Marie K Holt
@mkbholt.bsky.social
Behavioural neuroscientist interested in stress and food intake | New PI at Warwick University | Dane in the UK
Pinned
Marie K Holt
@mkbholt.bsky.social
· Jun 16
Assistant or Associate Professor in Mammalian Neuroscience (110565-0625) at University of Warwick
Start your UK & international job search for academic jobs, research jobs, science jobs and managerial jobs in leading universities and top...
www.jobs.ac.uk
Assistant Prof/Associate Prof position in Mammalian Neuroscience! 👩🔬👨🔬
My department is hiring! Closing on June 30th.
Please repost widely!
www.jobs.ac.uk/job/DNK944/a...
My department is hiring! Closing on June 30th.
Please repost widely!
www.jobs.ac.uk/job/DNK944/a...
Such a creative approach!
Even after recovery, relapse is heartbreakingly common in anorexia nervosa. Could the answer lie in the gut’s hidden signals? 🧵
October 2, 2025 at 7:19 AM
Such a creative approach!
Reposted by Marie K Holt
New preprint alert! The uterus expands ~500-fold in pregnancy, yet we know little about how pressures are sensed. Led by @yunxiao-dr.bsky.social, we show PIEZOs are required for contractions and birth in mice, with dual roles of PIEZO1 in muscle and PIEZO2 in neurons
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
PIEZO channels link mechanical forces to uterine contractions in parturition
Mechanical forces are extensively involved in pregnancy and parturition, but their precise roles and mechanisms remain poorly understood. Here, we identify mechanically activated ion channels PIEZO1 a...
www.biorxiv.org
September 18, 2025 at 3:23 PM
New preprint alert! The uterus expands ~500-fold in pregnancy, yet we know little about how pressures are sensed. Led by @yunxiao-dr.bsky.social, we show PIEZOs are required for contractions and birth in mice, with dual roles of PIEZO1 in muscle and PIEZO2 in neurons
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Marie K Holt
When we encounter the same reward repeatedly, we show variable responses; is this just noise?
In our new preprint, we replicate the association of BMI and disinhibited eating with variability of NAcc signals to reward. #neuroskyence 🩺
W/ @akuehnel.bsky.social
www.medrxiv.org/content/10.1...
In our new preprint, we replicate the association of BMI and disinhibited eating with variability of NAcc signals to reward. #neuroskyence 🩺
W/ @akuehnel.bsky.social
www.medrxiv.org/content/10.1...
September 8, 2025 at 6:44 AM
When we encounter the same reward repeatedly, we show variable responses; is this just noise?
In our new preprint, we replicate the association of BMI and disinhibited eating with variability of NAcc signals to reward. #neuroskyence 🩺
W/ @akuehnel.bsky.social
www.medrxiv.org/content/10.1...
In our new preprint, we replicate the association of BMI and disinhibited eating with variability of NAcc signals to reward. #neuroskyence 🩺
W/ @akuehnel.bsky.social
www.medrxiv.org/content/10.1...
Reposted by Marie K Holt
2 Lecturer (Assistant Prof) positions available @yorkpsychology.bsky.social! Come join our department!
#neuroskyence #cognition #psychscisky #neurojobs
jobs.york.ac.uk/vacancy/lect...
#neuroskyence #cognition #psychscisky #neurojobs
jobs.york.ac.uk/vacancy/lect...
Jobs - The University of York
jobs.york.ac.uk
July 21, 2025 at 1:32 PM
2 Lecturer (Assistant Prof) positions available @yorkpsychology.bsky.social! Come join our department!
#neuroskyence #cognition #psychscisky #neurojobs
jobs.york.ac.uk/vacancy/lect...
#neuroskyence #cognition #psychscisky #neurojobs
jobs.york.ac.uk/vacancy/lect...
Reposted by Marie K Holt
Are interoception and mental health linked? Many assume so, with interoception even described as a psychiatric “p-factor.” But in our latest preprint, we were surprised to find little evidence for such a connection. www.medrxiv.org/content/10.1... 🧵 Thread with our reflections on the matter 👇
Interoceptive Ability is Unrelated to Mental Health Symptoms: Evidence From a Large Scale Multi-Domain Psychophysical Investigation
Interoception-the sensing and perception of the internal viscera-is widely cast as a transdiagnostic mechanism linking brain-body interaction to mental illness. Prevailing models propose that altered ...
www.medrxiv.org
August 27, 2025 at 4:17 PM
Are interoception and mental health linked? Many assume so, with interoception even described as a psychiatric “p-factor.” But in our latest preprint, we were surprised to find little evidence for such a connection. www.medrxiv.org/content/10.1... 🧵 Thread with our reflections on the matter 👇
Reposted by Marie K Holt
the tldr of my thread is that, interoceptive sensing at rest has no relationship to mental health symptoms, and we think this is likely because we need to measure interoception during and after arousal, close in time to symptoms, with ecological measures.
Are interoception and mental health linked? Many assume so, with interoception even described as a psychiatric “p-factor.” But in our latest preprint, we were surprised to find little evidence for such a connection. www.medrxiv.org/content/10.1... 🧵 Thread with our reflections on the matter 👇
Interoceptive Ability is Unrelated to Mental Health Symptoms: Evidence From a Large Scale Multi-Domain Psychophysical Investigation
Interoception-the sensing and perception of the internal viscera-is widely cast as a transdiagnostic mechanism linking brain-body interaction to mental illness. Prevailing models propose that altered ...
www.medrxiv.org
August 28, 2025 at 7:01 AM
the tldr of my thread is that, interoceptive sensing at rest has no relationship to mental health symptoms, and we think this is likely because we need to measure interoception during and after arousal, close in time to symptoms, with ecological measures.
Reposted by Marie K Holt
Hey, it's out!
doi.org/10.1016/j.ce... Aligning Big Brains and Atlases, ABBA in short, is published in Cell Reports @cp-cellreports.bsky.social . @biancasilvalab.bsky.social's lab added an analysis pipeline on top of it (BraiAn) and did all the relevant biological work. What is it ? Short thread:
doi.org/10.1016/j.ce... Aligning Big Brains and Atlases, ABBA in short, is published in Cell Reports @cp-cellreports.bsky.social . @biancasilvalab.bsky.social's lab added an analysis pipeline on top of it (BraiAn) and did all the relevant biological work. What is it ? Short thread:
July 24, 2025 at 10:04 AM
Hey, it's out!
doi.org/10.1016/j.ce... Aligning Big Brains and Atlases, ABBA in short, is published in Cell Reports @cp-cellreports.bsky.social . @biancasilvalab.bsky.social's lab added an analysis pipeline on top of it (BraiAn) and did all the relevant biological work. What is it ? Short thread:
doi.org/10.1016/j.ce... Aligning Big Brains and Atlases, ABBA in short, is published in Cell Reports @cp-cellreports.bsky.social . @biancasilvalab.bsky.social's lab added an analysis pipeline on top of it (BraiAn) and did all the relevant biological work. What is it ? Short thread:
Reposted by Marie K Holt
Modern theories of emotion (especially “interoceptive inference”) often cite William James as a key inspiration. But what did James actually say about emotion, and is it supported by the data? Here’s a brief look at the core arguments and classic evidence. 🧵
July 13, 2025 at 7:47 AM
Modern theories of emotion (especially “interoceptive inference”) often cite William James as a key inspiration. But what did James actually say about emotion, and is it supported by the data? Here’s a brief look at the core arguments and classic evidence. 🧵
Reposted by Marie K Holt
Gut microbiome is associated with insula structure in neonates www.sciencedirect.com/science/arti...
Gut microbiome is associated with insula structure in neonates
The infant brain and gut microbiome both develop rapidly in early infancy. Growing evidence indicates that the gut microbiome plays a critical role in…
www.sciencedirect.com
June 26, 2025 at 4:37 PM
Gut microbiome is associated with insula structure in neonates www.sciencedirect.com/science/arti...
First go at expansion microscopy (bar the one time we accidentally washed the tissue down the sink...) and look at that neuron!😍
June 26, 2025 at 11:15 AM
First go at expansion microscopy (bar the one time we accidentally washed the tissue down the sink...) and look at that neuron!😍
Reposted by Marie K Holt
How nerve cells transfer their powerhouse mitochondria to fuel cancer cells @nature.com
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...
June 25, 2025 at 3:39 PM
How nerve cells transfer their powerhouse mitochondria to fuel cancer cells @nature.com
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...
Still a week to go to apply for our open position in Mammalian Neuroscience at University of Warwick!
Assistant Prof/Associate Prof position in Mammalian Neuroscience! 👩🔬👨🔬
My department is hiring! Closing on June 30th.
Please repost widely!
www.jobs.ac.uk/job/DNK944/a...
My department is hiring! Closing on June 30th.
Please repost widely!
www.jobs.ac.uk/job/DNK944/a...
Assistant or Associate Professor in Mammalian Neuroscience (110565-0625) at University of Warwick
Start your UK & international job search for academic jobs, research jobs, science jobs and managerial jobs in leading universities and top...
www.jobs.ac.uk
June 23, 2025 at 2:00 PM
Still a week to go to apply for our open position in Mammalian Neuroscience at University of Warwick!
Reposted by Marie K Holt
We created a photometry python package for unbiased standardised post-hoc analysis using bootstrapping confidence intervals
No more AUC or time bins analysis! Ever
Follow our simple step by step instructions.
@foldi.bsky.social @philjrdb.bsky.social
www.biorxiv.org/content/10.1...
No more AUC or time bins analysis! Ever
Follow our simple step by step instructions.
@foldi.bsky.social @philjrdb.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org
June 19, 2025 at 5:29 AM
We created a photometry python package for unbiased standardised post-hoc analysis using bootstrapping confidence intervals
No more AUC or time bins analysis! Ever
Follow our simple step by step instructions.
@foldi.bsky.social @philjrdb.bsky.social
www.biorxiv.org/content/10.1...
No more AUC or time bins analysis! Ever
Follow our simple step by step instructions.
@foldi.bsky.social @philjrdb.bsky.social
www.biorxiv.org/content/10.1...
Reposted by Marie K Holt
Excited about our new preprint: 1st successful genome-wide study of >61,000 panic attack and 29,000 panic disorder cases. www.medrxiv.org/content/10.1... We find 17 associations & evidence that peripheral neurons in eye, lungs and heart are involved in panic & other psychiatric disorders 1/n
June 17, 2025 at 10:50 AM
Excited about our new preprint: 1st successful genome-wide study of >61,000 panic attack and 29,000 panic disorder cases. www.medrxiv.org/content/10.1... We find 17 associations & evidence that peripheral neurons in eye, lungs and heart are involved in panic & other psychiatric disorders 1/n
Reposted by Marie K Holt
New work from my lab looking at how dopamine neurons are affected by stress and males and females! This paper comes to you through three rounds of major building construction, a pandemic, six months that we could not get TTX, some animal facility shenanigans and now is here on your internet!
Sex‐Specific Adaptations to VTA Circuits Following Subchronic Stress
Subchronic variable stress, a paradigm shown to have divergent behavioral effects in males and females, induces shared and distinct physiological adaptations in the VTA. While both males and females ...
onlinelibrary.wiley.com
June 12, 2025 at 3:34 PM
New work from my lab looking at how dopamine neurons are affected by stress and males and females! This paper comes to you through three rounds of major building construction, a pandemic, six months that we could not get TTX, some animal facility shenanigans and now is here on your internet!
Assistant Prof/Associate Prof position in Mammalian Neuroscience! 👩🔬👨🔬
My department is hiring! Closing on June 30th.
Please repost widely!
www.jobs.ac.uk/job/DNK944/a...
My department is hiring! Closing on June 30th.
Please repost widely!
www.jobs.ac.uk/job/DNK944/a...
Assistant or Associate Professor in Mammalian Neuroscience (110565-0625) at University of Warwick
Start your UK & international job search for academic jobs, research jobs, science jobs and managerial jobs in leading universities and top...
www.jobs.ac.uk
June 16, 2025 at 2:47 PM
Assistant Prof/Associate Prof position in Mammalian Neuroscience! 👩🔬👨🔬
My department is hiring! Closing on June 30th.
Please repost widely!
www.jobs.ac.uk/job/DNK944/a...
My department is hiring! Closing on June 30th.
Please repost widely!
www.jobs.ac.uk/job/DNK944/a...
Reposted by Marie K Holt
Here in the School of Biological & Behavioural Sciences at QMUL we are seeking to appoint a Teaching Fellow in #Bioinformatics. Please spread the word and encourage applications from suitable candidates. Deadline for applications is June 4th.
qmul-jobs.tal.net/vx/appcentre...
qmul-jobs.tal.net/vx/appcentre...
Teaching Fellow in Bioinformatics - QMUL Jobs
ID: 6278. Title: Teaching Fellow in Bioinformatics. Application Deadline:
qmul-jobs.tal.net
May 23, 2025 at 6:06 PM
Here in the School of Biological & Behavioural Sciences at QMUL we are seeking to appoint a Teaching Fellow in #Bioinformatics. Please spread the word and encourage applications from suitable candidates. Deadline for applications is June 4th.
qmul-jobs.tal.net/vx/appcentre...
qmul-jobs.tal.net/vx/appcentre...
Reposted by Marie K Holt
Excellent review by @talliezee.bsky.social and Matthew T. Birnie on the neurobiological mechanisms underlying the consequences of early life adversity. Highly recommended! www.cell.com/neuron/fullt...
The evolving neurobiology of early-life stress
This review explores the effects of early-life stress on brain development and cognitive
function, highlighting gaps in understanding perceived stress, vulnerable developmental
stages, underlying mole...
www.cell.com
May 23, 2025 at 9:35 AM
Excellent review by @talliezee.bsky.social and Matthew T. Birnie on the neurobiological mechanisms underlying the consequences of early life adversity. Highly recommended! www.cell.com/neuron/fullt...
Reposted by Marie K Holt
Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab
May 13, 2025 at 11:37 PM
Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab
Reposted by Marie K Holt
“The visa fees are so exceedingly high that it makes coming here very difficult for some people. We are fishing for the best scientists in the world. They want to come and work here because we are such an effective country at science, but if we have these high costs, they can and will go elsewhere.”
Is the UK paying the price for world’s most expensive visas? | The Observer
Competing political and economic goals on immigration are resulting in the loss of valuable skills and talent in the UK
observer.co.uk
May 12, 2025 at 10:03 AM
“The visa fees are so exceedingly high that it makes coming here very difficult for some people. We are fishing for the best scientists in the world. They want to come and work here because we are such an effective country at science, but if we have these high costs, they can and will go elsewhere.”
Reposted by Marie K Holt
Microglia are often framed as driving maladaptive behavior in stress and depression, but what if they're important for treatment as well?
In the final project from my graduate studies, we explored whether microglial BDNF supports the effects of low-dose ketamine.
www.biorxiv.org/content/10.1...
In the final project from my graduate studies, we explored whether microglial BDNF supports the effects of low-dose ketamine.
www.biorxiv.org/content/10.1...
Microglial brain-derived neurotrophic factor (BDNF) supports the behavioral and synaptogenic effects of ketamine
Microglia have been implicated in the pathogenesis for several psychiatric disorders, yet comparatively little is known about their role in treatments for these conditions. Prior work showed that the ...
www.biorxiv.org
May 13, 2025 at 12:53 PM
Microglia are often framed as driving maladaptive behavior in stress and depression, but what if they're important for treatment as well?
In the final project from my graduate studies, we explored whether microglial BDNF supports the effects of low-dose ketamine.
www.biorxiv.org/content/10.1...
In the final project from my graduate studies, we explored whether microglial BDNF supports the effects of low-dose ketamine.
www.biorxiv.org/content/10.1...
Reposted by Marie K Holt
Brain/behaviour people - come to beautiful Scotland - we are recruiting in psychology and neuroscience across all grades! Closes May 12. Details below, and please re-post 🙏
www.nature.com/naturecareer...
More about us here: www.gla.ac.uk/schools/psyc...
#neuroskyence #neurojobs
www.nature.com/naturecareer...
More about us here: www.gla.ac.uk/schools/psyc...
#neuroskyence #neurojobs
Professor, Senior Lecturer/Lecturer and Lecturer posts - Glasgow City (GB) job with University of Glasgow | 12838283
University of Glasgow College of Medical, Veterinary and Life Sciences School of Psychology & Neuroscience Professor in Cognitive Neuroscience/Psy...
www.nature.com
May 8, 2025 at 7:04 AM
Brain/behaviour people - come to beautiful Scotland - we are recruiting in psychology and neuroscience across all grades! Closes May 12. Details below, and please re-post 🙏
www.nature.com/naturecareer...
More about us here: www.gla.ac.uk/schools/psyc...
#neuroskyence #neurojobs
www.nature.com/naturecareer...
More about us here: www.gla.ac.uk/schools/psyc...
#neuroskyence #neurojobs
Reposted by Marie K Holt
These are not good news for us foreigners who are (or plan to be) co-PI an NIH grants @altnih4science.bsky.social. Anybody who knows whether they plan to terminate ongoing R01 grants?
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Exclusive: NIH to end billions of dollars in foreign research grants
Move by US biomedical agency jeopardizes thousands of projects on infectious diseases, cancer and more.
www.nature.com
May 2, 2025 at 7:19 AM
These are not good news for us foreigners who are (or plan to be) co-PI an NIH grants @altnih4science.bsky.social. Anybody who knows whether they plan to terminate ongoing R01 grants?
www.nature.com/articles/d41...
www.nature.com/articles/d41...
www.nature.com/articles/s42...
GIP is such a strange hormone. I'm glad these two companion papers can shed some light on the mystery...
GIP is such a strange hormone. I'm glad these two companion papers can shed some light on the mystery...
GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice - Nature Metabolism
This study, together with a companion manuscript, show that, in mice, weight loss as a result of GIP receptor antagonism requires, and potentiates, functional GLP-1 receptor signalling in the brain, e...
www.nature.com
May 2, 2025 at 8:57 AM
www.nature.com/articles/s42...
GIP is such a strange hormone. I'm glad these two companion papers can shed some light on the mystery...
GIP is such a strange hormone. I'm glad these two companion papers can shed some light on the mystery...
