Marlowe Tessmer
@marlowetessmer.bsky.social
Executive Editor of Clinical Cancer Research, published by AACR @theaacr.bsky.social. Brown & Northwestern Alum, home chef by night. Opinions are my own. clincancerres.aacrjournals.org @aacrjournals.bsky.social
Image of a metastatic lymph node from a patient with oral squamous cell carcinoma. Multiplex immunohistochemical staining highlights the spatial interplay of PERK+ macrophages, activated fibroblasts & tumor cells in an immunosuppressive niche. Article by Zhang et al. aacrjournals.org/clincancerre...
May 26, 2025 at 5:45 PM
Image of a metastatic lymph node from a patient with oral squamous cell carcinoma. Multiplex immunohistochemical staining highlights the spatial interplay of PERK+ macrophages, activated fibroblasts & tumor cells in an immunosuppressive niche. Article by Zhang et al. aacrjournals.org/clincancerre...
Congratulations to Joseph C. Murray, MD, PhD, recipient of the 2025 Clinical Cancer Research Early Career Award, which recognizes the outstanding contributions of #earlycareer investigators. Learn more: brnw.ch/21wSfdm @hopkinspress.bsky.social @theaacr.bsky.social
#AACR25
#AACR25
April 27, 2025 at 11:29 AM
Congratulations to Joseph C. Murray, MD, PhD, recipient of the 2025 Clinical Cancer Research Early Career Award, which recognizes the outstanding contributions of #earlycareer investigators. Learn more: brnw.ch/21wSfdm @hopkinspress.bsky.social @theaacr.bsky.social
#AACR25
#AACR25
If you enjoyed the session “Cancer Predisposition in Childhood Cancer: Implications for Prevention, Surveillance, Interception, and Survivorship Care ", then check out the recent series on the topic in Clinical Cancer Research. #AACR25 brnw.ch/21wSeVa
April 26, 2025 at 6:04 PM
If you enjoyed the session “Cancer Predisposition in Childhood Cancer: Implications for Prevention, Surveillance, Interception, and Survivorship Care ", then check out the recent series on the topic in Clinical Cancer Research. #AACR25 brnw.ch/21wSeVa
The cover shows a portion of a gastric cancer biopsy from a HER2+ patient. For details, see the article by Lim and colleagues on page 1476 of this issue of Clinical Cancer Research.
April 22, 2025 at 1:10 PM
The cover shows a portion of a gastric cancer biopsy from a HER2+ patient. For details, see the article by Lim and colleagues on page 1476 of this issue of Clinical Cancer Research.
The cover shows adjacent normal rectal tissue that was fixed and stained with antibodies to Ki-67 (green) and K-18 (red) with DAPI (blue). For more information, see the article by Chaudhary and colleagues in this issue of Clinical Cancer Research.
April 4, 2025 at 1:36 PM
The cover shows adjacent normal rectal tissue that was fixed and stained with antibodies to Ki-67 (green) and K-18 (red) with DAPI (blue). For more information, see the article by Chaudhary and colleagues in this issue of Clinical Cancer Research.
This cover shows the localization of MUC16 in the membrane & cytoplasmic compartments of a renal medullary carcinoma cell. DNA is blue, MUC16 is green, & actin is red, with merged MUC16 & actin appearing as yellow. For details, see the article by Grimm & colleagues on page 1057 of this issue of CCR.
March 19, 2025 at 7:00 PM
This cover shows the localization of MUC16 in the membrane & cytoplasmic compartments of a renal medullary carcinoma cell. DNA is blue, MUC16 is green, & actin is red, with merged MUC16 & actin appearing as yellow. For details, see the article by Grimm & colleagues on page 1057 of this issue of CCR.
This cover image shows staining of MUC5AC (green) colocalizing with cMET (red) in breast cancer brain metastatasis. Data suggests a new potential therapeutic target. For details, see the article by Maurya & colleagues in the March 1 issue of Clinical Cancer Research. aacrjournals.org/clincancerre...
March 4, 2025 at 2:06 PM
This cover image shows staining of MUC5AC (green) colocalizing with cMET (red) in breast cancer brain metastatasis. Data suggests a new potential therapeutic target. For details, see the article by Maurya & colleagues in the March 1 issue of Clinical Cancer Research. aacrjournals.org/clincancerre...
Cool cover image showing a turmor section from a patient with advanced head & neck squamous cell carcinoma. Immunohistochemical staining highlights the tumor microenvironment spatial architecture & various immune cell populations surrounding the tumor. See the article by Hanna and colleagues in CCR.
February 18, 2025 at 9:06 PM
Cool cover image showing a turmor section from a patient with advanced head & neck squamous cell carcinoma. Immunohistochemical staining highlights the tumor microenvironment spatial architecture & various immune cell populations surrounding the tumor. See the article by Hanna and colleagues in CCR.
The cover shows a section of a breast tumor. Staining shows cell-surface expression of antibody-drug conjugate target TROP2 (tumor-associated calcium signal transducer 2). For details, see the article by Meric-Bernstam and colleagues on page 573 of this issue of CCR. aacrjournals.org/clincancerre...
February 3, 2025 at 4:32 PM
The cover shows a section of a breast tumor. Staining shows cell-surface expression of antibody-drug conjugate target TROP2 (tumor-associated calcium signal transducer 2). For details, see the article by Meric-Bernstam and colleagues on page 573 of this issue of CCR. aacrjournals.org/clincancerre...
The cover shows a section of a CODEX image from a patient with recurrent glioblastoma. Prior to PD-1 blockade plus re-irradiation treatment, T cells localize in the perivascular space, whereas after treatment, they migrate deeper into the tumor. Article by Iwamoto. aacrjournals.org/clincancerre...
January 31, 2025 at 2:15 PM
The cover shows a section of a CODEX image from a patient with recurrent glioblastoma. Prior to PD-1 blockade plus re-irradiation treatment, T cells localize in the perivascular space, whereas after treatment, they migrate deeper into the tumor. Article by Iwamoto. aacrjournals.org/clincancerre...
The cover shows a tumor section from a patient w/pancreatic ductal adenocarcinoma. Staining depicts an immunogenic tumor microenvironment w/high counts of CD3+ (yellow) and CD8+ (green) tumor-infiltrating lymphocytes & decreased counts of CD68+ macrophages (orange). aacrjournals.org/clincancerre...
January 16, 2025 at 12:53 PM
The cover shows a tumor section from a patient w/pancreatic ductal adenocarcinoma. Staining depicts an immunogenic tumor microenvironment w/high counts of CD3+ (yellow) and CD8+ (green) tumor-infiltrating lymphocytes & decreased counts of CD68+ macrophages (orange). aacrjournals.org/clincancerre...
This cover image depicts a representation of a prostatic tumor shedding cell-free DNA into the bloodstream. For details, see the article by Chauhan and colleagues on page 151 of this issue of Clinical Cancer Research. aacrjournals.org/clincancerre...
January 6, 2025 at 12:35 PM
This cover image depicts a representation of a prostatic tumor shedding cell-free DNA into the bloodstream. For details, see the article by Chauhan and colleagues on page 151 of this issue of Clinical Cancer Research. aacrjournals.org/clincancerre...
Out today in Clinical Cancer Research - RAD51 testing in patients with early HER2-negative breast cancer and homologous recombination deficiency: post-hoc analysis of the GeparOla trial aacrjournals.org/clincancerre...
December 30, 2024 at 9:12 PM
Out today in Clinical Cancer Research - RAD51 testing in patients with early HER2-negative breast cancer and homologous recombination deficiency: post-hoc analysis of the GeparOla trial aacrjournals.org/clincancerre...
This cover shows a section of tumor tissue from a patient with hepatocellular carcinoma. Staining shows lymphocyte aggregate & tertiary lymphoid structures closely associated with the clinical response in resectable & unresectable hepatocellular carcinoma. Article by Kurebayashi et al in this issue.
December 30, 2024 at 9:05 PM
This cover shows a section of tumor tissue from a patient with hepatocellular carcinoma. Staining shows lymphocyte aggregate & tertiary lymphoid structures closely associated with the clinical response in resectable & unresectable hepatocellular carcinoma. Article by Kurebayashi et al in this issue.
Time is running out to nominate an outstanding early career investigator who has published in Clinical Cancer Research. Find out more here bit.ly/3ANzCow
December 6, 2024 at 12:10 PM
Time is running out to nominate an outstanding early career investigator who has published in Clinical Cancer Research. Find out more here bit.ly/3ANzCow
Here's something completely different...
Just made some boozy Christmas rum balls. Happy to share the recipe if anyone is interested.
Just made some boozy Christmas rum balls. Happy to share the recipe if anyone is interested.
December 4, 2024 at 1:40 PM
Here's something completely different...
Just made some boozy Christmas rum balls. Happy to share the recipe if anyone is interested.
Just made some boozy Christmas rum balls. Happy to share the recipe if anyone is interested.
Hello December!
This cover shows a representative image of healthy stomach tissue, the predominant site of CLDN18.2 expression. The authors developed a CLDN18.2-targeting CAR-T therapy showing effectiveness in CLDN18.2+ tumors. Article by Barrett et al in this issue. aacrjournals.org/clincancerres
This cover shows a representative image of healthy stomach tissue, the predominant site of CLDN18.2 expression. The authors developed a CLDN18.2-targeting CAR-T therapy showing effectiveness in CLDN18.2+ tumors. Article by Barrett et al in this issue. aacrjournals.org/clincancerres
December 2, 2024 at 12:25 PM
Hello December!
This cover shows a representative image of healthy stomach tissue, the predominant site of CLDN18.2 expression. The authors developed a CLDN18.2-targeting CAR-T therapy showing effectiveness in CLDN18.2+ tumors. Article by Barrett et al in this issue. aacrjournals.org/clincancerres
This cover shows a representative image of healthy stomach tissue, the predominant site of CLDN18.2 expression. The authors developed a CLDN18.2-targeting CAR-T therapy showing effectiveness in CLDN18.2+ tumors. Article by Barrett et al in this issue. aacrjournals.org/clincancerres
Hot off the press from Fred Hutchinson Cancer Center:
A clinical trial describing the use of CAR-T cells targeting ROR1 for both hematologic and solid tumors. aacrjournals.org/clincancerre...
A clinical trial describing the use of CAR-T cells targeting ROR1 for both hematologic and solid tumors. aacrjournals.org/clincancerre...
November 21, 2024 at 5:53 PM
Hot off the press from Fred Hutchinson Cancer Center:
A clinical trial describing the use of CAR-T cells targeting ROR1 for both hematologic and solid tumors. aacrjournals.org/clincancerre...
A clinical trial describing the use of CAR-T cells targeting ROR1 for both hematologic and solid tumors. aacrjournals.org/clincancerre...
CCR is updating our series from the AACR Childhood Cancer Predisposition Workshop. Generated by an international cohort of leading pediatric cancer experts in order to provide recommendations for screening surveillance of childhood cancer predisposition syndromes. aacrjournals.org/clincancerre...
November 21, 2024 at 3:47 PM
CCR is updating our series from the AACR Childhood Cancer Predisposition Workshop. Generated by an international cohort of leading pediatric cancer experts in order to provide recommendations for screening surveillance of childhood cancer predisposition syndromes. aacrjournals.org/clincancerre...
CCR Perspectives in Regulatory Science & Policy Comprehensive report addressing a major issue in oncology, focused on solutions by FDA's Lola A. Fashoyin-Aje
Driving Diversity & Inclusion in Cancer Drug Development –Industry & Regulatory Perspectives, Current Practices, Opportunities, & Challenges
Driving Diversity & Inclusion in Cancer Drug Development –Industry & Regulatory Perspectives, Current Practices, Opportunities, & Challenges
November 21, 2024 at 3:41 PM
CCR Perspectives in Regulatory Science & Policy Comprehensive report addressing a major issue in oncology, focused on solutions by FDA's Lola A. Fashoyin-Aje
Driving Diversity & Inclusion in Cancer Drug Development –Industry & Regulatory Perspectives, Current Practices, Opportunities, & Challenges
Driving Diversity & Inclusion in Cancer Drug Development –Industry & Regulatory Perspectives, Current Practices, Opportunities, & Challenges
Check out the expert review series "Immunotherapy: Facts and Hopes" at Clinical Cancer Research.
aacrjournals.org/clincancerre...
aacrjournals.org/clincancerre...
November 21, 2024 at 3:25 PM
Check out the expert review series "Immunotherapy: Facts and Hopes" at Clinical Cancer Research.
aacrjournals.org/clincancerre...
aacrjournals.org/clincancerre...
Enjoying this space.
November 20, 2024 at 1:15 PM
Enjoying this space.
Ready to move Clinical Cancer Research to bluer skies.
The cover shows a section of an endometrial biopsy from a patient with endometrial cancer used for spatial transcriptomic profiling. See the article by Bowen and colleagues of this issue. clincancerres.aacrjournals.org #CancerResearch
The cover shows a section of an endometrial biopsy from a patient with endometrial cancer used for spatial transcriptomic profiling. See the article by Bowen and colleagues of this issue. clincancerres.aacrjournals.org #CancerResearch
November 19, 2024 at 11:07 PM
Ready to move Clinical Cancer Research to bluer skies.
The cover shows a section of an endometrial biopsy from a patient with endometrial cancer used for spatial transcriptomic profiling. See the article by Bowen and colleagues of this issue. clincancerres.aacrjournals.org #CancerResearch
The cover shows a section of an endometrial biopsy from a patient with endometrial cancer used for spatial transcriptomic profiling. See the article by Bowen and colleagues of this issue. clincancerres.aacrjournals.org #CancerResearch