Malte Mederacke
@maltemederacke.bsky.social
PhD in Dagmar Ibers lab @ ETH Zürich.
How does development really work? Beyond genes and networks towards an holistic mechanistic view
How does development really work? Beyond genes and networks towards an holistic mechanistic view
Reposted by Malte Mederacke
Many thanks to the PhD students and postdocs at D-BSSE in Basel for hosting me in their seminar series — and to the PIs at the Biozentrum, University of Basel, for inspiring conversations. @bsse.ethz.ch @biozentrum.unibas.ch
November 12, 2025 at 10:48 AM
Many thanks to the PhD students and postdocs at D-BSSE in Basel for hosting me in their seminar series — and to the PIs at the Biozentrum, University of Basel, for inspiring conversations. @bsse.ethz.ch @biozentrum.unibas.ch
Reposted by Malte Mederacke
🚨 Join us TODAY for two really exciting talks on the emergence of the fractal bronchial tree and tortoise/ crocodile head scale patterning!🚨
@rorylcooper.bsky.social
@maltemederacke.bsky.social
@rorylcooper.bsky.social
@maltemederacke.bsky.social
🚨 TLM Online Seminar Series - 05.11.25 | 16:00 UK
Malte Mederacke: "The emergence of the fractal bronchial tree"
Rory Cooper: " The mechanics of crocodile and tortoise head scale patterning"
Please repost & to attend online please register to our 📧for the zoom link: lists.cam.ac.uk/sympa/subscr...
Malte Mederacke: "The emergence of the fractal bronchial tree"
Rory Cooper: " The mechanics of crocodile and tortoise head scale patterning"
Please repost & to attend online please register to our 📧for the zoom link: lists.cam.ac.uk/sympa/subscr...
November 5, 2025 at 9:56 AM
🚨 Join us TODAY for two really exciting talks on the emergence of the fractal bronchial tree and tortoise/ crocodile head scale patterning!🚨
@rorylcooper.bsky.social
@maltemederacke.bsky.social
@rorylcooper.bsky.social
@maltemederacke.bsky.social
Reposted by Malte Mederacke
🚨 Join us tomorrow for two really exciting talks on the emergence of the fractal bronchial tree and tortoise/ crocodile head scale patterning!🚨 @rorylcooper.bsky.social @maltemederacke.bsky.social
🚨 TLM Online Seminar Series - 05.11.25 | 16:00 UK
Malte Mederacke: "The emergence of the fractal bronchial tree"
Rory Cooper: " The mechanics of crocodile and tortoise head scale patterning"
Please repost & to attend online please register to our 📧for the zoom link: lists.cam.ac.uk/sympa/subscr...
Malte Mederacke: "The emergence of the fractal bronchial tree"
Rory Cooper: " The mechanics of crocodile and tortoise head scale patterning"
Please repost & to attend online please register to our 📧for the zoom link: lists.cam.ac.uk/sympa/subscr...
November 4, 2025 at 8:58 AM
🚨 Join us tomorrow for two really exciting talks on the emergence of the fractal bronchial tree and tortoise/ crocodile head scale patterning!🚨 @rorylcooper.bsky.social @maltemederacke.bsky.social
Reposted by Malte Mederacke
Very happy to share our latest work extending iterative immunofluorescence to in toto imaging of early zebrafish embryos (3D-4i), integrated with a 3D-dedicated image analysis pipeline! 🐟🔬📊
Huge kudos to Max Hess for this PhD milestone! 💪
@lucaspelkmans.bsky.social shorturl.at/cO0u7
Let's zoom in!
Huge kudos to Max Hess for this PhD milestone! 💪
@lucaspelkmans.bsky.social shorturl.at/cO0u7
Let's zoom in!
October 29, 2025 at 2:20 PM
Very happy to share our latest work extending iterative immunofluorescence to in toto imaging of early zebrafish embryos (3D-4i), integrated with a 3D-dedicated image analysis pipeline! 🐟🔬📊
Huge kudos to Max Hess for this PhD milestone! 💪
@lucaspelkmans.bsky.social shorturl.at/cO0u7
Let's zoom in!
Huge kudos to Max Hess for this PhD milestone! 💪
@lucaspelkmans.bsky.social shorturl.at/cO0u7
Let's zoom in!
Reposted by Malte Mederacke
I’ll be speaking about the mechanical development of crocodile and tortoise head scales next Wednesday at 4pm for the @tlmcambridge.bsky.social seminar series. Subscribe to the mailing list to hear more about my work, and that of @maltemederacke.bsky.social!
lists.cam.ac.uk/sympa/subscr...
lists.cam.ac.uk/sympa/subscr...
October 30, 2025 at 11:39 AM
I’ll be speaking about the mechanical development of crocodile and tortoise head scales next Wednesday at 4pm for the @tlmcambridge.bsky.social seminar series. Subscribe to the mailing list to hear more about my work, and that of @maltemederacke.bsky.social!
lists.cam.ac.uk/sympa/subscr...
lists.cam.ac.uk/sympa/subscr...
Reposted by Malte Mederacke
New preprint from the lab! We discovered a transient fluidization in the basal region of human forebrains by tracking microdroplets in cerebral organoids.This “basal fluidization”, absent in gorilla and mouse, may contribute to greater surface expansion in human forebrains
1/
doi.org/10.1101/2025...
1/
doi.org/10.1101/2025...
October 8, 2025 at 1:05 PM
New preprint from the lab! We discovered a transient fluidization in the basal region of human forebrains by tracking microdroplets in cerebral organoids.This “basal fluidization”, absent in gorilla and mouse, may contribute to greater surface expansion in human forebrains
1/
doi.org/10.1101/2025...
1/
doi.org/10.1101/2025...
Reposted by Malte Mederacke
There are certainly worse crimes, but there really should be some sort of law against creating new image file formats
October 7, 2025 at 4:33 PM
There are certainly worse crimes, but there really should be some sort of law against creating new image file formats
Reposted by Malte Mederacke
Out now: Simulating Organogenesis in #COMSOL: Tissue Patterning with Directed Cell Migration
We provide a detailed walkthrough of how to implement #DCM partial integro-differential equation models - enabling accessible simulations of tissue patterning and morphogenesis.
arxiv.org/pdf/2509.08930
We provide a detailed walkthrough of how to implement #DCM partial integro-differential equation models - enabling accessible simulations of tissue patterning and morphogenesis.
arxiv.org/pdf/2509.08930
September 12, 2025 at 5:23 AM
Out now: Simulating Organogenesis in #COMSOL: Tissue Patterning with Directed Cell Migration
We provide a detailed walkthrough of how to implement #DCM partial integro-differential equation models - enabling accessible simulations of tissue patterning and morphogenesis.
arxiv.org/pdf/2509.08930
We provide a detailed walkthrough of how to implement #DCM partial integro-differential equation models - enabling accessible simulations of tissue patterning and morphogenesis.
arxiv.org/pdf/2509.08930
Reposted by Malte Mederacke
Hello Bluesky: Long time listener, first time poster! Excited to share the first publication of my Ph.D. work studying the development of appendage shapes in @plosbiology.org! The zebrafish caudal fin is quite distinctive, and we examine the timing and mechanisms of how its shape might come to be!
Caudal fins show great variation in shape between diverse fish species. New research reveals that #developmental cues in embryonic tissues involving the Sonic hedgehog pathway imprint fin #morphology, highlighting a critical window for modulating appendage morphology. 🧪
plos.io/4mydLnA
plos.io/4mydLnA
August 26, 2025 at 2:11 PM
Hello Bluesky: Long time listener, first time poster! Excited to share the first publication of my Ph.D. work studying the development of appendage shapes in @plosbiology.org! The zebrafish caudal fin is quite distinctive, and we examine the timing and mechanisms of how its shape might come to be!
Reposted by Malte Mederacke
Our paper "Morphogen gradients can convey position and time in growing tissues" is now out in Newton @cp-newton.bsky.social
Quite fitting to see this novel idea that morphogen gradients not only encode position, but can also time & synchronise development over long distances out in a new journal.
Quite fitting to see this novel idea that morphogen gradients not only encode position, but can also time & synchronise development over long distances out in a new journal.
August 25, 2025 at 10:23 AM
Our paper "Morphogen gradients can convey position and time in growing tissues" is now out in Newton @cp-newton.bsky.social
Quite fitting to see this novel idea that morphogen gradients not only encode position, but can also time & synchronise development over long distances out in a new journal.
Quite fitting to see this novel idea that morphogen gradients not only encode position, but can also time & synchronise development over long distances out in a new journal.
Reposted by Malte Mederacke
Hot off the press!!! Proudly presenting our lab's new review on how do cells communicate to control organ size :) We focus specially on dynamic connections that operate at different timescales to regulate organ growth and morphogenesis. #devbio #SizeandShape www.sciencedirect.com/science/arti...
Start-Shape-Stop: Cell communication mechanisms controlling organ size
Accurate growth control is critical for the achievement of proportional organs during animal development and repair processes. Either extra or deficie…
www.sciencedirect.com
August 9, 2025 at 8:39 AM
Hot off the press!!! Proudly presenting our lab's new review on how do cells communicate to control organ size :) We focus specially on dynamic connections that operate at different timescales to regulate organ growth and morphogenesis. #devbio #SizeandShape www.sciencedirect.com/science/arti...
If you are interested how cell movement can generate beautiful patterns: check out out new preprint!
How can cells self-organize rapidly into complex patterns during development?
Let’s explore a powerful and underappreciated mechanism: Directed Cell Migration (DCM).
Preprint @biorxivpreprint.bsky.social : doi.org/10.1101/2025...
👇Thread 🧵(1/11)
Let’s explore a powerful and underappreciated mechanism: Directed Cell Migration (DCM).
Preprint @biorxivpreprint.bsky.social : doi.org/10.1101/2025...
👇Thread 🧵(1/11)
July 30, 2025 at 7:19 AM
If you are interested how cell movement can generate beautiful patterns: check out out new preprint!
Reposted by Malte Mederacke
Are you a C++ expert and interested in making 3D cell-based tissue simulations with #SimuCell3D ever more powerful? Please apply and join us as #Master student, #PhD student or #Post-Doc!!
jobs.ethz.ch/job/view/JOP...
jobs.ethz.ch/job/view/JOP...
x.com/DagmarIber/s...
jobs.ethz.ch/job/view/JOP...
jobs.ethz.ch/job/view/JOP...
x.com/DagmarIber/s...
PhD Position - 3D Cell-Based Tissue Simulation Framework
jobs.ethz.ch
June 11, 2025 at 11:30 AM
Are you a C++ expert and interested in making 3D cell-based tissue simulations with #SimuCell3D ever more powerful? Please apply and join us as #Master student, #PhD student or #Post-Doc!!
jobs.ethz.ch/job/view/JOP...
jobs.ethz.ch/job/view/JOP...
x.com/DagmarIber/s...
jobs.ethz.ch/job/view/JOP...
jobs.ethz.ch/job/view/JOP...
x.com/DagmarIber/s...
Reposted by Malte Mederacke
The last part of @paulknabl.bsky.social 's PhD is now available at www.biorxiv.org/content/10.1...
Paul showed that BMP signaling is active in the diffuse nervous system of the sea anemone Nematostella and the box jellyfish Tripedalia. Moreover, suppression of BMP signaling in Nematostella leads...
Paul showed that BMP signaling is active in the diffuse nervous system of the sea anemone Nematostella and the box jellyfish Tripedalia. Moreover, suppression of BMP signaling in Nematostella leads...
The anti-neural role of BMP signaling is a side effect of its global function in dorsoventral patterning
In Bilateria with centralized nervous systems (e.g. in vertebrates or arthropods), the minimum of the BMP signaling activity gradient defines the position of the central nervous system. BMP-dependent ...
www.biorxiv.org
June 9, 2025 at 8:57 AM
The last part of @paulknabl.bsky.social 's PhD is now available at www.biorxiv.org/content/10.1...
Paul showed that BMP signaling is active in the diffuse nervous system of the sea anemone Nematostella and the box jellyfish Tripedalia. Moreover, suppression of BMP signaling in Nematostella leads...
Paul showed that BMP signaling is active in the diffuse nervous system of the sea anemone Nematostella and the box jellyfish Tripedalia. Moreover, suppression of BMP signaling in Nematostella leads...
Reposted by Malte Mederacke
Sea anemone development challenges long-held views on the evolution of germ layer and body axis formation
A study by researchers at the Uni Vienna published in @naturecomms.bsky.social has uncovered a surprising difference in how β-catenin functions in sea anemones compared to other animals. #evosky
A study by researchers at the Uni Vienna published in @naturecomms.bsky.social has uncovered a surprising difference in how β-catenin functions in sea anemones compared to other animals. #evosky
Sea anemone development challenges long-held views on the evolution of germ layer and body axis formation
For over twenty years, scientists thought they had understood the role of β-catenin in early animal development. β-Catenin, a key molecular signal, was believed to have the same fundamental function a...
lifesciences.univie.ac.at
March 18, 2025 at 7:37 AM
Sea anemone development challenges long-held views on the evolution of germ layer and body axis formation
A study by researchers at the Uni Vienna published in @naturecomms.bsky.social has uncovered a surprising difference in how β-catenin functions in sea anemones compared to other animals. #evosky
A study by researchers at the Uni Vienna published in @naturecomms.bsky.social has uncovered a surprising difference in how β-catenin functions in sea anemones compared to other animals. #evosky
Reposted by Malte Mederacke
Our atlas of BMP signaling activity in adult Nematostella is finally out! Fantastic, meticulous work and beautiful illustrations by @paulknabl.bsky.social
Thanks, @fwf-at.bsky.social for funding our work!
bmcbiol.biomedcentral.com/articles/10....
Thanks, @fwf-at.bsky.social for funding our work!
bmcbiol.biomedcentral.com/articles/10....
A whole-body atlas of BMP signaling activity in an adult sea anemone - BMC Biology
Background BMP signaling is responsible for the second body axis patterning in Bilateria and in the bilaterally symmetric members of the bilaterian sister clade Cnidaria—corals and sea anemones. Howev...
bmcbiol.biomedcentral.com
February 21, 2025 at 6:53 PM
Our atlas of BMP signaling activity in adult Nematostella is finally out! Fantastic, meticulous work and beautiful illustrations by @paulknabl.bsky.social
Thanks, @fwf-at.bsky.social for funding our work!
bmcbiol.biomedcentral.com/articles/10....
Thanks, @fwf-at.bsky.social for funding our work!
bmcbiol.biomedcentral.com/articles/10....
Reposted by Malte Mederacke
Static morphogen scaling enables proportional growth in tissue growth model inspired by axolotl limb regeneration https://www.biorxiv.org/content/10.1101/2025.02.14.638295v1
February 18, 2025 at 4:49 AM
Static morphogen scaling enables proportional growth in tissue growth model inspired by axolotl limb regeneration https://www.biorxiv.org/content/10.1101/2025.02.14.638295v1
Reposted by Malte Mederacke
The evolution of shape diversity through the lens of physics—explored in our new paper! A fruitful collaboration between our lab @EMBL, Salbreux’s lab @unige & others, led by @BailleulRichar1—now independent at @ENS_ULM—& Nicolas Cuny. bit.ly/3WRqdEa
February 9, 2025 at 12:39 PM
The evolution of shape diversity through the lens of physics—explored in our new paper! A fruitful collaboration between our lab @EMBL, Salbreux’s lab @unige & others, led by @BailleulRichar1—now independent at @ENS_ULM—& Nicolas Cuny. bit.ly/3WRqdEa
Reposted by Malte Mederacke
Pleased to share our latest review "Coordination of nephrogenesis with branching of the urinary collecting system, the vasculature and the nervous system"
authors.elsevier.com/a/1kXJ6Fzn7S...
authors.elsevier.com/a/1kXJ6Fzn7S...
January 31, 2025 at 3:07 PM
Pleased to share our latest review "Coordination of nephrogenesis with branching of the urinary collecting system, the vasculature and the nervous system"
authors.elsevier.com/a/1kXJ6Fzn7S...
authors.elsevier.com/a/1kXJ6Fzn7S...
Reposted by Malte Mederacke
Latest from the lab!
I've been seeking the ultimate modulator that regulates the tempo of multiple developmental processes simultaneously, and metabolism has been an attractive candidate for such a global tempo modulator.
However, I was wrong. 1/
www.nature.com/articles/s41...
I've been seeking the ultimate modulator that regulates the tempo of multiple developmental processes simultaneously, and metabolism has been an attractive candidate for such a global tempo modulator.
However, I was wrong. 1/
www.nature.com/articles/s41...
Metabolic activities are selective modulators for individual segmentation clock processes - Nature Communications
Metabolism has been considered an attractive candidate as a global modulator of the tempo of multiple developmental processes, including somite segmentation timing. Here they demonstrate that metaboli...
www.nature.com
January 24, 2025 at 6:37 PM
Latest from the lab!
I've been seeking the ultimate modulator that regulates the tempo of multiple developmental processes simultaneously, and metabolism has been an attractive candidate for such a global tempo modulator.
However, I was wrong. 1/
www.nature.com/articles/s41...
I've been seeking the ultimate modulator that regulates the tempo of multiple developmental processes simultaneously, and metabolism has been an attractive candidate for such a global tempo modulator.
However, I was wrong. 1/
www.nature.com/articles/s41...
Reposted by Malte Mederacke
We present a simple yet comprehensive model integrating multiple mechanical forces to guide lung development.
These principles operate during both development and disease, providing a dynamic framework to understand and predict lung remodeling processes.
👇Thread 🧵(9/9)
These principles operate during both development and disease, providing a dynamic framework to understand and predict lung remodeling processes.
👇Thread 🧵(9/9)
January 15, 2025 at 8:27 AM
We present a simple yet comprehensive model integrating multiple mechanical forces to guide lung development.
These principles operate during both development and disease, providing a dynamic framework to understand and predict lung remodeling processes.
👇Thread 🧵(9/9)
These principles operate during both development and disease, providing a dynamic framework to understand and predict lung remodeling processes.
👇Thread 🧵(9/9)
Reposted by Malte Mederacke
The emergence of the fractal bronchial tree https://www.biorxiv.org/content/10.1101/2025.01.13.632436v1
January 14, 2025 at 12:31 AM
The emergence of the fractal bronchial tree https://www.biorxiv.org/content/10.1101/2025.01.13.632436v1
Big parts of my PhD work is now out on bioRxiv!!
We look at how biophysical parameters shape the fractal lung during development and disease.
Go check it out:
www.biorxiv.org/content/10.1...
We look at how biophysical parameters shape the fractal lung during development and disease.
Go check it out:
www.biorxiv.org/content/10.1...
January 15, 2025 at 8:32 AM
Big parts of my PhD work is now out on bioRxiv!!
We look at how biophysical parameters shape the fractal lung during development and disease.
Go check it out:
www.biorxiv.org/content/10.1...
We look at how biophysical parameters shape the fractal lung during development and disease.
Go check it out:
www.biorxiv.org/content/10.1...
Reposted by Malte Mederacke
How does an #embryo build an energy-efficient #fractal #lung in time for the first breath at birth? 🫁
Discover the mechanical forces shaping the bronchial tree in our latest preprint: #LungDevelopment #Mechanobiology
doi.org/10.1101/2025...
👇Thread 🧵(1/9)
Discover the mechanical forces shaping the bronchial tree in our latest preprint: #LungDevelopment #Mechanobiology
doi.org/10.1101/2025...
👇Thread 🧵(1/9)
January 15, 2025 at 8:27 AM
How does an #embryo build an energy-efficient #fractal #lung in time for the first breath at birth? 🫁
Discover the mechanical forces shaping the bronchial tree in our latest preprint: #LungDevelopment #Mechanobiology
doi.org/10.1101/2025...
👇Thread 🧵(1/9)
Discover the mechanical forces shaping the bronchial tree in our latest preprint: #LungDevelopment #Mechanobiology
doi.org/10.1101/2025...
👇Thread 🧵(1/9)
Reposted by Malte Mederacke
🎉 We're excited to share our new research in @nature.com ! We reveal that crocodile head scales self-organize through compressive folding of the skin - a mechanical twist on their development & evolution!
Please read & share 🐊🔬 @genevunige.bsky.social
Please read & share 🐊🔬 @genevunige.bsky.social
Self-organized patterning of crocodile head scales by compressive folding - Nature
Crocodile head scales self-organize through purely mechanical compressive skin folding rather than a patterning process controlled by gene interactions.
www.nature.com
January 8, 2025 at 12:15 PM
🎉 We're excited to share our new research in @nature.com ! We reveal that crocodile head scales self-organize through compressive folding of the skin - a mechanical twist on their development & evolution!
Please read & share 🐊🔬 @genevunige.bsky.social
Please read & share 🐊🔬 @genevunige.bsky.social