MJ Koh Group
@mjkoh87.bsky.social
Research Group in the Department of Chemistry at the National University of Singapore (NUS). Transforming chemical & carbohydrate synthesis through base metal catalysis, radical cross-coupling & molecular editing.
Reposted by MJ Koh Group
Another week, another atom swap! This one features adorable--and adorably versatile--oxetanes!
cen.acs.org/synthesis/At...
cen.acs.org/synthesis/At...
Atom swap unlocks a world of 4-membered rings
Molecular-editing method trades oxygen for other atoms to diversify fragments on the fly
cen.acs.org
October 16, 2025 at 8:47 PM
Another week, another atom swap! This one features adorable--and adorably versatile--oxetanes!
cen.acs.org/synthesis/At...
cen.acs.org/synthesis/At...
Reposted by MJ Koh Group
A new photocatalytic atom-swapping method enables efficient conversion of oxetanes into diverse four-membered saturated rings, streamlining access to key pharmaceutical building blocks. doi.org/g96442
Atom-swapping blueprint could streamline synthesis of pharmaceutical building blocks
Researchers from NUS have pioneered a photocatalytic atom-swapping transformation that converts oxetanes into a variety of four-membered saturated cyclic molecules, which are key scaffolds in medicinal chemistry.
phys.org
October 16, 2025 at 3:49 PM
A new photocatalytic atom-swapping method enables efficient conversion of oxetanes into diverse four-membered saturated rings, streamlining access to key pharmaceutical building blocks. doi.org/g96442
Reposted by MJ Koh Group
Swapping oxygen in oxetanes? 🪄 Done! With skeletal editing 🙌🏼🦴✨ My latest @chemistryworld.com story covers a cool strategy to introduce nitrogen, carbon, or sulfur instead at a single stroke 🖌️🎨 Amazing, almost magic @nature.com paper by @mjkoh87.bsky.social 👉🏼 www.chemistryworld.com/news/stimula...
‘Stimulating discovery’ leads to strategy to swap oxygen in saturated rings
Skeletal editing pushed beyond aromatic structures, sparking new opportunities in drug discovery
www.chemistryworld.com
October 16, 2025 at 9:13 AM
Swapping oxygen in oxetanes? 🪄 Done! With skeletal editing 🙌🏼🦴✨ My latest @chemistryworld.com story covers a cool strategy to introduce nitrogen, carbon, or sulfur instead at a single stroke 🖌️🎨 Amazing, almost magic @nature.com paper by @mjkoh87.bsky.social 👉🏼 www.chemistryworld.com/news/stimula...
Atom-swapping in a saturated heterocycle? We report a photocatalytic transmutation strategy in @nature.com that exchanges O within an oxetane for N, S, C & even dual atoms, affording various non-aromatic cyclic pharmacophores. #skeletalediting #atomswap #photocatalysis www.nature.com/articles/s41...
October 15, 2025 at 3:16 PM
Atom-swapping in a saturated heterocycle? We report a photocatalytic transmutation strategy in @nature.com that exchanges O within an oxetane for N, S, C & even dual atoms, affording various non-aromatic cyclic pharmacophores. #skeletalediting #atomswap #photocatalysis www.nature.com/articles/s41...
Reposted by MJ Koh Group
Now online:
Review article by Achyut R. Gogoi, Ángel Rentería-Gómez, Tong-De Tan, Jun Wei Ng, Ming Joo Koh & Osvaldo Gutierrez
Iron-catalysed radical difunctionalization of alkenes
www.nature.com/articles/s44... ($)
#Chemsky
Review article by Achyut R. Gogoi, Ángel Rentería-Gómez, Tong-De Tan, Jun Wei Ng, Ming Joo Koh & Osvaldo Gutierrez
Iron-catalysed radical difunctionalization of alkenes
www.nature.com/articles/s44... ($)
#Chemsky
Iron-catalysed radical difunctionalization of alkenes - Nature Synthesis
Three-component, iron-based catalytic transformations offer a promising and sustainable approach to building complex molecules in a single step. This Review highlights advances and ongoing challenges ...
www.nature.com
September 4, 2025 at 10:02 AM
Now online:
Review article by Achyut R. Gogoi, Ángel Rentería-Gómez, Tong-De Tan, Jun Wei Ng, Ming Joo Koh & Osvaldo Gutierrez
Iron-catalysed radical difunctionalization of alkenes
www.nature.com/articles/s44... ($)
#Chemsky
Review article by Achyut R. Gogoi, Ángel Rentería-Gómez, Tong-De Tan, Jun Wei Ng, Ming Joo Koh & Osvaldo Gutierrez
Iron-catalysed radical difunctionalization of alkenes
www.nature.com/articles/s44... ($)
#Chemsky
Reposted by MJ Koh Group
Applications are now open for the Stanford Science Fellows postdoctoral program, opportunity to join an exciting community of scholars!
stanfordsciencefellows.stanford.edu
stanfordsciencefellows.stanford.edu
Science Fellows
stanfordsciencefellows.stanford.edu
August 27, 2025 at 10:10 PM
Applications are now open for the Stanford Science Fellows postdoctoral program, opportunity to join an exciting community of scholars!
stanfordsciencefellows.stanford.edu
stanfordsciencefellows.stanford.edu
Cool to have Todd Hyster from Princeton University with us today at NUS Chemistry in Singapore. Photo credits: Jie Wu, Yu Zhao. #photoenzymatic #catalysis
August 4, 2025 at 12:44 PM
Cool to have Todd Hyster from Princeton University with us today at NUS Chemistry in Singapore. Photo credits: Jie Wu, Yu Zhao. #photoenzymatic #catalysis
It's a privilege to have Marisa Kozlowski from
@pennchemistry.bsky.social with us today at NUS Chemistry in Singapore. Photo credit: Yixin Lu. #organicchemistry #OrgLett
@pennchemistry.bsky.social with us today at NUS Chemistry in Singapore. Photo credit: Yixin Lu. #organicchemistry #OrgLett
June 23, 2025 at 11:37 AM
It's a privilege to have Marisa Kozlowski from
@pennchemistry.bsky.social with us today at NUS Chemistry in Singapore. Photo credit: Yixin Lu. #organicchemistry #OrgLett
@pennchemistry.bsky.social with us today at NUS Chemistry in Singapore. Photo credit: Yixin Lu. #organicchemistry #OrgLett
Excited to see our recent difluorocarbene skeletal expansion chemistry being used to make a molecule of the week! Read more about making difluorooxetanes from here: lnkd.in/gad_5fNq
Now available from Enamine: new.enaminestore.com/catalog/EN30...
Now available from Enamine: new.enaminestore.com/catalog/EN30...
May 23, 2025 at 3:58 PM
Excited to see our recent difluorocarbene skeletal expansion chemistry being used to make a molecule of the week! Read more about making difluorooxetanes from here: lnkd.in/gad_5fNq
Now available from Enamine: new.enaminestore.com/catalog/EN30...
Now available from Enamine: new.enaminestore.com/catalog/EN30...
A new skeletal expansion approach to make γ-lactam pharmacophores by Cu-catalyzed difluorocarbene insertion into azetidines. It turns out that some γ-lactam scaffolds are harder to access than azetidines. Just accepted in @angewandtechemie.bsky.social. onlinelibrary.wiley.com/doi/10.1002/...
Site‐Selective Carbonylation of Azetidines via Copper‐Catalyzed Difluorocarbene Insertion
γ-Lactams are privileged five-membered pharmaco-phores in numerous bioactive compounds, but access to these motifs typically rely on cycloaddition/substitution chemistry involving activated substrate...
onlinelibrary.wiley.com
April 7, 2025 at 5:13 PM
A new skeletal expansion approach to make γ-lactam pharmacophores by Cu-catalyzed difluorocarbene insertion into azetidines. It turns out that some γ-lactam scaffolds are harder to access than azetidines. Just accepted in @angewandtechemie.bsky.social. onlinelibrary.wiley.com/doi/10.1002/...
Our latest work in @naturechemistry.bsky.social using copper catalysis to promote difluorocarbene insertion into epoxides, allowing us to access an interesting but elusive class of α,α-difluoro-oxetane pharmacophores. www.nature.com/articles/s41...
Catalytic difluorocarbene insertion enables access to fluorinated oxetane isosteres - Nature Chemistry
Catalytic methods to introduce fluorine into the backbone of small-ring heterocycles are challenging due to the problems of strain-induced ring cleavage and defluorination. Now, a copper catalyst medi...
www.nature.com
February 22, 2025 at 3:26 AM
Our latest work in @naturechemistry.bsky.social using copper catalysis to promote difluorocarbene insertion into epoxides, allowing us to access an interesting but elusive class of α,α-difluoro-oxetane pharmacophores. www.nature.com/articles/s41...