LUMICKS
@lumicks.bsky.social
Empowering scientists with tools that reveal crucial insights not available before, at the molecular and cellular level | Dynamic single-molecule & Cell Avidity
Pinned
Cryo–electron microscopy visualization of RAD51 filament assembly and end-capping by XRCC3-RAD51C-RAD51D-XRCC2
Homologous recombination repairs DNA double strand breaks and protects stalled replication forks, but how the five RAD51 paralogs contribute to these processes remains unclear. Mutations in the RAD51 ...
www.science.org
We thought we knew how DNA repair worked. We were wrong.
See the new publication from @science.org shifts the paradigm: www.science.org/doi/10.1126/...
See comment for our digest:
See the new publication from @science.org shifts the paradigm: www.science.org/doi/10.1126/...
See comment for our digest:
We are dedicated to making sure every LUMICKS user has the tools they need to succeed. That’s why we created LUMICKS University, your free, all-in-one gateway to mastering single-molecule experiments.
Join the 63% of C-Trap users who are already there:
www.lumicks.com/documentatio...
Join the 63% of C-Trap users who are already there:
www.lumicks.com/documentatio...
LUMICKS University
Your gateway to mastering single-molecule experiments
www.lumicks.com
January 20, 2026 at 1:57 PM
We are dedicated to making sure every LUMICKS user has the tools they need to succeed. That’s why we created LUMICKS University, your free, all-in-one gateway to mastering single-molecule experiments.
Join the 63% of C-Trap users who are already there:
www.lumicks.com/documentatio...
Join the 63% of C-Trap users who are already there:
www.lumicks.com/documentatio...
We thought we knew how DNA repair worked. We were wrong.
See the new publication from @science.org shifts the paradigm: www.science.org/doi/10.1126/...
See comment for our digest:
See the new publication from @science.org shifts the paradigm: www.science.org/doi/10.1126/...
See comment for our digest:
Cryo–electron microscopy visualization of RAD51 filament assembly and end-capping by XRCC3-RAD51C-RAD51D-XRCC2
Homologous recombination repairs DNA double strand breaks and protects stalled replication forks, but how the five RAD51 paralogs contribute to these processes remains unclear. Mutations in the RAD51 ...
www.science.org
January 16, 2026 at 8:56 AM
We thought we knew how DNA repair worked. We were wrong.
See the new publication from @science.org shifts the paradigm: www.science.org/doi/10.1126/...
See comment for our digest:
See the new publication from @science.org shifts the paradigm: www.science.org/doi/10.1126/...
See comment for our digest:
Jan 31 is the abstract deadline for SMBio26 Sheffield. Join us again this year for the 3rd single-molecule research symposium in the UK!
Present your research alongside some of the most inspiring scientists in the field.
Some spots are still available!
Program & registration --> bit.ly/3NtxZlM
Present your research alongside some of the most inspiring scientists in the field.
Some spots are still available!
Program & registration --> bit.ly/3NtxZlM
January 14, 2026 at 3:55 PM
Jan 31 is the abstract deadline for SMBio26 Sheffield. Join us again this year for the 3rd single-molecule research symposium in the UK!
Present your research alongside some of the most inspiring scientists in the field.
Some spots are still available!
Program & registration --> bit.ly/3NtxZlM
Present your research alongside some of the most inspiring scientists in the field.
Some spots are still available!
Program & registration --> bit.ly/3NtxZlM
May your science shine bright this time of year, and the next✨.
Happy holidays to the #singlemolecule community here on Bluesky, from everyone at LUMICKS.
Happy holidays to the #singlemolecule community here on Bluesky, from everyone at LUMICKS.
December 23, 2025 at 2:57 PM
May your science shine bright this time of year, and the next✨.
Happy holidays to the #singlemolecule community here on Bluesky, from everyone at LUMICKS.
Happy holidays to the #singlemolecule community here on Bluesky, from everyone at LUMICKS.
Published in Cancer Cell🎉 researchers in Upenn finds high Cell Avidity unlocked superior solid tumor killing.
Targeting KRAS, team of Dr. Daniel Powell showed that strong and stable cell-cell interaction is critical for therapeutic function in the solid tumor context.
www.cell.com/cancer-cell/...
Targeting KRAS, team of Dr. Daniel Powell showed that strong and stable cell-cell interaction is critical for therapeutic function in the solid tumor context.
www.cell.com/cancer-cell/...
Mutant KRAS peptide targeted CAR-T cells engineered for cancer therapy
Benton et al. identify binders against common mutant KRAS neoantigens and create peptide-centric
CAR-T cells (NeoCARs). NeoCARs demonstrate a robust anti-tumor response against cancer
cells expressing...
www.cell.com
December 19, 2025 at 10:37 AM
Published in Cancer Cell🎉 researchers in Upenn finds high Cell Avidity unlocked superior solid tumor killing.
Targeting KRAS, team of Dr. Daniel Powell showed that strong and stable cell-cell interaction is critical for therapeutic function in the solid tumor context.
www.cell.com/cancer-cell/...
Targeting KRAS, team of Dr. Daniel Powell showed that strong and stable cell-cell interaction is critical for therapeutic function in the solid tumor context.
www.cell.com/cancer-cell/...
CAR T therapy saves lives. But some myeloma patients develop serious delayed toxicities months later.
At #ASH2025, Penn researchers led by @marcoruella.bsky.social revealed why:
👉 CD4⁺ CAR T cells show much stronger Cell Avidity to BCMA than CD8⁺ cells.
See more in the comment ⬇️
At #ASH2025, Penn researchers led by @marcoruella.bsky.social revealed why:
👉 CD4⁺ CAR T cells show much stronger Cell Avidity to BCMA than CD8⁺ cells.
See more in the comment ⬇️
December 12, 2025 at 10:38 AM
CAR T therapy saves lives. But some myeloma patients develop serious delayed toxicities months later.
At #ASH2025, Penn researchers led by @marcoruella.bsky.social revealed why:
👉 CD4⁺ CAR T cells show much stronger Cell Avidity to BCMA than CD8⁺ cells.
See more in the comment ⬇️
At #ASH2025, Penn researchers led by @marcoruella.bsky.social revealed why:
👉 CD4⁺ CAR T cells show much stronger Cell Avidity to BCMA than CD8⁺ cells.
See more in the comment ⬇️
How do cells untangle their DNA under the mechanical stress of mitosis?
Last week, Dr. Erin Cutts (the University of Sheffield) shared her new discoveries using LUMICKS C-Trap single-molecule visualization.
If you missed it, it's now available on demand! www.lumicks.com/webinars/sin...
Last week, Dr. Erin Cutts (the University of Sheffield) shared her new discoveries using LUMICKS C-Trap single-molecule visualization.
If you missed it, it's now available on demand! www.lumicks.com/webinars/sin...
December 10, 2025 at 9:34 AM
How do cells untangle their DNA under the mechanical stress of mitosis?
Last week, Dr. Erin Cutts (the University of Sheffield) shared her new discoveries using LUMICKS C-Trap single-molecule visualization.
If you missed it, it's now available on demand! www.lumicks.com/webinars/sin...
Last week, Dr. Erin Cutts (the University of Sheffield) shared her new discoveries using LUMICKS C-Trap single-molecule visualization.
If you missed it, it's now available on demand! www.lumicks.com/webinars/sin...
Reposted by LUMICKS
Christmas came early! New science toy from @lumicks.bsky.social for @thernainstitute.bsky.social - very excited to get this all set up and operational.
December 5, 2025 at 1:44 PM
Christmas came early! New science toy from @lumicks.bsky.social for @thernainstitute.bsky.social - very excited to get this all set up and operational.
A new NSMB study captured one of the clearest real-time views of how DNA transcribes to RNA with the LUMICKS C-Trap. 🧬
It reveals mechanism of action of the transcription machine: small disruptions can cause cancer, aging, etc.
Congrats to all the authors!
www.nature.com/articles/s41...
It reveals mechanism of action of the transcription machine: small disruptions can cause cancer, aging, etc.
Congrats to all the authors!
www.nature.com/articles/s41...
Kinetic control of mammalian transcription elongation - Nature Structural & Molecular Biology
By reconstituting and visualizing mammalian transcription elongation at the single-molecule level, Wang et al. dissected the effects of individual elongation factors on the speed of RNA polymerase II,...
www.nature.com
December 4, 2025 at 10:23 AM
A new NSMB study captured one of the clearest real-time views of how DNA transcribes to RNA with the LUMICKS C-Trap. 🧬
It reveals mechanism of action of the transcription machine: small disruptions can cause cancer, aging, etc.
Congrats to all the authors!
www.nature.com/articles/s41...
It reveals mechanism of action of the transcription machine: small disruptions can cause cancer, aging, etc.
Congrats to all the authors!
www.nature.com/articles/s41...
⏳ Last chance to register! Tomorrow, Dr. Erin Cutts will reveal how she used the LUMICKS C-Trap to directly visualize TOP2A resolving DNA entanglements, a first-of-its-kind view of this key cancer drug target. Join her talk: bit.ly/48nOhoc
December 2, 2025 at 11:00 AM
⏳ Last chance to register! Tomorrow, Dr. Erin Cutts will reveal how she used the LUMICKS C-Trap to directly visualize TOP2A resolving DNA entanglements, a first-of-its-kind view of this key cancer drug target. Join her talk: bit.ly/48nOhoc
Introducing: 🎓 LUMICKS University 🎓
Your new gateway to mastering single-molecule experiments: tutorials, up-to-date documentations, scripts, and tips to help you learn faster and work smarter.
👉 Check it out (free for LUMICKS customers): lumicks.com/documentatio...
Your new gateway to mastering single-molecule experiments: tutorials, up-to-date documentations, scripts, and tips to help you learn faster and work smarter.
👉 Check it out (free for LUMICKS customers): lumicks.com/documentatio...
LUMICKS University
Your gateway to mastering single-molecule experiments
lumicks.com
November 25, 2025 at 3:12 PM
Introducing: 🎓 LUMICKS University 🎓
Your new gateway to mastering single-molecule experiments: tutorials, up-to-date documentations, scripts, and tips to help you learn faster and work smarter.
👉 Check it out (free for LUMICKS customers): lumicks.com/documentatio...
Your new gateway to mastering single-molecule experiments: tutorials, up-to-date documentations, scripts, and tips to help you learn faster and work smarter.
👉 Check it out (free for LUMICKS customers): lumicks.com/documentatio...
Amazing to see the C-Trap in action! We’re proud that the C-Trap plays a part in supporting cancer research in
@freudlab.bsky.social lab at @kucancercenter.bsky.social! 🙌
@freudlab.bsky.social lab at @kucancercenter.bsky.social! 🙌
Grateful to host Sen. Moran and NIH Director Jay Bhattacharyya in the lab today. Proud of our trainees, who showcased their work using the @lumicks.bsky.social C-Trap and the KU Cryo-EM Facility. Their dedication shows how federal investment drives cancer research at @kucancercenter.bsky.social.
November 25, 2025 at 7:16 AM
Amazing to see the C-Trap in action! We’re proud that the C-Trap plays a part in supporting cancer research in
@freudlab.bsky.social lab at @kucancercenter.bsky.social! 🙌
@freudlab.bsky.social lab at @kucancercenter.bsky.social! 🙌
How do our cells untangle their DNA during division? What happens when this process goes wrong? In a new study, Dr Erin Cutts uncovers DNA entanglements during early mitosis in real time at the single-molecule level. Join the upcoming webinar to learn how Erin made these discoveries: bit.ly/48nOhoc
November 19, 2025 at 3:46 PM
How do our cells untangle their DNA during division? What happens when this process goes wrong? In a new study, Dr Erin Cutts uncovers DNA entanglements during early mitosis in real time at the single-molecule level. Join the upcoming webinar to learn how Erin made these discoveries: bit.ly/48nOhoc
Are you working on cell therapy? Looking for a reliable indicator to predict patient outcomes from preclinical immune assays?
👉 Last chance to register for LIVE webinar by Prof. Peter Chockley on how Cell Avidity measurements predict leukemia patient survival after transplant: bit.ly/3JHMzou
👉 Last chance to register for LIVE webinar by Prof. Peter Chockley on how Cell Avidity measurements predict leukemia patient survival after transplant: bit.ly/3JHMzou
November 17, 2025 at 1:52 PM
Are you working on cell therapy? Looking for a reliable indicator to predict patient outcomes from preclinical immune assays?
👉 Last chance to register for LIVE webinar by Prof. Peter Chockley on how Cell Avidity measurements predict leukemia patient survival after transplant: bit.ly/3JHMzou
👉 Last chance to register for LIVE webinar by Prof. Peter Chockley on how Cell Avidity measurements predict leukemia patient survival after transplant: bit.ly/3JHMzou
New! The teams of Simon Boulton and Steve West combined cryo-EM, biochemical assays and the C-Trap to "define the structure and function of a previously uncharacterized complex in the context of DNA double-strand break repair, and replication fork stabilization and restart".
bit.ly/43RG6xU
bit.ly/43RG6xU
Cryo–electron microscopy visualization of RAD51 filament assembly and end-capping by XRCC3-RAD51C-RAD51D-XRCC2
Homologous recombination repairs DNA double strand breaks and protects stalled replication forks, but how the five RAD51 paralogs contribute to these processes remains unclear. Mutations in the RAD51 ...
www.science.org
November 10, 2025 at 8:22 AM
New! The teams of Simon Boulton and Steve West combined cryo-EM, biochemical assays and the C-Trap to "define the structure and function of a previously uncharacterized complex in the context of DNA double-strand break repair, and replication fork stabilization and restart".
bit.ly/43RG6xU
bit.ly/43RG6xU
Can Cell Avidity help predict stem cell transplant success?
Prof. Peter Chockley (The Ohio State University) and his team used Cell Avidity to uncover a previously unknown NK cell–tumor interaction whose strength correlates with patient survival.
Curious? Register for the webinar: bit.ly/3Lov39i
Prof. Peter Chockley (The Ohio State University) and his team used Cell Avidity to uncover a previously unknown NK cell–tumor interaction whose strength correlates with patient survival.
Curious? Register for the webinar: bit.ly/3Lov39i
November 5, 2025 at 4:11 PM
Can Cell Avidity help predict stem cell transplant success?
Prof. Peter Chockley (The Ohio State University) and his team used Cell Avidity to uncover a previously unknown NK cell–tumor interaction whose strength correlates with patient survival.
Curious? Register for the webinar: bit.ly/3Lov39i
Prof. Peter Chockley (The Ohio State University) and his team used Cell Avidity to uncover a previously unknown NK cell–tumor interaction whose strength correlates with patient survival.
Curious? Register for the webinar: bit.ly/3Lov39i
Targeting FACT in cancer cells has shown efficacy in preclinical trials, but by which mechanism? Unclear.
Enter: this new study from the Bustamante Lab at UC Berkeley. It reveals that NDF-FACT condensates form on transcribing PolII and enhance nucleosome disassembly and PolII progression.
Enter: this new study from the Bustamante Lab at UC Berkeley. It reveals that NDF-FACT condensates form on transcribing PolII and enhance nucleosome disassembly and PolII progression.
October 3, 2025 at 10:41 AM
Targeting FACT in cancer cells has shown efficacy in preclinical trials, but by which mechanism? Unclear.
Enter: this new study from the Bustamante Lab at UC Berkeley. It reveals that NDF-FACT condensates form on transcribing PolII and enhance nucleosome disassembly and PolII progression.
Enter: this new study from the Bustamante Lab at UC Berkeley. It reveals that NDF-FACT condensates form on transcribing PolII and enhance nucleosome disassembly and PolII progression.
TODAY: Join Dr. Barden for his talk on innovative techniques underlying rational CAR design. Register for a live seat or post-event recording: bit.ly/464vLyZ
Welcome! You are invited to join a webinar: Rational CAR design: integrating affinity and tonic signaling. After registering, you will receive a confirmation email about joining the webinar.
The success of chimeric antigen receptor (CAR) T cell therapy for hematological malignancies has not yet translated into long-term elimination of solid tumors, indicating the need for adequate tuning ...
bit.ly
September 23, 2025 at 9:26 AM
TODAY: Join Dr. Barden for his talk on innovative techniques underlying rational CAR design. Register for a live seat or post-event recording: bit.ly/464vLyZ
Reposted by LUMICKS
It has been a blast 💥!Awesome atmosphere, networking & knowledge exchange at @biophychrom.bsky.social
Huge thanks 🙏 to all the Participants, Rachel & Kinga from @biochemsoc.bsky.social & the Sponsors @plasmidsaurus.bsky.social @lumicks.bsky.social @emanuellissek.bsky.social @ei-science.bsky.social
Huge thanks 🙏 to all the Participants, Rachel & Kinga from @biochemsoc.bsky.social & the Sponsors @plasmidsaurus.bsky.social @lumicks.bsky.social @emanuellissek.bsky.social @ei-science.bsky.social
September 20, 2025 at 11:12 AM
It has been a blast 💥!Awesome atmosphere, networking & knowledge exchange at @biophychrom.bsky.social
Huge thanks 🙏 to all the Participants, Rachel & Kinga from @biochemsoc.bsky.social & the Sponsors @plasmidsaurus.bsky.social @lumicks.bsky.social @emanuellissek.bsky.social @ei-science.bsky.social
Huge thanks 🙏 to all the Participants, Rachel & Kinga from @biochemsoc.bsky.social & the Sponsors @plasmidsaurus.bsky.social @lumicks.bsky.social @emanuellissek.bsky.social @ei-science.bsky.social
Finding the right CAR affinity is tricky: too low fails, too high impairs function. Measuring cell avidity helps define the productive window, where affinity + avidity drive CAR clustering, persistence & efficacy.
👉 Join Dr. Markus Barden: bit.ly/464vLyZ
👉 Join Dr. Markus Barden: bit.ly/464vLyZ
September 17, 2025 at 12:47 PM
Finding the right CAR affinity is tricky: too low fails, too high impairs function. Measuring cell avidity helps define the productive window, where affinity + avidity drive CAR clustering, persistence & efficacy.
👉 Join Dr. Markus Barden: bit.ly/464vLyZ
👉 Join Dr. Markus Barden: bit.ly/464vLyZ
TODAY: Discover how Prof. Taekjip Ha (Harvard University) used the LUMICKS C-Trap to uncover real-time dynamics of chromatin remodelers and transcription factors at the single-molecule level.
Join the webinar: bit.ly/3VdxuNs
Join the webinar: bit.ly/3VdxuNs
September 10, 2025 at 12:27 PM
TODAY: Discover how Prof. Taekjip Ha (Harvard University) used the LUMICKS C-Trap to uncover real-time dynamics of chromatin remodelers and transcription factors at the single-molecule level.
Join the webinar: bit.ly/3VdxuNs
Join the webinar: bit.ly/3VdxuNs
CAR T cell therapy has revolutionized treatment for blood cancers, but why does it still not work on solid tumors?
Register for this upcoming webinar by Markus Barden (postdoc from Hinrich Abken's lab, Leibniz Institute for Immunotherapy) to learn more: bit.ly/464vLyZ
Register for this upcoming webinar by Markus Barden (postdoc from Hinrich Abken's lab, Leibniz Institute for Immunotherapy) to learn more: bit.ly/464vLyZ
September 5, 2025 at 3:59 PM
CAR T cell therapy has revolutionized treatment for blood cancers, but why does it still not work on solid tumors?
Register for this upcoming webinar by Markus Barden (postdoc from Hinrich Abken's lab, Leibniz Institute for Immunotherapy) to learn more: bit.ly/464vLyZ
Register for this upcoming webinar by Markus Barden (postdoc from Hinrich Abken's lab, Leibniz Institute for Immunotherapy) to learn more: bit.ly/464vLyZ
Looking back at a fantastic SMBio 2025 China at Hefei this past week 💪! Thank you USTC and Guoqiang Bi & Sai Li for hosting and co-organizing this memorable event for the single-molecule community.
September 2, 2025 at 2:05 PM
Looking back at a fantastic SMBio 2025 China at Hefei this past week 💪! Thank you USTC and Guoqiang Bi & Sai Li for hosting and co-organizing this memorable event for the single-molecule community.
This guide can empower you to bridge the gap between cellular biology and single-molecule biophysics 👇.
Read: "Accelerating DNA-Protein Interaction Experiments with Nuclear Extracts in the C-Trap". Created in collaboration with Prof. Bennett Van Houten (University of Pittsburgh).
bit.ly/4fPnHXk
Read: "Accelerating DNA-Protein Interaction Experiments with Nuclear Extracts in the C-Trap". Created in collaboration with Prof. Bennett Van Houten (University of Pittsburgh).
bit.ly/4fPnHXk
Accelerating DNA-protein interaction experiments with nuclear extracts in the C-Trap - Application Note - LUMICKS
Category: DNA-Binding proteins | Access our application note titled 'Accelerating DNA-protein interaction experiments with nuclear extracts in the C-Trap' .
www.lumicks.com
August 25, 2025 at 2:32 PM
This guide can empower you to bridge the gap between cellular biology and single-molecule biophysics 👇.
Read: "Accelerating DNA-Protein Interaction Experiments with Nuclear Extracts in the C-Trap". Created in collaboration with Prof. Bennett Van Houten (University of Pittsburgh).
bit.ly/4fPnHXk
Read: "Accelerating DNA-Protein Interaction Experiments with Nuclear Extracts in the C-Trap". Created in collaboration with Prof. Bennett Van Houten (University of Pittsburgh).
bit.ly/4fPnHXk
Congrats on your new C-Trap system! We’re excited to support your journey in single-molecule research and are fully committed to helping you make scientific breakthroughs!
🧪🧬NEWS - Research facility allows to monitor molecules in motion
At the new C-Trap Facility, scientist can now manipulate and observe dynamic molecular processes in real time.🔬
Curious to learn more? Take a look here👇:
www.upsc.se/about-upsc/n...
📸 Mattias Pettersson @umeauniversitet.bsky.social
At the new C-Trap Facility, scientist can now manipulate and observe dynamic molecular processes in real time.🔬
Curious to learn more? Take a look here👇:
www.upsc.se/about-upsc/n...
📸 Mattias Pettersson @umeauniversitet.bsky.social
August 21, 2025 at 8:23 AM
Congrats on your new C-Trap system! We’re excited to support your journey in single-molecule research and are fully committed to helping you make scientific breakthroughs!