Morwan Osman
@morwan.me
Mycobacteriologist and Postdoctoral Fellow in the York Bioenergetics Lab, University Of York (@jnb-lab.bsky.social).
Formerly: @pembroke1347.bsky.social & @mrclmb.bsky.social. @mcbseattle.bsky.social PhD.
Formerly: @pembroke1347.bsky.social & @mrclmb.bsky.social. @mcbseattle.bsky.social PhD.
Pinned
Morwan Osman
@morwan.me
· Dec 6
Finally we are able to share our story on the molecular mechanism of the transformative anti-tuberculosis drug bedaquiline within living cells
www.biorxiv.org/content/10.1...
A (hopefully) broadly-accessible tutorial below ⬇️ (it ended up being really long!)
www.biorxiv.org/content/10.1...
A (hopefully) broadly-accessible tutorial below ⬇️ (it ended up being really long!)
bioRxiv Manuscript Processing System
Manuscript Processing System for bioRxiv.
submit.biorxiv.org
Our first TB preprint with @jnb-lab.bsky.social is out! Using spectroscopic techniques from our lab, we resolve the exact mode of action of everyone's favourite TB drug, bedaquiline. I'd like to add a few comments about the microbiology part of the picture! #TBsky #MicroSky (1/7)
Reposted by Morwan Osman
It’s 12 November, so it’s time to mark the 55th anniversary of the exploding whale of Oregon, an attempt to clear a cetacean carcass from a beach which prompted one reporter to say “The blast blasted blubber beyond all believable bounds”
November 12, 2025 at 9:58 AM
It’s 12 November, so it’s time to mark the 55th anniversary of the exploding whale of Oregon, an attempt to clear a cetacean carcass from a beach which prompted one reporter to say “The blast blasted blubber beyond all believable bounds”
Reposted by Morwan Osman
Exciting news! I have two positions open in my lab at the UoManchester: one PDRA and one Research Tech.
Join our team to study evolutionary mycology and help us understand antifungal resistance in fungal pathogens. A fantastic opportunity to join the brilliant Manchester Fungal Infection Group!
Join our team to study evolutionary mycology and help us understand antifungal resistance in fungal pathogens. A fantastic opportunity to join the brilliant Manchester Fungal Infection Group!
November 5, 2025 at 3:35 PM
Exciting news! I have two positions open in my lab at the UoManchester: one PDRA and one Research Tech.
Join our team to study evolutionary mycology and help us understand antifungal resistance in fungal pathogens. A fantastic opportunity to join the brilliant Manchester Fungal Infection Group!
Join our team to study evolutionary mycology and help us understand antifungal resistance in fungal pathogens. A fantastic opportunity to join the brilliant Manchester Fungal Infection Group!
Reposted by Morwan Osman
Considering the LMB for your PhD?
We’ve got over 25 projects available, covering a wide array of topics. Check them out here: www2.mrc-lmb.cam.ac.uk/students/int...
Apply by 2nd DEC for Autumn 2026 admission.
We’ve got over 25 projects available, covering a wide array of topics. Check them out here: www2.mrc-lmb.cam.ac.uk/students/int...
Apply by 2nd DEC for Autumn 2026 admission.
November 10, 2025 at 2:03 PM
Considering the LMB for your PhD?
We’ve got over 25 projects available, covering a wide array of topics. Check them out here: www2.mrc-lmb.cam.ac.uk/students/int...
Apply by 2nd DEC for Autumn 2026 admission.
We’ve got over 25 projects available, covering a wide array of topics. Check them out here: www2.mrc-lmb.cam.ac.uk/students/int...
Apply by 2nd DEC for Autumn 2026 admission.
Reposted by Morwan Osman
📢 Interested in #chromosomes 🧬 & #archaea thriving at the edge of life? PhD project in York,UK on how archaea pass on their genome to daughter cells.Friendly supervisors: me, @steve-quinn-lab.bsky.social & @georgerheath.bsky.social
www.findaphd.com/phds/project...
📅 January 7, 2026
Please RP🙏thx!
www.findaphd.com/phds/project...
📅 January 7, 2026
Please RP🙏thx!
November 9, 2025 at 5:20 PM
📢 Interested in #chromosomes 🧬 & #archaea thriving at the edge of life? PhD project in York,UK on how archaea pass on their genome to daughter cells.Friendly supervisors: me, @steve-quinn-lab.bsky.social & @georgerheath.bsky.social
www.findaphd.com/phds/project...
📅 January 7, 2026
Please RP🙏thx!
www.findaphd.com/phds/project...
📅 January 7, 2026
Please RP🙏thx!
Reposted by Morwan Osman
A great collaboration with Jukka Corander and colleagues, to define the population structure of this important global pathogen
A first step towards identifying candidate antigens for new improved vaccines...
@tropicalmedicine.ox.ac.uk @wellcometrust.bsky.social
www.nature.com/articles/s41...
A first step towards identifying candidate antigens for new improved vaccines...
@tropicalmedicine.ox.ac.uk @wellcometrust.bsky.social
www.nature.com/articles/s41...
Genetic population structure of Haemophilus influenzae at local and global scales - Nature Microbiology
Large-scale sequencing and population genomic analyses reveal frequent transmission, a highly admixed global population structure and evidence of pervasive negative selection in Haemophilus influenzae...
www.nature.com
November 1, 2025 at 10:16 AM
A great collaboration with Jukka Corander and colleagues, to define the population structure of this important global pathogen
A first step towards identifying candidate antigens for new improved vaccines...
@tropicalmedicine.ox.ac.uk @wellcometrust.bsky.social
www.nature.com/articles/s41...
A first step towards identifying candidate antigens for new improved vaccines...
@tropicalmedicine.ox.ac.uk @wellcometrust.bsky.social
www.nature.com/articles/s41...
Reposted by Morwan Osman
Reposted by Morwan Osman
Looking for an AMR-themed PhD project? Join us to investigate antibiotic tolerance in Staphylococcus aureus through a fully funded MRC DTP PhD studentship starting in September 2026.
This project is close collaboration with @kateduncan.bsky.social and @mycobacterium-ncl.bsky.social.
This project is close collaboration with @kateduncan.bsky.social and @mycobacterium-ncl.bsky.social.
MRC DiMeN Doctoral Training Partnership: Resensitisation of antibiotic-tolerant Staphylococcus aureus small colony variants at Newcastle University on FindAPhD.com
PhD Project - MRC DiMeN Doctoral Training Partnership: Resensitisation of antibiotic-tolerant Staphylococcus aureus small colony variants at Newcastle University, listed on FindAPhD.com
www.findaphd.com
November 1, 2025 at 11:11 AM
Looking for an AMR-themed PhD project? Join us to investigate antibiotic tolerance in Staphylococcus aureus through a fully funded MRC DTP PhD studentship starting in September 2026.
This project is close collaboration with @kateduncan.bsky.social and @mycobacterium-ncl.bsky.social.
This project is close collaboration with @kateduncan.bsky.social and @mycobacterium-ncl.bsky.social.
Reposted by Morwan Osman
🔬Want to develop a blood test for dementia? A fully funded PhD position is available in our lab to probe and detect single molecules! Join our team @york.ac.uk
! Find out more & apply by 4th Dec:
tinyurl.com/yt36p9tx
@ybri-uoy.bsky.social @ei-science.bsky.social @timcraggs.bsky.social
! Find out more & apply by 4th Dec:
tinyurl.com/yt36p9tx
@ybri-uoy.bsky.social @ei-science.bsky.social @timcraggs.bsky.social
October 31, 2025 at 4:14 PM
🔬Want to develop a blood test for dementia? A fully funded PhD position is available in our lab to probe and detect single molecules! Join our team @york.ac.uk
! Find out more & apply by 4th Dec:
tinyurl.com/yt36p9tx
@ybri-uoy.bsky.social @ei-science.bsky.social @timcraggs.bsky.social
! Find out more & apply by 4th Dec:
tinyurl.com/yt36p9tx
@ybri-uoy.bsky.social @ei-science.bsky.social @timcraggs.bsky.social
Reposted by Morwan Osman
www.biorxiv.org/content/10.1...
Read it if you dare. Happy Halloween
Read it if you dare. Happy Halloween
VadK, a Non-Canonical Kinase that Regulates the Methylcitrate Cycle and is Essential for Mycobacterium tuberculosis Virulence
The evolution of new enzymatic functions is constrained and guided by the architecture of an organisms metabolic and regulatory networks as well as by environmental constraints. Here, we identify a pr...
www.biorxiv.org
October 31, 2025 at 5:05 PM
www.biorxiv.org/content/10.1...
Read it if you dare. Happy Halloween
Read it if you dare. Happy Halloween
Reposted by Morwan Osman
🔊 Applications for the tenure-track illuminate global challenge fellowships at Queen’s are now open!
Comes with 5 years protected research time, a PhD studentship, & 60k start-up. I had one of these before getting my FLF, happy to chat to anyone interested!
www.qub.ac.uk/Research/fel...
Comes with 5 years protected research time, a PhD studentship, & 60k start-up. I had one of these before getting my FLF, happy to chat to anyone interested!
www.qub.ac.uk/Research/fel...
Our Illuminate Global Challenges Fellowships | Research | Queen's University Belfast
www.qub.ac.uk
October 30, 2025 at 12:19 PM
🔊 Applications for the tenure-track illuminate global challenge fellowships at Queen’s are now open!
Comes with 5 years protected research time, a PhD studentship, & 60k start-up. I had one of these before getting my FLF, happy to chat to anyone interested!
www.qub.ac.uk/Research/fel...
Comes with 5 years protected research time, a PhD studentship, & 60k start-up. I had one of these before getting my FLF, happy to chat to anyone interested!
www.qub.ac.uk/Research/fel...
Reposted by Morwan Osman
October 30, 2025 at 2:46 AM
Reposted by Morwan Osman
In which we all learn the phrase “ballistic microscopy”:
Blasting Through Cells
www.science.org
October 29, 2025 at 4:48 PM
In which we all learn the phrase “ballistic microscopy”:
Reposted by Morwan Osman
🎥🎞️🇿🇦(2023) The short documentary explores stories of individuals & families affected by #Tuberculosis spotlighting battles not just against the physical difficulties of diseases but also the societal judgment that accompanies it. Stigma, born of misinformation and fear, hinders early Dx & Rx.
I Survived - A Film About Stigma and TB
YouTube video by Eh!woza
www.youtube.com
October 17, 2025 at 5:08 PM
🎥🎞️🇿🇦(2023) The short documentary explores stories of individuals & families affected by #Tuberculosis spotlighting battles not just against the physical difficulties of diseases but also the societal judgment that accompanies it. Stigma, born of misinformation and fear, hinders early Dx & Rx.
Reposted by Morwan Osman
Have you ever looked at the night sky and wondered if there’s a chlorophyll f in the reaction centre of Photosystem I from far-red light adapted cyanobacteria? 🦠
Well, we did (don’t judge) and the work that followed is now out as a First Release in @science.org
www.science.org/doi/10.1126/...
Well, we did (don’t judge) and the work that followed is now out as a First Release in @science.org
www.science.org/doi/10.1126/...
Locating the missing chlorophylls f in far-red photosystem I
The discovery of chlorophyll f-containing photosystems, with their long-wavelength photochemistry, represented a distinct, low-energy paradigm for oxygenic photosynthesis. Structural studies on chloro...
www.science.org
October 11, 2025 at 10:37 AM
Have you ever looked at the night sky and wondered if there’s a chlorophyll f in the reaction centre of Photosystem I from far-red light adapted cyanobacteria? 🦠
Well, we did (don’t judge) and the work that followed is now out as a First Release in @science.org
www.science.org/doi/10.1126/...
Well, we did (don’t judge) and the work that followed is now out as a First Release in @science.org
www.science.org/doi/10.1126/...
Reposted by Morwan Osman
Our collaborative work with W Im lab is now published as V1 in @elife.bsky.social alongside with reviewers comments.
We will update this version to answer to reviewers comment but we believe that this version is already a good start to understand mycomembrane structure!
doi.org/10.7554/eLif...
We will update this version to answer to reviewers comment but we believe that this version is already a good start to understand mycomembrane structure!
doi.org/10.7554/eLif...
Dynamic Architecture of Mycobacterial Outer Membranes Revealed by All-Atom Simulations
doi.org
October 11, 2025 at 7:43 AM
Our collaborative work with W Im lab is now published as V1 in @elife.bsky.social alongside with reviewers comments.
We will update this version to answer to reviewers comment but we believe that this version is already a good start to understand mycomembrane structure!
doi.org/10.7554/eLif...
We will update this version to answer to reviewers comment but we believe that this version is already a good start to understand mycomembrane structure!
doi.org/10.7554/eLif...
Reposted by Morwan Osman
This is amazing. I laughed out loud www.theguardian.com/lifeandstyle...
![As 32-year-old Rich points out, though, "it's not like using ChatGPT guarantees success".
When he met someone in a bar one Friday night and swapped social media handles, he asked AI what his next move should be.
ChatGPT discerned that sending an initial message on Monday midmorning would set the right pace. "Then it gave me some options for what the message could be," says Rich.
"Keep it light, warm, and low-stakes so it reads as genuine interest without urgency," the bot advised. "Something like: Hey Sarah, still laughing about [tiny shared moment/reference if you've got one] - good to meet you!" Rich went back and forth with ChatGPT until he felt they'd hit upon exactly the right message ("Hey Sarah, it was lovely to meet you") but sadly she never replied, he says. "It's been two weeks now."](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:ugcmot4f3ool6cottht63wx4/bafkreierpoqvjgg5hqx3zhtlfmvrfq3vaakb3h5wppcdzrvs5jh3zr7ce4@jpeg)
October 12, 2025 at 7:57 AM
This is amazing. I laughed out loud www.theguardian.com/lifeandstyle...
Reposted by Morwan Osman
A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging
Naked mole rats get much older than closely related mamals of a similar size. cGAS mutations may have an important role in this.
www.science.org/doi/...
1/9
Naked mole rats get much older than closely related mamals of a similar size. cGAS mutations may have an important role in this.
www.science.org/doi/...
1/9
A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging
Efficient DNA repair might make possible the longevity of naked mole-rats. However, whether they have distinctive mechanisms to optimize functions of DNA repair suppressors is unclear. We find that naked mole-rat cyclic guanosine monophosphate–adenosine ...
www.science.org
October 9, 2025 at 9:31 PM
A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging
Naked mole rats get much older than closely related mamals of a similar size. cGAS mutations may have an important role in this.
www.science.org/doi/...
1/9
Naked mole rats get much older than closely related mamals of a similar size. cGAS mutations may have an important role in this.
www.science.org/doi/...
1/9
Reposted by Morwan Osman
A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine
October 6, 2025 at 11:21 AM
A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine
Reposted by Morwan Osman
📢 PhD Opportunity @crick.ac.uk
Want to help fight against antimicrobial resistance? Join us in London! Open to international applicants.
We have non-clinical & clinical PhD positions to accelerate antibiotic discovery across bacterial species.
November deadlines. More details ⬇️🧵
Want to help fight against antimicrobial resistance? Join us in London! Open to international applicants.
We have non-clinical & clinical PhD positions to accelerate antibiotic discovery across bacterial species.
November deadlines. More details ⬇️🧵
PhD students
Our PhD programme attracts the brightest scientific minds and is an opportunity for talented people to embark on their career in biomedical research.
www.crick.ac.uk
October 6, 2025 at 9:40 AM
📢 PhD Opportunity @crick.ac.uk
Want to help fight against antimicrobial resistance? Join us in London! Open to international applicants.
We have non-clinical & clinical PhD positions to accelerate antibiotic discovery across bacterial species.
November deadlines. More details ⬇️🧵
Want to help fight against antimicrobial resistance? Join us in London! Open to international applicants.
We have non-clinical & clinical PhD positions to accelerate antibiotic discovery across bacterial species.
November deadlines. More details ⬇️🧵
Reposted by Morwan Osman
📣📣We're seeking a postdoc to join us at the @mrclmb.bsky.social to investigate neuroimmune interactomes in tumour & viral immunity.
If you find fascinating & want to learn about #neuroscience & #immunology, tracing neurons, molecular biology & #flowcytometry, apply!
🧠🫁👀🩸🔬
mrc.tal.net/vx/mobile-0/...
If you find fascinating & want to learn about #neuroscience & #immunology, tracing neurons, molecular biology & #flowcytometry, apply!
🧠🫁👀🩸🔬
mrc.tal.net/vx/mobile-0/...
October 1, 2025 at 11:26 AM
📣📣We're seeking a postdoc to join us at the @mrclmb.bsky.social to investigate neuroimmune interactomes in tumour & viral immunity.
If you find fascinating & want to learn about #neuroscience & #immunology, tracing neurons, molecular biology & #flowcytometry, apply!
🧠🫁👀🩸🔬
mrc.tal.net/vx/mobile-0/...
If you find fascinating & want to learn about #neuroscience & #immunology, tracing neurons, molecular biology & #flowcytometry, apply!
🧠🫁👀🩸🔬
mrc.tal.net/vx/mobile-0/...
Reposted by Morwan Osman
Very happy to see this work accepted, congrats! It really elegantly confirms how evolution of Mtb virulence and transmission is largely driven by expression of secreted proteins. Very important impact on correlate of protection studies for vaccines as well.
Now online! Evolution of Mycobacterium tuberculosis transcription regulation is associated with increased transmission and drug resistance
Evolution of Mycobacterium tuberculosis transcription regulation is associated with increased transmission and drug resistance
Mycobacterium tuberculosis isolates have a complex phylogenetic structure and vary in clinical phenotypes. Combining high-throughput RNA-seq and global population genomics reveals gene expression as an axis of variation in host interaction. Underscoring this, variants in a regulator of a key virulence pathway are associated with increased transmission and drug resistance.
dlvr.it
September 30, 2025 at 7:22 PM
Very happy to see this work accepted, congrats! It really elegantly confirms how evolution of Mtb virulence and transmission is largely driven by expression of secreted proteins. Very important impact on correlate of protection studies for vaccines as well.
Reposted by Morwan Osman
Extremely happy to share the fruit of a beautiful collaborative research study.
France 🇫🇷, Russia 🇷🇺 and USA 🇺🇸 teaming up to tackle a long-standing question in the TB field! 🧫🦠💊🥼🩺
Our latest Preprint on Pyrazinamide Mode of Action against M.tuberculosis is online! 👇👇👇
doi.org/10.1101/2025...
France 🇫🇷, Russia 🇷🇺 and USA 🇺🇸 teaming up to tackle a long-standing question in the TB field! 🧫🦠💊🥼🩺
Our latest Preprint on Pyrazinamide Mode of Action against M.tuberculosis is online! 👇👇👇
doi.org/10.1101/2025...
Pyrazinamide kills Mycobacterium tuberculosis via pH-driven weak-acid permeation and cytosolic acidification
Pyrazinamide (PZA) is a cornerstone drug in tuberculosis (TB) treatment with a strong bactericidal activity in vivo on both actively and non-replicating bacterial subpopulations. Yet the precise mode ...
doi.org
September 29, 2025 at 5:51 AM
Extremely happy to share the fruit of a beautiful collaborative research study.
France 🇫🇷, Russia 🇷🇺 and USA 🇺🇸 teaming up to tackle a long-standing question in the TB field! 🧫🦠💊🥼🩺
Our latest Preprint on Pyrazinamide Mode of Action against M.tuberculosis is online! 👇👇👇
doi.org/10.1101/2025...
France 🇫🇷, Russia 🇷🇺 and USA 🇺🇸 teaming up to tackle a long-standing question in the TB field! 🧫🦠💊🥼🩺
Our latest Preprint on Pyrazinamide Mode of Action against M.tuberculosis is online! 👇👇👇
doi.org/10.1101/2025...
Reposted by Morwan Osman
The takeaway:
👉 Accommodating the radical right on immigration doesn’t win back voters.
👉 It alienates the progressive base.
👉 And it raises the salience of the very issue the radical right owns.
In short: it’s electoral self-harm.
👉 Accommodating the radical right on immigration doesn’t win back voters.
👉 It alienates the progressive base.
👉 And it raises the salience of the very issue the radical right owns.
In short: it’s electoral self-harm.
September 5, 2025 at 6:50 AM
The takeaway:
👉 Accommodating the radical right on immigration doesn’t win back voters.
👉 It alienates the progressive base.
👉 And it raises the salience of the very issue the radical right owns.
In short: it’s electoral self-harm.
👉 Accommodating the radical right on immigration doesn’t win back voters.
👉 It alienates the progressive base.
👉 And it raises the salience of the very issue the radical right owns.
In short: it’s electoral self-harm.
Reposted by Morwan Osman
📢 New paper in @nature.com
Microbes rock 🎸🤘 with sulfide and iron minerals
I am very excited to share our recent study, which describes a previously unknown microbial energy metabolism ⚡⚡⚡🦠🧫⚡⚡⚡
🆕 Microbial iron oxide respiration coupled to sulfide oxidation - MISO
www.nature.com/articles/s41...
Microbes rock 🎸🤘 with sulfide and iron minerals
I am very excited to share our recent study, which describes a previously unknown microbial energy metabolism ⚡⚡⚡🦠🧫⚡⚡⚡
🆕 Microbial iron oxide respiration coupled to sulfide oxidation - MISO
www.nature.com/articles/s41...
Microbial iron oxide respiration coupled to sulfide oxidation - Nature
Genomic and biochemical analyses of prokaryotic sulfur metabolism identify diverse microorganisms with the capacity to oxidize sulfide using iron(iii).
www.nature.com
August 27, 2025 at 8:17 PM
📢 New paper in @nature.com
Microbes rock 🎸🤘 with sulfide and iron minerals
I am very excited to share our recent study, which describes a previously unknown microbial energy metabolism ⚡⚡⚡🦠🧫⚡⚡⚡
🆕 Microbial iron oxide respiration coupled to sulfide oxidation - MISO
www.nature.com/articles/s41...
Microbes rock 🎸🤘 with sulfide and iron minerals
I am very excited to share our recent study, which describes a previously unknown microbial energy metabolism ⚡⚡⚡🦠🧫⚡⚡⚡
🆕 Microbial iron oxide respiration coupled to sulfide oxidation - MISO
www.nature.com/articles/s41...
Reposted by Morwan Osman
Applications for faculty positions at Rockefeller are now open! We are seeking exceptional, creative scientists to join our faculty.
Learn more below:
Learn more below:
Faculty recruitment - Our Scientists
Applications for faculty positions are currently being accepted. Application deadline is October 6, 2025.
www.rockefeller.edu
August 20, 2025 at 3:13 PM
Applications for faculty positions at Rockefeller are now open! We are seeking exceptional, creative scientists to join our faculty.
Learn more below:
Learn more below: