Omar Kamileen
LightNews LightNews
banner
omarkamileen.bsky.social
Omar Kamileen
@omarkamileen.bsky.social
82 followers 270 following 18 posts
An impatient optimist. 🇩🇪🇱🇰
Posts Replies Media Videos
Reposted by Omar Kamileen
maddyseale.bsky.social
And now we have Arabidopsis plants with 8 chromosomes instead of 10 and no obvious phenotypic differences, this week in @science.org
#PlantScience
Paper here: www.science.org/doi/10.1126/...

Perspective here:
www.science.org/doi/10.1126/...
CRISPR-Cas–mediated heritable chromosome fusions in Arabidopsis
The genome of Arabidopsis thaliana consists of 10 chromosomes. By inducing CRISPR-Cas–mediated breaks at subcentromeric and subtelomeric sequences, we fused entire chromosome arms, obtaining two eight...
www.science.org
November 21, 2025 at 10:20 AM
Reposted by Omar Kamileen
natbiotech.nature.com
Multimodal learning enables chat-based exploration of single-cell data - @bocklab.bsky.social @cemm.oeaw.ac.at @meduniwien.ac.at go.nature.com/3WPGJnW
Multimodal learning enables chat-based exploration of single-cell data - Nature Biotechnology
CellWhisperer uses multimodal learning of transcriptomes and text to answer questions about single-cell RNA-sequencing data.
go.nature.com
November 11, 2025 at 4:58 PM
Reposted by Omar Kamileen
plantenzo.bsky.social
Tension, suspense, or narrative arc in a story is the stuff that keeps the reader going. But how do you introduce suspense in a scientific article? That is what my latest post is all about.
aboutacademicwritingandzo.substack.com/p/how-to-wri...

#AcademicWriting #WritingTips #NarrativeArc #Suspense
How to write your paper like a page turner
Working my way through scientific articles I often lose my focus.
aboutacademicwritingandzo.substack.com
November 6, 2025 at 1:22 PM
omarkamileen.bsky.social
www.nature.com/articles/s41... Really fabulous work! Animal pigments engineered in bacteria.
Growth-coupled microbial biosynthesis of the animal pigment xanthommatin - Nature Biotechnology
A growth-coupled biosynthetic pathway enables xathommatin synthesis in the soil bacterium Pseudomonas putida.
www.nature.com
November 3, 2025 at 10:09 PM
Reposted by Omar Kamileen
natbiotech.nature.com
Agrobacterium-mediated transformation of plants and fungi is enhanced by plasmid copy number variants go.nature.com/3CdewQS
rdcu.be/eNaje
Binary vector copy number engineering improves Agrobacterium-mediated transformation - Nature Biotechnology
Agrobacterium-mediated transformation of plants and fungi is enhanced by plasmid copy number variants.
go.nature.com
October 31, 2025 at 3:04 AM
Reposted by Omar Kamileen
mykang.bsky.social
Excited to see our paper online! We combined scMS and scRNA-seq from the same plant cells 🌱 — a step toward true single-cell multi-omics in plants.
Overview 👇
October 27, 2025 at 6:32 PM
Reposted by Omar Kamileen
yokoyama-ryo.bsky.social
Discovery and engineering of the biosynthesis of rotenoids www.nature.com/articles/s44... @natsynth.nature.com
Discovery and engineering of the biosynthesis of rotenoids - Nature Synthesis
Rotenoids are natural insecticides from Fabaceae plants. Here the complete biosynthetic pathway to make rotenoids is elucidated in Amorpha fruticosa and Tephrosia vogelii, revealing a unique Fe(II)-de...
www.nature.com
October 21, 2025 at 8:41 PM
Reposted by Omar Kamileen
maitecolinas.bsky.social
Very exciting to finally see our iridoid cyclase ICYC online @natplants.nature.com!
A joined effort with Robin Buell’s lab with Josh Wood generating snRNA-seq, and my student Chloée Tymen performing the initial experiment.
#natprod
#PlantScience
@mpi-ce.bsky.social
www.nature.com/articles/s41...
Discovery of iridoid cyclase completes the iridoid pathway in asterids - Nature Plants
Iridoids are terpenoid metabolites found in thousands of plants. Using single-cell transcriptomics, the authors discovered an unexpected enzyme that has been neofunctionalized to catalyse the cyclization required to form the iridoid scaffold.
www.nature.com
October 3, 2025 at 9:39 AM
Reposted by Omar Kamileen
hiroshi-maeda.bsky.social
Our new study in Nature Plants maps how "multi-tasking" enzymes in plants transfer nitrogen, a key step toward improving crop N use efficiency. 🌱

Big thanks to our collaborators from Max Planck, Hokkaido Univ, & MSU, and for support from @NSF and @DOE.

Learn more: rdcu.be/eFOFN

#PlantMetabolism
Mapping multi-substrate specificity of Arabidopsis aminotransferases
Nature Plants - Systematic characterization of Arabidopsis aminotransferase family enzymes uncovered many previously unrecognized activities and revealed their multi-substrate specificity, aspects...
rdcu.be
September 12, 2025 at 11:40 AM
Reposted by Omar Kamileen
sattelylab.bsky.social
Beautiful work by Yaereen and former lab member Kevin! Learn more about the anti-cancer compound homoharringtonine and its'biosynthesis in plants here 🌿https://www.biorxiv.org/content/10.1101/2025.08.26.672243v1
Discovery of homoharringtonine pathway enzymes reveals a whole plant model for coordinated biosynthesis
Plants have evolved to produce diverse molecules that inhibit protein translation. A lead example is homoharringtonine (HHT), both a key tool for ribosomal profiling and an FDA-approved treatment for ...
www.biorxiv.org
September 2, 2025 at 10:13 PM
Reposted by Omar Kamileen
yokoyama-ryo.bsky.social
The multilayered regulation of aromatic amino acid biosynthesis in plants: Trends in Biochemical Sciences www.cell.com/trends/bioch...
The multilayered regulation of aromatic amino acid biosynthesis in plants
The shikimate and aromatic amino acid (AAA) biosynthetic pathways are crucial for the production of L-phenylalanine (Phe), L-tyrosine (Tyr), and L-tryptophan (Trp), as well as vitamins, hormones, and ...
www.cell.com
August 28, 2025 at 12:20 AM
Reposted by Omar Kamileen
itaiyanai.bsky.social
Discovery happens less when you're trying to be the expert and more when you're trying to be the learner.
August 27, 2025 at 3:24 AM
Reposted by Omar Kamileen
yokoyama-ryo.bsky.social
Protein Structural Phylogenetics academic.oup.com/gbe/article/...
Protein Structural Phylogenetics
Abstract. Protein structural phylogenetics is an interdisciplinary branch of molecular evolution that (i) uses 3D structural data to trace evolutionary his
academic.oup.com
August 26, 2025 at 4:33 PM
Reposted by Omar Kamileen
mmzdouc.bsky.social
Into natural product biosynthesis & tailoring enzymes? Frustrated by the lack of a dedicated resource to explore their functions? Tired of endless literature searches for reaction info? Meet the MITE database, freely available at mite.bioinformatics.nl. Preprint: doi.org/10.26434/che... (1/8)
August 21, 2025 at 10:52 AM
Reposted by Omar Kamileen
natbiotech.nature.com
Inspired by natural molecular glues, drug hunters are chasing protein–protein interactions with next-gen small molecules tuned for enhanced tissue specificity and reduced toxicity www.nature.com/articles/s41...
rdcu.be/eAC91
Natural molecular glues spur next-gen small molecules for ‘undruggable’ targets - Nature Biotechnology
Inspired by natural molecular glues, drug hunters are chasing protein–protein interactions with next-gen small molecules tuned for enhanced tissue specificity and reduced toxicity.
www.nature.com
August 13, 2025 at 6:27 PM
Reposted by Omar Kamileen
sattelylab.bsky.social
Couldn't have said it better! Great job @taralowensohn.bsky.social, Will, and Chun! Special thanks to the Gao lab at @stanford.edu #singlecell #plantbiology
cmcclune.bsky.social Conor McClune @cmcclune.bsky.social · Aug 7
A truly enabling new approach by @taralowensohn.bsky.social Will Cody and @sattelylab.bsky.social to probe plant genetics at scale.

Single-gene-per-cell delivery coupled to an effective transcriptional selection system

www.biorxiv.org/content/10.1...
August 7, 2025 at 10:37 PM
Reposted by Omar Kamileen
cmcclune.bsky.social
A truly enabling new approach by @taralowensohn.bsky.social Will Cody and @sattelylab.bsky.social to probe plant genetics at scale.

Single-gene-per-cell delivery coupled to an effective transcriptional selection system

www.biorxiv.org/content/10.1...
August 7, 2025 at 8:51 PM
Reposted by Omar Kamileen
maitecolinas.bsky.social
Ingenane biosynthesis enzymes in @newphyt.bsky.social by @matildeflorean.bsky.social, @carstenschotte.bsky.social from @oconnorlab.bsky.social @mpi-ce.bsky.social in collaboration with Ian Graham lab members.
#natprod
#PlantScience

doi.org/10.1111/nph....
Identification of BAHD‐acyltransferase enzymes involved in ingenane diterpenoid biosynthesis
The plant family Euphorbiaceae is an abundant source of structurally complex diterpenoids, many of which have reported anticancer, anti-HIV, and anti-inflammatory activities. Among these, ingenol-3-...
doi.org
July 21, 2025 at 1:38 PM
Reposted by Omar Kamileen
natchembio.nature.com
Here, the authors @oconnorlab.bsky.social @mpi-ce.bsky.social uncover the mechanism of epimerization behind uncommon 3R-containing alkaloids in Mitragyna speciosa (Kratom) and study their inclusion in downstream biosynthesis #PlantScience #natprod

www.nature.com/articles/s41...
Enzymatic epimerization of monoterpene indole alkaloids in kratom - Nature Chemical Biology
Monoterpene indole alkaloids are formed via a 3S stereoselective condensation between secologanin and tryptamine. Here the authors uncover the mechanism of epimerization behind uncommon 3R-containing ...
www.nature.com
July 16, 2025 at 7:19 PM
Reposted by Omar Kamileen
laura-gunn.bsky.social
SynBio: it’s what plants crave
doi.org/10.1093/jxb/...
J Exp Bot Insights article from *Dan Hong Loh* - she discusses the impacts of Rubisco SynBio tool expansions from Archer et al. 2025 (doi.org/10.1093/jxb/...).
A SynBio explosion: a whole new world for Rubisco engineering
This article comments on:Archer J, Kathpalia M, Lee B, Li S, Wang T. 2025. Effects of chaperone selectivity on the assembly of plant Rubisco orthologs in E
doi.org
July 3, 2025 at 5:05 PM
Reposted by Omar Kamileen
elife.bsky.social
Heron is a new intuitive software tool that helps researchers design complex experiments even if they don’t have in-depth technical expertise.
🔗
Streamlining experimental setups
A new software tool called Heron helps researchers to design and run complex experimental systems without needing in-depth technical expertise.
buff.ly
July 17, 2025 at 10:28 PM
Reposted by Omar Kamileen
cp-trendsplantsci.bsky.social
July Issue. Read FREE: Sequencing historical RNA: unrealized potential to increase understanding of the plant tree of life (see cover); Decoding the evolution of C4 photosynthesis; Transcellular regulation of ETI-induced cell death; & much more
www.cell.com/trends/plant...
#plantscience
July 14, 2025 at 7:09 PM
Reposted by Omar Kamileen
ewingt-phd.bsky.social
Researchers @emoryuniversity.bsky.social observe #longevity benefit of #psilocybin #psychedelic mushroom

news.emory.edu/stories/2025...

— extended human skin & lung cell lifespan by 50%
— increase aged mice survival by 30%
— reduces oxidative stress
— improves DNA repair

🧪 #health #science #aging
Psilocybin delays aging, extends lifespan, new Emory study suggests | Emory University | Atlanta GA
Emory University researchers identified that psilocin, a byproduct of consuming psilocybin, the active ingredient in psychedelic mushrooms, actively delays aging in cells and organisms.
news.emory.edu
July 12, 2025 at 8:18 PM
Reposted by Omar Kamileen
addgene.bsky.social
Want to become a cloning wizard? 🪄
Our latest blog post is packed with hands-on tips for mastering Modular Cloning — advice on how to prepare for the process, handle reagents, high-throughput methods, and more.
Start your MoClo quest here:
https://twp.ai/4io9Rn
blog.addgene.org
Tips and Tricks for Using Golden Gate Modular Cloning (MoClo)
twp.ai
July 8, 2025 at 2:05 PM
Reposted by Omar Kamileen
pammarrone.bsky.social
Yes when I was on the board of @cornelluniversity.bsky.social the women profs told us exactly this..and even moreso for the minority profs: minority students flocked to them as role models to ask for mentoring and advice, taking time away from the Prof's own research #womeninscience #womeninstem
amydiehl.bsky.social Amy Diehl, Ph.D. @amydiehl.bsky.social · Jul 7
In a study of professors, women got 378 new work requests over 4 weeks vs 118 for men. Women spent more time on service, advising & teaching; men on research. Orgs should track who is taking extra duties & ensure they are rewarded and distributed fairly. www.forbes.com/sites/kimels...
Being Too Helpful At Work Can Hurt Your Career—Here’s How To Say No
Women are more likely to take on behind-the-scenes duties at work—extra tasks like onboarding or event planning—and it's hurting their careers. Here's how to say no.
www.forbes.com
July 7, 2025 at 8:09 PM