicanadeinmunologia.org/xxvi-congres...
💡 Explora, actualízate y vive la experiencia de los Cursos Pre-Congreso.
📅 27 de septiembre | Modalidad presencial
🎟 ¡Cupo limitado!
🔗 Más detalles en: sociedadmexicanadeinmunologia.org/xxvi-congres...
September 27, 2025 at 4:48 AM
Mañana comenzamos!!
Reposted by Otoniel Rodriguez
@biorxivpreprint.bsky.social CD8+ T cells regulate the bioenergetic reprogramming of lymphoid organs and the heart during viral infection
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
August 24, 2025 at 6:23 PM
@biorxivpreprint.bsky.social CD8+ T cells regulate the bioenergetic reprogramming of lymphoid organs and the heart during viral infection
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Otoniel Rodriguez
Our TRM modeling paper is now published in PLOS Computational Biology! In this paper, we fit dynamical (ODE) models to single-cell flow cytometry data using a variational autoencoder that has a GMM with time-dependent weights as prior. journals.plos.org/ploscompbiol...
A variational deep-learning approach to modeling memory T cell dynamics
Author summary After an influenza infection, antibodies provide strong protection—but only against the same strain. Because influenza rapidly mutates its surface proteins, this protection soon becomes...
journals.plos.org
August 24, 2025 at 9:01 PM
Our TRM modeling paper is now published in PLOS Computational Biology! In this paper, we fit dynamical (ODE) models to single-cell flow cytometry data using a variational autoencoder that has a GMM with time-dependent weights as prior. journals.plos.org/ploscompbiol...
Reposted by Otoniel Rodriguez
Stem-like peripheral helper T cells seed effector peripheral helper T cells in rheumatoid arthritis @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
August 15, 2025 at 7:26 PM
Stem-like peripheral helper T cells seed effector peripheral helper T cells in rheumatoid arthritis @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Otoniel Rodriguez
Succinate enhances mitochondrial fitness and induces epigenetic reprogramming to promote CD8+ T cell stemness, thereby augmenting antitumor immunity
www.cell.com/immunity/ful... @cp-immunity.bsky.social
www.cell.com/immunity/ful... @cp-immunity.bsky.social
August 15, 2025 at 3:05 AM
Succinate enhances mitochondrial fitness and induces epigenetic reprogramming to promote CD8+ T cell stemness, thereby augmenting antitumor immunity
www.cell.com/immunity/ful... @cp-immunity.bsky.social
www.cell.com/immunity/ful... @cp-immunity.bsky.social
Reposted by Otoniel Rodriguez
Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control
@cp-cellmetabolism.bsky.social @drrgjoneslab.bsky.social
www.cell.com/cell-metabol...
@cp-cellmetabolism.bsky.social @drrgjoneslab.bsky.social
www.cell.com/cell-metabol...
August 5, 2025 at 5:15 PM
Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control
@cp-cellmetabolism.bsky.social @drrgjoneslab.bsky.social
www.cell.com/cell-metabol...
@cp-cellmetabolism.bsky.social @drrgjoneslab.bsky.social
www.cell.com/cell-metabol...
Reposted by Otoniel Rodriguez
Our paper is out! Check out this beautiful story where we uncovered that the costimulatory molecule ICOS is detrimental for PD-1+ CD8 T cells.
Sustained ICOS signaling reduces memory-like features of progenitor exhausted CD8 T cells in chronic viral infection and liver cancer.
Sustained ICOS signaling reduces memory-like features of progenitor exhausted CD8 T cells in chronic viral infection and liver cancer.
July 8, 2025 at 1:05 PM
Our paper is out! Check out this beautiful story where we uncovered that the costimulatory molecule ICOS is detrimental for PD-1+ CD8 T cells.
Sustained ICOS signaling reduces memory-like features of progenitor exhausted CD8 T cells in chronic viral infection and liver cancer.
Sustained ICOS signaling reduces memory-like features of progenitor exhausted CD8 T cells in chronic viral infection and liver cancer.
Reposted by Otoniel Rodriguez
ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox | Science www.science.org/doi/10.1126/...
ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox
Maintenance of mitochondrial redox homeostasis is of fundamental importance to cellular health. Mitochondria harbor a host of intrinsic antioxidant defenses, but the contribution of extrinsic, nonmito...
www.science.org
July 10, 2025 at 6:06 PM
ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox | Science www.science.org/doi/10.1126/...
Reposted by Otoniel Rodriguez
T follicular helper and regulatory cells in human lymphoid tissue mature distinctly, defined by PD-1 and ICOS protein levels @lgraca.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
July 11, 2025 at 6:36 PM
T follicular helper and regulatory cells in human lymphoid tissue mature distinctly, defined by PD-1 and ICOS protein levels @lgraca.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Otoniel Rodriguez
'Male CD8+ T cells stimulated with IL-15 exhibited greater bystander activation, including increased NKG2D expression and greater antigen-independent cytotoxicity against tumor cells compared with female CD8+ T cells.'
#immunology #immunosky
onlinelibrary.wiley.com/doi/10.1002/...
#immunology #immunosky
onlinelibrary.wiley.com/doi/10.1002/...
Biological Sex Influences Human Bystander CD8+ T Cell Activation
CD8+ T cells isolated from male donors exhibit greater IL-15–driven bystander activation, NKG2D expression, and cytotoxicity than female CD8+ cells. This study reveals a sex-based difference in innat....
onlinelibrary.wiley.com
June 27, 2025 at 6:18 AM
'Male CD8+ T cells stimulated with IL-15 exhibited greater bystander activation, including increased NKG2D expression and greater antigen-independent cytotoxicity against tumor cells compared with female CD8+ T cells.'
#immunology #immunosky
onlinelibrary.wiley.com/doi/10.1002/...
#immunology #immunosky
onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Otoniel Rodriguez
🧬 CD28 vs. TCR: not a one-size-fits-all signal.
New study by Cayman Williams et al. shows CD28 co-stimulation shapes naïve & memory CD4⁺ T cells differently - and can even act independently of TCR in memory cells.
📖 https://bit.ly/44MG7UD
##Tcells #Immunology
New study by Cayman Williams et al. shows CD28 co-stimulation shapes naïve & memory CD4⁺ T cells differently - and can even act independently of TCR in memory cells.
📖 https://bit.ly/44MG7UD
##Tcells #Immunology
July 6, 2025 at 1:16 PM
🧬 CD28 vs. TCR: not a one-size-fits-all signal.
New study by Cayman Williams et al. shows CD28 co-stimulation shapes naïve & memory CD4⁺ T cells differently - and can even act independently of TCR in memory cells.
📖 https://bit.ly/44MG7UD
##Tcells #Immunology
New study by Cayman Williams et al. shows CD28 co-stimulation shapes naïve & memory CD4⁺ T cells differently - and can even act independently of TCR in memory cells.
📖 https://bit.ly/44MG7UD
##Tcells #Immunology
Reposted by Otoniel Rodriguez
Presentation of immunoregulatory sialoglycans on T cells is divergent between mice and humans @cp-cellreports.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
July 3, 2025 at 1:47 PM
Presentation of immunoregulatory sialoglycans on T cells is divergent between mice and humans @cp-cellreports.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Reposted by Otoniel Rodriguez
🔔¡Ampliamos la fecha de recepción de resúmenes del 3 al 10 de julio!
No queremos que te pierdas la oportunidad de presentar tu trabajo en el XXVI Congreso Nacional de Inmunología.
¡No olvides subir tu resumen. Te esperamos!
🔗Link en la bio
#SMInmunologia #CongresoMexicanoDeInmunologia
No queremos que te pierdas la oportunidad de presentar tu trabajo en el XXVI Congreso Nacional de Inmunología.
¡No olvides subir tu resumen. Te esperamos!
🔗Link en la bio
#SMInmunologia #CongresoMexicanoDeInmunologia
July 3, 2025 at 4:35 PM
🔔¡Ampliamos la fecha de recepción de resúmenes del 3 al 10 de julio!
No queremos que te pierdas la oportunidad de presentar tu trabajo en el XXVI Congreso Nacional de Inmunología.
¡No olvides subir tu resumen. Te esperamos!
🔗Link en la bio
#SMInmunologia #CongresoMexicanoDeInmunologia
No queremos que te pierdas la oportunidad de presentar tu trabajo en el XXVI Congreso Nacional de Inmunología.
¡No olvides subir tu resumen. Te esperamos!
🔗Link en la bio
#SMInmunologia #CongresoMexicanoDeInmunologia
Reposted by Otoniel Rodriguez
Purinergic signaling modulates CD4+ T cells with cytotoxic potential during Trypanosoma cruzi infection @jclinical-invest.bsky.social
www.jci.org/articles/vie...
www.jci.org/articles/vie...
July 3, 2025 at 1:25 AM
Purinergic signaling modulates CD4+ T cells with cytotoxic potential during Trypanosoma cruzi infection @jclinical-invest.bsky.social
www.jci.org/articles/vie...
www.jci.org/articles/vie...
Reposted by Otoniel Rodriguez
Proximity between LAG-3 and the T cell receptor guides suppression of T cell activation and autoimmunity @cellcellpress.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
June 30, 2025 at 3:52 PM
Proximity between LAG-3 and the T cell receptor guides suppression of T cell activation and autoimmunity @cellcellpress.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Otoniel Rodriguez
Succinate induces Treg dysfunction by inhibiting succinyl-CoA generation. Succinyl-CoA is necessary for FOXP3 succinylation and protection of FOXP3 from proteasome degradation.
Wang et al – 2025 @natureportfolio.nature.com
www.nature.com/articles/s41...
Wang et al – 2025 @natureportfolio.nature.com
www.nature.com/articles/s41...
June 28, 2025 at 5:21 PM
Succinate induces Treg dysfunction by inhibiting succinyl-CoA generation. Succinyl-CoA is necessary for FOXP3 succinylation and protection of FOXP3 from proteasome degradation.
Wang et al – 2025 @natureportfolio.nature.com
www.nature.com/articles/s41...
Wang et al – 2025 @natureportfolio.nature.com
www.nature.com/articles/s41...
Reposted by Otoniel Rodriguez
Klein and colleagues find that cathepsin L shapes CD4+ T cell selection by promoting full repertoire diversity and fine-tuning CD4+ T cell functionality. Read it here: rdcu.be/etDy2
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Cathepsin L-dependent positive selection shapes clonal composition and functional fitness of CD4+ T cells
Nature Immunology - Klein and colleagues show that the lysosomal cysteine protease cathepsin L shapes the diversity and optimizes the fitness of clones that enter the CD4+ T cell repertoire.
rdcu.be
June 26, 2025 at 8:35 PM
Klein and colleagues find that cathepsin L shapes CD4+ T cell selection by promoting full repertoire diversity and fine-tuning CD4+ T cell functionality. Read it here: rdcu.be/etDy2
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Otoniel Rodriguez
📢 ¿Listo para llevar tu conocimiento al siguiente nivel? 🔬💻📝🌱
💡 Explora, actualízate y vive la experiencia de los Cursos Pre-Congreso.
📅 27 de septiembre | Modalidad presencial
🎟 ¡Cupo limitado!
🔗 Más detalles en: sociedadmexicanadeinmunologia.org/xxvi-congres...
💡 Explora, actualízate y vive la experiencia de los Cursos Pre-Congreso.
📅 27 de septiembre | Modalidad presencial
🎟 ¡Cupo limitado!
🔗 Más detalles en: sociedadmexicanadeinmunologia.org/xxvi-congres...
June 24, 2025 at 3:54 PM
📢 ¿Listo para llevar tu conocimiento al siguiente nivel? 🔬💻📝🌱
💡 Explora, actualízate y vive la experiencia de los Cursos Pre-Congreso.
📅 27 de septiembre | Modalidad presencial
🎟 ¡Cupo limitado!
🔗 Más detalles en: sociedadmexicanadeinmunologia.org/xxvi-congres...
💡 Explora, actualízate y vive la experiencia de los Cursos Pre-Congreso.
📅 27 de septiembre | Modalidad presencial
🎟 ¡Cupo limitado!
🔗 Más detalles en: sociedadmexicanadeinmunologia.org/xxvi-congres...
Reposted by Otoniel Rodriguez
🏳️🌈 El Comité de Equidad, Diversidad e Inclusión de la Sociedad Mexicana de Inmunología te invita a su seminario extraordinario este 24 de junio. 🏳️🌈
Regístrate en la página de la SMI:
sociedadmexicanadeinmunologia.org/seminario-ex...
Regístrate en la página de la SMI:
sociedadmexicanadeinmunologia.org/seminario-ex...
June 23, 2025 at 1:41 PM
🏳️🌈 El Comité de Equidad, Diversidad e Inclusión de la Sociedad Mexicana de Inmunología te invita a su seminario extraordinario este 24 de junio. 🏳️🌈
Regístrate en la página de la SMI:
sociedadmexicanadeinmunologia.org/seminario-ex...
Regístrate en la página de la SMI:
sociedadmexicanadeinmunologia.org/seminario-ex...
Se extendió la fecha!. Nos vemos en Chihuahua en el Congreso de la SMI!. #Inmunologia @sminmunologia.bsky.social
June 19, 2025 at 3:38 AM
Se extendió la fecha!. Nos vemos en Chihuahua en el Congreso de la SMI!. #Inmunologia @sminmunologia.bsky.social
Reposted by Otoniel Rodriguez
Genomic analyses of mother–father–fetus trios after early pregnancy loss uncover contributions from chromosomal abnormalities and subtle genetic variants
www.nature.com/articles/d41...
@nature.com
www.nature.com/articles/s41...
www.nature.com/articles/d41...
@nature.com
www.nature.com/articles/s41...
June 17, 2025 at 4:02 PM
Genomic analyses of mother–father–fetus trios after early pregnancy loss uncover contributions from chromosomal abnormalities and subtle genetic variants
www.nature.com/articles/d41...
@nature.com
www.nature.com/articles/s41...
www.nature.com/articles/d41...
@nature.com
www.nature.com/articles/s41...
Reposted by Otoniel Rodriguez
🚨 ¡Recuerda, el próximo lunes 9 de junio es la fecha límite para el envío de resúmenes!
No olvides enviar tu trabajo al XXVI Congreso Nacional de Inmunología. Te queremos ver ahí 😉
🔗 Link en la bio
#SMInmunología #CongresoDeInmunología #Chihuahua2025
No olvides enviar tu trabajo al XXVI Congreso Nacional de Inmunología. Te queremos ver ahí 😉
🔗 Link en la bio
#SMInmunología #CongresoDeInmunología #Chihuahua2025
June 5, 2025 at 5:41 AM
🚨 ¡Recuerda, el próximo lunes 9 de junio es la fecha límite para el envío de resúmenes!
No olvides enviar tu trabajo al XXVI Congreso Nacional de Inmunología. Te queremos ver ahí 😉
🔗 Link en la bio
#SMInmunología #CongresoDeInmunología #Chihuahua2025
No olvides enviar tu trabajo al XXVI Congreso Nacional de Inmunología. Te queremos ver ahí 😉
🔗 Link en la bio
#SMInmunología #CongresoDeInmunología #Chihuahua2025
Cada vez más cerca. Nos vemos en el Congreso Nacional de Inmunología en Chihuahua! @sminmunologia.bsky.social
@marionbrunck.bsky.social @kempisla.bsky.social @eugecc.bsky.social
Y más...
@marionbrunck.bsky.social @kempisla.bsky.social @eugecc.bsky.social
Y más...
May 30, 2025 at 5:59 PM
Cada vez más cerca. Nos vemos en el Congreso Nacional de Inmunología en Chihuahua! @sminmunologia.bsky.social
@marionbrunck.bsky.social @kempisla.bsky.social @eugecc.bsky.social
Y más...
@marionbrunck.bsky.social @kempisla.bsky.social @eugecc.bsky.social
Y más...