Mizrahi Lab
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mizrahilab.bsky.social
Mizrahi Lab
@mizrahilab.bsky.social
We are involved in understanding the ecological and evolutionary forces that shape microbial communities in nature.

Visit our website - lifewp.bgu.ac.il/wp/imizrahi/
Twitter - https://x.com/LabMizrahi
Pinned
Excited to share our new @natecoevo.nature.com
paper. We identified microbes found across nearly all ruminants that act as the functional backbone of both the rumen ecosystem and the host, with major implications for food security and climate change mitigation. (1/8)
www.nature.com/articles/s41...
Our understanding of the microbiome is growing daily, but we still lack the ability to effectively engineer these ecosystems for human health and the environment.

This perspective piece explores why precision control remains such a challenge:
www.mdpi.com/2076-2607/14...
www.mdpi.com
February 18, 2026 at 9:15 AM
Reposted by Mizrahi Lab
If you are interested in investigating horizontal gene transfer by phages and virus-like particles using computational approaches, this postdoc position in the Callahan Lab could be for you

jobs.ncsu.edu/postings/226...
Postdoctoral Research Scholar
The Callahan Lab at NC State University (https://callahanlab.cvm.ncsu.edu/team/) is seeking a postdoctoral scholar to study the transfer of DNA between bacteria (horizontal gene transfer;HGT) by virus...
jobs.ncsu.edu
February 15, 2026 at 5:35 PM
The Holobiont concept treats host and microbiome as one unit, but we often lack the "how."

A new study from @tovefall.bsky.social & Marju Orho-Melander of ~28k people just bridged that gap. We aren't just "carrying" microbes; our DNA is hardcoded to sense them.

www.nature.com/articles/s41...
Genome-wide association analyses highlight the role of the intestinal molecular environment in human gut microbiota variation - Nature Genetics
Population-based studies from Sweden with replication in Norway identify associations between host genetic variants and gut microbial composition and implicate short-chain fatty acid chemosensors as m...
www.nature.com
February 15, 2026 at 9:34 AM
Proximity between microbes can hold a lot of information about how they interact.

Really cool study from @harriswang.bsky.social showing how Spatial Sequencing can be used to deduce more from the microbial world by understanding physical proximity.

Really cool work!
www.nature.com/articles/s41...
SAMPL-seq reveals micron-scale spatial hubs in the human gut microbiome - Nature Microbiology
Split-And-pool Metagenomic Plot-sampling sequencing (SAMPL-seq) can be applied to complex microbial communities to reveal spatial co-localization of microbes at the micron scale.
www.nature.com
February 12, 2026 at 2:40 PM
Reposted by Mizrahi Lab
Very interesting theoretical paper on BEF and species interactions, presenting an elegant partitioning of species effects on ecosystem function.

www.biorxiv.org/content/10.1...
Beyond biomass: how interactions shape species’ role for ecosystem functioning
Assessing the functional role of species in a changing world is critical for effectively preserving ecosystems. Intuitively, this role should relate to how the loss of a species ultimately impacts a function. We introduce the notion of a species dynamic contribution, which takes into account biotic interactions as they develop in the community. Contrary to the static contribution —a measure of what a species directly does— the dynamic contribution captures what the presence of the species causes. Using both model simulations and empirical data from a ciliate microcosm experiment, we demonstrate that dynamic and static contributions of species are generically unrelated. Our novel characterization of species’ functional contributions reveals that, due to biotic interactions, rare species that do not possess unique functional traits are just as likely as any other species to play an important role for ecosystem functioning. ### Competing Interest Statement The authors have declared no competing interest.
www.biorxiv.org
January 29, 2026 at 6:31 AM
Reposted by Mizrahi Lab
New paper out in PNAS!!! 🎉

Do more plasmid copies mean faster evolution?

🧵 Dive into the story

www.pnas.org/doi/10.1073/...
Plasmid mutation rates scale with copy number | PNAS
Plasmids are extrachromosomal DNA molecules that spread by horizontal transfer and shape bacterial evolution. Plasmids are typically present at mul...
www.pnas.org
January 27, 2026 at 12:02 PM
Reposted by Mizrahi Lab
It is widely accepted that #T6SS -mediated intoxication occurs only on solid surfaces, where prolonged cell-cell interactions are forced, and not in liquid environments. But is this generalization true? Our new preprint says it isn't. A 🧵 ...
biorxiv.org/content/10.6...
🦠
Aeromonas adhesins facilitate kin and non-kin attachment to enable T6SS-mediated antagonism in liquid
Bacterial ability to deploy the type VI secretion system (T6SS) against rivals requires prolonged cell-cell interactions. Such interactions are facilitated on solid surfaces but are assumed to be absent in liquid, leading to the conventional dismissal of T6SS-mediated competition in liquid environments. Here, we find that Aeromonas jandaei employs its T6SS to eliminate diverse bacterial competitors in liquid media. Using a workflow that monitors interbacterial competition via prey luminescence, we demonstrate that auto-aggregation and co-aggregation, facilitated by distinct adhesins, enable kin and non-kin recognition and intoxication in a T6SS-dependent manner. Furthermore, we show that another marine bacterium, Vibrio coralliilyticus , employs T6SS to intoxicate rivals in liquid media. Collectively, our results indicate that T6SS-mediated competition in liquid is more common in marine bacteria than previously anticipated, and can be facilitated by diverse molecular mechanisms that govern cell aggregation. ### Competing Interest Statement The authors have declared no competing interest. Israel Science Foundation, https://ror.org/04sazxf24, 1362/21, 2174/22 Swiss National Science Foundation, 51NF40_180541
biorxiv.org
January 28, 2026 at 12:37 PM
Reposted by Mizrahi Lab
New paper by Saskia Wilmsen and me just came out BioEssays:

A new classification framework to understand evolutionary transitions in individuality

Please find the OA paper here:

onlinelibrary.wiley.com/doi/10.1002/...
A New Classification Framework to Understand Evolutionary Transitions in Individuality
Classifying biological entities based on whether and how the two fundamental aspects physiological and evolutionary components are represented yields six types of structural organization. The resulti...
onlinelibrary.wiley.com
January 27, 2026 at 4:21 PM
Beyond the basics!
We’re hearing from researchers across the field on how they use proteomics to drive discovery. A huge thank you to @finkel-lab.bsky.social for the brilliant presentation on “Conserved bacterial antagonism towards algae and plants”. 🍀
@manuelkleiner.bsky.social
January 27, 2026 at 9:05 AM
Reposted by Mizrahi Lab
A new paper from the lab on virus-like particles called eCISs www.nature.com/articles/s41...

How bacteria evolved thousands of precision nanoinjectors?

Some bacteria don’t secrete toxins — they inject them using phage-derived machines called extracellular contractile injection systems (eCISs).
A comprehensive catalogue of receptor-binding domains in extracellular contractile injection systems - Nature Communications
Extracellular contractile injection systems (eCISs) are bacteriophage tail-derived toxin delivery complexes that are present in many prokaryotes. Here, the authors present an analysis of eCIS tail fib...
www.nature.com
January 26, 2026 at 1:26 PM
Thrilled to host @manuelkleiner.bsky.social for a week at @bengurionuniv.bsky.social for a MetaProteomics workshop!
No better start than a seminar on "Advanced Metaproteomic Approaches To Investigate Functional Host-Microbiota Interactions." 🧬
January 25, 2026 at 10:27 AM
The "core microbiome" is a fundamental concept defining what is shared across a species. While we study it in ruminants, how far does this concept scale? New research in @plosone.org provides a perspective on how specialized microbiomes persist in glacial insects.

journals.plos.org/plosone/arti...
High microbial diversity in glacial habitats uncoupled from the specialized microbiomes of resident chironomid fauna
Ecosystems associated with retreating glaciers are undergoing rapid transformation in the context of a changing climate. Invertebrate fauna, including the Chironomidae insect family (non-biting midges...
journals.plos.org
January 22, 2026 at 2:32 PM
Reposted by Mizrahi Lab
Reposted by Mizrahi Lab
Out Now! A phage protein screen identifies triggers of the bacterial innate immune system #MicroSky
A phage protein screen identifies triggers of the bacterial innate immune system
Nature Microbiology, Published online: 16 January 2026; doi:10.1038/s41564-025-02239-6A library of 400 phage protein-coding genes is used to find a trove of antiphage systems, revealing systems that target tail fibre and major capsid proteins.
go.nature.com
January 16, 2026 at 4:53 PM
Reposted by Mizrahi Lab
A new platform for scientific collaboration is here. The ASM Applied & Environmental Microbiology (AEM) Scientific Unit unites experts in the microbial sciences to translate discovery into solutions for climate resilience, food security, & sustainability. asm.social/2LI
January 15, 2026 at 9:48 PM
Reposted by Mizrahi Lab
1/4 Ever wanted to predict bacterial protein-protein interactions (PPI) on a large scale?
We wanted to, but realized there’s no such algorithm that is both rapid and optimized for bacterial protein analysis.
This led our ⭐️Chen Agassy⭐️ to develop B-PPI: doi.org/10.64898/202...
January 7, 2026 at 9:15 AM
Exciting new paper just out from @sarilog.bsky.social
Using dilution cultivation from the Baltic Sea, they recovered previously uncultivated abundant microbes, many sporting streamlined genomes and relying heavily on community cross-feedind.

Great work!

www.nature.com/articles/s42...
Client Challenge
www.nature.com
January 14, 2026 at 2:12 PM
Reposted by Mizrahi Lab
Please do not miss the opportunity to apply for this exciting PhD position in my lab.

The project will providefundamental insights into the coevolution of cross-feeding microbial consortia within and between species.

The deadline ends this week.

Looking forward to receiving your application.
I am very excited to announce that a fully funded PhD position is available in my group.

Topic: Synergistic coevolution in mono-specific and multi-species microbial consortia

Please RT or forward this information to interested candidates.

Deadline: 11.01.26

More info:

shorturl.at/f1TuF
January 5, 2026 at 3:36 PM
Reposted by Mizrahi Lab
As 2025 comes to a close, we are proud to share a new study from Prof. Itzhak Mizrahi and his lab @mizrahilab.bsky.social at Ben-Gurion University of the Negev, published in ISME Journal. @isme-microbes.bsky.social. (1/8)
December 31, 2025 at 1:58 PM
As the year comes to a close, we are thrilled to share our final publication of 2025 at ISMEj! 🎉In this paper we reveals a persistent 'auxiliary' rumen microbiome that colonizes early in life and continues to shape rumen function well into adulthood. (1/7)
academic.oup.com/ismej/articl...
December 27, 2025 at 9:28 PM
Really happy to see Nature Reviews Genetics dedicate a whole focus issue to the eco-evolutionary genomics of microorganisms. Great to see this field getting the spotlight!

www.nature.com/collections/...
Eco-evolutionary genomics of microorganisms
Genomic approaches have transformed how we study microorganisms, which shape nearly every aspect of life on Earth.
www.nature.com
December 17, 2025 at 9:33 AM
Reposted by Mizrahi Lab
Calling all archaeal enthusiasts! 🔬🔥 From molecular machines to microbial communities, Archaea never fail to surprise us!
We are excited to announce the 2026 EMBO Workshop on the Molecular Biology of Archaea, 6–10 July in Cambridge, UK!
Sign up here: meetings.embo.org/event/26-arc...
#ArchaeaSky
December 16, 2025 at 2:18 PM
Excited to share our lab’s latest paper in Microbiome! 🧬 We’ve developed "ProFiT-SPEci-FISH", a new pipeline to solve a classic problem: linking plasmids to their specific bacterial hosts in complex samples like the human gut. (1/7)

link.springer.com/article/10.1...
ProFiT-SPEci-FISH: a novel approach for linking plasmids to hosts in complex microbial communities at the single-cell level - Microbiome
Background Plasmids are influential drivers of bacterial evolution, facilitating horizontal gene transfer and shaping microbial communities. Current knowledge on plasmid persistence and mobilization i...
link.springer.com
December 15, 2025 at 1:36 PM
In our new paper in @natcomms.nature.com We discovered how Ruminococcus bromil organizes and regulates its enzyme complex to efficiently break down resistant starch, forming a key metabolic foundation for the human gut ecosystem. (1/12)

📄 www.nature.com/articles/s41...
December 9, 2025 at 5:20 PM