LUMICKS
@lumicks.bsky.social
Empowering scientists with tools that reveal crucial insights not available before, at the molecular and cellular level | Dynamic single-molecule & Cell Avidity
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LUMICKS
@lumicks.bsky.social
· Feb 7
Hey Bluesky! 🌤️ We just flew in from elsewhere and are eager to explore the region here! 🐦 Please re-share this post so we can follow you and help grow the single-molecule and cell avidity communities on here! 🔬⚗️
New! The teams of Simon Boulton and Steve West combined cryo-EM, biochemical assays and the C-Trap to "define the structure and function of a previously uncharacterized complex in the context of DNA double-strand break repair, and replication fork stabilization and restart".
bit.ly/43RG6xU
bit.ly/43RG6xU
Cryo–electron microscopy visualization of RAD51 filament assembly and end-capping by XRCC3-RAD51C-RAD51D-XRCC2
Homologous recombination repairs DNA double strand breaks and protects stalled replication forks, but how the five RAD51 paralogs contribute to these processes remains unclear. Mutations in the RAD51 ...
www.science.org
November 10, 2025 at 8:22 AM
New! The teams of Simon Boulton and Steve West combined cryo-EM, biochemical assays and the C-Trap to "define the structure and function of a previously uncharacterized complex in the context of DNA double-strand break repair, and replication fork stabilization and restart".
bit.ly/43RG6xU
bit.ly/43RG6xU
Can Cell Avidity help predict stem cell transplant success?
Prof. Peter Chockley (The Ohio State University) and his team used Cell Avidity to uncover a previously unknown NK cell–tumor interaction whose strength correlates with patient survival.
Curious? Register for the webinar: bit.ly/3Lov39i
Prof. Peter Chockley (The Ohio State University) and his team used Cell Avidity to uncover a previously unknown NK cell–tumor interaction whose strength correlates with patient survival.
Curious? Register for the webinar: bit.ly/3Lov39i
November 5, 2025 at 4:11 PM
Can Cell Avidity help predict stem cell transplant success?
Prof. Peter Chockley (The Ohio State University) and his team used Cell Avidity to uncover a previously unknown NK cell–tumor interaction whose strength correlates with patient survival.
Curious? Register for the webinar: bit.ly/3Lov39i
Prof. Peter Chockley (The Ohio State University) and his team used Cell Avidity to uncover a previously unknown NK cell–tumor interaction whose strength correlates with patient survival.
Curious? Register for the webinar: bit.ly/3Lov39i
Targeting FACT in cancer cells has shown efficacy in preclinical trials, but by which mechanism? Unclear.
Enter: this new study from the Bustamante Lab at UC Berkeley. It reveals that NDF-FACT condensates form on transcribing PolII and enhance nucleosome disassembly and PolII progression.
Enter: this new study from the Bustamante Lab at UC Berkeley. It reveals that NDF-FACT condensates form on transcribing PolII and enhance nucleosome disassembly and PolII progression.
October 3, 2025 at 10:41 AM
Targeting FACT in cancer cells has shown efficacy in preclinical trials, but by which mechanism? Unclear.
Enter: this new study from the Bustamante Lab at UC Berkeley. It reveals that NDF-FACT condensates form on transcribing PolII and enhance nucleosome disassembly and PolII progression.
Enter: this new study from the Bustamante Lab at UC Berkeley. It reveals that NDF-FACT condensates form on transcribing PolII and enhance nucleosome disassembly and PolII progression.
TODAY: Join Dr. Barden for his talk on innovative techniques underlying rational CAR design. Register for a live seat or post-event recording: bit.ly/464vLyZ
Welcome! You are invited to join a webinar: Rational CAR design: integrating affinity and tonic signaling. After registering, you will receive a confirmation email about joining the webinar.
The success of chimeric antigen receptor (CAR) T cell therapy for hematological malignancies has not yet translated into long-term elimination of solid tumors, indicating the need for adequate tuning ...
bit.ly
September 23, 2025 at 9:26 AM
TODAY: Join Dr. Barden for his talk on innovative techniques underlying rational CAR design. Register for a live seat or post-event recording: bit.ly/464vLyZ
Reposted by LUMICKS
It has been a blast 💥!Awesome atmosphere, networking & knowledge exchange at @biophychrom.bsky.social
Huge thanks 🙏 to all the Participants, Rachel & Kinga from @biochemsoc.bsky.social & the Sponsors @plasmidsaurus.bsky.social @lumicks.bsky.social @emanuellissek.bsky.social @ei-science.bsky.social
Huge thanks 🙏 to all the Participants, Rachel & Kinga from @biochemsoc.bsky.social & the Sponsors @plasmidsaurus.bsky.social @lumicks.bsky.social @emanuellissek.bsky.social @ei-science.bsky.social
September 20, 2025 at 11:12 AM
It has been a blast 💥!Awesome atmosphere, networking & knowledge exchange at @biophychrom.bsky.social
Huge thanks 🙏 to all the Participants, Rachel & Kinga from @biochemsoc.bsky.social & the Sponsors @plasmidsaurus.bsky.social @lumicks.bsky.social @emanuellissek.bsky.social @ei-science.bsky.social
Huge thanks 🙏 to all the Participants, Rachel & Kinga from @biochemsoc.bsky.social & the Sponsors @plasmidsaurus.bsky.social @lumicks.bsky.social @emanuellissek.bsky.social @ei-science.bsky.social
Finding the right CAR affinity is tricky: too low fails, too high impairs function. Measuring cell avidity helps define the productive window, where affinity + avidity drive CAR clustering, persistence & efficacy.
👉 Join Dr. Markus Barden: bit.ly/464vLyZ
👉 Join Dr. Markus Barden: bit.ly/464vLyZ
September 17, 2025 at 12:47 PM
Finding the right CAR affinity is tricky: too low fails, too high impairs function. Measuring cell avidity helps define the productive window, where affinity + avidity drive CAR clustering, persistence & efficacy.
👉 Join Dr. Markus Barden: bit.ly/464vLyZ
👉 Join Dr. Markus Barden: bit.ly/464vLyZ
TODAY: Discover how Prof. Taekjip Ha (Harvard University) used the LUMICKS C-Trap to uncover real-time dynamics of chromatin remodelers and transcription factors at the single-molecule level.
Join the webinar: bit.ly/3VdxuNs
Join the webinar: bit.ly/3VdxuNs
September 10, 2025 at 12:27 PM
TODAY: Discover how Prof. Taekjip Ha (Harvard University) used the LUMICKS C-Trap to uncover real-time dynamics of chromatin remodelers and transcription factors at the single-molecule level.
Join the webinar: bit.ly/3VdxuNs
Join the webinar: bit.ly/3VdxuNs
CAR T cell therapy has revolutionized treatment for blood cancers, but why does it still not work on solid tumors?
Register for this upcoming webinar by Markus Barden (postdoc from Hinrich Abken's lab, Leibniz Institute for Immunotherapy) to learn more: bit.ly/464vLyZ
Register for this upcoming webinar by Markus Barden (postdoc from Hinrich Abken's lab, Leibniz Institute for Immunotherapy) to learn more: bit.ly/464vLyZ
September 5, 2025 at 3:59 PM
CAR T cell therapy has revolutionized treatment for blood cancers, but why does it still not work on solid tumors?
Register for this upcoming webinar by Markus Barden (postdoc from Hinrich Abken's lab, Leibniz Institute for Immunotherapy) to learn more: bit.ly/464vLyZ
Register for this upcoming webinar by Markus Barden (postdoc from Hinrich Abken's lab, Leibniz Institute for Immunotherapy) to learn more: bit.ly/464vLyZ
Looking back at a fantastic SMBio 2025 China at Hefei this past week 💪! Thank you USTC and Guoqiang Bi & Sai Li for hosting and co-organizing this memorable event for the single-molecule community.
September 2, 2025 at 2:05 PM
Looking back at a fantastic SMBio 2025 China at Hefei this past week 💪! Thank you USTC and Guoqiang Bi & Sai Li for hosting and co-organizing this memorable event for the single-molecule community.
This guide can empower you to bridge the gap between cellular biology and single-molecule biophysics 👇.
Read: "Accelerating DNA-Protein Interaction Experiments with Nuclear Extracts in the C-Trap". Created in collaboration with Prof. Bennett Van Houten (University of Pittsburgh).
bit.ly/4fPnHXk
Read: "Accelerating DNA-Protein Interaction Experiments with Nuclear Extracts in the C-Trap". Created in collaboration with Prof. Bennett Van Houten (University of Pittsburgh).
bit.ly/4fPnHXk
Accelerating DNA-protein interaction experiments with nuclear extracts in the C-Trap - Application Note - LUMICKS
Category: DNA-Binding proteins | Access our application note titled 'Accelerating DNA-protein interaction experiments with nuclear extracts in the C-Trap' .
www.lumicks.com
August 25, 2025 at 2:32 PM
This guide can empower you to bridge the gap between cellular biology and single-molecule biophysics 👇.
Read: "Accelerating DNA-Protein Interaction Experiments with Nuclear Extracts in the C-Trap". Created in collaboration with Prof. Bennett Van Houten (University of Pittsburgh).
bit.ly/4fPnHXk
Read: "Accelerating DNA-Protein Interaction Experiments with Nuclear Extracts in the C-Trap". Created in collaboration with Prof. Bennett Van Houten (University of Pittsburgh).
bit.ly/4fPnHXk
Congrats on your new C-Trap system! We’re excited to support your journey in single-molecule research and are fully committed to helping you make scientific breakthroughs!
🧪🧬NEWS - Research facility allows to monitor molecules in motion
At the new C-Trap Facility, scientist can now manipulate and observe dynamic molecular processes in real time.🔬
Curious to learn more? Take a look here👇:
www.upsc.se/about-upsc/n...
📸 Mattias Pettersson @umeauniversitet.bsky.social
At the new C-Trap Facility, scientist can now manipulate and observe dynamic molecular processes in real time.🔬
Curious to learn more? Take a look here👇:
www.upsc.se/about-upsc/n...
📸 Mattias Pettersson @umeauniversitet.bsky.social
August 21, 2025 at 8:23 AM
Congrats on your new C-Trap system! We’re excited to support your journey in single-molecule research and are fully committed to helping you make scientific breakthroughs!
About 2 months ago, our product managers Bas Groen and Adalberto Costessi introduced the latest upgrades for the C-Trap.
Catch the intro from LUMICKS product managers on how to make your C-Trap faster, easier, and more reproducible. Watch now: www.lumicks.com/webinars/c-t...
Catch the intro from LUMICKS product managers on how to make your C-Trap faster, easier, and more reproducible. Watch now: www.lumicks.com/webinars/c-t...
Watch: C-Trap Accelerator Suite - LUMICKS
Speaker: LUMICKS, . In this webinar, we discuss C-Trap Accelerator Suite. Category:
www.lumicks.com
August 20, 2025 at 11:25 AM
About 2 months ago, our product managers Bas Groen and Adalberto Costessi introduced the latest upgrades for the C-Trap.
Catch the intro from LUMICKS product managers on how to make your C-Trap faster, easier, and more reproducible. Watch now: www.lumicks.com/webinars/c-t...
Catch the intro from LUMICKS product managers on how to make your C-Trap faster, easier, and more reproducible. Watch now: www.lumicks.com/webinars/c-t...
Discuss single-molecule science with world-renowned Prof.
𝗧𝗮𝗲𝗸𝗷𝗶𝗽 𝗛𝗮 (Harvard)! Join the upcoming 𝗡𝗮𝘁𝘂𝗿𝗲 𝘄𝗲𝗯𝗶𝗻𝗮𝗿 to learn how dynamic single-molecule tools reveal new mechanisms behind nucleosome mobilization and transcriptional control!
Registrations are now open:
𝗧𝗮𝗲𝗸𝗷𝗶𝗽 𝗛𝗮 (Harvard)! Join the upcoming 𝗡𝗮𝘁𝘂𝗿𝗲 𝘄𝗲𝗯𝗶𝗻𝗮𝗿 to learn how dynamic single-molecule tools reveal new mechanisms behind nucleosome mobilization and transcriptional control!
Registrations are now open:
Nature Portfolio webcasts
If you’ve already registered, please log in to the webcast.
web.lumicks.com
August 14, 2025 at 6:05 PM
Discuss single-molecule science with world-renowned Prof.
𝗧𝗮𝗲𝗸𝗷𝗶𝗽 𝗛𝗮 (Harvard)! Join the upcoming 𝗡𝗮𝘁𝘂𝗿𝗲 𝘄𝗲𝗯𝗶𝗻𝗮𝗿 to learn how dynamic single-molecule tools reveal new mechanisms behind nucleosome mobilization and transcriptional control!
Registrations are now open:
𝗧𝗮𝗲𝗸𝗷𝗶𝗽 𝗛𝗮 (Harvard)! Join the upcoming 𝗡𝗮𝘁𝘂𝗿𝗲 𝘄𝗲𝗯𝗶𝗻𝗮𝗿 to learn how dynamic single-molecule tools reveal new mechanisms behind nucleosome mobilization and transcriptional control!
Registrations are now open:
𝗪𝗲’𝗿𝗲 𝗽𝗿𝗼𝘂𝗱 𝘁𝗼 𝘀𝘂𝗽𝗽𝗼𝗿𝘁 𝘁𝗵𝗲 𝗣𝗮𝗿𝗸𝗲𝗿 𝗜𝗻𝘀𝘁𝗶𝘁𝘂𝘁𝗲 𝗳𝗼𝗿 𝗖𝗮𝗻𝗰𝗲𝗿 𝗜𝗺𝗺𝘂𝗻𝗼𝘁𝗵𝗲𝗿𝗮𝗽𝘆 (𝗣𝗜𝗖𝗜) 𝗡𝗲𝘁𝘄𝗼𝗿𝗸 𝗶𝗻 𝘁𝗵𝗲 𝗳𝗶𝗴𝗵𝘁 𝗮𝗴𝗮𝗶𝗻𝘀𝘁 𝗰𝗮𝗻𝗰𝗲𝗿. @parkerici.bsky.social
August 8, 2025 at 8:41 AM
𝗪𝗲’𝗿𝗲 𝗽𝗿𝗼𝘂𝗱 𝘁𝗼 𝘀𝘂𝗽𝗽𝗼𝗿𝘁 𝘁𝗵𝗲 𝗣𝗮𝗿𝗸𝗲𝗿 𝗜𝗻𝘀𝘁𝗶𝘁𝘂𝘁𝗲 𝗳𝗼𝗿 𝗖𝗮𝗻𝗰𝗲𝗿 𝗜𝗺𝗺𝘂𝗻𝗼𝘁𝗵𝗲𝗿𝗮𝗽𝘆 (𝗣𝗜𝗖𝗜) 𝗡𝗲𝘁𝘄𝗼𝗿𝗸 𝗶𝗻 𝘁𝗵𝗲 𝗳𝗶𝗴𝗵𝘁 𝗮𝗴𝗮𝗶𝗻𝘀𝘁 𝗰𝗮𝗻𝗰𝗲𝗿. @parkerici.bsky.social
🛎️ SMBio Nordics abstract deadline postponed to August 8
Allowing for some (well-deserved) offline time of the single-molecule community during the Nordic summer, the organisation of SMBio 2025 Nordics decided to delay the abstract deadline with ~2 weeks until August 8. Submit here: bit.ly/4l3Sxgx
Allowing for some (well-deserved) offline time of the single-molecule community during the Nordic summer, the organisation of SMBio 2025 Nordics decided to delay the abstract deadline with ~2 weeks until August 8. Submit here: bit.ly/4l3Sxgx
SMBio 2025 Nordics - Symposium - LUMICKS
We are excited to share that we are organizing the SMBio 2025 Nordics, aimed at bringing together our current and future Nordic C-trap users for two days of engaging discussions and networking. Follow...
bit.ly
July 28, 2025 at 1:04 PM
🛎️ SMBio Nordics abstract deadline postponed to August 8
Allowing for some (well-deserved) offline time of the single-molecule community during the Nordic summer, the organisation of SMBio 2025 Nordics decided to delay the abstract deadline with ~2 weeks until August 8. Submit here: bit.ly/4l3Sxgx
Allowing for some (well-deserved) offline time of the single-molecule community during the Nordic summer, the organisation of SMBio 2025 Nordics decided to delay the abstract deadline with ~2 weeks until August 8. Submit here: bit.ly/4l3Sxgx
Final day (!) to register for SMBio Nordics symposium, where top researchers of Northern Europe will come together to talk breakthrough single-molecule science: lumicks.com/event/symposium/smbio-nordics-2025
SMBio 2025 Nordics - Symposium - LUMICKS
We are excited to share that we are organizing the SMBio 2025 Nordics, aimed at bringing together our current and future Nordic C-trap users for two days of engaging discussions and networking. Follow...
www.lumicks.com
July 24, 2025 at 6:55 PM
Final day (!) to register for SMBio Nordics symposium, where top researchers of Northern Europe will come together to talk breakthrough single-molecule science: lumicks.com/event/symposium/smbio-nordics-2025
Speed up C-Trap user training, assay troubleshooting or performance verification 👉 try the new C-Trap Reference Kit.
The kit provides standardized and validated reagents for a complete DNA-protein binding assay, incl. data analysis with reference values.
Find the protocol & more: bit.ly/4mcXuUM
The kit provides standardized and validated reagents for a complete DNA-protein binding assay, incl. data analysis with reference values.
Find the protocol & more: bit.ly/4mcXuUM
July 23, 2025 at 1:38 PM
Speed up C-Trap user training, assay troubleshooting or performance verification 👉 try the new C-Trap Reference Kit.
The kit provides standardized and validated reagents for a complete DNA-protein binding assay, incl. data analysis with reference values.
Find the protocol & more: bit.ly/4mcXuUM
The kit provides standardized and validated reagents for a complete DNA-protein binding assay, incl. data analysis with reference values.
Find the protocol & more: bit.ly/4mcXuUM
Get up to 50x data throughput for C-Trap experiments. 👇
A new high-throughput method, called DNA repeat assembly, enables researchers to quickly build long DNA constructs (up to 100 kb) made of many repeats of a DNA sequence of interest.
A new high-throughput method, called DNA repeat assembly, enables researchers to quickly build long DNA constructs (up to 100 kb) made of many repeats of a DNA sequence of interest.
July 21, 2025 at 2:41 PM
Get up to 50x data throughput for C-Trap experiments. 👇
A new high-throughput method, called DNA repeat assembly, enables researchers to quickly build long DNA constructs (up to 100 kb) made of many repeats of a DNA sequence of interest.
A new high-throughput method, called DNA repeat assembly, enables researchers to quickly build long DNA constructs (up to 100 kb) made of many repeats of a DNA sequence of interest.
Abstract deadline for the SMBio 2025 Nordics is approaching soon! Register with the link --> lumicks.com/event/symposium/smbio-nordics-2025
July 16, 2025 at 8:14 AM
Abstract deadline for the SMBio 2025 Nordics is approaching soon! Register with the link --> lumicks.com/event/symposium/smbio-nordics-2025
🧬 In a new study, researchers from Fernando Moreno ’s group observed KorB sliding to distant sites & stalling via KorA which directly visualizes the process of long-range repression.
This is the first time this regulatory mechanism has been visualized at the single-molecule level.
This is the first time this regulatory mechanism has been visualized at the single-molecule level.
July 14, 2025 at 1:30 PM
🧬 In a new study, researchers from Fernando Moreno ’s group observed KorB sliding to distant sites & stalling via KorA which directly visualizes the process of long-range repression.
This is the first time this regulatory mechanism has been visualized at the single-molecule level.
This is the first time this regulatory mechanism has been visualized at the single-molecule level.
Exciting Single-Molecule Mini Symposium and C-Trap Launch event at @uniregensburg.bsky.social! If you're nearby, don't miss it! 🧬🧑🏫🎉 @caliskanlab.bsky.social @curiousdina.bsky.social @beliulab.bsky.social
Interested in this technology? Come join us on 28.07.25 at the Single-Molecule Mini Symposium and C-Trap Launch event!
July 11, 2025 at 11:21 AM
Exciting Single-Molecule Mini Symposium and C-Trap Launch event at @uniregensburg.bsky.social! If you're nearby, don't miss it! 🧬🧑🏫🎉 @caliskanlab.bsky.social @curiousdina.bsky.social @beliulab.bsky.social
There's a new double microfluidics module available for C-Trap users. What does it bring you?
👉 Having two independent microfluidics modules maximizes data acquisition time by enabling flow-cell cleaning in parallel with experimental execution. (1/3)
👉 Having two independent microfluidics modules maximizes data acquisition time by enabling flow-cell cleaning in parallel with experimental execution. (1/3)
July 8, 2025 at 12:35 PM
There's a new double microfluidics module available for C-Trap users. What does it bring you?
👉 Having two independent microfluidics modules maximizes data acquisition time by enabling flow-cell cleaning in parallel with experimental execution. (1/3)
👉 Having two independent microfluidics modules maximizes data acquisition time by enabling flow-cell cleaning in parallel with experimental execution. (1/3)
“It’s really a bit of science fiction.”
In his latest interview with #SoftBankVisionFund, LUMICKS CEO Hugo de Wit shares how we're equipping researchers to uncover the molecular mechanisms behind cancer and other diseases.
www.linkedin.com/posts/softba...
In his latest interview with #SoftBankVisionFund, LUMICKS CEO Hugo de Wit shares how we're equipping researchers to uncover the molecular mechanisms behind cancer and other diseases.
www.linkedin.com/posts/softba...
LUMICKS’ latest biotech innovation seems like a call from the future, but it may change how researchers find cancer cures. | SoftBank Investment Advisers
LUMICKS’ latest biotech innovation seems like a call from the future, but it may change how researchers find cancer cures. The company’s C-TRAP tool is best described as two laser beams that can stret...
www.linkedin.com
July 7, 2025 at 9:10 AM
“It’s really a bit of science fiction.”
In his latest interview with #SoftBankVisionFund, LUMICKS CEO Hugo de Wit shares how we're equipping researchers to uncover the molecular mechanisms behind cancer and other diseases.
www.linkedin.com/posts/softba...
In his latest interview with #SoftBankVisionFund, LUMICKS CEO Hugo de Wit shares how we're equipping researchers to uncover the molecular mechanisms behind cancer and other diseases.
www.linkedin.com/posts/softba...
New for C-Trap users: the Accelerator Suite is here!
7 upgrades across hardware, software & kits to make your experiments faster, easier & more reproducible.
🎙️ Join our launch webinar to learn more + ask your questions live!
🔗 Register: www.lumicks.com/event/webina...
7 upgrades across hardware, software & kits to make your experiments faster, easier & more reproducible.
🎙️ Join our launch webinar to learn more + ask your questions live!
🔗 Register: www.lumicks.com/event/webina...
July 4, 2025 at 12:40 PM
New for C-Trap users: the Accelerator Suite is here!
7 upgrades across hardware, software & kits to make your experiments faster, easier & more reproducible.
🎙️ Join our launch webinar to learn more + ask your questions live!
🔗 Register: www.lumicks.com/event/webina...
7 upgrades across hardware, software & kits to make your experiments faster, easier & more reproducible.
🎙️ Join our launch webinar to learn more + ask your questions live!
🔗 Register: www.lumicks.com/event/webina...
New technology app note 👉 bit.ly/44JH0xe
Golden Gate technology: seamlessly ligate DNA fragments in any order into one backbone and test multiple target sequences in a single C-Trap experiment. This enables assays like DNA sequence-specific looping and boosts sequence-screening workflow speed 🐇.
Golden Gate technology: seamlessly ligate DNA fragments in any order into one backbone and test multiple target sequences in a single C-Trap experiment. This enables assays like DNA sequence-specific looping and boosts sequence-screening workflow speed 🐇.
Golden Gate meets C-Trap: A powerful combination for unprecedented molecular insights - Application Note - LUMICKS
Category: DNA-Binding proteins | Access our application note titled 'Golden Gate meets C-Trap: A powerful combination for unprecedented molecular insights' .
bit.ly
July 2, 2025 at 2:32 PM
New technology app note 👉 bit.ly/44JH0xe
Golden Gate technology: seamlessly ligate DNA fragments in any order into one backbone and test multiple target sequences in a single C-Trap experiment. This enables assays like DNA sequence-specific looping and boosts sequence-screening workflow speed 🐇.
Golden Gate technology: seamlessly ligate DNA fragments in any order into one backbone and test multiple target sequences in a single C-Trap experiment. This enables assays like DNA sequence-specific looping and boosts sequence-screening workflow speed 🐇.