Mike Tadross
@miketadross.bsky.social
Dad | Engineer | Neuroscientist | BLM | Lift As You Climb
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Mike Tadross
@miketadross.bsky.social
· Jan 26
Tadross WinterBrain
YouTube video by mtadross
youtu.be
“Why Facts Don't Work”—my talk at Winter Brain. Thanks to Joyce Woo for organizing “Synaptic Control of Mesolimbic DA Neurons” & co-presenters Tom Hnasko, Abigail Elerding, Miguel Lujan, Thomas Jhou. Sorry I missed it (thanks United!) but silver lining—here’s the recording: youtu.be/vZAZ6uCkkWI
Reposted by Mike Tadross
Excited to be joining a fantastic community of neuroscientists!
Congrats to HHMI Freeman Hrabowski Scholars @channyskye.bsky.social , Josefina del Mármol (@delmarmollab.bsky.social), @yvetteefisher.bsky.social and Theanne Griffith (@doctheagrif.bsky.social), named 2025 McKnight Scholars for their demonstrated commitment to neuroscience & mentoring others! 🌟
June 20, 2025 at 9:34 PM
Excited to be joining a fantastic community of neuroscientists!
Reposted by Mike Tadross
The lab is officially up & running at Duke! 🥳
Huge thanks to @dukemedschool.bsky.social for the amazing space, & to our lab team for getting everything installed & operational within a month 😅
Excited for what’s ahead!
Huge thanks to @dukemedschool.bsky.social for the amazing space, & to our lab team for getting everything installed & operational within a month 😅
Excited for what’s ahead!
May 5, 2025 at 7:09 PM
The lab is officially up & running at Duke! 🥳
Huge thanks to @dukemedschool.bsky.social for the amazing space, & to our lab team for getting everything installed & operational within a month 😅
Excited for what’s ahead!
Huge thanks to @dukemedschool.bsky.social for the amazing space, & to our lab team for getting everything installed & operational within a month 😅
Excited for what’s ahead!
Reposted by Mike Tadross
Happy Birthday Dick Tsien! So happy to join former labmembers in celebration. Amazing to be reminded of the breath and depth of your contribution to science - with a strong flavor of "what is the underlying mechanism" @deisseroth.bsky.social @yulonglilab.bsky.social
May 3, 2025 at 10:52 PM
Happy Birthday Dick Tsien! So happy to join former labmembers in celebration. Amazing to be reminded of the breath and depth of your contribution to science - with a strong flavor of "what is the underlying mechanism" @deisseroth.bsky.social @yulonglilab.bsky.social
Honored to speak at Tsien@80—a beautiful reminder that mentorship, curiosity, and generosity leave the deepest legacy. Thank you, Dick Tsien, for welcoming me into your scientific family. Happy 80th! 🎉 #DickTsien80
May 5, 2025 at 8:46 PM
Honored to speak at Tsien@80—a beautiful reminder that mentorship, curiosity, and generosity leave the deepest legacy. Thank you, Dick Tsien, for welcoming me into your scientific family. Happy 80th! 🎉 #DickTsien80
Reposted by Mike Tadross
As an author on the paper Vinny skewers here, I say ouch and read this.
Tool development and optimization in nonhuman primates is a lot harder than making an Excel spreadsheet.
April 21, 2025 at 9:01 PM
As an author on the paper Vinny skewers here, I say ouch and read this.
Reposted by Mike Tadross
Superb Duke piece on Alzheimer's Research:
today.duke.edu/2025/04/how-...
today.duke.edu/2025/04/how-...
How Public Supported Studies Bring This Researcher and Patient Closer to a Cure for Alzheimer’s | Duke Today
today.duke.edu
April 28, 2025 at 12:53 PM
Superb Duke piece on Alzheimer's Research:
today.duke.edu/2025/04/how-...
today.duke.edu/2025/04/how-...
Reposted by Mike Tadross
Over 50 yrs since the discovery of protein kinases, 80% of human kinases still have ≤20 known substrates, and many are “dark.” I'm EXCITED to announce our new work towards solving this- combining (1) deep learning with (2) proximity proteomics in vivo! ➡️
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
April 28, 2025 at 10:00 PM
Over 50 yrs since the discovery of protein kinases, 80% of human kinases still have ≤20 known substrates, and many are “dark.” I'm EXCITED to announce our new work towards solving this- combining (1) deep learning with (2) proximity proteomics in vivo! ➡️
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Mike Tadross
"This is a massive loss for neuroscience,” says Cory Miller.
By @avaskham.bsky.social
www.thetransmitter.org/funding/u-s-...
By @avaskham.bsky.social
www.thetransmitter.org/funding/u-s-...
U.S. BRAIN Initiative set to lose $81 million this year
A government spending bill, approved today by the House of Representatives, allocates 20 percent less funding for the program than last year.
www.thetransmitter.org
March 12, 2025 at 7:10 PM
"This is a massive loss for neuroscience,” says Cory Miller.
By @avaskham.bsky.social
www.thetransmitter.org/funding/u-s-...
By @avaskham.bsky.social
www.thetransmitter.org/funding/u-s-...
Reposted by Mike Tadross
Still, while thrilled our 2 TTIs and 3 staff scientists were rescued, many other great scientists were terminated, incl lab and core staff
Dear all, Because of your help shining light on this all 15 were reinstated today. This is a huge win for science - When We Fight We Win!!!
On Valentine’s day, 15 Assistant Professors at NIH who had started their research labs in the last 2 years were fired. Their scientific expertise was built over 10-12 years of training, most if not all of which was supported by NIH. The start up funds for their laboratories were paid by NIH
March 13, 2025 at 2:56 AM
Still, while thrilled our 2 TTIs and 3 staff scientists were rescued, many other great scientists were terminated, incl lab and core staff
Reposted by Mike Tadross
wtaf
There are days in life that shake you.
I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University
& academic career... 1/🧵
I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University
& academic career... 1/🧵
March 19, 2025 at 1:11 AM
wtaf
Reposted by Mike Tadross
🚨 New lab paper!🚨
A dream study of mine for nearly 20 yrs not possible until now thanks to NIH 🧠 funding & 1st-author lead @seeber.bsky.social
We tracked hippocampal activity as people walked memory-guided paths & imagined them again. Did brain patterns reappear?🧵👇
www.nature.com/articles/s41...
A dream study of mine for nearly 20 yrs not possible until now thanks to NIH 🧠 funding & 1st-author lead @seeber.bsky.social
We tracked hippocampal activity as people walked memory-guided paths & imagined them again. Did brain patterns reappear?🧵👇
www.nature.com/articles/s41...
Human neural dynamics of real-world and imagined navigation - Nature Human Behaviour
Seeber et al. studied brain recordings from implanted electrodes in freely moving humans. Neural dynamics encoded actual and imagined routes similarly, demonstrating parallels between navigational, im...
www.nature.com
March 10, 2025 at 4:52 PM
🚨 New lab paper!🚨
A dream study of mine for nearly 20 yrs not possible until now thanks to NIH 🧠 funding & 1st-author lead @seeber.bsky.social
We tracked hippocampal activity as people walked memory-guided paths & imagined them again. Did brain patterns reappear?🧵👇
www.nature.com/articles/s41...
A dream study of mine for nearly 20 yrs not possible until now thanks to NIH 🧠 funding & 1st-author lead @seeber.bsky.social
We tracked hippocampal activity as people walked memory-guided paths & imagined them again. Did brain patterns reappear?🧵👇
www.nature.com/articles/s41...
Reposted by Mike Tadross
Suthana et al. studied brain recordings from implanted electrodes in freely moving humans. They show that neural dynamics encoded actual and imagined routes similarly. @suthanalab.bsky.social @seeber.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Human neural dynamics of real-world and imagined navigation - Nature Human Behaviour
Seeber et al. studied brain recordings from implanted electrodes in freely moving humans. Neural dynamics encoded actual and imagined routes similarly, demonstrating parallels between navigational, im...
www.nature.com
March 10, 2025 at 9:31 PM
Suthana et al. studied brain recordings from implanted electrodes in freely moving humans. They show that neural dynamics encoded actual and imagined routes similarly. @suthanalab.bsky.social @seeber.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Mike Tadross
“Why Facts Don't Work”—my talk at Winter Brain. Thanks to Joyce Woo for organizing “Synaptic Control of Mesolimbic DA Neurons” & co-presenters Tom Hnasko, Abigail Elerding, Miguel Lujan, Thomas Jhou. Sorry I missed it (thanks United!) but silver lining—here’s the recording: youtu.be/vZAZ6uCkkWI
Tadross WinterBrain
YouTube video by mtadross
youtu.be
January 26, 2025 at 5:08 PM
“Why Facts Don't Work”—my talk at Winter Brain. Thanks to Joyce Woo for organizing “Synaptic Control of Mesolimbic DA Neurons” & co-presenters Tom Hnasko, Abigail Elerding, Miguel Lujan, Thomas Jhou. Sorry I missed it (thanks United!) but silver lining—here’s the recording: youtu.be/vZAZ6uCkkWI
Reposted by Mike Tadross
Same with general University functions. They think that taking away the words diversity, equity, and inclusion changes things. Libs love their labels (on that I agree 😅) so banning "DEI" will make us all cry. That's really their point, as juvenile as it is. But just live DEI, be it. Can't ban that.
To all us NIH grant holders: we must prioritize diversity ideals, even if the current goverment doesn't. Double down on making STEM open to all. We hold the dollars so we still have power. Never forget that you are not the powerless.
Before it is all taken down, a good reminder that the NIH has (or maybe had) an expansive definition of what constitutes diversity. So this means less participation by #womeninSTEM, #URMinSTEM, #disabledinSTEM, plus those that grew up rural, #firstgen, unhoused, or low-income.
#academicSky 🧪👩🔬 2/n
#academicSky 🧪👩🔬 2/n
January 25, 2025 at 7:25 AM
Same with general University functions. They think that taking away the words diversity, equity, and inclusion changes things. Libs love their labels (on that I agree 😅) so banning "DEI" will make us all cry. That's really their point, as juvenile as it is. But just live DEI, be it. Can't ban that.
Reposted by Mike Tadross
Let me give a concrete example of the importance of applications with high risk-high reward as well as the role of NIH staff in taking risks.
Decades ago, a physical chemist proposed ideas about doing mass spectrometry on proteins (when this was deemed probably impossible).
1/n
Decades ago, a physical chemist proposed ideas about doing mass spectrometry on proteins (when this was deemed probably impossible).
1/n
January 26, 2025 at 9:51 PM
Let me give a concrete example of the importance of applications with high risk-high reward as well as the role of NIH staff in taking risks.
Decades ago, a physical chemist proposed ideas about doing mass spectrometry on proteins (when this was deemed probably impossible).
1/n
Decades ago, a physical chemist proposed ideas about doing mass spectrometry on proteins (when this was deemed probably impossible).
1/n
“Why Facts Don't Work”—my talk at Winter Brain. Thanks to Joyce Woo for organizing “Synaptic Control of Mesolimbic DA Neurons” & co-presenters Tom Hnasko, Abigail Elerding, Miguel Lujan, Thomas Jhou. Sorry I missed it (thanks United!) but silver lining—here’s the recording: youtu.be/vZAZ6uCkkWI
Tadross WinterBrain
YouTube video by mtadross
youtu.be
January 26, 2025 at 5:08 PM
“Why Facts Don't Work”—my talk at Winter Brain. Thanks to Joyce Woo for organizing “Synaptic Control of Mesolimbic DA Neurons” & co-presenters Tom Hnasko, Abigail Elerding, Miguel Lujan, Thomas Jhou. Sorry I missed it (thanks United!) but silver lining—here’s the recording: youtu.be/vZAZ6uCkkWI
Reposted by Mike Tadross
Tune uses epigenetic editing to control gene expression without modifying the DNA sequence itself. The startup's technology is based on research from Tune co-founder and Duke BME Professor Charles Gersbach.
Seattle biotech startup Tune Therapeutics lands $175M to support clinical research
Tune Therapeutics' co-founders, from left: Akira Matsuno, chief financial officer; Charles Gersbach; and Fyodor Urnov, who also serves on the startup's
www.geekwire.com
January 13, 2025 at 7:57 PM
Tune uses epigenetic editing to control gene expression without modifying the DNA sequence itself. The startup's technology is based on research from Tune co-founder and Duke BME Professor Charles Gersbach.
Reposted by Mike Tadross
Received bad news about Carl Olson. Sad to hear that he passed away. Carl was a major influence on my early years as an Assistant Prof, with our labs down the hall from each other. He was a highly rigorous neurophysiologist, with a wry sense of humor. Please see attached images for more info.
December 2, 2024 at 12:30 AM
Received bad news about Carl Olson. Sad to hear that he passed away. Carl was a major influence on my early years as an Assistant Prof, with our labs down the hall from each other. He was a highly rigorous neurophysiologist, with a wry sense of humor. Please see attached images for more info.
Reposted by Mike Tadross
More catchup :) 2 bioRxiv preprints related to our goals of mapping and modeling entire brains: Dense Continuous Membrane Labeling and Expansion Microscopy..., synthneuro.org/publications... Scaling Properties for Artificial Neural Network Models of Entire C. elegans, synthneuro.org/publications...
November 19, 2024 at 5:15 PM
More catchup :) 2 bioRxiv preprints related to our goals of mapping and modeling entire brains: Dense Continuous Membrane Labeling and Expansion Microscopy..., synthneuro.org/publications... Scaling Properties for Artificial Neural Network Models of Entire C. elegans, synthneuro.org/publications...