Luke Allsopp
@lukeallsopp.bsky.social
Senior Lecturer Imperial College London
Microbiology Bacteriology Scientist Biofilm Bacteria Nature T6SS and bacterial competition
Microbiology Bacteriology Scientist Biofilm Bacteria Nature T6SS and bacterial competition
Reposted by Luke Allsopp
Some #Pseudomonas aeruginosa strains naturally lack the major virulence system T3SS. 🦠 @inaattree.bsky.social & @cbuch.bsky.social labs reveal that avirulent isolates still produce valuable metabolites (e.g. rhamnolipids, elastase, pyoverdine)—making them promising for #biotech use.
buff.ly/JST7ZR1
buff.ly/JST7ZR1
October 4, 2025 at 10:01 AM
Some #Pseudomonas aeruginosa strains naturally lack the major virulence system T3SS. 🦠 @inaattree.bsky.social & @cbuch.bsky.social labs reveal that avirulent isolates still produce valuable metabolites (e.g. rhamnolipids, elastase, pyoverdine)—making them promising for #biotech use.
buff.ly/JST7ZR1
buff.ly/JST7ZR1
Reposted by Luke Allsopp
So happy to share this! Bacteriocins were first discovered over 100 years ago, but what do they actually do? We look at >1000 bacteriocin plasmids and find links to virulence and antimicrobial resistance, and frequent bacteriocin sharing in Enterobacteriaceae.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Bacterial warfare is associated with virulence and antimicrobial resistance - Nature Communications
Bacteria employ a range of competition systems that deliver toxins to inhibit competing strains. This study shows that these systems are particularly important for the ecology of virulent and antibiot...
www.nature.com
November 5, 2025 at 7:32 AM
So happy to share this! Bacteriocins were first discovered over 100 years ago, but what do they actually do? We look at >1000 bacteriocin plasmids and find links to virulence and antimicrobial resistance, and frequent bacteriocin sharing in Enterobacteriaceae.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Luke Allsopp
Rare disease research needs a more integrated and collaborative approach.
Next week, experts from across our 4 Translational Centres for Rare Disease, will meet to discuss the year's progress, share knowledge, and discuss the challenges and opportunities to come.
Next week, experts from across our 4 Translational Centres for Rare Disease, will meet to discuss the year's progress, share knowledge, and discuss the challenges and opportunities to come.
November 4, 2025 at 9:15 AM
Rare disease research needs a more integrated and collaborative approach.
Next week, experts from across our 4 Translational Centres for Rare Disease, will meet to discuss the year's progress, share knowledge, and discuss the challenges and opportunities to come.
Next week, experts from across our 4 Translational Centres for Rare Disease, will meet to discuss the year's progress, share knowledge, and discuss the challenges and opportunities to come.
Great kick off meeting for the Precision CF Innovation Hub @imperialnhli.bsky.social @janedaviescf.bsky.social. Awesome talks and a real energy. Thanks to funders @lifearc.bsky.social and @cysticfibrosis.org.uk
October 22, 2025 at 8:51 AM
Great kick off meeting for the Precision CF Innovation Hub @imperialnhli.bsky.social @janedaviescf.bsky.social. Awesome talks and a real energy. Thanks to funders @lifearc.bsky.social and @cysticfibrosis.org.uk
Reposted by Luke Allsopp
New in JB: Bhattacharya, Zhang, & Yu review the current state of knowledge around protein trafficking across the membrane by gram-positive bacteria with a focus on the model organisms Bacillus subtilis and Staphylococcus aureus.
journals.asm.org/doi/10.1128/...
@asm.org
#JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org
#JBacteriology
October 21, 2025 at 12:44 PM
New in JB: Bhattacharya, Zhang, & Yu review the current state of knowledge around protein trafficking across the membrane by gram-positive bacteria with a focus on the model organisms Bacillus subtilis and Staphylococcus aureus.
journals.asm.org/doi/10.1128/...
@asm.org
#JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org
#JBacteriology
Reposted by Luke Allsopp
Today is #WorldPhageDay! One of our key aims is to advance #phagetherapy, which uses natural viruses called #phage to target bacteria instead of antibiotics. We are working to develop new phage combinations, test the best way of giving them, and ensure the UK can produce phage at medical standards.
October 22, 2025 at 8:16 AM
Today is #WorldPhageDay! One of our key aims is to advance #phagetherapy, which uses natural viruses called #phage to target bacteria instead of antibiotics. We are working to develop new phage combinations, test the best way of giving them, and ensure the UK can produce phage at medical standards.
Reposted by Luke Allsopp
Thrilled to share that two of our papers with @jrpenades.bsky.social & GoogleDeepMind
are now out in @cellpress.bsky.social
1️⃣Microbial piracy: tinyurl.com/yvf6t3b3
2️⃣AI co-scientist mirrors experimental science: tinyurl.com/2dym92kj
@imperialcollegeldn.bsky.social
@imperiallifesci.bsky.social
are now out in @cellpress.bsky.social
1️⃣Microbial piracy: tinyurl.com/yvf6t3b3
2️⃣AI co-scientist mirrors experimental science: tinyurl.com/2dym92kj
@imperialcollegeldn.bsky.social
@imperiallifesci.bsky.social
September 9, 2025 at 3:06 PM
Thrilled to share that two of our papers with @jrpenades.bsky.social & GoogleDeepMind
are now out in @cellpress.bsky.social
1️⃣Microbial piracy: tinyurl.com/yvf6t3b3
2️⃣AI co-scientist mirrors experimental science: tinyurl.com/2dym92kj
@imperialcollegeldn.bsky.social
@imperiallifesci.bsky.social
are now out in @cellpress.bsky.social
1️⃣Microbial piracy: tinyurl.com/yvf6t3b3
2️⃣AI co-scientist mirrors experimental science: tinyurl.com/2dym92kj
@imperialcollegeldn.bsky.social
@imperiallifesci.bsky.social
Reposted by Luke Allsopp
Please RT! Call for Fellows! If you’re a structural biologist and wanting to start your lab by applying for an external Fellowship then we at Imperial may be excited to host you. Synthetic biologists too.. Please submit expression of interest with details below 🙏
www.imperial.ac.uk/media/imperi...
www.imperial.ac.uk/media/imperi...
www.imperial.ac.uk
July 28, 2025 at 4:13 PM
Please RT! Call for Fellows! If you’re a structural biologist and wanting to start your lab by applying for an external Fellowship then we at Imperial may be excited to host you. Synthetic biologists too.. Please submit expression of interest with details below 🙏
www.imperial.ac.uk/media/imperi...
www.imperial.ac.uk/media/imperi...
Reposted by Luke Allsopp
Several years of work with several great collaborators, that combined computational biology, molecular microbiology, biochemistry, structural biology and mycology assay culminated in today's publication on discovery of novel bacterial toxins:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Systematic discovery of antibacterial and antifungal bacterial toxins - Nature Microbiology
Genome sequence mining and computational analyses lead to the discovery and functional characterization of conserved bacterial toxins with activity against bacteria and fungi.
www.nature.com
October 22, 2024 at 5:37 PM
Several years of work with several great collaborators, that combined computational biology, molecular microbiology, biochemistry, structural biology and mycology assay culminated in today's publication on discovery of novel bacterial toxins:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Luke Allsopp
Preparing for ETOX meeting in Bilbao with Yaara, Tracy, and Luke @lukeallsopp.bsky.social @proftracypalmer.bsky.social
June 29, 2025 at 12:15 PM
Preparing for ETOX meeting in Bilbao with Yaara, Tracy, and Luke @lukeallsopp.bsky.social @proftracypalmer.bsky.social
Reposted by Luke Allsopp
This week I celebrate 10 years at FILM, the Facility for Imaging by Light Microscopy @imperialcollegeldn.bsky.social @imperialnhli.bsky.social
Thank you to all the students, researchers and colleagues who used the facility and supported us!
Here's to many more years of imaging 🥳🎉🔬
Thank you to all the students, researchers and colleagues who used the facility and supported us!
Here's to many more years of imaging 🥳🎉🔬
June 20, 2025 at 7:36 AM
This week I celebrate 10 years at FILM, the Facility for Imaging by Light Microscopy @imperialcollegeldn.bsky.social @imperialnhli.bsky.social
Thank you to all the students, researchers and colleagues who used the facility and supported us!
Here's to many more years of imaging 🥳🎉🔬
Thank you to all the students, researchers and colleagues who used the facility and supported us!
Here's to many more years of imaging 🥳🎉🔬
Reposted by Luke Allsopp
Today is Wear Yellow Day to raise awareness of and fundraise for Cystic Fibrosis. Teams of @janedaviescf.bsky.social, @lukeallsopp.bsky.social and Hughes in yellow. Researching towards unlocking a life unlimited for people with CF @cysticfibrosis.org.uk
www.cysticfibrosis.org.uk/get-involved...
www.cysticfibrosis.org.uk/get-involved...
June 13, 2025 at 1:09 PM
Today is Wear Yellow Day to raise awareness of and fundraise for Cystic Fibrosis. Teams of @janedaviescf.bsky.social, @lukeallsopp.bsky.social and Hughes in yellow. Researching towards unlocking a life unlimited for people with CF @cysticfibrosis.org.uk
www.cysticfibrosis.org.uk/get-involved...
www.cysticfibrosis.org.uk/get-involved...
Reposted by Luke Allsopp
Harriet Ellis, a postdoc in @lukeallsopp.bsky.social's Group, is uncovering how Pseudomonas aeruginosa – a key bacterial threat in cystic fibrosis – adapts & causes infection. 💛🦠 #CFweek
Discover how her work could help fight lung infections 👇 blogs.imperial.ac.uk/nhli/2025/06...
Discover how her work could help fight lung infections 👇 blogs.imperial.ac.uk/nhli/2025/06...
June 11, 2025 at 8:51 AM
Harriet Ellis, a postdoc in @lukeallsopp.bsky.social's Group, is uncovering how Pseudomonas aeruginosa – a key bacterial threat in cystic fibrosis – adapts & causes infection. 💛🦠 #CFweek
Discover how her work could help fight lung infections 👇 blogs.imperial.ac.uk/nhli/2025/06...
Discover how her work could help fight lung infections 👇 blogs.imperial.ac.uk/nhli/2025/06...
#Myth busting #immunology, promoting #critical thinking and the awe of #science !!!
Super enjoyed @dandavis101.bsky.social lecture at the @ri-science.bsky.social on Saturday!
Super enjoyed @dandavis101.bsky.social lecture at the @ri-science.bsky.social on Saturday!
June 9, 2025 at 10:00 AM
#Myth busting #immunology, promoting #critical thinking and the awe of #science !!!
Super enjoyed @dandavis101.bsky.social lecture at the @ri-science.bsky.social on Saturday!
Super enjoyed @dandavis101.bsky.social lecture at the @ri-science.bsky.social on Saturday!
Enjoyed @dandavis101.bsky.social lecture at @ri-science.bsky.social on Saturday night. Myth busting and promoting critical thinking with a clear passion for scientific discovery!!
June 9, 2025 at 9:56 AM
Enjoyed @dandavis101.bsky.social lecture at @ri-science.bsky.social on Saturday night. Myth busting and promoting critical thinking with a clear passion for scientific discovery!!
Reposted by Luke Allsopp
White-nose disease in bats:
The causative agent is not a single fungal species but 2 sympatric cryptic species with host specialization & geographically differentiated populations
The source of the North American species has been traced to giant maze-caves of a region in Ukraine
#MicroSky
The causative agent is not a single fungal species but 2 sympatric cryptic species with host specialization & geographically differentiated populations
The source of the North American species has been traced to giant maze-caves of a region in Ukraine
#MicroSky
Two distinct host-specialized fungal species cause white-nose disease in bats - Nature
The identification of two cryptic species of the fungal pathogen that causes white-nose disease in bats highlights the need to integrate studies of genetic variability in pathogens into disease survei...
www.nature.com
June 3, 2025 at 8:44 AM
White-nose disease in bats:
The causative agent is not a single fungal species but 2 sympatric cryptic species with host specialization & geographically differentiated populations
The source of the North American species has been traced to giant maze-caves of a region in Ukraine
#MicroSky
The causative agent is not a single fungal species but 2 sympatric cryptic species with host specialization & geographically differentiated populations
The source of the North American species has been traced to giant maze-caves of a region in Ukraine
#MicroSky
Reposted by Luke Allsopp
“I was confident that macrophages would digest the microplastics and everything would be fine. I was truly surprised by what we found,” explained Adam Soloff, PhD, to Futura on his latest study on microplastics, which he presented at #ATS2025.
Read more: www.futura-sciences.com/en/i-was-rea...
Read more: www.futura-sciences.com/en/i-was-rea...
June 2, 2025 at 8:16 PM
“I was confident that macrophages would digest the microplastics and everything would be fine. I was truly surprised by what we found,” explained Adam Soloff, PhD, to Futura on his latest study on microplastics, which he presented at #ATS2025.
Read more: www.futura-sciences.com/en/i-was-rea...
Read more: www.futura-sciences.com/en/i-was-rea...
Reposted by Luke Allsopp
A bacterial regulatory uORF senses multiple classes of ribosome-targeting antibiotics
elifesciences.org/articles/101...
elifesciences.org/articles/101...
A bacterial regulatory uORF senses multiple classes of ribosome-targeting antibiotics
An upstream open-reading frame in Escherichia coli regulates expression of the downstream genes in response to diverse translation stresses.
elifesciences.org
June 3, 2025 at 7:05 AM
A bacterial regulatory uORF senses multiple classes of ribosome-targeting antibiotics
elifesciences.org/articles/101...
elifesciences.org/articles/101...
Reposted by Luke Allsopp
I talked to 15 teachers/professors about how AI and ChatGPT is ruining their lives:
www.404media.co/teachers-are...
www.404media.co/teachers-are...
Teachers Are Not OK
AI, ChatGPT, and LLMs "have absolutely blown up what I try to accomplish with my teaching."
www.404media.co
June 2, 2025 at 2:13 PM
I talked to 15 teachers/professors about how AI and ChatGPT is ruining their lives:
www.404media.co/teachers-are...
www.404media.co/teachers-are...
Reposted by Luke Allsopp
Our researchers have created the first high-res map of the lung airway wall, revealing how cell organisation & interactions are disrupted in asthma 🫁
Published in @natimmunol.nature.com, it's a key step towards understanding the mechanisms that drive the disease
www.imperial.ac.uk/news/264294/...
Published in @natimmunol.nature.com, it's a key step towards understanding the mechanisms that drive the disease
www.imperial.ac.uk/news/264294/...
Pioneering spatial map of the airways could transform understanding of asthma | Imperial News | Imperial College London
Researchers have identified distinct differences in the spatial organisation of cells in the airway of healthy people and those with asthma.
www.imperial.ac.uk
May 23, 2025 at 8:11 AM
Our researchers have created the first high-res map of the lung airway wall, revealing how cell organisation & interactions are disrupted in asthma 🫁
Published in @natimmunol.nature.com, it's a key step towards understanding the mechanisms that drive the disease
www.imperial.ac.uk/news/264294/...
Published in @natimmunol.nature.com, it's a key step towards understanding the mechanisms that drive the disease
www.imperial.ac.uk/news/264294/...
Reposted by Luke Allsopp
**NEW Doctoral Training Programme just launched!!** This exciting programme on Microbial Genomics for Health Protection is joint between @imibirmingham.bsky.social and UKHSA @ukhsa.bsky.social. 9 brilliant projects available!!
An exciting new Doctoral Training Programme in Microbial Genomics for Health Protection, in collaboration with the UK Health Security Agency @ukhsa.bsky.social, has just launched, funded by @nihr.bsky.social there are 9 PhD projects available (UK students only) www.birmingham.ac.uk/research/cen...
PhD Microbial Genomics for Health Protection, Biosciences - University of Birmingham
PhD in Microbial Genomics, exciting new Doctoral Training Programme in Microbial Genomics for Health Protection in collaboration with the UK Health Security Agency (UKHSA) launches
www.birmingham.ac.uk
May 23, 2025 at 10:36 AM
**NEW Doctoral Training Programme just launched!!** This exciting programme on Microbial Genomics for Health Protection is joint between @imibirmingham.bsky.social and UKHSA @ukhsa.bsky.social. 9 brilliant projects available!!
Brilliant Athena Swan Lecture by Dame Kate Bingham at @imperialcollegeldn.bsky.social ‘getting up in the morning and knowing your work will have an impact on someone- is my biggest driver’
May 7, 2025 at 12:47 PM
Brilliant Athena Swan Lecture by Dame Kate Bingham at @imperialcollegeldn.bsky.social ‘getting up in the morning and knowing your work will have an impact on someone- is my biggest driver’
Reposted by Luke Allsopp
UKRI's budget for 2025-26 confirmed...finally
5 months after spending review, and 1 day before financial year starts
As @resprofnews.bsky.social has been reporting, it's less than flat cash (£8.8bn), despite DSIT's R&D budget rising
Via @annamckie.bsky.social
More details to come
5 months after spending review, and 1 day before financial year starts
As @resprofnews.bsky.social has been reporting, it's less than flat cash (£8.8bn), despite DSIT's R&D budget rising
Via @annamckie.bsky.social
More details to come
Ministers confirm UK Research and Innovation budget will fall - Research Professional News
Funding agency’s allocation drops by £300m for 2025-26, despite rising R&D spending at science department
www.researchprofessionalnews.com
April 4, 2025 at 6:50 AM
UKRI's budget for 2025-26 confirmed...finally
5 months after spending review, and 1 day before financial year starts
As @resprofnews.bsky.social has been reporting, it's less than flat cash (£8.8bn), despite DSIT's R&D budget rising
Via @annamckie.bsky.social
More details to come
5 months after spending review, and 1 day before financial year starts
As @resprofnews.bsky.social has been reporting, it's less than flat cash (£8.8bn), despite DSIT's R&D budget rising
Via @annamckie.bsky.social
More details to come
Impactful study in @naturemedicine.bsky.social Eating more plants during pregnancy linked to lower neurodevelopmental disorders - #WOW
www.nature.com/articles/s42...
www.nature.com/articles/s42...
A western dietary pattern during pregnancy is associated with neurodevelopmental disorders in childhood and adolescence
Nature Metabolism - Leveraging four large, longitudinal, prospectively-followed mother–child cohorts, this study shows that a western diet in early–mid-pregnancy is associated with...
www.nature.com
April 4, 2025 at 8:45 AM
Impactful study in @naturemedicine.bsky.social Eating more plants during pregnancy linked to lower neurodevelopmental disorders - #WOW
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Reposted by Luke Allsopp
Watching the US take a wrecking ball to science 💔 🤯
Reminder of the importance of doing science in the open. Put data, software, resources in public domain, where no single govt can erase them. This is our collective knowledge. Distributed data systems are essential.
www.nature.com/articles/s41...
Reminder of the importance of doing science in the open. Put data, software, resources in public domain, where no single govt can erase them. This is our collective knowledge. Distributed data systems are essential.
www.nature.com/articles/s41...
Genomic data sharing: you don’t know what you’ve got (till it’s gone) - Nature Reviews Genetics
Reflecting on the core values of early data sharing agreements, the Bermuda Principles and the Fort Lauderdale Agreement, Kathryn E. Holt and Michael Inouye emphasize the need to reaffirm our commitme...
www.nature.com
March 17, 2025 at 9:08 PM
Watching the US take a wrecking ball to science 💔 🤯
Reminder of the importance of doing science in the open. Put data, software, resources in public domain, where no single govt can erase them. This is our collective knowledge. Distributed data systems are essential.
www.nature.com/articles/s41...
Reminder of the importance of doing science in the open. Put data, software, resources in public domain, where no single govt can erase them. This is our collective knowledge. Distributed data systems are essential.
www.nature.com/articles/s41...