Oliver Mortusewicz
@mortusewicz.bsky.social
Principal Researcher @ Karolinska Institutet & Scilifelab. Interested in understanding molecular mechanism of DNA repair and targeting the DDR for cancer therapy
Genome Stability | DNA replication | Cancer therapy
Genome Stability | DNA replication | Cancer therapy
Amazing work and truly inspiring!
Sharing our latest work tracking DNA damage inheritance by Live+QIBC www.nature.com/articles/s41.... Huge congrats to @apanagopoulos.bsky.social, M. Stout and all co-authors for this tour de force! Beautifully summarized by @s-j-aitken.bsky.social & E. Reilly www.nature.com/articles/d41...
May 22, 2025 at 6:37 AM
Amazing work and truly inspiring!
Reposted by Oliver Mortusewicz
New @nature.com
An ingenious way to track DNA replication patterns at the single-cell level that leads to cell heterogeneity and daughter cells that can potentially give rise to cancer
www.nature.com/articles/s41...
An ingenious way to track DNA replication patterns at the single-cell level that leads to cell heterogeneity and daughter cells that can potentially give rise to cancer
www.nature.com/articles/s41...
May 21, 2025 at 5:17 PM
New @nature.com
An ingenious way to track DNA replication patterns at the single-cell level that leads to cell heterogeneity and daughter cells that can potentially give rise to cancer
www.nature.com/articles/s41...
An ingenious way to track DNA replication patterns at the single-cell level that leads to cell heterogeneity and daughter cells that can potentially give rise to cancer
www.nature.com/articles/s41...
🚀 Thrilled to share our latest review: "Uracil-induced replication stress drives mutations, genome instability, anti-cancer treatment efficacy, and resistance"
👉 doi.org/10.1016/j.mo...
#CancerResearch #DNARepair #ReplicationStress #MolecularCell #GenomicInstability #CancerTherapy #Uracil
👉 doi.org/10.1016/j.mo...
#CancerResearch #DNARepair #ReplicationStress #MolecularCell #GenomicInstability #CancerTherapy #Uracil
Redirecting
doi.org
May 20, 2025 at 8:07 AM
🚀 Thrilled to share our latest review: "Uracil-induced replication stress drives mutations, genome instability, anti-cancer treatment efficacy, and resistance"
👉 doi.org/10.1016/j.mo...
#CancerResearch #DNARepair #ReplicationStress #MolecularCell #GenomicInstability #CancerTherapy #Uracil
👉 doi.org/10.1016/j.mo...
#CancerResearch #DNARepair #ReplicationStress #MolecularCell #GenomicInstability #CancerTherapy #Uracil
Reposted by Oliver Mortusewicz
Great perspective on the importance of conventional chemotherapy.
Despite many many decades of successful use, do we understand how these drugs work?
www.nature.com/articles/s41...
Despite many many decades of successful use, do we understand how these drugs work?
www.nature.com/articles/s41...
December 18, 2024 at 9:06 PM
Great perspective on the importance of conventional chemotherapy.
Despite many many decades of successful use, do we understand how these drugs work?
www.nature.com/articles/s41...
Despite many many decades of successful use, do we understand how these drugs work?
www.nature.com/articles/s41...
Reposted by Oliver Mortusewicz
Very happy to have been able to contribute to this amazing story! Check out the paper at Nature Communications and the 🧵 by @nckvalerie.bsky.social below 👇. We believe #CeTeam will be an invaluable tool for #drugdiscovery and #targetvalidation in #cells
🔗: www.nature.com/articles/s41...
🔗: www.nature.com/articles/s41...
December 11, 2024 at 7:20 PM
Very happy to have been able to contribute to this amazing story! Check out the paper at Nature Communications and the 🧵 by @nckvalerie.bsky.social below 👇. We believe #CeTeam will be an invaluable tool for #drugdiscovery and #targetvalidation in #cells
🔗: www.nature.com/articles/s41...
🔗: www.nature.com/articles/s41...
Couldn't have wished for a better first post here. I’m very happy and grateful to have received a #BlueSkyGrant from #KarolinskaInstitutet. This will allow us to validate the DNA Glycosylase #SMUG1 as a #target to exploit uracil toxicity in combination #therapy for colorectal #cancer.
Blue Sky Research Grant Recipients
The Blue Sky Research Grant for Innovative Cancer Research is a one-year grant, providing SEK 500 000, to support an innovative pilot project aimed at demonstrating proof of principle. The project sho...
ki.se
December 11, 2024 at 7:05 PM
Couldn't have wished for a better first post here. I’m very happy and grateful to have received a #BlueSkyGrant from #KarolinskaInstitutet. This will allow us to validate the DNA Glycosylase #SMUG1 as a #target to exploit uracil toxicity in combination #therapy for colorectal #cancer.