In this Perspective, the functions of the recently identified post-translational-modification protein l-lactylation in the regulation of cellular metabolism and signalling are discussed, highlighting the potential of l-lactylation as a therapeutic target.

Developing genetic access to transcriptionally distinct enteric neurons in vivo enables the examination of morphological heterogeneity across cell types as well as cell-type-specific influences on GI ...

This Review summarizes our current knowledge about the genetic underpinnings of metabolic-dysfunction-associated steatotic liver disease and highlights its causal association with type 2 diabetes and insulin resistance.

Covid-19 has been linked to cardiovascular complications, but the long-term impacts, particularly for mild infections, are not well understood. Here, the authors investigate the long-term impacts of Covid-19 on cardiovascular disease using data on the whole population of Sweden aged 40-75 years.

Pilley et al. describe how metabolite levels change in 12 organs from male and female mice across five ages, spanning adolescence to old age. They reveal that organs show distinct age- and sex-specific changes in metabolism. They also develop metabolic clocks that predict putative metabolic drivers of aging, including hydroxyproline.

Information about the roles of each author of a paper can help to build trust, integrity and responsible research assessment. Coordinated efforts are needed to consolidate progress.

Nature Metabolism, Published online: 24 November 2025; doi:10.1038/s42255-025-01414-7We show that the size of the mitochondrial NAD+ pool in hepatocytes is regulated by SLC25A51 expression in vivo. We further find that selectively increasing mitochondrial NAD+ is sufficient to improve liver regeneration after partial hepatectomy, equivalent to the effect of systemic high-dose NAD+ precursor supplementation.

This Review explores the complex relationship between obesity and psoriatic disease. The authors highlight the underlying mechanisms that drive this association and propose a comprehensive approach to...

In cognitively normal older adults at risk for Alzheimer’s dementia, physical inactivity was associated with faster tau protein buildup and cognitive decline.

Kenny and Scharenberg et al. provide a broad overview of the fundamental aspects of choline metabolism and cellular handling, and how it impacts physiology and pathology.

This study identifies BNST theta and prefrontal BNST coherence as intracranial biomarkers predicting depression outcomes after DBS. Lower activity predicted better long-term benefit, linking brain circuits to emotional bias and anxiety.

Wadhwa et al. examine how respiratory bacterial and viral pathogens exploit host metabolism to evade immune responses and influence disease outcomes. They underscore the need for deeper insight into i...

Biopharma’s reawakened interest in cardiovascular diseases spans new targets and modalities, with more convenient formulations to boost access and adherence.

Gel-based device inspired by the cooling powers of milk assesses peppers whose burn ranges from mild to dangerous.

Could a microbe that can smuggle antigens into the immune system of the gut provide a simple way to treat cancers?

In this Review, the authors summarize epidemiological trends of type 2 diabetes in China, discuss unique risk factors contributing to diabetes risk in the Chinese population and highlight how recent advances from multi-omics studies can affect treatment of diabetes in China.

Universities are in thrall to a rankings system that prioritizes narrow aspects of academic life. Three changes would give institutions the freedom to explore fresh ways of working.

Flutters, knots and other stomach sensations tied to nervousness are all examples of the gut-brain axis in action.