Marlowe Tessmer
@marlowetessmer.bsky.social
Executive Editor of Clinical Cancer Research, published by AACR @theaacr.bsky.social. Brown & Northwestern Alum, home chef by night. Opinions are my own. clincancerres.aacrjournals.org @aacrjournals.bsky.social
FDA-AACR Strategies for Optimizing Dosages for Oncology Drug Products: Early Phase Trials Using Innovative Trial Designs and Biomarkers url: aacrjournals.org/clincancerre...
FDA-AACR Strategies for Optimizing Dosages for Oncology Drug Products: Early Phase Trials Using Innovative Trial Designs and Biomarkers
Abstract. Dosage selection for oncology drugs has traditionally relied on initial dose-finding trials to determine a maximum tolerated dose (MTD), which is then further evaluated in approval-supportin...
aacrjournals.org
October 22, 2025 at 7:20 PM
FDA-AACR Strategies for Optimizing Dosages for Oncology Drug Products: Early Phase Trials Using Innovative Trial Designs and Biomarkers url: aacrjournals.org/clincancerre...
FDA-AACR Strategies for Optimizing Dosages for Oncology Drug Products: Selecting Optimized Dosages for Registrational Trials url: aacrjournals.org/clincancerre...
FDA-AACR Strategies for Optimizing Dosages for Oncology Drug Products: Selecting Optimized Dosages for Registrational Trials
Abstract. The maximum tolerated dose has historically been the recommended phase two dose, and this dosage has typically been evaluated in registrational clinical trials for oncology drugs. With the e...
aacrjournals.org
October 22, 2025 at 7:20 PM
FDA-AACR Strategies for Optimizing Dosages for Oncology Drug Products: Selecting Optimized Dosages for Registrational Trials url: aacrjournals.org/clincancerre...
FDA-AACR Strategies for Optimizing Dosages for Oncology Drug Products: Selecting Dosages for First-In-Human Trials url: aacrjournals.org/clincancerre...
FDA-AACR Strategies for Optimizing Dosages for Oncology Drug Products: Selecting Dosages for First-In-Human Trials
Abstract. Dosage optimization has become a focus in oncology drug development, as highlighted by recent U.S. Food and Drug Administration initiatives including Project Optimus. Traditionally, most onc...
aacrjournals.org
October 22, 2025 at 7:19 PM
FDA-AACR Strategies for Optimizing Dosages for Oncology Drug Products: Selecting Dosages for First-In-Human Trials url: aacrjournals.org/clincancerre...
Check out these articles in CCR.
#OnlineFirst Just published in Clinical Cancer Research: Perspectives in Regulatory Science and Policy—
FDA-AACR Strategies for Optimizing Dosages for Oncology Drug Products
Check out this series of three papers discussing innovative strategies for dosage optimization.
FDA-AACR Strategies for Optimizing Dosages for Oncology Drug Products
Check out this series of three papers discussing innovative strategies for dosage optimization.
October 9, 2025 at 2:58 PM
Check out these articles in CCR.
Reposted by Marlowe Tessmer
Sign up to receive alerts directly to your inbox to keep up with the latest published issues: buff.ly/O6OYSDp
October 7, 2025 at 4:07 PM
Sign up to receive alerts directly to your inbox to keep up with the latest published issues: buff.ly/O6OYSDp
Reposted by Marlowe Tessmer
Joseph C. Murray, MD, PhD, recipient of the 2025 Clinical Cancer Research Early Career Award, speaks about the questions that drive his research. To learn more, watch the full interview: buff.ly/fa085VG
October 3, 2025 at 4:08 PM
Joseph C. Murray, MD, PhD, recipient of the 2025 Clinical Cancer Research Early Career Award, speaks about the questions that drive his research. To learn more, watch the full interview: buff.ly/fa085VG
Reposted by Marlowe Tessmer
Check out Editors' Picks from the July issues, covering cancer mortality hotspots in the US, the mechanisms of chemotherapy-induced hearing loss, and how AI might help pair patients with the right therapy and predict combination therapies that can prevent cancer escape. buff.ly/yK3WqW5
Editors’ Picks, July 2025: U.S. Cancer Mortality Hotspots, Chemotherapy-induced Hearing Loss, and More
In July 2025, the AACR's journals editors highlighted studies on U.S. cancer mortality hotspots, chemotherapy-induced hearing loss, and more.
buff.ly
July 30, 2025 at 4:02 PM
Check out Editors' Picks from the July issues, covering cancer mortality hotspots in the US, the mechanisms of chemotherapy-induced hearing loss, and how AI might help pair patients with the right therapy and predict combination therapies that can prevent cancer escape. buff.ly/yK3WqW5
Reposted by Marlowe Tessmer
👉 Recently published in Clinical Cancer Research: A population-level real-world analysis and single-center validation of melanoma brain metastasis epidemiology following dual-agent immunotherapy 🔗 doi.org/10.1158/1078... #EANOessentials #NeuroOncology #BrainMetastases #brainMets #medsky
July 11, 2025 at 8:18 AM
👉 Recently published in Clinical Cancer Research: A population-level real-world analysis and single-center validation of melanoma brain metastasis epidemiology following dual-agent immunotherapy 🔗 doi.org/10.1158/1078... #EANOessentials #NeuroOncology #BrainMetastases #brainMets #medsky
Reposted by Marlowe Tessmer
If you are attending #AACRai25, meet the AACR Journals’ editors during breakfast on Friday, July 11th from 7AM – 8AM, featuring Kevin Burton, PhD, of Cancer Research, Emily Frieben, PhD, of Cancer Research Communications, and Tali Lev, PhD, of Cancer Discovery.
July 9, 2025 at 1:08 PM
If you are attending #AACRai25, meet the AACR Journals’ editors during breakfast on Friday, July 11th from 7AM – 8AM, featuring Kevin Burton, PhD, of Cancer Research, Emily Frieben, PhD, of Cancer Research Communications, and Tali Lev, PhD, of Cancer Discovery.
Image of a metastatic lymph node from a patient with oral squamous cell carcinoma. Multiplex immunohistochemical staining highlights the spatial interplay of PERK+ macrophages, activated fibroblasts & tumor cells in an immunosuppressive niche. Article by Zhang et al. aacrjournals.org/clincancerre...
May 26, 2025 at 5:45 PM
Image of a metastatic lymph node from a patient with oral squamous cell carcinoma. Multiplex immunohistochemical staining highlights the spatial interplay of PERK+ macrophages, activated fibroblasts & tumor cells in an immunosuppressive niche. Article by Zhang et al. aacrjournals.org/clincancerre...
This snazzy image shows a region of pancreatic cysts, intraductal papillary mucinous neoplasms. The authors performed digital spatial transcriptomic profiling & found distinct indolent & malignant transcriptomic states. For more detail, see the article by Iyer et al. aacrjournals.org/clincancerre...
Volume 31 Issue 9 | Clinical Cancer Research | American Association for Cancer Research
aacrjournals.org
May 6, 2025 at 1:42 PM
This snazzy image shows a region of pancreatic cysts, intraductal papillary mucinous neoplasms. The authors performed digital spatial transcriptomic profiling & found distinct indolent & malignant transcriptomic states. For more detail, see the article by Iyer et al. aacrjournals.org/clincancerre...
Reposted by Marlowe Tessmer
On day 4 of #AACR25 researchers shared data on combining liquid and tissue biopsies for tailored therapy selection, a decrease in breast cancer mortality, and clinical trial results for antibody-based therapies. Read more takeaways on the #AACRBlog: www.aacr.org/blog/2025/04...
April 30, 2025 at 11:17 AM
On day 4 of #AACR25 researchers shared data on combining liquid and tissue biopsies for tailored therapy selection, a decrease in breast cancer mortality, and clinical trial results for antibody-based therapies. Read more takeaways on the #AACRBlog: www.aacr.org/blog/2025/04...
Today is the day!!! Come by the #AACR25 booth to meet myself and Editor-in-Chief, Timothy Yap for Clinical Cancer Research. 2:00, booth #2615.
Are you attending #AACR25 and are thinking about submitting your work to Clincal Cancer Research? Come meet the Editor-in-Chief, Timothy Yap and Executive Editor, Marlowe Tessmer at South Hall A1-2 Booth 2615 Monday 4/28 at 2:00PM. Or contact us to discuss your research.
See you in Chicago.
See you in Chicago.
Timothy A. Yap, MBBS, PhD, has been appointed editor-in-chief of the AACR journal Clinical Cancer Research. Dr. Yap is co-director for the AACR/ASCO Methods in Clinical Cancer Research Workshop and a past cochair of the AACR Annual Meeting Clinical Trials Committee. www.aacr.org/about-the-aa...
April 28, 2025 at 2:12 PM
Today is the day!!! Come by the #AACR25 booth to meet myself and Editor-in-Chief, Timothy Yap for Clinical Cancer Research. 2:00, booth #2615.
This is a potential game changer for many cancers.
Impressive opening plenary presentation from @johannajoyce.bsky.social on Unraveling the complexity of cancer ecosystems. She highlighted the importance of the fibrotic niche and potential therapeutic approaches that target it #AACR25
April 28, 2025 at 11:28 AM
This is a potential game changer for many cancers.
Congratulations to Joseph C. Murray, MD, PhD, recipient of the 2025 Clinical Cancer Research Early Career Award, which recognizes the outstanding contributions of #earlycareer investigators. Learn more: brnw.ch/21wSfdm @hopkinspress.bsky.social @theaacr.bsky.social
#AACR25
#AACR25
April 27, 2025 at 11:29 AM
Congratulations to Joseph C. Murray, MD, PhD, recipient of the 2025 Clinical Cancer Research Early Career Award, which recognizes the outstanding contributions of #earlycareer investigators. Learn more: brnw.ch/21wSfdm @hopkinspress.bsky.social @theaacr.bsky.social
#AACR25
#AACR25
Congratulations Sandra Misale! @sandramisale.bsky.social! It was nice meeting you last night. #AACR25
Congratulations to the 2025 Cancer Discovery Early Career Award winner: Sandra Misale! @sandramisale.bsky.social #AACR25
April 27, 2025 at 11:26 AM
Congratulations Sandra Misale! @sandramisale.bsky.social! It was nice meeting you last night. #AACR25
Check out this thread from @seplon.bsky.social and then go see the pediatric cancer series here brnw.ch/21wSeVa
#AACR25
#AACR25
April 26, 2025 at 6:07 PM
Check out this thread from @seplon.bsky.social and then go see the pediatric cancer series here brnw.ch/21wSeVa
#AACR25
#AACR25
If you enjoyed the session “Cancer Predisposition in Childhood Cancer: Implications for Prevention, Surveillance, Interception, and Survivorship Care ", then check out the recent series on the topic in Clinical Cancer Research. #AACR25 brnw.ch/21wSeVa
April 26, 2025 at 6:04 PM
If you enjoyed the session “Cancer Predisposition in Childhood Cancer: Implications for Prevention, Surveillance, Interception, and Survivorship Care ", then check out the recent series on the topic in Clinical Cancer Research. #AACR25 brnw.ch/21wSeVa
Are you attending #AACR25 and are thinking about submitting your work to Clincal Cancer Research? Come meet the Editor-in-Chief, Timothy Yap and Executive Editor, Marlowe Tessmer at South Hall A1-2 Booth 2615 Monday 4/28 at 2:00PM. Or contact us to discuss your research.
See you in Chicago.
See you in Chicago.
Timothy A. Yap, MBBS, PhD, has been appointed editor-in-chief of the AACR journal Clinical Cancer Research. Dr. Yap is co-director for the AACR/ASCO Methods in Clinical Cancer Research Workshop and a past cochair of the AACR Annual Meeting Clinical Trials Committee. www.aacr.org/about-the-aa...
April 23, 2025 at 1:14 PM
Are you attending #AACR25 and are thinking about submitting your work to Clincal Cancer Research? Come meet the Editor-in-Chief, Timothy Yap and Executive Editor, Marlowe Tessmer at South Hall A1-2 Booth 2615 Monday 4/28 at 2:00PM. Or contact us to discuss your research.
See you in Chicago.
See you in Chicago.
Hot off the press in Clinical Cancer Research -
ctDNA Clearance as an Early Indicator of Improved Clinical Outcomes in Advanced NSCLC Treated with TKI: Findings from an Aggregate Analysis of Eight Clinical Trials aacrjournals.org/clincancerre...
ctDNA Clearance as an Early Indicator of Improved Clinical Outcomes in Advanced NSCLC Treated with TKI: Findings from an Aggregate Analysis of Eight Clinical Trials aacrjournals.org/clincancerre...
ctDNA Clearance as an Early Indicator of Improved Clinical Outcomes in Advanced NSCLC Treated with TKI: Findings from an Aggregate Analysis of Eight Clinical Trials
AbstractPurpose:. Circulating tumor DNA (ctDNA) holds promise as an early endpoint to predict overall survival (OS). The creation and structured interrogation of aggregated datasets inform the hypothe...
aacrjournals.org
April 23, 2025 at 12:25 PM
Hot off the press in Clinical Cancer Research -
ctDNA Clearance as an Early Indicator of Improved Clinical Outcomes in Advanced NSCLC Treated with TKI: Findings from an Aggregate Analysis of Eight Clinical Trials aacrjournals.org/clincancerre...
ctDNA Clearance as an Early Indicator of Improved Clinical Outcomes in Advanced NSCLC Treated with TKI: Findings from an Aggregate Analysis of Eight Clinical Trials aacrjournals.org/clincancerre...
The cover shows a portion of a gastric cancer biopsy from a HER2+ patient. For details, see the article by Lim and colleagues on page 1476 of this issue of Clinical Cancer Research.
April 22, 2025 at 1:10 PM
The cover shows a portion of a gastric cancer biopsy from a HER2+ patient. For details, see the article by Lim and colleagues on page 1476 of this issue of Clinical Cancer Research.
When you are planning your itinerary for #AACR25, don't forget to contact me and schedule a time so we can talk about submitting your work to Clinical Cancer Research or any questions that you have about the Journal.
See you in Chicago!
See you in Chicago!
Make the most of your #AACR25 experience with in-person and virtual options, the AACR Runners for Research 5K Run/Walk, a performance by the CheckPoints, and more. Preview highlights in AACR Annual Meeting News: www.aacrmeetingnews.org/news/prepari...
April 15, 2025 at 12:43 PM
When you are planning your itinerary for #AACR25, don't forget to contact me and schedule a time so we can talk about submitting your work to Clinical Cancer Research or any questions that you have about the Journal.
See you in Chicago!
See you in Chicago!
The cover shows adjacent normal rectal tissue that was fixed and stained with antibodies to Ki-67 (green) and K-18 (red) with DAPI (blue). For more information, see the article by Chaudhary and colleagues in this issue of Clinical Cancer Research.
April 4, 2025 at 1:36 PM
The cover shows adjacent normal rectal tissue that was fixed and stained with antibodies to Ki-67 (green) and K-18 (red) with DAPI (blue). For more information, see the article by Chaudhary and colleagues in this issue of Clinical Cancer Research.
Reposted by Marlowe Tessmer
March is #MultipleMyelomaAwarenessMonth. AACR Project GENIE offers valuable insights into the genomic landscape of multiple myeloma, with 1,167 patients and 1,548 sequenced tumor samples. #AACRGENIE: www.aacr.org/professional... Powering the future of precision oncology.
March 23, 2025 at 10:07 PM
March is #MultipleMyelomaAwarenessMonth. AACR Project GENIE offers valuable insights into the genomic landscape of multiple myeloma, with 1,167 patients and 1,548 sequenced tumor samples. #AACRGENIE: www.aacr.org/professional... Powering the future of precision oncology.