Mike Hildebrand
@mikehildebrand7.bsky.social
Neuroscience Professor at Carleton University. Studying spinal mechanisms of pain using translational models.
Reposted by Mike Hildebrand
Thrilled to share our latest preprint using single nuq sequencing and Xenium to define neuron organisation and sex differences in glia within human spinal cord. Truly a collaborative effort, with a big shoutout to Katherin Gabriel and @tedpricethepainguy.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A molecular map of the human spinal dorsal and ventral horn defines arrangement of neuronal types and glial sex differences
The spinal cord is the gateway for sensory information from the body as it ascends to the brain, as well as a major motor output center of the nervous system. It is also a key location for sensory-mot...
www.biorxiv.org
November 1, 2025 at 10:46 AM
Thrilled to share our latest preprint using single nuq sequencing and Xenium to define neuron organisation and sex differences in glia within human spinal cord. Truly a collaborative effort, with a big shoutout to Katherin Gabriel and @tedpricethepainguy.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Mike Hildebrand
One of the most beautiful things in the world❤️ #patchclamp #EIRatio
October 17, 2025 at 5:14 PM
One of the most beautiful things in the world❤️ #patchclamp #EIRatio
Reposted by Mike Hildebrand
Our paper showing decreased KCC2 expression in the human spinal cord in people who died with a history of neuropathic pain is now published in PAIN: journals.lww.com/pain/abstrac... Great work from @oliviadavis.bsky.social and the teams of the De Koninck and Hildebrand labs. ❤️ 🇨🇦 collabs!
Decreased KCC2 expression in the human spinal dorsal horn... : PAIN
date there is no evidence supporting or opposing this hypothesis in humans. Here, we demonstrate that KCC2 expression is decreased in superficial dorsal horn neurons of organ donors who died with a do...
journals.lww.com
July 22, 2025 at 11:01 PM
Our paper showing decreased KCC2 expression in the human spinal cord in people who died with a history of neuropathic pain is now published in PAIN: journals.lww.com/pain/abstrac... Great work from @oliviadavis.bsky.social and the teams of the De Koninck and Hildebrand labs. ❤️ 🇨🇦 collabs!
Thrilled to celebrate graduation with these amazing honours thesis students from our team. All-stars that are all pursuing next career steps in research and medicine. The future is bright! 😊
June 18, 2025 at 6:42 PM
Thrilled to celebrate graduation with these amazing honours thesis students from our team. All-stars that are all pursuing next career steps in research and medicine. The future is bright! 😊
Reposted by Mike Hildebrand
The last 2 weeks have been a blur, but sadly I'm no longer at the NIH. Working for #painresearch at the NIH was a great honor and the best job of my life. As part of this amazing team, I'm proud to have worked on the HEAL 2025 Annual Report - pls share! heal.nih.gov/about/nih-he...
The NIH HEAL Initiative 2025 Annual Report: Research in Action | NIH HEAL Initiative
heal.nih.gov
May 14, 2025 at 8:51 PM
The last 2 weeks have been a blur, but sadly I'm no longer at the NIH. Working for #painresearch at the NIH was a great honor and the best job of my life. As part of this amazing team, I'm proud to have worked on the HEAL 2025 Annual Report - pls share! heal.nih.gov/about/nih-he...
So proud of these fabulous @carleton.ca students presenting their honours thesis projects! The future is bright for our Neuro department. 😊
April 10, 2025 at 4:01 PM
So proud of these fabulous @carleton.ca students presenting their honours thesis projects! The future is bright for our Neuro department. 😊
Reposted by Mike Hildebrand
The key to winning the trade war is doubling down on research, by @richardgold.bsky.social www.theglobeandmail.com/business/com... via @theglobeandmail.com
Opinion: The key to winning the trade war is doubling down on research
Canada’s productivity has been on a downward slide for decades. Donald Trump’s trade war has brought a renewed urgency to tackling the issue
www.theglobeandmail.com
March 30, 2025 at 7:35 PM
The key to winning the trade war is doubling down on research, by @richardgold.bsky.social www.theglobeandmail.com/business/com... via @theglobeandmail.com
Reposted by Mike Hildebrand
Michael Gold, founding president of USASP, explains why industry can’t fill the gap in funding from cuts to NIH in letter to the editor of local paper (Pittsburgh Post Gazette)
March 23, 2025 at 6:16 PM
Michael Gold, founding president of USASP, explains why industry can’t fill the gap in funding from cuts to NIH in letter to the editor of local paper (Pittsburgh Post Gazette)
Reposted by Mike Hildebrand
#NAPainSchool patient partner in 2023 Jennifer Daly-Cyr, a dedicated advocate and patient partner at the Chronic Pain Network was interviewed by Emily Mills.
💫Pushing the Boundaries of Patient Engagement in Pain Research: A Chat with Jennifer Daly-Cyr
💻 www.iasp-pain.org/publications...
💫Pushing the Boundaries of Patient Engagement in Pain Research: A Chat with Jennifer Daly-Cyr
💻 www.iasp-pain.org/publications...
February 19, 2025 at 4:29 PM
#NAPainSchool patient partner in 2023 Jennifer Daly-Cyr, a dedicated advocate and patient partner at the Chronic Pain Network was interviewed by Emily Mills.
💫Pushing the Boundaries of Patient Engagement in Pain Research: A Chat with Jennifer Daly-Cyr
💻 www.iasp-pain.org/publications...
💫Pushing the Boundaries of Patient Engagement in Pain Research: A Chat with Jennifer Daly-Cyr
💻 www.iasp-pain.org/publications...
Reposted by Mike Hildebrand
Very excited to share our new preprint: "Decreased KCC2 expression in the human spinal dorsal horn associated with chronic pain and long-term opioid use" led by @oliviadavis.bsky.social and Samuel Ferland, a collab between us, Yves De Koninck and Mike Hildebrand labs www.biorxiv.org/content/10.1...
Decreased KCC2 expression in the human spinal dorsal horn associated with chronic pain and long-term opioid use
Loss of GABAergic and glycinergic inhibitory efficacy in the spinal dorsal horn is associated with neuropathic pain and opioid-induced hyperalgesia in rodent models. Downregulation of the KCC2 chlorid...
www.biorxiv.org
January 20, 2025 at 2:05 PM
Very excited to share our new preprint: "Decreased KCC2 expression in the human spinal dorsal horn associated with chronic pain and long-term opioid use" led by @oliviadavis.bsky.social and Samuel Ferland, a collab between us, Yves De Koninck and Mike Hildebrand labs www.biorxiv.org/content/10.1...
How it started/ How it's going. 🥰 Merry Christmas, all!
December 25, 2024 at 12:32 AM
How it started/ How it's going. 🥰 Merry Christmas, all!
Interested in potential sex differences in gene expression in adult mouse spinal cord neurons? Excitatory versus inhibitory dorsal horn neurons? Check out this online tool and technical report that enables you to dig deeper. 👇😊
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
An Open‐Source Tool for Investigation of Differential RNA Expression Between Spinal Cord Cells of Male and Female Mice
Chronic pain is a highly debilitating condition that differs by type, prevalence, and severity between men and women. To uncover the molecular underpinnings of these differences, it is critical to an....
onlinelibrary.wiley.com
December 16, 2024 at 1:42 PM
Interested in potential sex differences in gene expression in adult mouse spinal cord neurons? Excitatory versus inhibitory dorsal horn neurons? Check out this online tool and technical report that enables you to dig deeper. 👇😊
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Loving this new Bluesky community. 😊 If you are in Ottawa, join us at Carleton tomorrow at 6 PM to hear of some exciting advancements in pain research, management and support! 👇 No worries if you haven't registered yet. We'll save some refreshments and snacks for you. 😉 ☕️ 🍪
November 27, 2024 at 1:19 PM
Loving this new Bluesky community. 😊 If you are in Ottawa, join us at Carleton tomorrow at 6 PM to hear of some exciting advancements in pain research, management and support! 👇 No worries if you haven't registered yet. We'll save some refreshments and snacks for you. 😉 ☕️ 🍪