Oliver Mueller-Cajar
@omc111.bsky.social
Cellular biochemistry of CO2 assimilation, NTU Singapore
Sign up for the inaugural Singapore Biosciences Symposium at SBS, NTU. We have an outstanding lineup of speakers at the intersection of plant biology and biomolecular condensates!
www.ntu.edu.sg/sbs/symposiu...
www.ntu.edu.sg/sbs/symposiu...
SBS 2025
www.ntu.edu.sg
October 3, 2025 at 2:43 AM
Sign up for the inaugural Singapore Biosciences Symposium at SBS, NTU. We have an outstanding lineup of speakers at the intersection of plant biology and biomolecular condensates!
www.ntu.edu.sg/sbs/symposiu...
www.ntu.edu.sg/sbs/symposiu...
Reposted by Oliver Mueller-Cajar
What limits rubisco function? Is it the chemical mechanism? Evolution? In this paper, @prywes.bsky.social et. al explore this question by assaying >99% of single amino acid mutants in Form II rubisco (1/7) doi.org/10.1038/s415...
January 24, 2025 at 8:27 PM
What limits rubisco function? Is it the chemical mechanism? Evolution? In this paper, @prywes.bsky.social et. al explore this question by assaying >99% of single amino acid mutants in Form II rubisco (1/7) doi.org/10.1038/s415...
Noam presents the most state of the art Rubisco search engine.. great to see this out!
Fun to see it out in print! I was really lucky to have an amazing team to work with on this. If this sort of work seems interesting to you or someone you know, please feel free to reach out (planning to staff a lab later this year).
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A map of the rubisco biochemical landscape - Nature
A massively parallel assay developed to map the essential photosynthetic enzyme rubisco showed that non-trivial biochemical changes and improvements in CO2 affinity are possible, signposting further e...
www.nature.com
January 23, 2025 at 12:08 PM
Noam presents the most state of the art Rubisco search engine.. great to see this out!
Wow, chloroplast base editing leads to faster Rubisco and more biomass in Arabidopsis! www.biorxiv.org/content/10.1...
Chloroplast genome editing of Rubisco boosts photosynthesis and plant growth
Photosynthetic inefficiencies limit the productivity and sustainability of crop production and the resilience of agriculture to future societal and environmental challenges. Ribulose-1,5-bisphosphate ...
www.biorxiv.org
January 4, 2025 at 9:50 AM
Wow, chloroplast base editing leads to faster Rubisco and more biomass in Arabidopsis! www.biorxiv.org/content/10.1...
Reposted by Oliver Mueller-Cajar
A great way to end the week - catching up with @omc111.bsky.social and Shawn Lum to discuss links between ANU and NTU, and ideas for how to extend thermal tolerance of photosynthesis. @ouranu.bsky.social
November 22, 2024 at 8:50 AM
A great way to end the week - catching up with @omc111.bsky.social and Shawn Lum to discuss links between ANU and NTU, and ideas for how to extend thermal tolerance of photosynthesis. @ouranu.bsky.social
Reposted by Oliver Mueller-Cajar
Beautiful study by Martin, Alistair, and crew on the membrane tubules that traverse the Chlamydomonas pyrenoid and help deliver a high concentration of #CO2 to Rubisco 🧪🌾
Nice work by @mjonikas.bsky.social impressive to see progress in reconstituting algal CO2 fixing organelle in plants with a build- to-learn approach #synbio one step closer! doi.org/10.1038/s414... @natureplants.bsky.social
SAGA1 and MITH1 produce matrix-traversing membranes in the CO2-fixing pyrenoid - Nature Plants
Two algal proteins, MITH1 and SAGA1, play key roles in formation of membranes that deliver CO2 to the pyrenoid, a CO2-concentrating organelle. Their discovery marks a key milestone towards engineering...
doi.org
November 19, 2024 at 1:22 PM
Beautiful study by Martin, Alistair, and crew on the membrane tubules that traverse the Chlamydomonas pyrenoid and help deliver a high concentration of #CO2 to Rubisco 🧪🌾
Reposted by Oliver Mueller-Cajar
New Letter: "Rubisco supplies pyruvate for the 2-C-methyl-d-erythritol-4-phosphate pathway" rdcu.be/dVZMj
Rubisco fixes CO2. Its lesser-known side job is supplying pyruvate in the chloroplast, an observation that solves a long-standing paradox of central metabolism. #PlantScience
Rubisco fixes CO2. Its lesser-known side job is supplying pyruvate in the chloroplast, an observation that solves a long-standing paradox of central metabolism. #PlantScience
October 4, 2024 at 10:19 AM
New Letter: "Rubisco supplies pyruvate for the 2-C-methyl-d-erythritol-4-phosphate pathway" rdcu.be/dVZMj
Rubisco fixes CO2. Its lesser-known side job is supplying pyruvate in the chloroplast, an observation that solves a long-standing paradox of central metabolism. #PlantScience
Rubisco fixes CO2. Its lesser-known side job is supplying pyruvate in the chloroplast, an observation that solves a long-standing paradox of central metabolism. #PlantScience
Reposted by Oliver Mueller-Cajar
November 18, 2024 at 9:04 AM
Reposted by Oliver Mueller-Cajar
Doing good science is 90% finding a science buddy to constantly talk to about the project.
November 9, 2024 at 10:53 PM
Doing good science is 90% finding a science buddy to constantly talk to about the project.
Reposted by Oliver Mueller-Cajar
BONUS! If IDPs are your jam, check out an ever-expanding starter pack!
go.bsky.app/J23B51L
go.bsky.app/J23B51L
November 10, 2024 at 7:38 PM
BONUS! If IDPs are your jam, check out an ever-expanding starter pack!
go.bsky.app/J23B51L
go.bsky.app/J23B51L
Reposted by Oliver Mueller-Cajar
Biomolecular condensate starter pack!
Trying to compile & to bring together biomolecular condensate enthusiasts & critics!
Please join this non-exhaustive (sorry!) collection & just ping me for addition.
#condensates, #phaseseparation, #granules, #IDPs
go.bsky.app/NFqmffa
Trying to compile & to bring together biomolecular condensate enthusiasts & critics!
Please join this non-exhaustive (sorry!) collection & just ping me for addition.
#condensates, #phaseseparation, #granules, #IDPs
go.bsky.app/NFqmffa
November 18, 2024 at 9:44 AM
Biomolecular condensate starter pack!
Trying to compile & to bring together biomolecular condensate enthusiasts & critics!
Please join this non-exhaustive (sorry!) collection & just ping me for addition.
#condensates, #phaseseparation, #granules, #IDPs
go.bsky.app/NFqmffa
Trying to compile & to bring together biomolecular condensate enthusiasts & critics!
Please join this non-exhaustive (sorry!) collection & just ping me for addition.
#condensates, #phaseseparation, #granules, #IDPs
go.bsky.app/NFqmffa
Reposted by Oliver Mueller-Cajar
I have a YouTube playlist (10 videos) for #MolecularBiology for my undergrad interns in the lab.
www.youtube.com/playlist?lis...
I usually have my interns watch these videos to get introduced to the basic concepts before I go show them how to in the lab.
www.youtube.com/playlist?lis...
I usually have my interns watch these videos to get introduced to the basic concepts before I go show them how to in the lab.
November 17, 2024 at 2:07 PM
I have a YouTube playlist (10 videos) for #MolecularBiology for my undergrad interns in the lab.
www.youtube.com/playlist?lis...
I usually have my interns watch these videos to get introduced to the basic concepts before I go show them how to in the lab.
www.youtube.com/playlist?lis...
I usually have my interns watch these videos to get introduced to the basic concepts before I go show them how to in the lab.
Nice, would be interesting to see whether RbcL is identical between clones or has diffused in sequence space given massive changes in CO2 concentration since the seed germinated..
Intriguing update on one of the oldest living organisms - the Pando aspen clone …
www.nature.com/articles/d41...
www.nature.com/articles/d41...
The world’s oldest tree? Genetic analysis traces evolution of iconic Pando forest
A vast colony of aspen clones could hold clues about how ancient organisms protect their genomes from harmful mutations.
www.nature.com
November 18, 2024 at 12:43 AM
Nice, would be interesting to see whether RbcL is identical between clones or has diffused in sequence space given massive changes in CO2 concentration since the seed germinated..
Reposted by Oliver Mueller-Cajar
I learned some stuff about Bluesky I did not know by reading this.
Maybe worth passing it on to others so we can all start getting the full benefit of the 🦋.
Maybe worth passing it on to others so we can all start getting the full benefit of the 🦋.
Here’s some cool stuff you can do with Bluesky
It’s not just an Alf pics repository.
www.theverge.com
November 17, 2024 at 8:55 AM
I learned some stuff about Bluesky I did not know by reading this.
Maybe worth passing it on to others so we can all start getting the full benefit of the 🦋.
Maybe worth passing it on to others so we can all start getting the full benefit of the 🦋.
Reposted by Oliver Mueller-Cajar
November 15, 2024 at 1:18 PM
Reposted by Oliver Mueller-Cajar
Here is a starter to a starter pack for the Aus plant science community. Let’s rebuild. #plantscience
Let me know if you want to be added. Help me find more.
go.bsky.app/AiLTKHH
Let me know if you want to be added. Help me find more.
go.bsky.app/AiLTKHH
November 15, 2024 at 10:21 PM
Here is a starter to a starter pack for the Aus plant science community. Let’s rebuild. #plantscience
Let me know if you want to be added. Help me find more.
go.bsky.app/AiLTKHH
Let me know if you want to be added. Help me find more.
go.bsky.app/AiLTKHH
Reposted by Oliver Mueller-Cajar
⚠️THREAD OF ALL SCIENCE-RELATED STARTER PACKS! ⚠️
🔄Share to help people finding its topic/field
- STRUCTURAL BIOLOGY
Structural Biology 1: bsky.app/starter-pack...
Structural Biology 2: bsky.app/starter-pack...
Crystallography: bsky.app/starter-pack...
Synchrotron&CryoEM: bsky.app/starter-pack...
🔄Share to help people finding its topic/field
- STRUCTURAL BIOLOGY
Structural Biology 1: bsky.app/starter-pack...
Structural Biology 2: bsky.app/starter-pack...
Crystallography: bsky.app/starter-pack...
Synchrotron&CryoEM: bsky.app/starter-pack...
November 17, 2024 at 6:48 PM
⚠️THREAD OF ALL SCIENCE-RELATED STARTER PACKS! ⚠️
🔄Share to help people finding its topic/field
- STRUCTURAL BIOLOGY
Structural Biology 1: bsky.app/starter-pack...
Structural Biology 2: bsky.app/starter-pack...
Crystallography: bsky.app/starter-pack...
Synchrotron&CryoEM: bsky.app/starter-pack...
🔄Share to help people finding its topic/field
- STRUCTURAL BIOLOGY
Structural Biology 1: bsky.app/starter-pack...
Structural Biology 2: bsky.app/starter-pack...
Crystallography: bsky.app/starter-pack...
Synchrotron&CryoEM: bsky.app/starter-pack...
I have a PhD scholarship available for a student to join my group at NTU Singapore in the January 2025 intake. The student will work on a project related to the cellular biochemistry of the diatom pyrenoid. Here is our first paper on the topic: www.pnas.org/doi/abs/10.1...
A linker protein from a red-type pyrenoid phase separates with Rubisco via oligomerizing sticker motifs | PNAS
The slow kinetics and poor substrate specificity of the key photosynthetic CO2-fixing
enzyme Rubisco have prompted the repeated evolution of Rubisc...
www.pnas.org
September 11, 2024 at 1:21 AM
I have a PhD scholarship available for a student to join my group at NTU Singapore in the January 2025 intake. The student will work on a project related to the cellular biochemistry of the diatom pyrenoid. Here is our first paper on the topic: www.pnas.org/doi/abs/10.1...
I love the periodic articles about chilly weather in Singapore. Some days we will have to deal with 23 degrees Celsius..
January 17, 2024 at 1:52 AM
I love the periodic articles about chilly weather in Singapore. Some days we will have to deal with 23 degrees Celsius..