David Margolis
@margolislab.bsky.social
Neuroscience lab at Rutgers
Pinned
Neuropathic pain drives time-dependent reorganization of corticostriatal circuits https://www.biorxiv.org/content/10.1101/2025.10.07.680927v1
A big step in the work of postdoc Arlene George. Nice work Arlene!!
Reposted by David Margolis
Anybody else worried that because of the long standing Republican war on SNAP people are going to experience painful hunger. Lets do something. @nanopharmnc.bsky.social and i are going to donate to some local nc food banks. Join us! Gonna match up to $500.
October 30, 2025 at 11:20 PM
Anybody else worried that because of the long standing Republican war on SNAP people are going to experience painful hunger. Lets do something. @nanopharmnc.bsky.social and i are going to donate to some local nc food banks. Join us! Gonna match up to $500.
Reposted by David Margolis
After 13 years in the US, I’ve made the difficult decision to leave. Having packed up everything and rethought about priorities, rather painstakingly, while I’m sad to leave the life I’ve made here, I’m also relieved that I won’t have to plan my life around immigration policies anymore.
October 31, 2025 at 4:08 AM
After 13 years in the US, I’ve made the difficult decision to leave. Having packed up everything and rethought about priorities, rather painstakingly, while I’m sad to leave the life I’ve made here, I’m also relieved that I won’t have to plan my life around immigration policies anymore.
Reposted by David Margolis
Thrilled that our paper is out today in Nature!
www.nature.com/articles/s4...
www.nature.com/articles/s4...
Sensory expectations shape neural population dynamics in motor circuits
Nature - Experiments with human volunteers and macaques show that expectations produced by probabilistic cueing of future sensory inputs shape motor circuit dynamics in order to increase the...
www.nature.com
October 29, 2025 at 4:11 PM
Thrilled that our paper is out today in Nature!
www.nature.com/articles/s4...
www.nature.com/articles/s4...
Reposted by David Margolis
Is it candy? Nope, it is a spooky 👻 cleared mouse 🧠 used for #fluorescencefriday movies
October 24, 2025 at 5:04 PM
Is it candy? Nope, it is a spooky 👻 cleared mouse 🧠 used for #fluorescencefriday movies
Reposted by David Margolis
🧠🌟🐭 Excited to share some of my postdoc work on the evolution of dexterity!
We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have:
(1) more corticospinal neurons (CSNs)
(2) better hand dexterity
(3) more dexterous climbing, which is linked to CSN number🧵
We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have:
(1) more corticospinal neurons (CSNs)
(2) better hand dexterity
(3) more dexterous climbing, which is linked to CSN number🧵
October 22, 2025 at 8:41 PM
🧠🌟🐭 Excited to share some of my postdoc work on the evolution of dexterity!
We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have:
(1) more corticospinal neurons (CSNs)
(2) better hand dexterity
(3) more dexterous climbing, which is linked to CSN number🧵
We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have:
(1) more corticospinal neurons (CSNs)
(2) better hand dexterity
(3) more dexterous climbing, which is linked to CSN number🧵
Reposted by David Margolis
The NIH institute director firing last Friday is very bad.
I made a video explainer about why.
Stay for last post, w link to @science.org story from @jocelynkaiser.bsky.social
1/4
🧪
I made a video explainer about why.
Stay for last post, w link to @science.org story from @jocelynkaiser.bsky.social
1/4
🧪
October 23, 2025 at 4:02 AM
The NIH institute director firing last Friday is very bad.
I made a video explainer about why.
Stay for last post, w link to @science.org story from @jocelynkaiser.bsky.social
1/4
🧪
I made a video explainer about why.
Stay for last post, w link to @science.org story from @jocelynkaiser.bsky.social
1/4
🧪
Reposted by David Margolis
I made a video about the shutdown, and why this government worker won’t be a pawn.
When the president and Supreme Court are both acting lawlessly, Congress must stand up and stop it.
US science is collapsing and Congress needs to act.
🧪
Full video here: www.instagram.com/reel/DP1tXXE...
When the president and Supreme Court are both acting lawlessly, Congress must stand up and stop it.
US science is collapsing and Congress needs to act.
🧪
Full video here: www.instagram.com/reel/DP1tXXE...
October 16, 2025 at 11:17 PM
I made a video about the shutdown, and why this government worker won’t be a pawn.
When the president and Supreme Court are both acting lawlessly, Congress must stand up and stop it.
US science is collapsing and Congress needs to act.
🧪
Full video here: www.instagram.com/reel/DP1tXXE...
When the president and Supreme Court are both acting lawlessly, Congress must stand up and stop it.
US science is collapsing and Congress needs to act.
🧪
Full video here: www.instagram.com/reel/DP1tXXE...
Reposted by David Margolis
basic research on wacky things like Gila monster venom are what gave us GLP-1 drugs that are treating diabetes, obesity, & addiction in new ways
this piece from @whyy.org is great
an analogy: navigation apps are great but don't tell you how to climb Mt. Everest & survive
whyy.org/segments/oze...
this piece from @whyy.org is great
an analogy: navigation apps are great but don't tell you how to climb Mt. Everest & survive
whyy.org/segments/oze...
October 15, 2025 at 3:56 AM
basic research on wacky things like Gila monster venom are what gave us GLP-1 drugs that are treating diabetes, obesity, & addiction in new ways
this piece from @whyy.org is great
an analogy: navigation apps are great but don't tell you how to climb Mt. Everest & survive
whyy.org/segments/oze...
this piece from @whyy.org is great
an analogy: navigation apps are great but don't tell you how to climb Mt. Everest & survive
whyy.org/segments/oze...
Reposted by David Margolis
The Nobel Prizes, 5 of 6 having so far gone to US based scientists, are a reminder of why we must stand up for science against this horrid administration. Here are some great Scientist Activists to follow.
go.bsky.app/14W5Rdk
go.bsky.app/14W5Rdk
October 8, 2025 at 1:16 AM
The Nobel Prizes, 5 of 6 having so far gone to US based scientists, are a reminder of why we must stand up for science against this horrid administration. Here are some great Scientist Activists to follow.
go.bsky.app/14W5Rdk
go.bsky.app/14W5Rdk
👀“experience of a punished outcome generates a BLA representation that is selectively replayed when animals subsequently abort choice of the large/risky reward option.”
⚡️“… risk leads to the incorporation of newly encoding BLA neurons into the pre-choice representation”
⚡️“… risk leads to the incorporation of newly encoding BLA neurons into the pre-choice representation”
Risk reshapes amygdala representation of choice https://www.biorxiv.org/content/10.1101/2025.10.06.680813v1
October 8, 2025 at 12:14 AM
👀“experience of a punished outcome generates a BLA representation that is selectively replayed when animals subsequently abort choice of the large/risky reward option.”
⚡️“… risk leads to the incorporation of newly encoding BLA neurons into the pre-choice representation”
⚡️“… risk leads to the incorporation of newly encoding BLA neurons into the pre-choice representation”
A big step in the work of postdoc Arlene George. Nice work Arlene!!
Neuropathic pain drives time-dependent reorganization of corticostriatal circuits https://www.biorxiv.org/content/10.1101/2025.10.07.680927v1
October 8, 2025 at 12:11 AM
A big step in the work of postdoc Arlene George. Nice work Arlene!!
Reposted by David Margolis
Controlled Delivery of a Neurotrophic Factor in the Adult Mouse Brain Using Engineered Microglia https://www.biorxiv.org/content/10.1101/2025.10.06.680702v1
October 7, 2025 at 11:15 PM
Controlled Delivery of a Neurotrophic Factor in the Adult Mouse Brain Using Engineered Microglia https://www.biorxiv.org/content/10.1101/2025.10.06.680702v1
Reposted by David Margolis
So many academics are on HB-1 visas. This is another attack by #RussellVought on universities and scientific research. Stop telling me anything this administration does is in good faith or with any sort of policy goal except destruction.
Critical part of the President's new $100,000 charge for H1-B visas: The Administration can also offer a $100,000 discount to any person, company, or industry that it wants. Replacing rules with arbitrary discretion.
Want visas? You know who to call and who to flatter.
Want visas? You know who to call and who to flatter.
September 20, 2025 at 9:55 PM
So many academics are on HB-1 visas. This is another attack by #RussellVought on universities and scientific research. Stop telling me anything this administration does is in good faith or with any sort of policy goal except destruction.
Reposted by David Margolis
And we are live!
Excited to announce the 2025 Multi-Agent Behavior Challenge on cross-lab supervised action recognition in mice 🐁🐀🖱️
Running on Kaggle until December 15th, with a $50,000 prize pool going to the top five submissions!
www.kaggle.com/competitions...
Excited to announce the 2025 Multi-Agent Behavior Challenge on cross-lab supervised action recognition in mice 🐁🐀🖱️
Running on Kaggle until December 15th, with a $50,000 prize pool going to the top five submissions!
www.kaggle.com/competitions...
September 18, 2025 at 6:24 PM
And we are live!
Excited to announce the 2025 Multi-Agent Behavior Challenge on cross-lab supervised action recognition in mice 🐁🐀🖱️
Running on Kaggle until December 15th, with a $50,000 prize pool going to the top five submissions!
www.kaggle.com/competitions...
Excited to announce the 2025 Multi-Agent Behavior Challenge on cross-lab supervised action recognition in mice 🐁🐀🖱️
Running on Kaggle until December 15th, with a $50,000 prize pool going to the top five submissions!
www.kaggle.com/competitions...
Reposted by David Margolis
Stimulus-Dependent Dopamine Dynamics from LocusCoeruleus Axons https://www.biorxiv.org/content/10.1101/2025.09.15.676390v1
September 16, 2025 at 8:18 AM
Stimulus-Dependent Dopamine Dynamics from LocusCoeruleus Axons https://www.biorxiv.org/content/10.1101/2025.09.15.676390v1
Reposted by David Margolis
Whether or not you are a US scientist, you’ll know that this US administration’s reckless ideology endangers the entire globe - the trajectory of human civilization and all life on Earth. Scientists please sign.
The EPA’s endangerment finding is under threat. This peer-reviewed climate science is essential to protecting public health & regulating greenhouse gases.
Scientists: add your name to AGU’s letter defending the science before 15 Sept.
Sign on ➡️ buff.ly/yuUbZo4
#ClimateScience #ScienceIsEssential
Scientists: add your name to AGU’s letter defending the science before 15 Sept.
Sign on ➡️ buff.ly/yuUbZo4
#ClimateScience #ScienceIsEssential
Sign on to Defend EPA Peer-Reviewed Climate Science | WorkForms
From requests, feedback to data collection and more. Turn your insights into action with customizable WorkForms.
lite.spr.ly
September 11, 2025 at 1:49 AM
Whether or not you are a US scientist, you’ll know that this US administration’s reckless ideology endangers the entire globe - the trajectory of human civilization and all life on Earth. Scientists please sign.
Glorious whiskers too
"Pat, why do you carry that ridiculous 600mm lens on long hikes?"
Buddy, I can see mountains reflected in the eyes of a trailside pika.
Buddy, I can see mountains reflected in the eyes of a trailside pika.
August 29, 2025 at 2:19 AM
Glorious whiskers too
Reposted by David Margolis
Adaptive learning is coordinated across behaviour, time and neurobiology (from synapses and dendrites, to astrocytes and the systems level).
If you’ve ever wondered how noradrenaline helps shape these multiscale learning processes, you might like this: www.cell.com/trends/cogni...
If you’ve ever wondered how noradrenaline helps shape these multiscale learning processes, you might like this: www.cell.com/trends/cogni...
August 29, 2025 at 1:35 AM
Adaptive learning is coordinated across behaviour, time and neurobiology (from synapses and dendrites, to astrocytes and the systems level).
If you’ve ever wondered how noradrenaline helps shape these multiscale learning processes, you might like this: www.cell.com/trends/cogni...
If you’ve ever wondered how noradrenaline helps shape these multiscale learning processes, you might like this: www.cell.com/trends/cogni...
Reposted by David Margolis
All donations goes straight to the project (+10% bonus donation will be added if you use my referral link above)
www.researchhub.com/fund/4309/ac...
www.researchhub.com/fund/4309/ac...
Accelerating What We Know About OCD: From Genes to Mice t...
Accelerating What We Know About OCD: From Genes to Mice to Bet...
www.researchhub.com
August 14, 2025 at 2:49 AM
All donations goes straight to the project (+10% bonus donation will be added if you use my referral link above)
www.researchhub.com/fund/4309/ac...
www.researchhub.com/fund/4309/ac...
‘ In response to a request for comment, Zhu told us, “I have retired and I am in Greenland. I do not have to talk to you.” ‘
Genomics pioneer George Church earns first retraction for anti-aging gene therapy paper
@averyorrall.bsky.social reports
@averyorrall.bsky.social reports
Genomics pioneer George Church earns first retraction for anti-aging gene therapy paper
George Church A paper coauthored by geneticist George Church has been retracted following an internal review at a university where several coauthors are based. The article appeared in the Proceedin…
retractionwatch.com
August 14, 2025 at 4:32 AM
‘ In response to a request for comment, Zhu told us, “I have retired and I am in Greenland. I do not have to talk to you.” ‘
Reposted by David Margolis
The biggest violent crime spree in Washington, DC, happened on January 6, 2021, and Trump pardoned hundreds of violent felons who were part of that.
TRUMP: Violent crime in DC is spiraling out of control so I'm deploying the National Guard
REALITY:
REALITY:
August 11, 2025 at 2:15 PM
The biggest violent crime spree in Washington, DC, happened on January 6, 2021, and Trump pardoned hundreds of violent felons who were part of that.
Reposted by David Margolis
All scientific grant funding must now be approved by a political appointee and "demonstrably advance the President's policy priorities."
I wonder where innovation will happen in the future? It won't be in the US
arstechnica.com/science/2025...
I wonder where innovation will happen in the future? It won't be in the US
arstechnica.com/science/2025...
New executive order puts all grants under political control
All new funding on hold until Trump administration can cancel any previously funded grants.
arstechnica.com
August 8, 2025 at 4:18 PM
All scientific grant funding must now be approved by a political appointee and "demonstrably advance the President's policy priorities."
I wonder where innovation will happen in the future? It won't be in the US
arstechnica.com/science/2025...
I wonder where innovation will happen in the future? It won't be in the US
arstechnica.com/science/2025...
Reposted by David Margolis
I really worry about the world the next generation or the one after it will be growing up to live in.
All scientific grant funding must now be approved by a political appointee and "demonstrably advance the President's policy priorities."
I wonder where innovation will happen in the future? It won't be in the US
arstechnica.com/science/2025...
I wonder where innovation will happen in the future? It won't be in the US
arstechnica.com/science/2025...
New executive order puts all grants under political control
All new funding on hold until Trump administration can cancel any previously funded grants.
arstechnica.com
August 9, 2025 at 12:59 AM
I really worry about the world the next generation or the one after it will be growing up to live in.
Reposted by David Margolis
Integrating and interpreting brain maps | doi.org/10.1016/j.ti...
Imaging and recording technologies make it possible to map multiple biological features of the brain. How can these features be conceptually integrated into a coherent understanding of brain structure and function? ⤵️
Imaging and recording technologies make it possible to map multiple biological features of the brain. How can these features be conceptually integrated into a coherent understanding of brain structure and function? ⤵️
August 4, 2025 at 2:27 PM
Integrating and interpreting brain maps | doi.org/10.1016/j.ti...
Imaging and recording technologies make it possible to map multiple biological features of the brain. How can these features be conceptually integrated into a coherent understanding of brain structure and function? ⤵️
Imaging and recording technologies make it possible to map multiple biological features of the brain. How can these features be conceptually integrated into a coherent understanding of brain structure and function? ⤵️