Nieves Peltzer
@nievespeltzer.bsky.social
Professor at University of Stuttgart, IBMG
Head of Genome Editing Department
Associated PI at University of Cologne, CMMC and CECAD
I’m interested in non-degradative #ubiquitination, #celldeath and #inflammation in metabolism and cancer
Head of Genome Editing Department
Associated PI at University of Cologne, CMMC and CECAD
I’m interested in non-degradative #ubiquitination, #celldeath and #inflammation in metabolism and cancer
Reposted by Nieves Peltzer
Don't forget to register for our #UbiquitinFunction meeting next July in Portugal! ☀️
Submit your abstract today to join our incredible speaker line up so far.
For more information: bit.ly/43amkx9
#FusionCellBio
Submit your abstract today to join our incredible speaker line up so far.
For more information: bit.ly/43amkx9
#FusionCellBio
October 12, 2025 at 1:11 PM
Don't forget to register for our #UbiquitinFunction meeting next July in Portugal! ☀️
Submit your abstract today to join our incredible speaker line up so far.
For more information: bit.ly/43amkx9
#FusionCellBio
Submit your abstract today to join our incredible speaker line up so far.
For more information: bit.ly/43amkx9
#FusionCellBio
Great conversations with wonderful @stefaniembader.bsky.social at @unistuttgart.bsky.social For a future of great science ahead!
June 12, 2025 at 11:59 AM
Great conversations with wonderful @stefaniembader.bsky.social at @unistuttgart.bsky.social For a future of great science ahead!
When in the presence of genius, just swing it. One of the most inspiring keynote speakers of all times @urialonlab.bsky.social. Thank you for the great discussions! @unistuttgart.bsky.social
June 4, 2025 at 1:13 PM
When in the presence of genius, just swing it. One of the most inspiring keynote speakers of all times @urialonlab.bsky.social. Thank you for the great discussions! @unistuttgart.bsky.social
Amazing day of science during the #SRCSB day at @unistuttgart.bsky.social closing with the #ErnstDieterGillesAward to the one and only Uri Alon @urialonlab.bsky.social for his pioneering and outstanding contributions to #systembiology and #systemsmedicine fields
June 4, 2025 at 1:07 PM
Amazing day of science during the #SRCSB day at @unistuttgart.bsky.social closing with the #ErnstDieterGillesAward to the one and only Uri Alon @urialonlab.bsky.social for his pioneering and outstanding contributions to #systembiology and #systemsmedicine fields
Outstanding paper where scientists discover Mlkl isoforms that differently regulate necroptosis and a drugable target against the necroptotic activity of Mlkl. Congratulations Uris Ros, Ana Garcia Sáez and everyone involved
#necroptosis
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
#necroptosis
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
ScienceDirect.com | Science, health and medical journals, full text articles and books.
kwnsfk27.r.eu-west-1.awstrack.me
April 15, 2025 at 4:37 AM
Outstanding paper where scientists discover Mlkl isoforms that differently regulate necroptosis and a drugable target against the necroptotic activity of Mlkl. Congratulations Uris Ros, Ana Garcia Sáez and everyone involved
#necroptosis
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
#necroptosis
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
Thank you @unistuttgart.bsky.social and for the audience for the believing in our concept #theinteractiverotunda for #glowupourcampus
March 19, 2025 at 7:41 PM
Thank you @unistuttgart.bsky.social and for the audience for the believing in our concept #theinteractiverotunda for #glowupourcampus
March 19, 2025 at 12:41 PM
Reposted by Nieves Peltzer
I'm super excited to share our study in collaboration with @jnpruneda.bsky.social, published today in @embojournal.org! We show that PARPs are modified with a non-canonical ester-linked mono-ADP-ribosylated ubiquitin species for the first time in cells: www.embopress.org/doi/full/10....
Ubiquitin is directly linked via an ester to protein-conjugated mono-ADP-ribose | The EMBO Journal
imageimageCertain E3 ligases have been found to ubiquitylate hydroxyl groups on free NAD+ and
ADP-ribose in vitro, but the in vivo occurrence of this dual post-translational modification
has remained ...
www.embopress.org
February 25, 2025 at 5:52 PM
I'm super excited to share our study in collaboration with @jnpruneda.bsky.social, published today in @embojournal.org! We show that PARPs are modified with a non-canonical ester-linked mono-ADP-ribosylated ubiquitin species for the first time in cells: www.embopress.org/doi/full/10....
Reposted by Nieves Peltzer
Our work on K63-polyubiquitin in membrane trafficking is out! Check out how we use a high affinity and specific sensor for K63-polyUb to identify K63-polyubiquitylated plasma membrane proteins in clusters of vesicles containing ATG9A.
Link: www.molbiolcell.org/doi/10.1091/...
Link: www.molbiolcell.org/doi/10.1091/...
Trafficking of K63-polyubiquitin modified membrane proteins in a macroautophagy-independent pathway is linked to ATG9A | Molecular Biology of the Cell
Cytoplasmic K63-linked polyubiquitin signals have well-established roles in endocytosis and selective autophagy. However, how these signals help to direct different cargos to different intracellular t...
www.molbiolcell.org
February 24, 2025 at 6:48 AM
Our work on K63-polyubiquitin in membrane trafficking is out! Check out how we use a high affinity and specific sensor for K63-polyUb to identify K63-polyubiquitylated plasma membrane proteins in clusters of vesicles containing ATG9A.
Link: www.molbiolcell.org/doi/10.1091/...
Link: www.molbiolcell.org/doi/10.1091/...
So cool! Thanks!
Excited to share our latest preprint on @biorxivpreprint.bsky.social: "The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-protein substrates in vitro".
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-protein substrates in vitro
HOIL-1 is a RING-between-RING (RBR)-family E3 ubiquitin ligase and component of the linear ubiquitin chain assembly complex (LUBAC). While most E3 ubiquitin ligases conjugate ubiquitin to protein lysi...
www.biorxiv.org
December 5, 2024 at 9:54 AM
So cool! Thanks!
Extremely happy for the second successful PhD in my lab. Dr. Veli congratulations for a fantastic PhD and for the wonderful scientist you became. Proud of you!
@cecad.bsky.social
@cecad.bsky.social
December 5, 2024 at 9:15 AM
Extremely happy for the second successful PhD in my lab. Dr. Veli congratulations for a fantastic PhD and for the wonderful scientist you became. Proud of you!
@cecad.bsky.social
@cecad.bsky.social
Beautiful work on NF-kB-driven inflammation in muscle driving cancer cachexia
November 26, 2024 at 6:35 PM
Beautiful work on NF-kB-driven inflammation in muscle driving cancer cachexia
Let's be the stone!
#womeninscience
#womeninscience
Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️
So how can we ever achieve #gender #equality?
We discuss various strategies in this #Cell Commentary
#WomeninSTEM
www.cell.com/cell/fulltex...
🧵 1/
So how can we ever achieve #gender #equality?
We discuss various strategies in this #Cell Commentary
#WomeninSTEM
www.cell.com/cell/fulltex...
🧵 1/
November 26, 2024 at 4:18 PM
Let's be the stone!
#womeninscience
#womeninscience
Interesting read of the weekend
posting here since bsky is taking off!
nature.com/articles/s41586-024-08146-w Congratulations to my good friend @keunwooryu.bsky.social and the Craig Thompson lab on uncovering metabolically distinct mitochondrial subpopulations. Really cool cell biology Keun!!
nature.com/articles/s41586-024-08146-w Congratulations to my good friend @keunwooryu.bsky.social and the Craig Thompson lab on uncovering metabolically distinct mitochondrial subpopulations. Really cool cell biology Keun!!
Cellular ATP demand creates metabolically distinct subpopulations of mitochondria - Nature
Mitochondria are able to maintain two competing metabolic pathways—oxidative phosphorylation and the reductive synthesis of proline and ornithine—by generating two mitochondrial subpopulations that ar...
nature.com
November 23, 2024 at 7:36 AM
Interesting read of the weekend
How did I miss this? Great study by @elodie-lafont.bsky.social team on the regulation of CD95-mediated cell death by UPR
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
IRE1 RNase controls CD95-mediated cell death | EMBO reports
imageimageDual regulation of Cell Death Receptor CD95 signalling by ER stress sensor IRE1. IRE1,
a mediator of the unfolded protein response (UPR), governs CD95/Fas expression and
CD95L-induced cell d...
www.embopress.org
November 21, 2024 at 11:04 PM
How did I miss this? Great study by @elodie-lafont.bsky.social team on the regulation of CD95-mediated cell death by UPR
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Reposted by Nieves Peltzer
Reposted by Nieves Peltzer
Let’s start the week an updated starter pack for ubiquitin and Ubl signalling, biology, and mechanisms. More than 40 profiles to follow.
go.bsky.app/3VPQofn
go.bsky.app/3VPQofn
November 18, 2024 at 9:37 AM
Let’s start the week an updated starter pack for ubiquitin and Ubl signalling, biology, and mechanisms. More than 40 profiles to follow.
go.bsky.app/3VPQofn
go.bsky.app/3VPQofn