Maria Felicita Gonzalez
@mariafelicita.bsky.social
Neurocientífica Puertorriqueña 🇵🇷 | Postdoctoral Researcher in the Herzog lab @WashU | Interested in the intersection between neuroscience-cancer-circadian clocks 🧠⏱️
Pinned
Hola Bluesky! Quick intro: I recently completed my PhD in Neuroscience at WashU, and I’m now a postdoc in the Herzog lab studying the interactions between brain cancer and circadian biology. Beyond the bench, I love teaching, mentoring, and creating spaces for historically excluded communities.
Reposted by Maria Felicita Gonzalez
#Circadian #medicine tests if treatment timing can improve patient outcomes. This paper by @mariafelicita.bsky.social @oliviawalch.bsky.social et al considers #chronodiagnostics ...how the outcome of a standard test for glioblastoma differs with time of biopsy. link.springer.com/article/10.1...
Circadian variation in MGMT promoter methylation and expression predicts sensitivity to temozolomide in glioblastoma - Journal of Neuro-Oncology
Purpose Recent studies show that glioblastoma (GBM) is more sensitive to temozolomide (TMZ) in the morning. In cells, inhibiting O6-Methylguanine-DNA-Methyltransferase (MGMT) abolished time-dependent ...
link.springer.com
October 22, 2025 at 1:04 PM
#Circadian #medicine tests if treatment timing can improve patient outcomes. This paper by @mariafelicita.bsky.social @oliviawalch.bsky.social et al considers #chronodiagnostics ...how the outcome of a standard test for glioblastoma differs with time of biopsy. link.springer.com/article/10.1...
Reposted by Maria Felicita Gonzalez
I see two Wash U neuro superstars in this lineup! Shout out to #cancerneuroscience futurists @mariafelicita.bsky.social and Sofi Salvatore Lannes.
March 14, 2025 at 1:26 AM
I see two Wash U neuro superstars in this lineup! Shout out to #cancerneuroscience futurists @mariafelicita.bsky.social and Sofi Salvatore Lannes.
Reposted by Maria Felicita Gonzalez
Inspired by artist Tauber-Arb and the discoveries of @mariafelicita.bsky.social, @oliviawalch.bsky.social made this to show how brain cancers grow in response to morning hormonal signals. What do you see?
January 15, 2025 at 9:28 AM
Inspired by artist Tauber-Arb and the discoveries of @mariafelicita.bsky.social, @oliviawalch.bsky.social made this to show how brain cancers grow in response to morning hormonal signals. What do you see?
Reposted by Maria Felicita Gonzalez
Our inaugural issue of 2025 is now live. Read our content for January here: www.cell.com/cancer-cell/...
January 13, 2025 at 6:30 PM
Our inaugural issue of 2025 is now live. Read our content for January here: www.cell.com/cancer-cell/...
Excited to share our latest article! We find that the brain tumor Glioblastoma has a circadian clock that syncs with its host’s environment. These tumors also hijack the circadian clock and use daily signals, like glucocorticoids, to grow 🧠⏱️ @erikherzog.bsky.social
More: www.cell.com/cancer-cell/...
More: www.cell.com/cancer-cell/...
Daily glucocorticoids promote glioblastoma growth and circadian synchrony to the host
Gonzalez-Aponte et al. identify daily glucocorticoid receptor signaling as an intrinsic driver of glioblastoma (GBM) progression and a synchronizer of tumor clock gene expression to the host. This work provides an intrinsic circadian driver, and therapeutic target, to slow GBM growth, and offers considerations for glucocorticoid use in the clinic.
www.cell.com
December 12, 2024 at 4:48 PM
Excited to share our latest article! We find that the brain tumor Glioblastoma has a circadian clock that syncs with its host’s environment. These tumors also hijack the circadian clock and use daily signals, like glucocorticoids, to grow 🧠⏱️ @erikherzog.bsky.social
More: www.cell.com/cancer-cell/...
More: www.cell.com/cancer-cell/...
Reposted by Maria Felicita Gonzalez
If you just moved to BlueSky and interested in #chronobiology, find some of your community here!
Want to be added? Reply with evidence your work relates to chronobiology.
go.bsky.app/Sw8L4aS
With all the new people coming over, I’ll repost weekly for the next month or so.
🧪 🌍 🦑 #EvoBio
Want to be added? Reply with evidence your work relates to chronobiology.
go.bsky.app/Sw8L4aS
With all the new people coming over, I’ll repost weekly for the next month or so.
🧪 🌍 🦑 #EvoBio
November 25, 2024 at 4:33 PM
If you just moved to BlueSky and interested in #chronobiology, find some of your community here!
Want to be added? Reply with evidence your work relates to chronobiology.
go.bsky.app/Sw8L4aS
With all the new people coming over, I’ll repost weekly for the next month or so.
🧪 🌍 🦑 #EvoBio
Want to be added? Reply with evidence your work relates to chronobiology.
go.bsky.app/Sw8L4aS
With all the new people coming over, I’ll repost weekly for the next month or so.
🧪 🌍 🦑 #EvoBio
Reposted by Maria Felicita Gonzalez
Want to join of a community of Latinx/a/o Scholars broadly throughout academia?
Please reply to this post if you want to be added!! Shout out to @larrylafountain.bsky.social for bringing us together!
go.bsky.app/NrJs1Hr
Please reply to this post if you want to be added!! Shout out to @larrylafountain.bsky.social for bringing us together!
go.bsky.app/NrJs1Hr
November 14, 2024 at 4:57 AM
Want to join of a community of Latinx/a/o Scholars broadly throughout academia?
Please reply to this post if you want to be added!! Shout out to @larrylafountain.bsky.social for bringing us together!
go.bsky.app/NrJs1Hr
Please reply to this post if you want to be added!! Shout out to @larrylafountain.bsky.social for bringing us together!
go.bsky.app/NrJs1Hr
Reposted by Maria Felicita Gonzalez
The best part of doing fieldwork in the tropical rainforest is waking up to views like this—lush, endless greens framed by the quiet of nature. Every glance out the window and every walk through the night reminds me why this ecosystem is so special and worth studying.
#herps #Colombia
#herps #Colombia
November 23, 2024 at 8:18 PM
First time presenting at #sno2024. Excited to learn about the fascinating new discoveries in #cancerneuroscience (and here’s me bringing a circadian biology twist⏱️🧠)! @neuroonc.bsky.social
November 23, 2024 at 6:21 PM
First time presenting at #sno2024. Excited to learn about the fascinating new discoveries in #cancerneuroscience (and here’s me bringing a circadian biology twist⏱️🧠)! @neuroonc.bsky.social
Reposted by Maria Felicita Gonzalez
"my least favorite thing in life is to be called “resilient,” bc it means that people only see me through the lens of difficulty. They love the idea that I am resilient, but they don’t actually care about any of the things that made me resilient."
@kss_phd www.vox.com/future-perfe...
@kss_phd www.vox.com/future-perfe...
Only 1 percent of neuroscience faculty is Black. Kaela Singleton hopes to change that.
Whatever you do, don’t call the Black in Neuro founder “resilient.”
www.vox.com
November 22, 2024 at 4:24 PM
"my least favorite thing in life is to be called “resilient,” bc it means that people only see me through the lens of difficulty. They love the idea that I am resilient, but they don’t actually care about any of the things that made me resilient."
@kss_phd www.vox.com/future-perfe...
@kss_phd www.vox.com/future-perfe...
Reposted by Maria Felicita Gonzalez
Extremely cool insights into circadian medicine for glioblastoma from Maria Gonzalez-Aponte, Erik Herzog, and their collaborators: pubmed.ncbi.nlm.nih.gov/38277015/
November 20, 2024 at 2:44 PM
Extremely cool insights into circadian medicine for glioblastoma from Maria Gonzalez-Aponte, Erik Herzog, and their collaborators: pubmed.ncbi.nlm.nih.gov/38277015/
Reposted by Maria Felicita Gonzalez
How I think about circadian entrainment (+sleep as a rhythm that can have or lack a groove)
November 21, 2024 at 5:09 PM
How I think about circadian entrainment (+sleep as a rhythm that can have or lack a groove)
Here’s a little bit of what we do. Timing is everything. We recently discovered that chemo for Glioblastoma, a deadly brain tumor, can be enhanced by delivering it in the morning. These tumors know the time of day, and we can use it to improve treatment. Read more: pubmed.ncbi.nlm.nih.gov/38277015/
November 21, 2024 at 8:57 PM
Here’s a little bit of what we do. Timing is everything. We recently discovered that chemo for Glioblastoma, a deadly brain tumor, can be enhanced by delivering it in the morning. These tumors know the time of day, and we can use it to improve treatment. Read more: pubmed.ncbi.nlm.nih.gov/38277015/
Hola Bluesky! Quick intro: I recently completed my PhD in Neuroscience at WashU, and I’m now a postdoc in the Herzog lab studying the interactions between brain cancer and circadian biology. Beyond the bench, I love teaching, mentoring, and creating spaces for historically excluded communities.
November 21, 2024 at 8:38 PM
Hola Bluesky! Quick intro: I recently completed my PhD in Neuroscience at WashU, and I’m now a postdoc in the Herzog lab studying the interactions between brain cancer and circadian biology. Beyond the bench, I love teaching, mentoring, and creating spaces for historically excluded communities.