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mcrcellmatrix.bsky.social
Manchester Cell Matrix Centre
@mcrcellmatrix.bsky.social
200 followers 160 following 10 posts
Matrix biology, cell-matrix research at the University of Manchester. Personal tweets. http://www.wellcome-matrix.org/
Posts Replies Media Videos
mcrcellmatrix.bsky.social
Amazing new paper from Clair Baldock's lab resolves the collagen VI microfibril structure by cryo-EM to reveal a cysteine-rich coiled-coil crucial for heterotrimerization & microfibril assembly. The structure also reveals a hotspot of collagen VI muscular dystrophy mutations that disrupt assembly.
Collagen VI microfibril structure reveals mechanism for molecular assembly and clustering of inherited pathogenic mutations
Nature Communications - Collagen VI microfibril cryo-EM structure resolves a cysteine-rich coiled-coil important for heterotrimerization and microfibril assembly, reveals a hotspot of collagen VI...
rdcu.be
August 15, 2025 at 6:32 AM
mcrcellmatrix.bsky.social
We are celebrating Three Decades of Discovery and Excellence at the Cell Matrix Centre!
June 25, 2025 at 10:35 AM
Reposted by Manchester Cell Matrix Centre
dev-journal.bsky.social
In preprints: unpicking chemical and mechanical crosstalk for axonal pathfinding

Dionn Hargreaves and Sarah Woolner @mcrcellmatrix.bsky.social‬ discuss the #preprint from @evapillai.bsky.social‬ ‪@sudimukherjee.bsky.social‬ @franzelab.bsky.social‬ et al.
journals.biologists.com/dev/article/...
In preprints: a new preprint curation initiative from Development
June 19, 2025 at 9:51 AM
mcrcellmatrix.bsky.social
We had a great day today at the Translation Manchester Showcase. Let us know, what does Translational research mean to you?
June 18, 2025 at 3:11 PM
Reposted by Manchester Cell Matrix Centre
martinhumphries.bsky.social
Congratulations to Tony Day of @mcrcellmatrix.bsky.social @fbmh-uom.bsky.social on his election to the Academy of Medical Sciences (‪@acmedsci.bsky.social). Tremendous contributions to basic and translational research on proteoglycans.
May 22, 2025 at 12:48 PM
mcrcellmatrix.bsky.social
Are you a PhD student or researcher passionate about cell-matrix research? Are you part of a research community that faces barriers to access or opportunity?

Our Visiting Scholar Scheme offers short-term research placements at the Manchester Cell-Matrix Centre.

Apply by May 30: lnkd.in/eppWKvH2
LinkedIn
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lnkd.in
May 6, 2025 at 11:52 AM
Reposted by Manchester Cell Matrix Centre
douglaspdyer.bsky.social
So excited to share our first neuro focused paper from the lab, we show that CXCL4 (PF4) is transported into the brain by proteoglycans within the endothelial glycocalyx and that GAG binding also mediates the pro neurogenesis effects of CXCL4. www.biorxiv.org/content/10.1...
April 28, 2025 at 7:42 AM
mcrcellmatrix.bsky.social
Today at the Manchester Cell Matrix Centre, we're excited to showcase another Woman in Science, Dharshika Jayalath (Pathiranage), Dharshika is a lab manager, whose research focuses on the circadian clock and circadian rhythms.

Watch Dharshika's video here: youtube.com/shorts/bS-KL...
Women in Science: Dharshika
YouTube video by Manchester Cell Matrix Centre
youtube.com
March 27, 2025 at 3:24 PM
mcrcellmatrix.bsky.social
Today at the Manchester Cell Matrix Centre, we're excited to showcase another Woman in Science, Dionn, a postdoctoral researcher specializing in Quantitative and Biophysical Biology.

Watch Dionn's video here: youtube.com/shorts/W57Gz...
Women in Science: Dionn
YouTube video by Manchester Cell Matrix Centre
youtube.com
March 26, 2025 at 2:09 PM
mcrcellmatrix.bsky.social
At the Manchester Cell Matrix Centre, we're showcasing our researchers' through a new video series. Kicking off with Women in Science, today we highlight Erin, a PhD student studying the ImmunoMatrix in Complex Disease and Project Lead of Research Hive.

Erin's video youtube.com/shorts/2xT0q...
Women in Science: Erin
YouTube video by Manchester Cell Matrix Centre
youtube.com
March 25, 2025 at 1:20 PM
Reposted by Manchester Cell Matrix Centre
sankarinagarajan.bsky.social
A fantastic postdoc opportunity available for talented PhD graduates to work in our CRUK funded PhD project.
jobs.manchester.ac.uk/internal/Job...
@mcr-breastcentre.bsky.social @mcrcnews.bsky.social @mcf-uom.bsky.social @mcrcellmatrix.bsky.social @official-uom.bsky.social @fbmh-uom.bsky.social
jobs.manchester.ac.uk
March 4, 2025 at 8:14 PM
Reposted by Manchester Cell Matrix Centre
tranejoan.bsky.social
Our lab's #1st manuscript from our #1st #PhD Katie is on #bioRxiv! Check it out 👇🏻

#macrophage regulation of fibroblast #collagen #circadian rhythm. #ImmunoECMatrix w/ @profandrewmac.bsky.social @tracyh9494.bsky.social @mcrcellmatrix.bsky.social @mcf-uom.bsky.social

www.biorxiv.org/content/10.1...
Macrophages promote collagen deposition through circadian regulation of fibroblasts
Collagen deposition in fibroblasts, the primary collagen-producing cells, is regulated by both macrophages and the circadian rhythm, although how these regulatory processes interact with one another i...
www.biorxiv.org
March 5, 2025 at 8:28 AM
mcrcellmatrix.bsky.social
We had a great time yesterday taking some #TimetoTalk. We thank everyone who took the time out of their day to just simply connect.
February 7, 2025 at 1:30 PM
Reposted by Manchester Cell Matrix Centre
cancerresearchuk.org
In the UK, nearly 1 in 2 people will get cancer in their lifetime. It's World Cancer Day today – a global day to raise awareness and take action against cancer 🌍

Whatever your cancer experience, share this post and help us get the word out.

#WorldCancerDay #WCD2025
Pink square graphic with black text which reads, 'World Cancer Day - 4 February'
February 4, 2025 at 8:09 AM
mcrcellmatrix.bsky.social
This research offers new insights into COVID-19 pathology and potential therapeutic targets. A great example of pushing the boundaries of matrix biology!

#MatrixBiology #Hyaluronan #LungHealth

@becky-dodd.bsky.social @profjudiallen.bsky.social
February 4, 2025 at 2:39 PM
Reposted by Manchester Cell Matrix Centre
rachellennon.bsky.social
We are hiring!!

How do basement membranes become stable structures during tissue growth? How can we measure turnover and dynamics?

Come and join our team to help us answer these questions!

@mcrcellmatrix.bsky.social
@stramerlab.bsky.social

More info 👇

www.jobs.ac.uk/job/DLN927/r...
Research Associate - Mechanisms Associated with Extracellular Matrix Assembly and Stability at The University of Manchester
Apply for the Research Associate - Mechanisms Associated with Extracellular Matrix Assembly and Stability role on jobs.ac.uk, the top job board for academic positions in higher education. View details...
www.jobs.ac.uk
January 27, 2025 at 10:08 AM
Reposted by Manchester Cell Matrix Centre
nabalabuic.bsky.social
Our paper entitled "The novel #ECM protein SNED1 mediates cell adhesion via the RGD-binding #integrins α5β1 and αvβ3" is now published in #OpenAccess in @jcellsci.bsky.social @biologists.bsky.social. Big congrats Dharma pdtr124.bsky.social and Nandini! doi.org/10.1242/jcs....
The novel ECM protein SNED1 mediates cell adhesion via the RGD-binding integrins α5β1 and αvβ3
Summary: The recently discovered extracellular matrix protein SNED1 promotes the adhesion of breast cancer cells and neural crest cells via interaction with α5β1 and αvβ3 integrins, the first SNED1 re...
doi.org
January 22, 2025 at 3:35 PM
Reposted by Manchester Cell Matrix Centre
thebyronlab.bsky.social
📣 PhD opportunity in the lab!

💡 Are you interested in developing biomaterials to understand how cancer cells sense their surroundings to control gene activity?

🔗 For info on the project, and for details on how to apply, click here: www.findaphd.com/phds/project...

📧 Do get in touch if interested!
(BBSRC NWD) Developing biomaterials to engineer how cancer cells sense force to regulate gene expression at The University of Manchester on FindAPhD.com
PhD Project - (BBSRC NWD) Developing biomaterials to engineer how cancer cells sense force to regulate gene expression at The University of Manchester, listed on FindAPhD.com
www.findaphd.com
December 20, 2024 at 11:20 AM
Reposted by Manchester Cell Matrix Centre
douglaspdyer.bsky.social
Please spread the word and sign up for our exciting spring meeting in Nottingham with amazing speakers on the topic of ECM, immunity and infection. An exciting and developing field! paacr4.wixsite.com/bsmb-spring2...
Home | BSMBSpring2025
paacr4.wixsite.com
January 7, 2025 at 9:14 AM
Reposted by Manchester Cell Matrix Centre
tranejoan.bsky.social
Very glad to see this study finally out (and mentioned on bsky already!)- it's been a huge #collaboration across different groups🙏🏻

Fibroblasts recycles (in a #circadian manner) #collagen to make new fibrils, which is enhanced in #fibrosis.

doi.org/10.7554/eLif...
@elife.bsky.social
Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis
Secretion and fibrillogenesis of collagen-I are separately controlled molecular pathways in the fibroblast, where surprisingly endocytic recycling is required for fibril formation and is increased in ...
doi.org
January 16, 2025 at 2:29 PM
mcrcellmatrix.bsky.social
We'll always have matrix... Happy holidays to all our members and collaborators.
Manchester Cell-Matrix Centre members
December 20, 2024 at 10:06 AM