Shayan Shamipour
@shamipourshayan.bsky.social
Fascinated by how embryos get their shapes and patterns 🐠
SNSF Ambizione junior group leader @UZH
Postdoc @Pelkmans lab | PhD @CPHeisenberg lab
SNSF Ambizione junior group leader @UZH
Postdoc @Pelkmans lab | PhD @CPHeisenberg lab
Pinned
Very happy to share our latest work extending iterative immunofluorescence to in toto imaging of early zebrafish embryos (3D-4i), integrated with a 3D-dedicated image analysis pipeline! 🐟🔬📊
Huge kudos to Max Hess for this PhD milestone! 💪
@lucaspelkmans.bsky.social shorturl.at/cO0u7
Let's zoom in!
Huge kudos to Max Hess for this PhD milestone! 💪
@lucaspelkmans.bsky.social shorturl.at/cO0u7
Let's zoom in!
Reposted by Shayan Shamipour
@sushantbangru.bsky.social and @rdiegmiller.bsky.social new review on regeneration is out in Nature Reviews Molecular Cell Biology. A fun piece to write and another great collaboration with @kenposs.bsky.social.
New Online! Signal control during tissue regeneration in adult animals
Signal control during tissue regeneration in adult animals
Nature Reviews Molecular Cell Biology, Published online: 11 November 2025; doi:10.1038/s41580-025-00917-1The ability to track single cells in vivo, combined with insights into chromatin structure, immune–tissue crosstalk, bioelectric and metabolic cues and quantitative modelling, is changing our understanding of how tissues are repaired and renewed. This Review discusses how signals are regulated during regeneration and future directions for a more quantitative understanding of regenerative biology.
bit.ly
November 13, 2025 at 8:48 PM
@sushantbangru.bsky.social and @rdiegmiller.bsky.social new review on regeneration is out in Nature Reviews Molecular Cell Biology. A fun piece to write and another great collaboration with @kenposs.bsky.social.
Reposted by Shayan Shamipour
We spy the latest works from the labs of @marymullins.bsky.social, Margot Kossman Williams (x2), @bruceappel.bsky.social, Vladimir Korzh, @ssumanas.bsky.social, @campaslab.bsky.social, @kenposs.bsky.social, @emiliapsantos.bsky.social among others! Do check it out!
You must have been looking forward to... October in preprints!
Check out the latest #preprints on #DevBio, #StemCell biology and related topics with, starting this month, @prelights.bsky.social picks 👇👀
thenode.biologists.com/october-in-p...
Check out the latest #preprints on #DevBio, #StemCell biology and related topics with, starting this month, @prelights.bsky.social picks 👇👀
thenode.biologists.com/october-in-p...
October in preprints - the Node
Welcome to our monthly trawl for developmental and stem cell biology (and related) preprints. The preprints this month are hosted on bioRxiv.
thenode.biologists.com
November 13, 2025 at 1:33 PM
We spy the latest works from the labs of @marymullins.bsky.social, Margot Kossman Williams (x2), @bruceappel.bsky.social, Vladimir Korzh, @ssumanas.bsky.social, @campaslab.bsky.social, @kenposs.bsky.social, @emiliapsantos.bsky.social among others! Do check it out!
Reposted by Shayan Shamipour
How can we organize current theoretical approaches for developmental biology - from information to dynamical systems & GRNs - into a common framework?
We propose to think along Marr's 3 levels: computational problem, algorithm, implementation
Check out our review:
arxiv.org/abs/2510.24536
We propose to think along Marr's 3 levels: computational problem, algorithm, implementation
Check out our review:
arxiv.org/abs/2510.24536
November 10, 2025 at 6:46 AM
How can we organize current theoretical approaches for developmental biology - from information to dynamical systems & GRNs - into a common framework?
We propose to think along Marr's 3 levels: computational problem, algorithm, implementation
Check out our review:
arxiv.org/abs/2510.24536
We propose to think along Marr's 3 levels: computational problem, algorithm, implementation
Check out our review:
arxiv.org/abs/2510.24536
Reposted by Shayan Shamipour
Interested in polarity and mechanics during epithelial morphogenesis? Considering joining us! Students to be hired initially as Research Associates. Postdocs encouraged to obtain fellowship, and we help/train you to do that. Apply to tinyurl.com/y6x489t5. Deadline Dec 15.
Please repost!
Please repost!
November 3, 2025 at 1:53 AM
Interested in polarity and mechanics during epithelial morphogenesis? Considering joining us! Students to be hired initially as Research Associates. Postdocs encouraged to obtain fellowship, and we help/train you to do that. Apply to tinyurl.com/y6x489t5. Deadline Dec 15.
Please repost!
Please repost!
Reposted by Shayan Shamipour
I’ll be speaking about the mechanical development of crocodile and tortoise head scales next Wednesday at 4pm for the @tlmcambridge.bsky.social seminar series. Subscribe to the mailing list to hear more about my work, and that of @maltemederacke.bsky.social!
lists.cam.ac.uk/sympa/subscr...
lists.cam.ac.uk/sympa/subscr...
October 30, 2025 at 11:39 AM
I’ll be speaking about the mechanical development of crocodile and tortoise head scales next Wednesday at 4pm for the @tlmcambridge.bsky.social seminar series. Subscribe to the mailing list to hear more about my work, and that of @maltemederacke.bsky.social!
lists.cam.ac.uk/sympa/subscr...
lists.cam.ac.uk/sympa/subscr...
Very happy to share our latest work extending iterative immunofluorescence to in toto imaging of early zebrafish embryos (3D-4i), integrated with a 3D-dedicated image analysis pipeline! 🐟🔬📊
Huge kudos to Max Hess for this PhD milestone! 💪
@lucaspelkmans.bsky.social shorturl.at/cO0u7
Let's zoom in!
Huge kudos to Max Hess for this PhD milestone! 💪
@lucaspelkmans.bsky.social shorturl.at/cO0u7
Let's zoom in!
October 29, 2025 at 2:20 PM
Very happy to share our latest work extending iterative immunofluorescence to in toto imaging of early zebrafish embryos (3D-4i), integrated with a 3D-dedicated image analysis pipeline! 🐟🔬📊
Huge kudos to Max Hess for this PhD milestone! 💪
@lucaspelkmans.bsky.social shorturl.at/cO0u7
Let's zoom in!
Huge kudos to Max Hess for this PhD milestone! 💪
@lucaspelkmans.bsky.social shorturl.at/cO0u7
Let's zoom in!
Reposted by Shayan Shamipour
Vertebral skeletal diversity in mammals is remarkable. How do the differences between vertebral size and shape develop and evolve? See how we tackled this question in our paper published in @natcomms.nature.com today!
October 10, 2025 at 6:46 PM
Vertebral skeletal diversity in mammals is remarkable. How do the differences between vertebral size and shape develop and evolve? See how we tackled this question in our paper published in @natcomms.nature.com today!
Reposted by Shayan Shamipour
Today my @nytimes.com colleagues and I are launching a new series called Lost Science. We interview US scientists who can no longer discover something new about our world, thanks to this year‘s cuts. Here is my first interview with a scientist who studied bees and fires. Gift link: nyti.ms/3IWXbiE
nyti.ms
October 8, 2025 at 11:29 PM
Today my @nytimes.com colleagues and I are launching a new series called Lost Science. We interview US scientists who can no longer discover something new about our world, thanks to this year‘s cuts. Here is my first interview with a scientist who studied bees and fires. Gift link: nyti.ms/3IWXbiE
Reposted by Shayan Shamipour
New preprint from the lab! We discovered a transient fluidization in the basal region of human forebrains by tracking microdroplets in cerebral organoids.This “basal fluidization”, absent in gorilla and mouse, may contribute to greater surface expansion in human forebrains
1/
doi.org/10.1101/2025...
1/
doi.org/10.1101/2025...
October 8, 2025 at 1:05 PM
New preprint from the lab! We discovered a transient fluidization in the basal region of human forebrains by tracking microdroplets in cerebral organoids.This “basal fluidization”, absent in gorilla and mouse, may contribute to greater surface expansion in human forebrains
1/
doi.org/10.1101/2025...
1/
doi.org/10.1101/2025...
Reposted by Shayan Shamipour
🧠 Join us @uzh-ch.bsky.social ! We are a new lab looking for PhDs, Postdocs & Master’s students interested in studying how human neural systems emerge & go awry using brain organoids, light-sheet imaging & genomics. 🚀 Deadline for LSZGS 1st Nov! www.lifescience-graduateschool.uzh.ch/en.html.
October 7, 2025 at 11:57 AM
🧠 Join us @uzh-ch.bsky.social ! We are a new lab looking for PhDs, Postdocs & Master’s students interested in studying how human neural systems emerge & go awry using brain organoids, light-sheet imaging & genomics. 🚀 Deadline for LSZGS 1st Nov! www.lifescience-graduateschool.uzh.ch/en.html.
Reposted by Shayan Shamipour
First, check out my recent bioRxiv preprint w/ @oweinerlab.bsky.social: www.biorxiv.org/content/10.1...
We find contractility shifts the proportion of implantation-competent embryos from young and aged females. Keep reading this for more info!
We find contractility shifts the proportion of implantation-competent embryos from young and aged females. Keep reading this for more info!
A mechanical origin for implantation defects in embryos from aged females
Women over 35 experience a marked reduction in fertility. The origin of these fertility defects appears to reside in the implantation capacity of the embryo itself, but the mechanistic basis of this i...
www.biorxiv.org
October 1, 2025 at 6:21 PM
First, check out my recent bioRxiv preprint w/ @oweinerlab.bsky.social: www.biorxiv.org/content/10.1...
We find contractility shifts the proportion of implantation-competent embryos from young and aged females. Keep reading this for more info!
We find contractility shifts the proportion of implantation-competent embryos from young and aged females. Keep reading this for more info!
Reposted by Shayan Shamipour
Our latest preprint! Into morphogenesis, Yap, ECM, signaling, vertex models, feedbacks/robustness? There is something here for everyone. We discovered a positive feedback loop that extends inner ear canals, and a built-in mechanism that shuts it down when morphogenesis is done. tinyurl.com/464wsjhd
September 26, 2025 at 12:55 PM
Our latest preprint! Into morphogenesis, Yap, ECM, signaling, vertex models, feedbacks/robustness? There is something here for everyone. We discovered a positive feedback loop that extends inner ear canals, and a built-in mechanism that shuts it down when morphogenesis is done. tinyurl.com/464wsjhd
Reposted by Shayan Shamipour
🚨 New paper out in @pnas.org! 🚨
We show that self-generated gradients allow heterogeneous cell mixtures to co-migrate efficiently over long distances —while optimizing their physical interactions!
(See below for 🧵)
www.pnas.org/doi/10.1073/... 🧪
We show that self-generated gradients allow heterogeneous cell mixtures to co-migrate efficiently over long distances —while optimizing their physical interactions!
(See below for 🧵)
www.pnas.org/doi/10.1073/... 🧪
August 22, 2025 at 6:11 AM
🚨 New paper out in @pnas.org! 🚨
We show that self-generated gradients allow heterogeneous cell mixtures to co-migrate efficiently over long distances —while optimizing their physical interactions!
(See below for 🧵)
www.pnas.org/doi/10.1073/... 🧪
We show that self-generated gradients allow heterogeneous cell mixtures to co-migrate efficiently over long distances —while optimizing their physical interactions!
(See below for 🧵)
www.pnas.org/doi/10.1073/... 🧪
Reposted by Shayan Shamipour
(1/10)
I am excited to finally share our work on avian left/right symmetry breaking with you. We reveal a tissue-scale active torque dipole generated at the Hensen’s node, thanks to crazy experiments by Julia @juliapfanzelter.bsky.social and some analysis by me.
doi.org/10.1101/2025...
I am excited to finally share our work on avian left/right symmetry breaking with you. We reveal a tissue-scale active torque dipole generated at the Hensen’s node, thanks to crazy experiments by Julia @juliapfanzelter.bsky.social and some analysis by me.
doi.org/10.1101/2025...
An active torque dipole across tissue layers drives avian left-right symmetry breaking
Unlike in mice, frogs, and fish, left-right (L/R) body axis formation in avian embryos does not arise from the chiral beat of cilia. Instead, a counter-clockwise tissue rotation around Hensen′ node, t...
doi.org
July 20, 2025 at 1:42 PM
(1/10)
I am excited to finally share our work on avian left/right symmetry breaking with you. We reveal a tissue-scale active torque dipole generated at the Hensen’s node, thanks to crazy experiments by Julia @juliapfanzelter.bsky.social and some analysis by me.
doi.org/10.1101/2025...
I am excited to finally share our work on avian left/right symmetry breaking with you. We reveal a tissue-scale active torque dipole generated at the Hensen’s node, thanks to crazy experiments by Julia @juliapfanzelter.bsky.social and some analysis by me.
doi.org/10.1101/2025...
Reposted by Shayan Shamipour
This postdoc position is still open! Apply if you want to come work with us on asymmetric cell divisions in spiralian embryos! postdocs.stanford.edu/prospective/...
July 7, 2025 at 8:51 PM
This postdoc position is still open! Apply if you want to come work with us on asymmetric cell divisions in spiralian embryos! postdocs.stanford.edu/prospective/...
Reposted by Shayan Shamipour
🚨 Second preprint of the week!
We uncover the multiscale dynamics of active viscoelastic buckling in epithelia.
We harness these mechanical instabilities for synthetic morphogenesis.
Led by @onenimesa.bsky.social 🙌. Theory by Marino Arroyo etal. @ibecbarcelona.eu
www.biorxiv.org/content/10.1...
We uncover the multiscale dynamics of active viscoelastic buckling in epithelia.
We harness these mechanical instabilities for synthetic morphogenesis.
Led by @onenimesa.bsky.social 🙌. Theory by Marino Arroyo etal. @ibecbarcelona.eu
www.biorxiv.org/content/10.1...
July 3, 2025 at 10:25 AM
🚨 Second preprint of the week!
We uncover the multiscale dynamics of active viscoelastic buckling in epithelia.
We harness these mechanical instabilities for synthetic morphogenesis.
Led by @onenimesa.bsky.social 🙌. Theory by Marino Arroyo etal. @ibecbarcelona.eu
www.biorxiv.org/content/10.1...
We uncover the multiscale dynamics of active viscoelastic buckling in epithelia.
We harness these mechanical instabilities for synthetic morphogenesis.
Led by @onenimesa.bsky.social 🙌. Theory by Marino Arroyo etal. @ibecbarcelona.eu
www.biorxiv.org/content/10.1...
Reposted by Shayan Shamipour
How to turn a layer of fibroblasts into a tulip 🌷?
Check out our new pre-print on shape-programmable living surfaces.
Led by @pauguillamat.bsky.social
www.biorxiv.org/content/10.1...
Check out our new pre-print on shape-programmable living surfaces.
Led by @pauguillamat.bsky.social
www.biorxiv.org/content/10.1...
June 30, 2025 at 5:22 PM
How to turn a layer of fibroblasts into a tulip 🌷?
Check out our new pre-print on shape-programmable living surfaces.
Led by @pauguillamat.bsky.social
www.biorxiv.org/content/10.1...
Check out our new pre-print on shape-programmable living surfaces.
Led by @pauguillamat.bsky.social
www.biorxiv.org/content/10.1...
📣 Symposium 2050 at the University of Zurich
Join us for this event exploring emerging directions in life sciences, presented by a diverse group of leading experts.
Free and open to all! More info/register:
ema.uzh.ch/RTTHF
Join us for this event exploring emerging directions in life sciences, presented by a diverse group of leading experts.
Free and open to all! More info/register:
ema.uzh.ch/RTTHF
July 1, 2025 at 8:26 AM
📣 Symposium 2050 at the University of Zurich
Join us for this event exploring emerging directions in life sciences, presented by a diverse group of leading experts.
Free and open to all! More info/register:
ema.uzh.ch/RTTHF
Join us for this event exploring emerging directions in life sciences, presented by a diverse group of leading experts.
Free and open to all! More info/register:
ema.uzh.ch/RTTHF
Reposted by Shayan Shamipour
That is a great reason for a first post! With a few days of delay, I am proud to share that my postdoc work at the @heisenbergcplab.bsky.social has finally been published on @cp-cellreports.bsky.social doi.org/10.1016/j.ce... Now a small (or maybe not) thread about the work!
Redirecting
doi.org
March 12, 2025 at 1:01 PM
That is a great reason for a first post! With a few days of delay, I am proud to share that my postdoc work at the @heisenbergcplab.bsky.social has finally been published on @cp-cellreports.bsky.social doi.org/10.1016/j.ce... Now a small (or maybe not) thread about the work!
Reposted by Shayan Shamipour
Stoked to present our latest, superbly led by Chris et al & @torres-sanchez.bsky.social We tackled a fundamental problem – how tissues are patterned during development – found that geometry-constrained ECM fractures pattern the myocardium in the vertebrate heart 1/n www.biorxiv.org/content/10.1...
March 10, 2025 at 2:43 AM
Stoked to present our latest, superbly led by Chris et al & @torres-sanchez.bsky.social We tackled a fundamental problem – how tissues are patterned during development – found that geometry-constrained ECM fractures pattern the myocardium in the vertebrate heart 1/n www.biorxiv.org/content/10.1...