Neil McCarthy
@neilemccarthy.bsky.social
Senior Lecturer in Mucosal Immunology at The Blizard Institute QMUL. Studying human gut γδ T-cell function in health and IBD.
Pinned
Neil McCarthy
@neilemccarthy.bsky.social
· Sep 21
Bacterial suppression of intestinal fungi via activation of human gut γδ T-cells
Gut symbionts condition mucosal immunity to resist infection by enteropathogens, but the specific microbes and mechanisms involved differ significantly between host species. In higher primates, bacter...
www.biorxiv.org
📚 NEW #gdT-cell PAPER from our team @QMUL.bsky.social! 🥳 'Bacterial suppression of intestinal fungi via activation of human gut γδ T-cells' out now on @biorxiv-immuno
www.biorxiv.org/content/10.1... Here's my first attempt at a 'Bluetorial'... 🧵 1/10 #gastrosky #IBDsky
www.biorxiv.org/content/10.1... Here's my first attempt at a 'Bluetorial'... 🧵 1/10 #gastrosky #IBDsky
Reposted by Neil McCarthy
A decade ago, research said giving young children peanut products can prevent allergies. A new study says that, 10 years later, tens of thousands of U.S. children have avoided allergies as a result. n.pr/4o3hKJO
Reversing peanut advice prevented tens of thousands of allergy cases, researchers say
A decade ago, research said giving young children peanut products can prevent allergies. A new study says that, 10 years later, tens of thousands of U.S. children have avoided allergies as a result.
n.pr
October 21, 2025 at 8:06 PM
A decade ago, research said giving young children peanut products can prevent allergies. A new study says that, 10 years later, tens of thousands of U.S. children have avoided allergies as a result. n.pr/4o3hKJO
Reposted by Neil McCarthy
'All three awards (...) honored achievements rooted in fundamental research from decades ago. Some experts interpret the selections by the Royal Swedish Academy of Sciences as representing the importance of slow, basic science, work pursued out of a desire to better understand the world.'
Nobel Prizes This Year Offer Three Cheers for Slow Science
www.nytimes.com
October 10, 2025 at 6:49 AM
'All three awards (...) honored achievements rooted in fundamental research from decades ago. Some experts interpret the selections by the Royal Swedish Academy of Sciences as representing the importance of slow, basic science, work pursued out of a desire to better understand the world.'
📚 NEW #gdT-cell PAPER from our team @QMUL.bsky.social! 🥳 'Bacterial suppression of intestinal fungi via activation of human gut γδ T-cells' out now on @biorxiv-immuno
www.biorxiv.org/content/10.1... Here's my first attempt at a 'Bluetorial'... 🧵 1/10 #gastrosky #IBDsky
www.biorxiv.org/content/10.1... Here's my first attempt at a 'Bluetorial'... 🧵 1/10 #gastrosky #IBDsky
Bacterial suppression of intestinal fungi via activation of human gut γδ T-cells
Gut symbionts condition mucosal immunity to resist infection by enteropathogens, but the specific microbes and mechanisms involved differ significantly between host species. In higher primates, bacter...
www.biorxiv.org
September 21, 2025 at 6:58 PM
📚 NEW #gdT-cell PAPER from our team @QMUL.bsky.social! 🥳 'Bacterial suppression of intestinal fungi via activation of human gut γδ T-cells' out now on @biorxiv-immuno
www.biorxiv.org/content/10.1... Here's my first attempt at a 'Bluetorial'... 🧵 1/10 #gastrosky #IBDsky
www.biorxiv.org/content/10.1... Here's my first attempt at a 'Bluetorial'... 🧵 1/10 #gastrosky #IBDsky
Reposted by Neil McCarthy
📚NEW #gdTcell PAPER ALERT! 'Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling' is now out in @mucosalimmunol.bsky.social! #gastrosky #GIsky #IBDsky Join us for a Bluetorial 🧵...
Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling
Intraepithelial lymphocytes expressing the γδ T cell receptor (γδ IEL) provide continuous surveillance of the intestinal epithelium. We report that mi…
www.sciencedirect.com
August 7, 2025 at 9:36 PM
📚NEW #gdTcell PAPER ALERT! 'Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling' is now out in @mucosalimmunol.bsky.social! #gastrosky #GIsky #IBDsky Join us for a Bluetorial 🧵...
Reposted by Neil McCarthy
Bacterial suppression of intestinal fungi via activation of human gut γδ T-cells https://www.biorxiv.org/content/10.1101/2025.09.17.676560v1
September 20, 2025 at 4:16 PM
Bacterial suppression of intestinal fungi via activation of human gut γδ T-cells https://www.biorxiv.org/content/10.1101/2025.09.17.676560v1
Reposted by Neil McCarthy
The “publish or perish” culture in academia creates its own kind of evolutionary pressure.
A scholar who studies human behavior through a cultural evolutionary lens explains how the relentless drive to publish can shape – and sometimes undermine – the quality of research.
buff.ly/SqnFR4g
A scholar who studies human behavior through a cultural evolutionary lens explains how the relentless drive to publish can shape – and sometimes undermine – the quality of research.
buff.ly/SqnFR4g
‘Publish or perish’ evolutionary pressures shape scientific publishing, for better and worse
Scientists write papers to share their results – and gain prestige and advance their careers. In this competitive field, selection can favor AI-written papers, citation cartels, paper mills and more.
buff.ly
September 14, 2025 at 6:48 PM
The “publish or perish” culture in academia creates its own kind of evolutionary pressure.
A scholar who studies human behavior through a cultural evolutionary lens explains how the relentless drive to publish can shape – and sometimes undermine – the quality of research.
buff.ly/SqnFR4g
A scholar who studies human behavior through a cultural evolutionary lens explains how the relentless drive to publish can shape – and sometimes undermine – the quality of research.
buff.ly/SqnFR4g
Reposted by Neil McCarthy
What happens to US public health without a fully functioning CDC? Americans will get a taste this upcoming cold and flu season.
How RFK Jr. Is Pushing the CDC to the Brink
A small but vocal contingent has long been demanding changes at the agency. With an ally in RFK Jr., it’s finally getting what it wants—to the horror of the scientists he’s sidelined.
bloom.bg
September 11, 2025 at 12:30 PM
What happens to US public health without a fully functioning CDC? Americans will get a taste this upcoming cold and flu season.
Reposted by Neil McCarthy
The perfect end to a great #gammadeltatoronto conference: our latest review has just been published in Advances in Immunology!
"Modulation of humoral immunity by γδ T cells: A potential adjuvant strategy for vaccination"
👉🏼 authors.elsevier.com/a/1l8ltErwXf...
#gdTcells @forum-gd.bsky.social
"Modulation of humoral immunity by γδ T cells: A potential adjuvant strategy for vaccination"
👉🏼 authors.elsevier.com/a/1l8ltErwXf...
#gdTcells @forum-gd.bsky.social
May 23, 2025 at 8:37 PM
The perfect end to a great #gammadeltatoronto conference: our latest review has just been published in Advances in Immunology!
"Modulation of humoral immunity by γδ T cells: A potential adjuvant strategy for vaccination"
👉🏼 authors.elsevier.com/a/1l8ltErwXf...
#gdTcells @forum-gd.bsky.social
"Modulation of humoral immunity by γδ T cells: A potential adjuvant strategy for vaccination"
👉🏼 authors.elsevier.com/a/1l8ltErwXf...
#gdTcells @forum-gd.bsky.social
Reposted by Neil McCarthy
🎉huge congratulations to Jake Samuel for passing his PhD viva with flying colours today! Big thanks to the examiners
@neilemccarthy.bsky.social and @nickbrooks22.bsky.social 🥳 and @cesiboy.bsky.social for Co-supervision! Looking forward to Dr Samuel’s gut-lymphatics-on-a-chip papers next! 🚀
@neilemccarthy.bsky.social and @nickbrooks22.bsky.social 🥳 and @cesiboy.bsky.social for Co-supervision! Looking forward to Dr Samuel’s gut-lymphatics-on-a-chip papers next! 🚀
March 28, 2025 at 3:58 PM
🎉huge congratulations to Jake Samuel for passing his PhD viva with flying colours today! Big thanks to the examiners
@neilemccarthy.bsky.social and @nickbrooks22.bsky.social 🥳 and @cesiboy.bsky.social for Co-supervision! Looking forward to Dr Samuel’s gut-lymphatics-on-a-chip papers next! 🚀
@neilemccarthy.bsky.social and @nickbrooks22.bsky.social 🥳 and @cesiboy.bsky.social for Co-supervision! Looking forward to Dr Samuel’s gut-lymphatics-on-a-chip papers next! 🚀
Reposted by Neil McCarthy
#Bluetorial: In our latest paper on #gdTcells and #IBD in #ScienceImmunology we found that γδ IEL number and regulatory function are severely compromised BEFORE ileal inflammation occurs, suggesting that γδ IELs may maintain IEL homeostasis in response to a pro-inflammatory microenvironment. 1/n
two men are riding a bicycle with a basket on it .
ALT: two men are riding a bicycle with a basket on it .
media.tenor.com
March 22, 2025 at 8:05 PM
#Bluetorial: In our latest paper on #gdTcells and #IBD in #ScienceImmunology we found that γδ IEL number and regulatory function are severely compromised BEFORE ileal inflammation occurs, suggesting that γδ IELs may maintain IEL homeostasis in response to a pro-inflammatory microenvironment. 1/n
Reposted by Neil McCarthy
In keeping with his decades-long crusade against vaccines, Robert F. Kennedy, Jr., initially downplayed the West Texas measles outbreak. Now he’s found himself tasked with the job of doing something about it.
The Dangers of R.F.K. Jr.’s Measles Response
The H.H.S. Secretary has touted over-the-counter remedies and stressed that the decision to vaccinate is “personal.”
www.newyorker.com
March 8, 2025 at 3:51 PM
In keeping with his decades-long crusade against vaccines, Robert F. Kennedy, Jr., initially downplayed the West Texas measles outbreak. Now he’s found himself tasked with the job of doing something about it.
Reposted by Neil McCarthy
As bird flu cases inundate more poultry and dairy farms, state officials worry that the Trump administration’s firings of federal scientists and other actions will undermine efforts to track the virus and protect Americans, reports @nhassanein.bsky.social.
As bird flu spreads, feds might undercut states by firing scientists, removing data
buff.ly
February 27, 2025 at 5:10 PM
As bird flu cases inundate more poultry and dairy farms, state officials worry that the Trump administration’s firings of federal scientists and other actions will undermine efforts to track the virus and protect Americans, reports @nhassanein.bsky.social.
Reposted by Neil McCarthy
An unvaccinated, school-age child has died in West Texas. It's the first known death from an outbreak that's infected more than 120 people.
First measles death reported in the West Texas outbreak is school-aged child | CNN
The first measles death in the growing outbreak in West Texas was a school-aged child.
www.cnn.com
February 26, 2025 at 8:59 PM
An unvaccinated, school-age child has died in West Texas. It's the first known death from an outbreak that's infected more than 120 people.
Reposted by Neil McCarthy
After a lifetime on the frontiers of the fight against HIV, researchers can finally see the end of the epidemic in sight. But thanks to the Trump administration’s executive orders, it’s unclear when—or possibly even ever—this breakthrough medicine will see the light of day.
This New Drug Could Help End the HIV Epidemic—but US Funding Cuts Are Killing Its Rollout
Lenacapavir, a twice yearly injection that prevents HIV transmission, was named the breakthrough medicine of 2024. But without US foreign aid dollars, its delivery to millions worldwide is under threa...
www.wired.com
February 21, 2025 at 8:02 PM
After a lifetime on the frontiers of the fight against HIV, researchers can finally see the end of the epidemic in sight. But thanks to the Trump administration’s executive orders, it’s unclear when—or possibly even ever—this breakthrough medicine will see the light of day.
Reposted by Neil McCarthy
Today is International Day of Women & Girls in Science.
Marie Curie, the first woman to win a Nobel Prize. Her contributions have left an indelible mark on the world of science & health & continue to inspire generations of scientists & innovators. 🔬 #WomenInScience #WomenInSTEM
Marie Curie, the first woman to win a Nobel Prize. Her contributions have left an indelible mark on the world of science & health & continue to inspire generations of scientists & innovators. 🔬 #WomenInScience #WomenInSTEM
February 11, 2025 at 7:52 AM
Today is International Day of Women & Girls in Science.
Marie Curie, the first woman to win a Nobel Prize. Her contributions have left an indelible mark on the world of science & health & continue to inspire generations of scientists & innovators. 🔬 #WomenInScience #WomenInSTEM
Marie Curie, the first woman to win a Nobel Prize. Her contributions have left an indelible mark on the world of science & health & continue to inspire generations of scientists & innovators. 🔬 #WomenInScience #WomenInSTEM
Reposted by Neil McCarthy
When asked to draw a scientist, school-age kids in the United States are increasingly sketching women, according to a study from 2018.
Read more on #WomenInScienceDay: https://scim.ag/4hOUuvx
Read more on #WomenInScienceDay: https://scim.ag/4hOUuvx
February 11, 2025 at 5:10 PM
When asked to draw a scientist, school-age kids in the United States are increasingly sketching women, according to a study from 2018.
Read more on #WomenInScienceDay: https://scim.ag/4hOUuvx
Read more on #WomenInScienceDay: https://scim.ag/4hOUuvx
Reposted by Neil McCarthy
This is the most relevant article to NIH and research cuts I’ve seen.
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
How a Canadian scientist and a venomous lizard helped pave the way for Ozempic - National | Globalnews.ca
In 1984, Dr. Daniel Drucker, an endocrinologist from the University of Toronto, discovered a hormone that helped pave the way for popular diabetes drugs such as Ozempic.
globalnews.ca
February 9, 2025 at 9:58 PM
This is the most relevant article to NIH and research cuts I’ve seen.
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
Reposted by Neil McCarthy
#hiring #postdoc
We are looking for a postdoc to work on anti-tumor gamma delta T cells in breast cancer metastasis mouse models. Apply here:
www.gla.ac.uk/explore/jobs...
We are looking for a postdoc to work on anti-tumor gamma delta T cells in breast cancer metastasis mouse models. Apply here:
www.gla.ac.uk/explore/jobs...
University of Glasgow - Explore - Jobs at Glasgow - Appointments - Research Associate (Breast Cancer Now) [164192]Search iconClose menu iconMenu icon bar 1Menu icon bar 2Menu icon bar 3
www.gla.ac.uk
February 7, 2025 at 10:23 AM
#hiring #postdoc
We are looking for a postdoc to work on anti-tumor gamma delta T cells in breast cancer metastasis mouse models. Apply here:
www.gla.ac.uk/explore/jobs...
We are looking for a postdoc to work on anti-tumor gamma delta T cells in breast cancer metastasis mouse models. Apply here:
www.gla.ac.uk/explore/jobs...
Reposted by Neil McCarthy
Highly recommended - the topic, the location and the supervisor!
#gdTcells #jobs @tcddublin.bsky.social
#gdTcells #jobs @tcddublin.bsky.social
January 23, 2025 at 7:16 AM
Highly recommended - the topic, the location and the supervisor!
#gdTcells #jobs @tcddublin.bsky.social
#gdTcells #jobs @tcddublin.bsky.social
Reposted by Neil McCarthy
They…turned off…National Institutes of Health grants? That’s nearly $50 billion of scientific research.
NIH appears to have canceled/postponed all of its study sections—the independent review panels that approve federal grants for health research.
Such grants fund the work/salaries of 300k people at more than 2,500 institutions
Such grants fund the work/salaries of 300k people at more than 2,500 institutions
All NIH study sections canceled indefinitely. This will halt science and devastate research budgets in universities.
January 22, 2025 at 9:38 PM
They…turned off…National Institutes of Health grants? That’s nearly $50 billion of scientific research.
Reposted by Neil McCarthy
Completely agree @profandrewmac.bsky.social! A pleasure to work with wonderful colleagues at several institutions including @mrccmm.bsky.social, @lydiabeckeriii.bsky.social and @uoe-eid.bsky.social. Fungi are major causes of asthma but why our immune cells do this is poorly understood.
Delighted to see our study on #DendriticCell control of #fungal #allergic airway #inflammation finally out in the wild! Spearheaded by @drpetercook.bsky.social, with so many fantastic collaborators - thanks to all! #ImmunoSky 🧪
rdcu.be/d68MU @lydiabeckeriii.bsky.social @edinburgh-uni.bsky.social
rdcu.be/d68MU @lydiabeckeriii.bsky.social @edinburgh-uni.bsky.social
Mgl2+ cDC2s coordinate fungal allergic airway type 2, but not type 17, inflammation in mice
Nature Communications - Fungal spores can promote immune responses of both type 2 (IL-4 / IL-5 / IL-13) and type 17 (IL-17). Here the authors characterise the subsets of cDC2 associated with type 2...
rdcu.be
January 22, 2025 at 6:30 PM
Completely agree @profandrewmac.bsky.social! A pleasure to work with wonderful colleagues at several institutions including @mrccmm.bsky.social, @lydiabeckeriii.bsky.social and @uoe-eid.bsky.social. Fungi are major causes of asthma but why our immune cells do this is poorly understood.
Reposted by Neil McCarthy
Today is a tough day for lots of people so will try and fill my timeline with good things to cheer/distract! I will kick off with this fabulous story of little “saunas” that help frogs fight off a deadly fungal infection 🧪
‘Frog saunas’ could save species from deadly fungal disease, study finds
Australian scientists create brick refuges in greenhouses to help green and golden bell frogs survive infection
www.theguardian.com
January 20, 2025 at 11:21 AM
Today is a tough day for lots of people so will try and fill my timeline with good things to cheer/distract! I will kick off with this fabulous story of little “saunas” that help frogs fight off a deadly fungal infection 🧪
Reposted by Neil McCarthy
For Blue Monday we can't think of anything more appropriate than this charming depiction of a man getting his face eaten off by a leopard.
#MosaicMonday
#MosaicMonday
January 20, 2025 at 9:30 AM
For Blue Monday we can't think of anything more appropriate than this charming depiction of a man getting his face eaten off by a leopard.
#MosaicMonday
#MosaicMonday
Reposted by Neil McCarthy
Our paper on nurturing a #PositiveResearchCulture within your #research #team published by @wellcometrust.bsky.social gives useful tips for your lab. As well as making you a good team leader, nurturing culture pays off in building your science: 1/11
wellcomeopenresearch.org/articles/9-3...
wellcomeopenresearch.org/articles/9-3...
wellcomeopenresearch.org
January 14, 2025 at 9:55 AM
Our paper on nurturing a #PositiveResearchCulture within your #research #team published by @wellcometrust.bsky.social gives useful tips for your lab. As well as making you a good team leader, nurturing culture pays off in building your science: 1/11
wellcomeopenresearch.org/articles/9-3...
wellcomeopenresearch.org/articles/9-3...