Maximilian Heeg
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maximilian.heeg.io
Maximilian Heeg
@maximilian.heeg.io
130 followers 61 following 17 posts
Assistant Investigator at @alleninstitute.bsky.social | Former postdoc @GoldrathLab | Pediatrician | Interested in tissue resident memory T cells and Immunodeficiencies | Mountain enthusiast ⛰ | 🐕
#immunology
Personal website: www.heeg.io
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Reposted by Maximilian Heeg
alleninstitute.org
Susan Kaech, PhD, has been selected to be the new EVP of our Immunology moonshot.

She currently leads the @salkinstitute.bsky.social NOMIS Center for Immunobiology & Microbial Pathogenesis.

🔗 alleninstitute.org/news/susan-k...

#Immunology #CellBio #ImmunoBio
Susan Kaech, Ph.D., named next leader of Allen Institute’s Immunology moonshot
Leader in immunology to advance the Institute’s next frontier in understanding the immune system’s role across health and disease
alleninstitute.org
October 21, 2025 at 4:51 PM
maximilian.heeg.io
So proud to be a co-author on this study and absolutely loved the beautiful thread by @marionpepper.bsky.social — high recommended 👇
marionpepper.bsky.social Marion Pepper @marionpepper.bsky.social · Oct 10
Asthma is a chronic disease characterized by acute, intermittent, recurrent episodes of airway inflammation. A decade of work developing the tools, techniques and collaborations needed to figure out how CD4+ T cells in the lungs propagate disease can be found here:
www.biorxiv.org/content/10.1...
Tertiary lymphoid structures support the development of allergen-specific progenitor CD4+ T cells
Tissue-resident memory CD4+ T cells (TRM) are key sentinels of the adaptive immune response that provide a rapid, robust inflammatory response upon reactivation in non-lymphoid tissues. While CD4+ TRM...
www.biorxiv.org
October 11, 2025 at 8:11 PM
Reposted by Maximilian Heeg
labwaggoner.bsky.social
@biorxivpreprint.bsky.social Tertiary lymphoid structures support the development of allergen-specific progenitor CD4+ T cells @marionpepper.bsky.social
www.biorxiv.org/content/10.1...
October 7, 2025 at 3:02 PM
Reposted by Maximilian Heeg
marionpepper.bsky.social
More coming on what this means but this was one of those stories that took almost a decade to come together but was well worth the time. Also check out a companion piece on @biorxiv by Patrick Brennan!
labwaggoner.bsky.social Waggoner Lab @labwaggoner.bsky.social · Oct 7
@biorxivpreprint.bsky.social Tertiary lymphoid structures support the development of allergen-specific progenitor CD4+ T cells @marionpepper.bsky.social
www.biorxiv.org/content/10.1...
October 9, 2025 at 2:38 AM
Reposted by Maximilian Heeg
rodrahimi.bsky.social
Very impressive paper by the Heeg and Goldrath labs using spatial transcriptomics to define CD8 Trm biology in the intestine in mice and humans. Congrats to @reinacampos.bsky.social and co-authors. #ImmunoSky
Tissue-resident memory CD8 T cell diversity is spatiotemporally imprinted - Nature
Profiling of the location and transcriptome of tissue-resident memory CD8 T cell formation at single-transcript resolution finds regionalized signalling as the basis of immune diversity in t...
www.nature.com
January 26, 2025 at 9:14 PM
maximilian.heeg.io
📢 Join our team at @alleninstitute.bsky.social! We're hiring a Bioinformatics Scientist II for spatial transcriptomics in immunology.
Our latest work in Nature shows how tissue architecture shapes immune cell diversity. Now we're expanding our team!
Learn more: alleninstitute.org/careers/jobs...
Jobs
We are working to solve the biggest mysteries in bioscience.
alleninstitute.org
January 31, 2025 at 7:07 PM
Reposted by Maximilian Heeg
erictopol.bsky.social
Spatial omics rides again, this time determining how immune CD8 T cells by location in the gut have different roles, such as killing function in the villus and backup reinforcements in the crypts
www.nature.com/articles/s41...
Good Explainer www.lji.org/news-events/...
@alleninstitute.bsky.social
January 22, 2025 at 11:30 PM
Reposted by Maximilian Heeg
jem.org
New: Amir Ferry, Ananda Goldrath and colleagues @ucsdhealthsci.bsky.social show that differentiation of tissue-resident memory T cells (TRM) is accompanied by the upregulation of the conventional DC1 (cDC1) chemoattractant, Xcl1. https://buff.ly/4hrKCYe

#MucosalImmunology #TumorImmunology
January 22, 2025 at 5:14 PM
Reposted by Maximilian Heeg
alleninstitute.org
When your gut is under attack, the immune system is activated. Like any good army, the roles of each cellular soldier depends on their location. 🧵

📸 Elena Lin/ @ucsdhealthsci.bsky.social

#ImmunoSky
January 22, 2025 at 8:17 PM
maximilian.heeg.io
Beautiful thread on how tissue-resident T cells organize in the gut post-infection from my co-conspirator @reinacampos.bsky.social. Our spatial multi-omics work revealed unexpected complexity in immune system architecture. Think less checkers, more 4D chess 🧬🔬
January 22, 2025 at 6:31 PM
Reposted by Maximilian Heeg
lji.org
New in @nature.com — LJI's @reinacampos.bsky.social and colleagues at @ucsdhealthsci.bsky.social and @alleninstitute.bsky.social track the amazing journey of T cells in the gut.

“For the first time, we were able to capture the formation of immunological memory in space and time."

bit.ly/40Tnlt7
T cells rise up to fight infections in the gut
Scientists show how a special group of T cells travels through the small intestine to combat pathogens
www.lji.org
January 22, 2025 at 5:28 PM
maximilian.heeg.io
Today in @nature.com. We mapped the spatial and temporal dynamics of intestinal tissue-resident memory CD8 T (TRM) cell differentiation.
🔗 www.nature.com/articles/s41....
@ucsandiego.bsky.social @lji.org @alleninstitute.bsky.social @amonell.bsky.social @reinacampos.bsky.social @GoldrathLab 🧵 1/10
Tissue-resident memory CD8 T cell diversity is spatiotemporally imprinted - Nature
Profiling of the location and transcriptome of tissue-resident memory CD8 T cell formation at single-transcript resolution finds regionalized signalling as the basis of immune diversity in t...
www.nature.com
January 22, 2025 at 4:15 PM