Mohsen Sadeghi
@mohsensadeghi.bsky.social
computational physicist, pretending to do bio/neuro stuff.
Staff Scientist at @zuseinstitute.bsky.social
Opinions expressed are solely my own.
https://mohsensadeghi.github.io
https://linkedin.com/in/drmohsensadeghi
Staff Scientist at @zuseinstitute.bsky.social
Opinions expressed are solely my own.
https://mohsensadeghi.github.io
https://linkedin.com/in/drmohsensadeghi
This is quite interesting. Mitochondrial 'DNA expulsion' triggers inflammation pathways.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Mitochondria expel tainted DNA — spurring age-related inflammation
Organelles spit out DNA contaminated with damaging components, leading to the activation of inflammatory enzymes, mouse experiments show.
www.nature.com
October 3, 2025 at 3:44 PM
This is quite interesting. Mitochondrial 'DNA expulsion' triggers inflammation pathways.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by Mohsen Sadeghi
Sad news: Jane Goodall has died. She did more than any other human for our understanding and appreciation of our closest relatives, the chimpanzees.
That chimpanzees are Endangered tells you everything about our species and about what made her so exceptional.
www.nytimes.com/2025/10/01/o...
That chimpanzees are Endangered tells you everything about our species and about what made her so exceptional.
www.nytimes.com/2025/10/01/o...
Jane Goodall, Eminent Primatologist Who Chronicled the Lives of Chimps, Dies at 91
www.nytimes.com
October 1, 2025 at 7:52 PM
Sad news: Jane Goodall has died. She did more than any other human for our understanding and appreciation of our closest relatives, the chimpanzees.
That chimpanzees are Endangered tells you everything about our species and about what made her so exceptional.
www.nytimes.com/2025/10/01/o...
That chimpanzees are Endangered tells you everything about our species and about what made her so exceptional.
www.nytimes.com/2025/10/01/o...
Very interesting:
people.idsia.ch/~juergen/who...
people.idsia.ch/~juergen/who...
Who invented convolutional neural networks?
Who invented convolutional neural networks?
people.idsia.ch
September 2, 2025 at 4:50 PM
Very interesting:
people.idsia.ch/~juergen/who...
people.idsia.ch/~juergen/who...
Somebody help these poor predators. They are in mortal danger, apparently.
August 1, 2025 at 1:48 PM
Somebody help these poor predators. They are in mortal danger, apparently.
When you don't bother to initiate your spam bot:
August 1, 2025 at 1:38 PM
When you don't bother to initiate your spam bot:
Reposted by Mohsen Sadeghi
Come work at Nature Methods! A dream job. I know from experience 😄
Nature Methods is hiring!
We are seeking a new editor with expertise in microscopy, imaging technology, and/or cell biology. The position is available in NYC/Jersey City or Shanghai/Beijing on a hybrid working model.
Apply by August 3!
springernature.wd3.myworkdayjobs.com/SpringerNatu...
We are seeking a new editor with expertise in microscopy, imaging technology, and/or cell biology. The position is available in NYC/Jersey City or Shanghai/Beijing on a hybrid working model.
Apply by August 3!
springernature.wd3.myworkdayjobs.com/SpringerNatu...
a yellow sign that says we 're hiring
ALT: a yellow sign that says we 're hiring
media.tenor.com
July 10, 2025 at 12:35 PM
Come work at Nature Methods! A dream job. I know from experience 😄
Peak zero-shot learning:
May 25, 2025 at 3:52 PM
Peak zero-shot learning:
American "Battle Royale"...
It's not Onion, and we're comfortably away from 1. April.
It's not Onion, and we're comfortably away from 1. April.
The Department of Homeland Security is vetting a pitch for a reality television show in which immigrants would compete against one another for U.S. citizenship.
DHS considering reality show in which immigrants compete for citizenship
The competition series was pitched by Rob Worsoff, a Canadian-born writer and producer who was behind A&E’s “Duck Dynasty” and Bravo’s “Millionaire Matchmaker.”
wapo.st
May 17, 2025 at 12:54 PM
American "Battle Royale"...
It's not Onion, and we're comfortably away from 1. April.
It's not Onion, and we're comfortably away from 1. April.
This is an interesting read. I knew about Nagel's work on coffee stains. And when I read this part, "...I mean, would you give tenure to someone who’s studying coffee stains?" it made me sad. There is less and less room for beauty and curiosity in science.
www.quantamagazine.org/finding-beau...
www.quantamagazine.org/finding-beau...
Finding Beauty and Truth in Mundane Occurrences | Quanta Magazine
The physicist Sidney Nagel delights in solving mysteries of the universe that are hiding in plain sight.
www.quantamagazine.org
May 16, 2025 at 9:02 PM
This is an interesting read. I knew about Nagel's work on coffee stains. And when I read this part, "...I mean, would you give tenure to someone who’s studying coffee stains?" it made me sad. There is less and less room for beauty and curiosity in science.
www.quantamagazine.org/finding-beau...
www.quantamagazine.org/finding-beau...
I'm a bit surprised by these numbers. There's bigger resistance than I would've guessed:
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Is it OK for AI to write science papers? Nature survey shows researchers are split
Poll of 5,000 researchers finds contrasting views on when it’s acceptable to involve AI and what needs to be disclosed.
www.nature.com
May 16, 2025 at 4:05 PM
I'm a bit surprised by these numbers. There's bigger resistance than I would've guessed:
www.nature.com/articles/d41...
www.nature.com/articles/d41...
One of those days in the lab.
May 2, 2025 at 2:25 PM
One of those days in the lab.
Another piece of scientific fact put into question by Trump's administration, where refuting the antiquated idea of biological race called "anti-american idealogy". It is interesting how similar patterns emerge with fascism.
www.bbc.com/future/artic...
www.bbc.com/future/artic...
'Biological reality': What genetics has taught us about race
As US President Donald Trump takes aim at the Smithsonian Institution for "anti-American ideology", Adam Rutherford examines what the science of genetics has taught us about race.
www.bbc.com
April 21, 2025 at 1:56 AM
Another piece of scientific fact put into question by Trump's administration, where refuting the antiquated idea of biological race called "anti-american idealogy". It is interesting how similar patterns emerge with fascism.
www.bbc.com/future/artic...
www.bbc.com/future/artic...
Reposted by Mohsen Sadeghi
Those trying to understand the tariffs as economic policy are dangerously naive.
No, the tariffs are a tool to collapse our democracy. A means to compel loyalty from every business that will need to petition Trump for relief.
1/ A 🧵 to explain his plan and how we fight back.
No, the tariffs are a tool to collapse our democracy. A means to compel loyalty from every business that will need to petition Trump for relief.
1/ A 🧵 to explain his plan and how we fight back.
April 3, 2025 at 3:29 AM
Those trying to understand the tariffs as economic policy are dangerously naive.
No, the tariffs are a tool to collapse our democracy. A means to compel loyalty from every business that will need to petition Trump for relief.
1/ A 🧵 to explain his plan and how we fight back.
No, the tariffs are a tool to collapse our democracy. A means to compel loyalty from every business that will need to petition Trump for relief.
1/ A 🧵 to explain his plan and how we fight back.
You're my kind of crazy (and old) if you find this coding walkthrough for controlling SID chip in C64 using machine code inside BASIC interpreter where IRQ mapping is used to turn the screen content into a real time music controller, the coolest thing.
www.youtube.com/watch?v=ly5B...
www.youtube.com/watch?v=ly5B...
Making 8-bit Music From Scratch at the Commodore 64 BASIC Prompt
YouTube video by lftkryo
www.youtube.com
March 30, 2025 at 5:42 PM
You're my kind of crazy (and old) if you find this coding walkthrough for controlling SID chip in C64 using machine code inside BASIC interpreter where IRQ mapping is used to turn the screen content into a real time music controller, the coolest thing.
www.youtube.com/watch?v=ly5B...
www.youtube.com/watch?v=ly5B...
I found this interview with Curtis Yarvin quite helpful in understanding a lot of non-sensical directions the US is headed. I am also genuinely frightened by how hard it has become to state the obvious in the face of the "techno-monarchy" ideas.
www.nytimes.com/2025/01/18/m...
www.nytimes.com/2025/01/18/m...
Curtis Yarvin Says Democracy Is Done. Powerful Conservatives Are Listening.
The once-fringe writer has long argued for an American monarchy. His ideas have found an audience in the incoming administration and Silicon Valley.
www.nytimes.com
March 14, 2025 at 5:11 AM
I found this interview with Curtis Yarvin quite helpful in understanding a lot of non-sensical directions the US is headed. I am also genuinely frightened by how hard it has become to state the obvious in the face of the "techno-monarchy" ideas.
www.nytimes.com/2025/01/18/m...
www.nytimes.com/2025/01/18/m...
Reposted by Mohsen Sadeghi
openRxiv has arrived!
We’re thrilled to announce the launch of openRxiv as an independent, researcher-led nonprofit to oversee bioRxiv and medRxiv, the world’s leading preprint servers for life and health sciences.
openrxiv.org/introducing-...
#openRxiv #OpenScience #Preprints #bioRxiv #medRxiv
We’re thrilled to announce the launch of openRxiv as an independent, researcher-led nonprofit to oversee bioRxiv and medRxiv, the world’s leading preprint servers for life and health sciences.
openrxiv.org/introducing-...
#openRxiv #OpenScience #Preprints #bioRxiv #medRxiv
March 11, 2025 at 1:18 PM
openRxiv has arrived!
We’re thrilled to announce the launch of openRxiv as an independent, researcher-led nonprofit to oversee bioRxiv and medRxiv, the world’s leading preprint servers for life and health sciences.
openrxiv.org/introducing-...
#openRxiv #OpenScience #Preprints #bioRxiv #medRxiv
We’re thrilled to announce the launch of openRxiv as an independent, researcher-led nonprofit to oversee bioRxiv and medRxiv, the world’s leading preprint servers for life and health sciences.
openrxiv.org/introducing-...
#openRxiv #OpenScience #Preprints #bioRxiv #medRxiv
For me, this altercation was the first time a leader of a country acted in front of Trump the way it made sense. Not surprisingly, as is the case with all bullies, it also brought the worst in Trump out. Need more of this.
bbc.com/news/videos/...
bbc.com/news/videos/...
Watch angry exchange between Trump and Zelensky at White House
The US president accused the Ukrainian leader of being disrespectful in a tense meeting in the Oval Office.
bbc.com
February 28, 2025 at 9:03 PM
For me, this altercation was the first time a leader of a country acted in front of Trump the way it made sense. Not surprisingly, as is the case with all bullies, it also brought the worst in Trump out. Need more of this.
bbc.com/news/videos/...
bbc.com/news/videos/...
Reposted by Mohsen Sadeghi
Hello blue sky! Excited to be a part of the scientific community on this platform.
February 15, 2025 at 1:37 PM
Hello blue sky! Excited to be a part of the scientific community on this platform.
OMG, great stand up comedy is going on at CPAC. 🤣
February 22, 2025 at 8:16 PM
OMG, great stand up comedy is going on at CPAC. 🤣
Honored to be part of this amazing work, where synaptic vesicle fusion has been studied by a clever combination of optogenetic stimulation and cryoET.
I welcomed the opportunity to contribute with mesoscopic simulations involving dynamic membranes. Preprint: www.biorxiv.org/content/10.1...
I welcomed the opportunity to contribute with mesoscopic simulations involving dynamic membranes. Preprint: www.biorxiv.org/content/10.1...
February 13, 2025 at 1:58 AM
Honored to be part of this amazing work, where synaptic vesicle fusion has been studied by a clever combination of optogenetic stimulation and cryoET.
I welcomed the opportunity to contribute with mesoscopic simulations involving dynamic membranes. Preprint: www.biorxiv.org/content/10.1...
I welcomed the opportunity to contribute with mesoscopic simulations involving dynamic membranes. Preprint: www.biorxiv.org/content/10.1...
Reposted by Mohsen Sadeghi
Excited to share our new preprint "Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons" www.biorxiv.org/content/10.1...
We combine optogenetic stimulation of neurons with in situ cryo-ET to characterize membrane dynamics during synaptic vesicle fusion ❄️🔬⏱️
We combine optogenetic stimulation of neurons with in situ cryo-ET to characterize membrane dynamics during synaptic vesicle fusion ❄️🔬⏱️
February 12, 2025 at 10:05 PM
Excited to share our new preprint "Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons" www.biorxiv.org/content/10.1...
We combine optogenetic stimulation of neurons with in situ cryo-ET to characterize membrane dynamics during synaptic vesicle fusion ❄️🔬⏱️
We combine optogenetic stimulation of neurons with in situ cryo-ET to characterize membrane dynamics during synaptic vesicle fusion ❄️🔬⏱️