Shuqi Li
@ninjainnnnnbos.bsky.social
Mtb enthusiast, Host-pathogen researcher at BWH. ex-New Yorker, Bostonian becoming
🇨🇳🇺🇸🌈
🇨🇳🇺🇸🌈
Reposted by Shuqi Li
We’re excited to share our latest study that reshapes our understanding of Mycobacterium tuberculosis (Mtb) lipid composition, with major implications for drug discovery, immunity, and vaccine development.
www.nature.com/articles/s41...
A thread.
www.nature.com/articles/s41...
A thread.
Mycobacterium tuberculosis overcomes phosphate starvation by extensively remodelling its lipidome with phosphorus-free lipids - Nature Communications
Here, the authors show that Mycobacterium tuberculosis manipulates lipid metabolism to overcome host restriction, by remodelling its lipidome and utilising host lipids as an alternative phosphate sour...
www.nature.com
December 22, 2025 at 1:11 PM
We’re excited to share our latest study that reshapes our understanding of Mycobacterium tuberculosis (Mtb) lipid composition, with major implications for drug discovery, immunity, and vaccine development.
www.nature.com/articles/s41...
A thread.
www.nature.com/articles/s41...
A thread.
CONGRATS to all for this fantastic work!
Does this create an Achilles’ heel, and can you drug it? Turns out: yes.
Congrats to Barbara, Vanisha, Liz, and the rest of the team.
www.nature.com/articles/s41...
Congrats to Barbara, Vanisha, Liz, and the rest of the team.
www.nature.com/articles/s41...
Transcription co-inhibition alters drug resistance evolution and enhances Mycobacterium tuberculosis clearance from granulomas - Nature Microbiology
Targeting two distinct steps of the transcription process yields synergistic antibiotics that kill non-replicating Mycobacterium tuberculosis and reduce drug resistance.
www.nature.com
December 3, 2025 at 12:22 PM
CONGRATS to all for this fantastic work!
Reposted by Shuqi Li
Excellent piece by @julieparsonnet.bsky.social on infectious diseases as root causes of a number of chronic human diseases; pausing research on bacterial and viral infections will limit efforts to cure neurodegeneration, autoimmune, metabolic disease as well as cancer
substack.com/inbox/post/1...
substack.com/inbox/post/1...
Infections cause everything
Another reason why RFK Jrs. MAHA plan is misguided
substack.com
May 30, 2025 at 4:29 PM
Excellent piece by @julieparsonnet.bsky.social on infectious diseases as root causes of a number of chronic human diseases; pausing research on bacterial and viral infections will limit efforts to cure neurodegeneration, autoimmune, metabolic disease as well as cancer
substack.com/inbox/post/1...
substack.com/inbox/post/1...
Reposted by Shuqi Li
Great minds… within 24 hrs both us at @nature.com and @science.org make similar appeals to the research community. And @holdenthorp.bsky.social and I didn’t even exchange notes about it ;-)
🧪
www.nature.com/articles/d41...
www.science.org/doi/10.1126/...
🧪
www.nature.com/articles/d41...
www.science.org/doi/10.1126/...
Come together, right now
The chaos, conflicting information, firings, and hurtful rhetoric of the Trump administration’s approach to science over the past month are causing anxiety, grief, and concern for the scientific commu...
www.science.org
February 25, 2025 at 7:51 PM
Great minds… within 24 hrs both us at @nature.com and @science.org make similar appeals to the research community. And @holdenthorp.bsky.social and I didn’t even exchange notes about it ;-)
🧪
www.nature.com/articles/d41...
www.science.org/doi/10.1126/...
🧪
www.nature.com/articles/d41...
www.science.org/doi/10.1126/...
Reposted by Shuqi Li
On changes to #NIH indirect rates, there is a law in place that prohibits NIH from making such changes without the approval of Congress. See Division D, Title II Section 224 of The Further Consolidated Appropriations Act, 2024 (Public Law No: 118-47) grants.nih.gov/grants/guide...
NOT-OD-24-110: Notice of Legislative Mandates in Effect for FY 2024
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Notice of Legislative Mandates in Effect for FY 2024 NOT-OD-24-110. NIH
grants.nih.gov
February 8, 2025 at 12:56 AM
On changes to #NIH indirect rates, there is a law in place that prohibits NIH from making such changes without the approval of Congress. See Division D, Title II Section 224 of The Further Consolidated Appropriations Act, 2024 (Public Law No: 118-47) grants.nih.gov/grants/guide...