Martin Sauvageau
@martinsauvageau.bsky.social
Assistant Professor @IRCM, @McGill Center for RNA Sciences, @UdeM.
RNA Biology, lncRNA, RNA Therapy, Genome Regulation sauvageaulab.org
RNA Biology, lncRNA, RNA Therapy, Genome Regulation sauvageaulab.org
Reposted by Martin Sauvageau
A preprint‼️that's bound to ruffle some 🪶 "Widespread DNA off-targeting confounds studies of RNA chromatin occupancy" led by our Micah Goldrich and Louis Delhaye from
Pieter Mestdagh in Ghent. TL;DR we show that many of lncRNA chromatin occupancy obtained are flawed www.biorxiv.org/content/10.1...
Pieter Mestdagh in Ghent. TL;DR we show that many of lncRNA chromatin occupancy obtained are flawed www.biorxiv.org/content/10.1...
November 13, 2025 at 9:26 AM
A preprint‼️that's bound to ruffle some 🪶 "Widespread DNA off-targeting confounds studies of RNA chromatin occupancy" led by our Micah Goldrich and Louis Delhaye from
Pieter Mestdagh in Ghent. TL;DR we show that many of lncRNA chromatin occupancy obtained are flawed www.biorxiv.org/content/10.1...
Pieter Mestdagh in Ghent. TL;DR we show that many of lncRNA chromatin occupancy obtained are flawed www.biorxiv.org/content/10.1...
Reposted by Martin Sauvageau
Next Codon Usage Meeting, May 31st to June 3rd, 2026 in Montreal right after the RNA Society Meeting. The list of speakers will be up soon.
sites.google.com/view/codonus...
sites.google.com/view/codonus...
codon usage
About the Conference
Codon usage bias—the preference for certain synonymous codons—is a key factor in genome regulation. Codon usage and synonymous codon mutations have been shown to influence gene ex...
sites.google.com
November 5, 2025 at 10:55 PM
Next Codon Usage Meeting, May 31st to June 3rd, 2026 in Montreal right after the RNA Society Meeting. The list of speakers will be up soon.
sites.google.com/view/codonus...
sites.google.com/view/codonus...
Reposted by Martin Sauvageau
📢 Paper Alert: tinyurl.com/yzy2d864. We characterized tRNA-overlapping lncRNA loci = tROLs! tROL perturbations silence
codon-biased genes in inter-chromosomal proximity. tROLs bridge the non-coding
and coding genomes. @sickkidsto.bsky.social @uoftpress.bsky.social
codon-biased genes in inter-chromosomal proximity. tROLs bridge the non-coding
and coding genomes. @sickkidsto.bsky.social @uoftpress.bsky.social
tRNA-overlapping long non-coding RNA loci repress codon-biased genes
Ahmed et al. define tRNA-overlapping lncRNAs (tROLs). tROLs in gene-dense regions
interact between chromosomes and depend on each other’s transcription. tROL perturbations
silence codon-biased genes i...
tinyurl.com
October 14, 2025 at 2:33 PM
📢 Paper Alert: tinyurl.com/yzy2d864. We characterized tRNA-overlapping lncRNA loci = tROLs! tROL perturbations silence
codon-biased genes in inter-chromosomal proximity. tROLs bridge the non-coding
and coding genomes. @sickkidsto.bsky.social @uoftpress.bsky.social
codon-biased genes in inter-chromosomal proximity. tROLs bridge the non-coding
and coding genomes. @sickkidsto.bsky.social @uoftpress.bsky.social
Reposted by Martin Sauvageau
While I was taking a holiday last week, 2 super exciting preprints dropped, adding to another posted 6 days prior.
These papers describe a remarkable role for *recessive* variants in *RNU2-2* causing developmental and epileptic encephalopathy
🧵 by the amazing @christeldepienne.bsky.social 👇
1/3
These papers describe a remarkable role for *recessive* variants in *RNU2-2* causing developmental and epileptic encephalopathy
🧵 by the amazing @christeldepienne.bsky.social 👇
1/3
After our study on RNU4-2 and RNU5B-1 published in May (Nava et al, Nature Genetics 2025), I am excited to share our new preprint reporting dominant and recessive variants in RNU2-2 as a frequent cause of developmental and epileptic encephalopathy (DEE).
📄 www.medrxiv.org/content/10.1...
📄 www.medrxiv.org/content/10.1...
Systematic analysis of snRNA genes reveals frequent RNU2-2 variants in dominant and recessive developmental and epileptic encephalopathies
Variants in spliceosomal small nuclear RNA (snRNA) genes RNU4-2 (ReNU syndrome), RNU5B-1 , and RNU2-2 have recently been linked to dominant neurodevelopmental disorders (NDDs), revealing a major, prev...
www.medrxiv.org
September 8, 2025 at 8:43 AM
While I was taking a holiday last week, 2 super exciting preprints dropped, adding to another posted 6 days prior.
These papers describe a remarkable role for *recessive* variants in *RNU2-2* causing developmental and epileptic encephalopathy
🧵 by the amazing @christeldepienne.bsky.social 👇
1/3
These papers describe a remarkable role for *recessive* variants in *RNU2-2* causing developmental and epileptic encephalopathy
🧵 by the amazing @christeldepienne.bsky.social 👇
1/3
Reposted by Martin Sauvageau
Congratulations to Dr. Côté on his appointment to the Canadian Academy of Health Sciences! This prestigious distinction recognizes his scientific leadership, the excellence of his health research as well as his commitment to collaboration and innovation in health.
🔗 bit.ly/3HGWhX3
🔗 bit.ly/3HGWhX3
August 21, 2025 at 12:02 PM
Congratulations to Dr. Côté on his appointment to the Canadian Academy of Health Sciences! This prestigious distinction recognizes his scientific leadership, the excellence of his health research as well as his commitment to collaboration and innovation in health.
🔗 bit.ly/3HGWhX3
🔗 bit.ly/3HGWhX3
Proud to see this work on a new #machinelearning model, ECSFinder, now online academic.oup.com/nar/article/...
This work was led by Vanda Gaonac'h-Lovejoy, a PhD student co-supervised with @martinalexsmith.bsky.social at @ramacgenomics.bsky.social in collab with Prof John Mattick.
Full thread 👇🏼
This work was led by Vanda Gaonac'h-Lovejoy, a PhD student co-supervised with @martinalexsmith.bsky.social at @ramacgenomics.bsky.social in collab with Prof John Mattick.
Full thread 👇🏼
August 25, 2025 at 4:04 PM
Proud to see this work on a new #machinelearning model, ECSFinder, now online academic.oup.com/nar/article/...
This work was led by Vanda Gaonac'h-Lovejoy, a PhD student co-supervised with @martinalexsmith.bsky.social at @ramacgenomics.bsky.social in collab with Prof John Mattick.
Full thread 👇🏼
This work was led by Vanda Gaonac'h-Lovejoy, a PhD student co-supervised with @martinalexsmith.bsky.social at @ramacgenomics.bsky.social in collab with Prof John Mattick.
Full thread 👇🏼
Reposted by Martin Sauvageau
I am so incredibly excited to share our latest work, on the exploration of #RNA secondary structure ensembles and discovery of RNA regulatory structural switches in bacteria and human cells, just out in
@natbiotech.nature.com: nature.com/articles/s41.... A short tread! (1/n)
@natbiotech.nature.com: nature.com/articles/s41.... A short tread! (1/n)
Identification of conserved RNA regulatory switches in living cells using RNA secondary structure ensemble mapping and covariation analysis - Nature Biotechnology
Transcriptome-scale maps of RNA secondary structure ensembles in living cells detect candidate RNA structural switches.
nature.com
July 27, 2025 at 5:03 PM
I am so incredibly excited to share our latest work, on the exploration of #RNA secondary structure ensembles and discovery of RNA regulatory structural switches in bacteria and human cells, just out in
@natbiotech.nature.com: nature.com/articles/s41.... A short tread! (1/n)
@natbiotech.nature.com: nature.com/articles/s41.... A short tread! (1/n)
Reposted by Martin Sauvageau
Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In @cp-cell.bsky.social, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. www.sciencedirect.com/science/arti...
July 26, 2025 at 7:15 PM
Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In @cp-cell.bsky.social, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. www.sciencedirect.com/science/arti...
Reposted by Martin Sauvageau
Online now at @cp-cell.bsky.social , the culmination of a 12-year effort. 🧵 to follow later this evening
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Repeat-element RNAs integrate a neuronal growth circuit
SINEs of recovery: A subset of small RNAs encoded by repetitive genomic elements are
induced by nerve lesion to regulate protein synthesis and enhance axonal growth.
www.cell.com
May 16, 2025 at 3:20 PM
Online now at @cp-cell.bsky.social , the culmination of a 12-year effort. 🧵 to follow later this evening
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Martin Sauvageau
🚨 @healthsciences.mcgill.ca is recruiting: Canada Excellence Research Chair in #RNA Neurotherapeutics
Looking for an established leader in RNA research in the brain with an innovative research program in RNA-related research in neuropsychiatry.
✍ Apply by July 4:
Looking for an established leader in RNA research in the brain with an innovative research program in RNA-related research in neuropsychiatry.
✍ Apply by July 4:
Canada Excellence Research Chair (CERC) in RNA Neurotherapeutics
Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at…
buff.ly
June 21, 2025 at 5:31 PM
🚨 @healthsciences.mcgill.ca is recruiting: Canada Excellence Research Chair in #RNA Neurotherapeutics
Looking for an established leader in RNA research in the brain with an innovative research program in RNA-related research in neuropsychiatry.
✍ Apply by July 4:
Looking for an established leader in RNA research in the brain with an innovative research program in RNA-related research in neuropsychiatry.
✍ Apply by July 4:
Reposted by Martin Sauvageau
Stop the doom scrolling! A new 🗞️ from my lab, describing one of our flagship projects of many years we are super excited to share:
"Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression".
A 🧵
biorxiv.org/content/earl...
"Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression".
A 🧵
biorxiv.org/content/earl...
Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression
Modes of action of long noncoding RNAs (lncRNAs) are poorly understood. CHASERR is a broadly expressed lncRNA located immediately upstream of the promoter of the CHD2 gene. We show that antisense olig...
biorxiv.org
May 29, 2025 at 12:35 PM
Stop the doom scrolling! A new 🗞️ from my lab, describing one of our flagship projects of many years we are super excited to share:
"Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression".
A 🧵
biorxiv.org/content/earl...
"Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression".
A 🧵
biorxiv.org/content/earl...
Reposted by Martin Sauvageau
Hello out there! Are you looking for a friendly community to share your RNA research and hear about some cool RNA biology? Register for @trendrna.bsky.social on July 10-11 now! Oral abstract deadline is May 30th! Co sponsored by @rnacanada.bsky.social!
We are excited to announce that registration for this year's Toronto RNA Enthusiasts' Day (TREnD) is now open!
July 10th, 1pm-4pm ET ONLINE for everyone
July 11th, 9am-7pm ET ONLINE across Canada and IN PERSON in Toronto
event.fourwaves.com/trend25/regi...
July 10th, 1pm-4pm ET ONLINE for everyone
July 11th, 9am-7pm ET ONLINE across Canada and IN PERSON in Toronto
event.fourwaves.com/trend25/regi...
May 23, 2025 at 9:06 PM
Hello out there! Are you looking for a friendly community to share your RNA research and hear about some cool RNA biology? Register for @trendrna.bsky.social on July 10-11 now! Oral abstract deadline is May 30th! Co sponsored by @rnacanada.bsky.social!
We are looking for a talented Research Assistant to work in the #RNATherapeutics Core Facility at the @ircm.bsky.social in beautiful Montreal.
More details on the position and on how to apply here:
www.ircm.qc.ca/en/position-...
More details on the position and on how to apply here:
www.ircm.qc.ca/en/position-...
Research Assistant - RNA Therapeutics Core Facility
www.ircm.qc.ca
May 20, 2025 at 9:01 PM
We are looking for a talented Research Assistant to work in the #RNATherapeutics Core Facility at the @ircm.bsky.social in beautiful Montreal.
More details on the position and on how to apply here:
www.ircm.qc.ca/en/position-...
More details on the position and on how to apply here:
www.ircm.qc.ca/en/position-...
Reposted by Martin Sauvageau
A 🧵 to walk those interested through this paper...
Online now at @cp-cell.bsky.social , the culmination of a 12-year effort. 🧵 to follow later this evening
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Repeat-element RNAs integrate a neuronal growth circuit
SINEs of recovery: A subset of small RNAs encoded by repetitive genomic elements are
induced by nerve lesion to regulate protein synthesis and enhance axonal growth.
www.cell.com
May 16, 2025 at 4:50 PM
A 🧵 to walk those interested through this paper...
Reposted by Martin Sauvageau
Reposted by Martin Sauvageau
For the first time, doctors have created a customized treatment using the revolutionary gene-editing technique known as CRISPR to treat a baby with a rare, life-threatening genetic disorder.
A promising genetic treatment tailor-made for a baby born with a rare disorder
For the first time, doctors have created a customized treatment using the revolutionary gene-editing technique known as CRISPR to treat a baby with a rare, life-threatening genetic disorder.
www.npr.org
May 15, 2025 at 5:19 PM
For the first time, doctors have created a customized treatment using the revolutionary gene-editing technique known as CRISPR to treat a baby with a rare, life-threatening genetic disorder.
Reposted by Martin Sauvageau
Next week! RNA Canada sponsored series:
Perspectives on RNA: RNA Chemistry and its applications, featuring Mark Taylor (UofToronto) Parrish Evers and John Pezacki (uOttawa) and Yihang Chen (ongene biotech Corporation). www.rnacanada.ca/etn/rna-cana...
Perspectives on RNA: RNA Chemistry and its applications, featuring Mark Taylor (UofToronto) Parrish Evers and John Pezacki (uOttawa) and Yihang Chen (ongene biotech Corporation). www.rnacanada.ca/etn/rna-cana...
May 14, 2025 at 9:55 PM
Next week! RNA Canada sponsored series:
Perspectives on RNA: RNA Chemistry and its applications, featuring Mark Taylor (UofToronto) Parrish Evers and John Pezacki (uOttawa) and Yihang Chen (ongene biotech Corporation). www.rnacanada.ca/etn/rna-cana...
Perspectives on RNA: RNA Chemistry and its applications, featuring Mark Taylor (UofToronto) Parrish Evers and John Pezacki (uOttawa) and Yihang Chen (ongene biotech Corporation). www.rnacanada.ca/etn/rna-cana...
Reposted by Martin Sauvageau
Beautiful paper
Exogenous RNA surveillance by proton-sensing TRIM25
Exogenous messenger RNAs (mRNAs) require cellular machinery for delivery and translation but also encounter inhibitory factors. To investigate their regulation, we performed genome-wide CRISPR screens...
www.science.org
April 7, 2025 at 9:43 PM
Beautiful paper
Reposted by Martin Sauvageau
It's difficult to focus on science with everything going on, but I still enjoy hearing about other people's work here, so I want to continue sharing ours. Congrats to postdoc Jong-Sun Lee for his outstanding work published in @cp-molcell.bsky.social! Details in thread👇
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
An ultraconserved snoRNA-like element in long noncoding RNA CRNDE promotes ribosome biogenesis and cell proliferation
Cancer cells frequently enhance ribosome production to support rapid growth. Here,
Lee et al. demonstrate that an isoform of lncRNA CRNDE containing an ultraconserved
element (CRNDEUCE) promotes 60S r...
www.cell.com
April 3, 2025 at 4:47 PM
It's difficult to focus on science with everything going on, but I still enjoy hearing about other people's work here, so I want to continue sharing ours. Congrats to postdoc Jong-Sun Lee for his outstanding work published in @cp-molcell.bsky.social! Details in thread👇
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Reposted by Martin Sauvageau
🧬 L'avenir de la médecine génomique et ses implications dans les thérapies #ARN
Rejoignez-nous pour un colloque organisé par @d2rmcgill.bsky.social et @AReNA lors du 92e Congrès de l’
@acfas.ca !
📅5 mai 2025 🕐12h45
💡 En savoir plus : mcgill.ca/dna-to-rna/f...
#ACFAS8
Rejoignez-nous pour un colloque organisé par @d2rmcgill.bsky.social et @AReNA lors du 92e Congrès de l’
@acfas.ca !
📅5 mai 2025 🕐12h45
💡 En savoir plus : mcgill.ca/dna-to-rna/f...
#ACFAS8
April 3, 2025 at 5:27 PM
🧬 L'avenir de la médecine génomique et ses implications dans les thérapies #ARN
Rejoignez-nous pour un colloque organisé par @d2rmcgill.bsky.social et @AReNA lors du 92e Congrès de l’
@acfas.ca !
📅5 mai 2025 🕐12h45
💡 En savoir plus : mcgill.ca/dna-to-rna/f...
#ACFAS8
Rejoignez-nous pour un colloque organisé par @d2rmcgill.bsky.social et @AReNA lors du 92e Congrès de l’
@acfas.ca !
📅5 mai 2025 🕐12h45
💡 En savoir plus : mcgill.ca/dna-to-rna/f...
#ACFAS8
Reposted by Martin Sauvageau
🚨 Appel à proposition 🚨
D2R lance un programme de financement pour soutenir la recherche à haut risque et à fort impact potentiel en #médecinegénomique et en #thérapiesARN !
$350 000 pour 2 ans
Date limite : 15 mai 2025
🔗https://buff.ly/Ub5D45x
D2R lance un programme de financement pour soutenir la recherche à haut risque et à fort impact potentiel en #médecinegénomique et en #thérapiesARN !
$350 000 pour 2 ans
Date limite : 15 mai 2025
🔗https://buff.ly/Ub5D45x
April 3, 2025 at 8:10 PM
🚨 Appel à proposition 🚨
D2R lance un programme de financement pour soutenir la recherche à haut risque et à fort impact potentiel en #médecinegénomique et en #thérapiesARN !
$350 000 pour 2 ans
Date limite : 15 mai 2025
🔗https://buff.ly/Ub5D45x
D2R lance un programme de financement pour soutenir la recherche à haut risque et à fort impact potentiel en #médecinegénomique et en #thérapiesARN !
$350 000 pour 2 ans
Date limite : 15 mai 2025
🔗https://buff.ly/Ub5D45x
If you’re interested in moving your lab to beautiful Montreal Canada, this program offers chairholders funding of up to 1M$ a year for 8 years. See link for details.
www.nature.com/naturecareer...
www.nature.com/naturecareer...
Canada Excellence Research Chairs (CERC) - Montréal, Quebec (CA) job with University of Montreal (UdeM) | 12838461
Canada Excellence Research Chairs (CERC)
www.nature.com
April 2, 2025 at 3:37 AM
If you’re interested in moving your lab to beautiful Montreal Canada, this program offers chairholders funding of up to 1M$ a year for 8 years. See link for details.
www.nature.com/naturecareer...
www.nature.com/naturecareer...
Reposted by Martin Sauvageau
Fantastic opportunity if you are interested in moving your lab to Montreal, Canada! Through this program, Chairholders will be awarded up to $1 million per year for a period of 8 years.
Contact me if you are interested.
www.nature.com/naturecareer...
Contact me if you are interested.
www.nature.com/naturecareer...
Canada Excellence Research Chairs (CERC) - Montréal, Quebec (CA) job with University of Montreal (UdeM) | 12838461
Canada Excellence Research Chairs (CERC)
www.nature.com
April 2, 2025 at 1:26 AM
Fantastic opportunity if you are interested in moving your lab to Montreal, Canada! Through this program, Chairholders will be awarded up to $1 million per year for a period of 8 years.
Contact me if you are interested.
www.nature.com/naturecareer...
Contact me if you are interested.
www.nature.com/naturecareer...
Reposted by Martin Sauvageau
The first paper from the Leppek lab is published today at @embojournal.org!! 🎉
We designed and evaluated a versatile toolbox for determining IRES activity in cells and embryonic tissues.
www.embopress.org/doi/full/10....
We designed and evaluated a versatile toolbox for determining IRES activity in cells and embryonic tissues.
www.embopress.org/doi/full/10....
March 13, 2025 at 2:11 PM
The first paper from the Leppek lab is published today at @embojournal.org!! 🎉
We designed and evaluated a versatile toolbox for determining IRES activity in cells and embryonic tissues.
www.embopress.org/doi/full/10....
We designed and evaluated a versatile toolbox for determining IRES activity in cells and embryonic tissues.
www.embopress.org/doi/full/10....
Reposted by Martin Sauvageau
At the #D2RSymposium2025, so far we’ve heard:
✔️ @mcgill.ca's LNP design research & a core platform on end-to-end sequencing for RNA therapies
✔️ llumina's multi omics assays
✔️ @usherbrooke.bsky.social on RNA anti-cancer therapies
✔️ UBC's research on a probe for optimizing RNA delivery
✔️ @mcgill.ca's LNP design research & a core platform on end-to-end sequencing for RNA therapies
✔️ llumina's multi omics assays
✔️ @usherbrooke.bsky.social on RNA anti-cancer therapies
✔️ UBC's research on a probe for optimizing RNA delivery
March 13, 2025 at 8:03 PM
At the #D2RSymposium2025, so far we’ve heard:
✔️ @mcgill.ca's LNP design research & a core platform on end-to-end sequencing for RNA therapies
✔️ llumina's multi omics assays
✔️ @usherbrooke.bsky.social on RNA anti-cancer therapies
✔️ UBC's research on a probe for optimizing RNA delivery
✔️ @mcgill.ca's LNP design research & a core platform on end-to-end sequencing for RNA therapies
✔️ llumina's multi omics assays
✔️ @usherbrooke.bsky.social on RNA anti-cancer therapies
✔️ UBC's research on a probe for optimizing RNA delivery