We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.

Would love to hear any feedback; we continue to believe that EvAM applied to AMR (learning evolutionary history) can be a powerful complement to genomic surveys (focussing on the present). Thanks for reading!
www.biorxiv.org/content/10.1...
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Understanding evolutionary dynamics lets us form future predictions. We tested these predictions with newly sequenced data from decades of clinical study in Tanzania. Fitted model retrospectively predicted those previously unobserved accumulation dynamics! 4/

Interesting, but very high-dimensional, so we project down to find the principal axes of diversity in evolutionary behaviour -- and what predicts them. They're linked both to public health region and drug use regimens 3/

Following the ideas in journals.asm.org/doi/full/10.... about applying evol accumulation modelling (EvAM) to AMR, we use genomics data to infer the orderings of character accumulation behind observed Klebsiella AMR profiles across countries (e.g. Romania here), with global average in D 2/

There'll be 2 PhD positions (math / microscopy) on MitoPhyto. But the Norwegian research council is also offering opportunities for non-European postdocs to come to Norway for 3 years associated with FRIPRO projects. Please DM me if interested!
www.forskningsradet.no/en/call-for-...

And very new indeed, here's HyperLAU, an approach using tools from linear algebra to capture uncertainty in (phylogenetically embedded) accumulation models that supports flexible model structure and data inputs @jessirenz.bsky.social ! arxiv.org/abs/2502.05872 . Would love to chat about these! 3/3

Here's a "picture guide" (led by Ramon) describing approaches for these models and their inference, from cancer to evol bio and other applications arxiv.org/abs/2312.06824 (also see Ramon and colleagues' great repo of software approaches for EvAM github.com/rdiaz02/EvAM...) 2/