Iain Johnston
@mitomaths.bsky.social
Stochastic Biology Group: using maths, stats, and experiments to learn about biology and disease. We love organelles and oDNA, evolution, noise, and inference.
https://org.uib.no/stochasticbiology/
https://org.uib.no/stochasticbiology/
Reposted by Iain Johnston
We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.
November 7, 2025 at 11:02 AM
We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.
Reposted by Iain Johnston
In some species, #mitochondria have lost functions: from specific complexes to the ability to produce #ATP (and more!). We examine the evolutionary pathways of this reduction, from yeast and mistletoe to parasite "MROs":
doi.org/10.1093/jeb/...
@mitomaths.bsky.social et al. 2025
doi.org/10.1093/jeb/...
@mitomaths.bsky.social et al. 2025
Convergent pathways of reductive mitochondrial evolution characterized with hypercubic inference
Abstract. For a striking example of mitochondrial behaviour beyond adenosine triphosphate (ATP) generation, consider mitochondrion-related organelles (MROs
doi.org
November 6, 2025 at 6:12 PM
In some species, #mitochondria have lost functions: from specific complexes to the ability to produce #ATP (and more!). We examine the evolutionary pathways of this reduction, from yeast and mistletoe to parasite "MROs":
doi.org/10.1093/jeb/...
@mitomaths.bsky.social et al. 2025
doi.org/10.1093/jeb/...
@mitomaths.bsky.social et al. 2025
Great to see this out there! We infer the evolutionary pathways behind patterns of AMR in Klebsiella across 102 states, finding globally consistent principles, state-specific deviations (and covariates), and validating evol predictions with new genomes. biorxiv.org/content/10.1... 1/
September 22, 2025 at 7:56 AM
Great to see this out there! We infer the evolutionary pathways behind patterns of AMR in Klebsiella across 102 states, finding globally consistent principles, state-specific deviations (and covariates), and validating evol predictions with new genomes. biorxiv.org/content/10.1... 1/
Celebrating grant award with a mountain run! MitoPhyto, a FRIPRO project, will combine modelling and microscopy to explore mitochondrial and mtDNA maintenance across non-bilaterian multicellular eukaryotes. Opportunities to come to Norway: please see next post
June 17, 2025 at 12:25 PM
Celebrating grant award with a mountain run! MitoPhyto, a FRIPRO project, will combine modelling and microscopy to explore mitochondrial and mtDNA maintenance across non-bilaterian multicellular eukaryotes. Opportunities to come to Norway: please see next post
Gratulerer med dagen alle sammen!
(non-Norway-based folks, happy Norwegian Constitution Day!)
(non-Norway-based folks, happy Norwegian Constitution Day!)
May 17, 2025 at 5:02 PM
Gratulerer med dagen alle sammen!
(non-Norway-based folks, happy Norwegian Constitution Day!)
(non-Norway-based folks, happy Norwegian Constitution Day!)
Reposted by Iain Johnston
Glad to share this review, which takes a narrative approach to explore mechanisms governing cytoplasmic inheritance. It highlights exciting advances in the field, while also pointing to the many open questions that remain. Have a read here: doi.org/10.1093/plph...
Cytoplasmic Inheritance: The Transmission of Plastid and Mitochondrial Genomes Across Cells and Generations
Abstract. In photosynthetic organisms, genetic material is stored in the nucleus and the two cytoplasmic organelles: plastids and mitochondria. While both
doi.org
May 5, 2025 at 10:47 AM
Glad to share this review, which takes a narrative approach to explore mechanisms governing cytoplasmic inheritance. It highlights exciting advances in the field, while also pointing to the many open questions that remain. Have a read here: doi.org/10.1093/plph...
Had a brilliant time at the 54th Jírovec’s Protozoological Days in Frymburk. Amazing organisms, amazing science, lots of exciting organelle work. Beautiful setting too! Thanks to all www.chromera.org/konference/5...
May 7, 2025 at 11:00 AM
Had a brilliant time at the 54th Jírovec’s Protozoological Days in Frymburk. Amazing organisms, amazing science, lots of exciting organelle work. Beautiful setting too! Thanks to all www.chromera.org/konference/5...
May trails on the way to the final Applied Statistics lecture of the semester!
May 7, 2025 at 10:57 AM
May trails on the way to the final Applied Statistics lecture of the semester!
View from the office as summer approaches
May 2, 2025 at 7:15 PM
View from the office as summer approaches
Reposted by Iain Johnston
Exciting permanent(!) #JobAlert for a #botanist to work in Bergen, Norway 🧪
PhD required, language proficiency required within two years. Apply by 25 April.
#Ecology #Restoration #Botany
PhD required, language proficiency required within two years. Apply by 25 April.
#Ecology #Restoration #Botany
NINA is expanding its expertise in vegetation ecology and restoration and is seeking a skilled and dedicated researcher to strengthen our team in Bergen.
nina-english.attract.reachmee.com/jobs/70-rese...
nina-english.attract.reachmee.com/jobs/70-rese...
April 1, 2025 at 5:32 AM
Exciting permanent(!) #JobAlert for a #botanist to work in Bergen, Norway 🧪
PhD required, language proficiency required within two years. Apply by 25 April.
#Ecology #Restoration #Botany
PhD required, language proficiency required within two years. Apply by 25 April.
#Ecology #Restoration #Botany
Reposted by Iain Johnston
Out today: Exciting intermediate between endosymbiont and organelle identified! Endosymbionts in Angomonas deanei lost nearly all bacterial cell division genes. Instead, we identified a host-encoded protein, ETP9, that became specialized for endosymbiont division. 1/2
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
March 19, 2025 at 8:29 PM
Out today: Exciting intermediate between endosymbiont and organelle identified! Endosymbionts in Angomonas deanei lost nearly all bacterial cell division genes. Instead, we identified a host-encoded protein, ETP9, that became specialized for endosymbiont division. 1/2
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Projector broke today, so a good old-school blackboard lecture on an intro to GLMs!
March 19, 2025 at 7:33 PM
Projector broke today, so a good old-school blackboard lecture on an intro to GLMs!
Reposted by Iain Johnston
Watching the US take a wrecking ball to science 💔 🤯
Reminder of the importance of doing science in the open. Put data, software, resources in public domain, where no single govt can erase them. This is our collective knowledge. Distributed data systems are essential.
www.nature.com/articles/s41...
Reminder of the importance of doing science in the open. Put data, software, resources in public domain, where no single govt can erase them. This is our collective knowledge. Distributed data systems are essential.
www.nature.com/articles/s41...
Genomic data sharing: you don’t know what you’ve got (till it’s gone) - Nature Reviews Genetics
Reflecting on the core values of early data sharing agreements, the Bermuda Principles and the Fort Lauderdale Agreement, Kathryn E. Holt and Michael Inouye emphasize the need to reaffirm our commitme...
www.nature.com
March 17, 2025 at 9:08 PM
Watching the US take a wrecking ball to science 💔 🤯
Reminder of the importance of doing science in the open. Put data, software, resources in public domain, where no single govt can erase them. This is our collective knowledge. Distributed data systems are essential.
www.nature.com/articles/s41...
Reminder of the importance of doing science in the open. Put data, software, resources in public domain, where no single govt can erase them. This is our collective knowledge. Distributed data systems are essential.
www.nature.com/articles/s41...
Great to see this out in final form! www.nature.com/articles/s41...
Continuous buildup of single-cell-specific mtDNA mutations throughout ageing, and their links with health. Mitos, scRNA, scATAC, models, ER, neuro... a smorgasbord of science! Congrats all! @syssig.bsky.social
Continuous buildup of single-cell-specific mtDNA mutations throughout ageing, and their links with health. Mitos, scRNA, scATAC, models, ER, neuro... a smorgasbord of science! Congrats all! @syssig.bsky.social
Cryptic mitochondrial DNA mutations coincide with mid-late life and are pathophysiologically informative in single cells across tissues and species - Nature Communications
Mitochondrial dysfunction is implicated in ageing. Here the authors report that across tissues and species, somatic mitochondrial DNA mutations in single cells (termed cryptic mutations) accumulate wi...
www.nature.com
March 7, 2025 at 6:56 PM
Great to see this out in final form! www.nature.com/articles/s41...
Continuous buildup of single-cell-specific mtDNA mutations throughout ageing, and their links with health. Mitos, scRNA, scATAC, models, ER, neuro... a smorgasbord of science! Congrats all! @syssig.bsky.social
Continuous buildup of single-cell-specific mtDNA mutations throughout ageing, and their links with health. Mitos, scRNA, scATAC, models, ER, neuro... a smorgasbord of science! Congrats all! @syssig.bsky.social
Started likelihood-based approaches for model selection in STAT200 today, one of my favourite things (and behind many of our research projects)! Combined with likelihood-free methods, my claim is that this is how we turn modelling (not really falsifiable) into science (testing hypotheses with data)
February 26, 2025 at 5:10 PM
Started likelihood-based approaches for model selection in STAT200 today, one of my favourite things (and behind many of our research projects)! Combined with likelihood-free methods, my claim is that this is how we turn modelling (not really falsifiable) into science (testing hypotheses with data)
A classic to celebrate this evening's proposal submission. If you haven't heard this before, I recommend sticking with it, it's somewhat unlikely you've heard a song like this before!
www.youtube.com/watch?v=rxjE...
Lyrics www.metalkingdom.net/lyrics-song/...
www.youtube.com/watch?v=rxjE...
Lyrics www.metalkingdom.net/lyrics-song/...
Grace
YouTube video by Devin Townsend Project - Topic
www.youtube.com
February 24, 2025 at 8:45 PM
A classic to celebrate this evening's proposal submission. If you haven't heard this before, I recommend sticking with it, it's somewhat unlikely you've heard a song like this before!
www.youtube.com/watch?v=rxjE...
Lyrics www.metalkingdom.net/lyrics-song/...
www.youtube.com/watch?v=rxjE...
Lyrics www.metalkingdom.net/lyrics-song/...
Some shots from wintery commutes in 2025!
February 20, 2025 at 8:51 PM
Some shots from wintery commutes in 2025!
Nice group meeting today, celebrating exciting new positions and discussing the diverse ways we do science with data! Thanks all
February 20, 2025 at 8:47 PM
Nice group meeting today, celebrating exciting new positions and discussing the diverse ways we do science with data! Thanks all
We've been thinking a lot about "accumulation models" lately -- inferring how systems accumulate features over time. May be mutations in a tumor, characters in evol bio, gene losses in oDNA. Here's an instance of the well-known Mk model that captures this picture academic.oup.com/bioinformati... 1/
February 20, 2025 at 8:45 PM
We've been thinking a lot about "accumulation models" lately -- inferring how systems accumulate features over time. May be mutations in a tumor, characters in evol bio, gene losses in oDNA. Here's an instance of the well-known Mk model that captures this picture academic.oup.com/bioinformati... 1/
Reposted by Iain Johnston
This year’s Mørketidens Mattemøte once again brought mathematicians from across Norway and the Nordic countries to @uitnorgesarktiske.bsky.social for two inspiring days of idea exchange and new connections.
Thanks to Tromsø Forskningsstiftelse and Trond Mohn forskningsstiftelse for the support !
Thanks to Tromsø Forskningsstiftelse and Trond Mohn forskningsstiftelse for the support !
January 25, 2025 at 6:26 PM
This year’s Mørketidens Mattemøte once again brought mathematicians from across Norway and the Nordic countries to @uitnorgesarktiske.bsky.social for two inspiring days of idea exchange and new connections.
Thanks to Tromsø Forskningsstiftelse and Trond Mohn forskningsstiftelse for the support !
Thanks to Tromsø Forskningsstiftelse and Trond Mohn forskningsstiftelse for the support !
Getting back on the reading after a busy semester start. These look exciting in the world of organelle genomes!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1... (congrats @sloanevolab.bsky.social et al.!)
www.biorxiv.org/content/10.1... (congrats @wallaceucsf.bsky.social et al.!)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1... (congrats @sloanevolab.bsky.social et al.!)
www.biorxiv.org/content/10.1... (congrats @wallaceucsf.bsky.social et al.!)
www.biorxiv.org
January 21, 2025 at 2:09 PM
Getting back on the reading after a busy semester start. These look exciting in the world of organelle genomes!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1... (congrats @sloanevolab.bsky.social et al.!)
www.biorxiv.org/content/10.1... (congrats @wallaceucsf.bsky.social et al.!)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1... (congrats @sloanevolab.bsky.social et al.!)
www.biorxiv.org/content/10.1... (congrats @wallaceucsf.bsky.social et al.!)
Advanced machine learning methods are cool, but here's why I'm excited to be teaching classic STAT200 (applied statistics) this spring! Featuring some of Bergen's mountains
youtu.be/IdC7SzPV6EU
youtu.be/IdC7SzPV6EU
Why I think classical applied statistics is cool
YouTube video by Stochastic Biology Group
youtu.be
January 9, 2025 at 11:28 AM
Advanced machine learning methods are cool, but here's why I'm excited to be teaching classic STAT200 (applied statistics) this spring! Featuring some of Bergen's mountains
youtu.be/IdC7SzPV6EU
youtu.be/IdC7SzPV6EU
First skitur of 2025, chasing the sunrise
January 2, 2025 at 11:52 AM
First skitur of 2025, chasing the sunrise
Happy new year! Write down 1 once, 2 twice, 3 three times, etc. 122333444455555.... Once you get to forty-five 45s, sum up all the digits you've written down. It's 2025 (45×45). 2025 is the only number except 1 for which this happens. Here's more 2025 fun www.numbersaplenty.com/2025
Properties of number 2025
All about number 2025 : over 180 properties tested, factorization, divisors, base conversions
www.numbersaplenty.com
January 1, 2025 at 3:15 PM
Happy new year! Write down 1 once, 2 twice, 3 three times, etc. 122333444455555.... Once you get to forty-five 45s, sum up all the digits you've written down. It's 2025 (45×45). 2025 is the only number except 1 for which this happens. Here's more 2025 fun www.numbersaplenty.com/2025
Reposted by Iain Johnston
A new biosensor is born 👼
The NAPstar family of genetically-encoded sensors for live NADP redox monitoring🔋🪫
Jointly with the Morgan lab & @riemerlab.bsky.social we looked in vitro, in yeast, plants & mammalian cells 🧪🦠🧫🌱
Where to go next? @naturecomms.bsky.social
doi.org/10.1038/s414...
The NAPstar family of genetically-encoded sensors for live NADP redox monitoring🔋🪫
Jointly with the Morgan lab & @riemerlab.bsky.social we looked in vitro, in yeast, plants & mammalian cells 🧪🦠🧫🌱
Where to go next? @naturecomms.bsky.social
doi.org/10.1038/s414...
A family of NADPH/NADP+ biosensors reveals in vivo dynamics of central redox metabolism across eukaryotes - Nature Communications
This article presents NAPstars, a family of genetically-encoded biosensors that enable real-time monitoring of NADP redox dynamics across species. The sensors reveal robust NADP redox regulation, cell...
doi.org
December 19, 2024 at 4:43 PM
A new biosensor is born 👼
The NAPstar family of genetically-encoded sensors for live NADP redox monitoring🔋🪫
Jointly with the Morgan lab & @riemerlab.bsky.social we looked in vitro, in yeast, plants & mammalian cells 🧪🦠🧫🌱
Where to go next? @naturecomms.bsky.social
doi.org/10.1038/s414...
The NAPstar family of genetically-encoded sensors for live NADP redox monitoring🔋🪫
Jointly with the Morgan lab & @riemerlab.bsky.social we looked in vitro, in yeast, plants & mammalian cells 🧪🦠🧫🌱
Where to go next? @naturecomms.bsky.social
doi.org/10.1038/s414...