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Nanion Technologies
@naniontech.bsky.social
For 20+ years, Nanion combines exceptional instrumentation with trusted scientific support, to accelerate successful drug development and scientific discoveries.
Attending WSCC26 in Grindelwald? Let’s connect.

Feb 4–6, the global sodium channel community meets in person. Our Senior Scientist Markus Rapedius will be on site and presenting a poster on APC-based analysis of excitability in ALS iPSC-derived motor neurons (with Axol).

#WSCC26 #SodiumChannels
January 26, 2026 at 2:02 PM
We’re pleased to announce Prof. Glenn King and his team at the Institute for Molecular Bioscience, The University of Queensland, as winners of the 2025 SyncroPatch 384 Research Grant.

Congratulations to Prof. King and team 👏

Learn more: https://ow.ly/NQVn50XZLzX

#IonChannels #Grant #APC
January 21, 2026 at 2:01 PM
We’re pleased to announce Medha Pathak (UC Irvine, US) as a winner of the 2025 SyncroPatch 384 Research Grant, together with co-PIs Francesco Tombola, Jerome Lacroix, and Lyna Luo.

Congratulations to the entire team 👏

More details here: https://ow.ly/K3Pf50XZLic

#IonChannels #APC #Grant
January 20, 2026 at 3:01 PM
𝗙𝗲𝗯𝗿𝘂𝗮𝗿𝘆 = 𝗕𝗶𝗼𝗽𝗵𝘆𝘀𝗶𝗰𝗮𝗹 𝗦𝗼𝗰𝗶𝗲𝘁𝘆 𝗺𝗼𝗻𝘁𝗵 🔬

We’re heading to #BPS2026 with a full program of activities.
Find us at Booth #528 for live demos and discussions on ion channels, transporters & biophysics.

Will you be there?
https://ow.ly/79Yi50XZBkg

#Events #APC #Biophysics
January 19, 2026 at 3:01 PM
𝟮𝟰 𝘆𝗲𝗮𝗿𝘀 𝗼𝗳 𝗡𝗮𝗻𝗶𝗼𝗻, 𝗱𝗿𝗶𝘃𝗲𝗻 𝗯𝘆 𝘀𝗰𝗶𝗲𝗻𝗰𝗲 𝗮𝗻𝗱 𝗰𝗼𝗹𝗹𝗮𝗯𝗼𝗿𝗮𝘁𝗶𝗼𝗻 🎉

As we start 2026, we’re grateful for a year shaped by community, exchange, and shared progress. We’ve captured key moments from 2025 in our Annual Review.

Read more 👉 https://ow.ly/VmJC50XXc4z

#TeamNanion #Anniversary
January 15, 2026 at 1:45 PM
Why early safety assessment needs a new approach

Animal models and simple assays often miss human-specific risk.
New Approach Methodologies (NAMs) combine human-relevant biology with scalable in vitro tools to enable earlier, more predictive safety insight.

Read more: https://ow.ly/Bm5650XWCKU
January 14, 2026 at 2:02 PM
Renal ion channels have been linked to kidney disease for decades, yet they remain underexplored as drug targets.

This blog connects basic channel biology with ongoing drug discovery efforts, from APOL1 to TRPC and PKD.

Read the full blog: https://ow.ly/lJjg50XW5Eb

#APC #IonChannels
January 14, 2026 at 12:10 PM
𝗔𝗽𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻𝘀 𝗮𝗿𝗲 𝗼𝗽𝗲𝗻 𝗳𝗼𝗿 𝘁𝗵𝗲 𝗦𝘆𝗻𝗰𝗿𝗼𝗣𝗮𝘁𝗰𝗵 𝟯𝟴𝟰 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗚𝗿𝗮𝗻𝘁!

Get 9 months with the system, consumables, and full support to accelerate your research.

Deadline: Oct 31. Apply now!

ow.ly/9gx050X0OOW

#APC #IonChannels #Electrophysiology
SyncroPatch 384 Research Grant - Nanion Technologies
In 2025, we are offering the chance for you to win a SyncroPatch 384 for 9 months.
ow.ly
September 23, 2025 at 1:22 PM
Reduce variability in NaV studies with adaptive voltage clamp on the SyncroPatch 384.

Tailor Vhalf per well, gain better IC50 precision, and study state-dependent effects with confidence.

Check out the flyer to see how it works!
ow.ly/8QMU50WFXei

#APC #IonChannels #NaV #Electrophysiology
August 14, 2025 at 12:45 PM
How do CaV1.2 mutations drive both arrhythmias and neuro symptoms in Timothy syndrome?

Join Ivy Dick on June 12 to learn how high-throughput patch clamp reveals mutation-specific gating changes tied to clinical outcomes.

📍https://ow.ly/PxZY50W72H7

#PatchClamp #Channelopathies #IonChannels
June 10, 2025 at 2:29 PM
In a recent study, researchers developed and validated an automated #patchclamp ( #APC ) approach using the SyncroPatch 384 platform to detect #ENaC - mediated currents in a high-throughput format.

Read more here:
www.nanion.de/news/automat...
Automated patch clamp for ENaC drug discovery - Nanion Technologies
The epithelial sodium channel (ENaC) plays a central role in regulating sodium balance, blood pressure, and pulmonary fluid clearance. Despite its clinical relevance, progress in discovering new ENaC-...
www.nanion.de
May 15, 2025 at 3:45 PM
Most cardiac gene variants are still classed as “uncertain.”

Join us on Thursday to learn how APC is helping reclassify VUS and improve clinical decisions.

🗓️ May 8 | 16:00–17:00 CEST
🔗 ow.ly/RQfB50VFl93

Hope to see you there!
#CardiacGenetics #APC #VUS #LQTS #Brugada
May 5, 2025 at 3:08 PM
How do beta-lactam antibiotics get into our cells, and how can we use that to design better drugs?

Join our webinar on May 14 to explore new insights into PepT2, drug uptake, and delivery.

🔗 Register: ow.ly/1mCL50Vo2j8

#PepT2 #DrugDesign #CryoEM #Webinar
April 28, 2025 at 12:34 PM
Why is NHE9 active in endosomes but silent at the membrane?

A new Nature Communications study reveals a lipid switch: PI(3,5)P₂ stabilizes NHE9’s dimer only in endosomes.

🔗Read the full article to find out more: ow.ly/zrsR50VAAZW

#MembraneTransport #CryoEM #SSME
April 15, 2025 at 4:46 PM
Join us in exactly one month for our next transporters webinar!

Dr. Joanne Parker (University of Oxford) will present research insights on PepT2 (SLC15A2), a key player in beta-lactam antibiotic transport.

📅 May 14, 2025 | 🕓 16:00–17:00 CEST

🔗 Register here: ow.ly/1mCL50Vo2j8

#MembraneTransport
Webinar: Understanding antibiotic uptake via PepT2 - Nanion Technologies
Date: May 14, 2025 Time: 16:00 – 17:00 CEST Location: Online via Zoom
ow.ly
April 14, 2025 at 9:28 AM
𝗖𝗮𝗻 𝘄𝗲 𝗶𝗺𝗽𝗿𝗼𝘃𝗲 𝘁𝗵𝗲 𝘄𝗮𝘆 𝘄𝗲 𝗶𝗻𝘁𝗲𝗿𝗽𝗿𝗲𝘁 𝗰𝗮𝗿𝗱𝗶𝗮𝗰 𝗴𝗲𝗻𝗲 𝘃𝗮𝗿𝗶𝗮𝗻𝘁𝘀?

Join Dr. Chai Ng (Victor Chang Cardiac Research Institute) on May 8 to explore APC’s role in variant classification for inherited arrhythmias.

🔗 ow.ly/XrnO50VymFI

#Webinar @chaiannng.bsky.social @victorchang.edu.au
April 11, 2025 at 10:19 AM
iPSC-CMs are powerful, but their immaturity limits their predictive value. A recent study from TU Dresden shows how combining metabolic medium, nanopatterning, and electrostimulation significantly enhances structural and electrophysiological maturation.

🔗 lnkd.in/dipXpmyN

#Cardiac #iPSC #APC
April 10, 2025 at 3:03 PM
TRPV3 is a temperature-sensitive, ligand-gated ion channel known for its role in warmth perception.

It can be activated by heat (~ 38˚C) or by 2-APB, and we have explored both activation modes using APC with temp control.

Read the app note: ow.ly/YMp850R6hwG
#TRPV3 #IonChannels #Electrophysiology
April 9, 2025 at 1:53 PM
Cryo-EM reveals how cholesterol and sphingomyelin shape the structure and stability of a membrane pore formed by the toxin Fav.

Electrophysiology with the Orbit Mini confirms cholesterol reduces current noise.

🔗 Read more in the paper: ow.ly/sPmJ50VusCf

#CryoEM #MembraneBiophysics #Orbitmini
April 4, 2025 at 9:19 AM
𝗛𝗼𝘄 𝗱𝗼 𝗯𝗲𝘁𝗮-𝗹𝗮𝗰𝘁𝗮𝗺 𝗮𝗻𝘁𝗶𝗯𝗶𝗼𝘁𝗶𝗰𝘀 𝗲𝗻𝘁𝗲𝗿 𝘁𝗵𝗲 𝗯𝗼𝗱𝘆?
And why does it matter for drug design?

Join us on May 14 as Joanne Parker (University of Oxford) presents new insights into the structure and function of PepT2, a key transporter in beta-lactam pharmacokinetics.
ow.ly/1mCL50Vo2j8

#MembraneTransport
April 2, 2025 at 9:22 AM
Understanding cardiac function needs more than one readout

This flyer shows how combining electrophysiology, contractility & viability data offers deeper insights into drug effects & disease models.

Discover more in the flyer: ow.ly/LGRs50VnV0o

#CardiacResearch #iPSC
March 25, 2025 at 2:12 PM
Studying pore-forming toxins? At Nanion, we provide advanced tools - parallel bilayer recording stations, GUVs, and planar patch clamp systems - to help researchers get a clearer picture of how these toxins work.

Learn more: www.linkedin.com/feed/update/...

#PFT #toxins #electrophysiology
March 14, 2025 at 4:26 PM
Working with toxins & ion channels? Testing multiple fractions and screening channels with limited samples is tough. That’s why more scientists are turning to automated patch clamp for faster, reliable results. Curious? Learn more: www.nanion.de/application-... #ionchannels #toxins #patchclamp
Toxins and venom-derived peptides - Nanion Technologies
Ion channels are complex proteins that control the flow of ions across cell and organelle membranes. Ion channels are present in every cell type and thereby control neuronal excitability, cardiac, ske...
www.nanion.de
March 14, 2025 at 4:22 PM
𝗝𝗼𝗶𝗻 𝘂𝘀 𝗮𝘁 𝘁𝗵𝗲 𝗠𝗲𝗺𝗯𝗿𝗮𝗻𝗲 𝗣𝗵𝘆𝘀𝗶𝗼𝗹𝗼𝗴𝘆 𝗦𝘆𝗺𝗽𝗼𝘀𝗶𝘂𝗺!

From ion channels to drug discovery—discover what’s next in electrophysiology. Connect with leading experts in Napa Valley!

📅 Apr 30–May 1

𝗟𝗶𝗺𝗶𝘁𝗲𝗱-𝗧𝗶𝗺𝗲 𝗢𝗳𝗳𝗲𝗿: 𝟭𝟱% 𝗢𝗳𝗳 𝗧𝗶𝗰𝗸𝗲𝘁𝘀
Register now 🔗 ow.ly/SmfE50VgoHz

#MPS25 #MembranePhysiology
March 13, 2025 at 4:18 PM
Venom-derived toxins offer unique precision in ion channel research. We tested Huwentoxin-IV, TTX, GsMTx4 & α-Conotoxin MI on NaV1.7 and nAChR to explore their blocking effects. Want to learn more?
Read more in the full study: ow.ly/bKoG50Vgpy3
#IonChannels #DrugDiscovery #APC
March 12, 2025 at 2:32 PM