Loïc Ongena
@longena.bsky.social
PhD student @University of Liège (BE) interested in RNA biology and Transcription Factors
Check out our new lab paper out in @natcomms.nature.com
doi.org/10.1038/s414...
EWSR1::FLI1, the main oncogenic driver of Ewing sarcoma and a notoriously challenging drug target, has mostly been studied for its role in transcriptional deregulation 🧬
But it turns out not to be its only function...
doi.org/10.1038/s414...
EWSR1::FLI1, the main oncogenic driver of Ewing sarcoma and a notoriously challenging drug target, has mostly been studied for its role in transcriptional deregulation 🧬
But it turns out not to be its only function...
Subversion of mRNA degradation pathways by EWSR1::FLI1 represents a therapeutic vulnerability in Ewing sarcoma - Nature Communications
The EWSR1::FLI1 fusion protein is the oncogenic driver of Ewing sarcoma (EwS). Here, the authors find that EWSR1::FLI1 plays a non-canonical role in mRNA decay via interactions with the CCR4-NOT deade...
doi.org
July 26, 2025 at 8:42 AM
Check out our new lab paper out in @natcomms.nature.com
doi.org/10.1038/s414...
EWSR1::FLI1, the main oncogenic driver of Ewing sarcoma and a notoriously challenging drug target, has mostly been studied for its role in transcriptional deregulation 🧬
But it turns out not to be its only function...
doi.org/10.1038/s414...
EWSR1::FLI1, the main oncogenic driver of Ewing sarcoma and a notoriously challenging drug target, has mostly been studied for its role in transcriptional deregulation 🧬
But it turns out not to be its only function...
Reposted by Loïc Ongena
👀 Currently at 586 signatures! WOW!
📈 Can we get to 1000 signatures by 5pm et? (This would really help part 2 of our 5 point action plan...)
✍️ SIGN AND SHARE, DORKS!
#StandUpforScience
#SummerFightforScience
📈 Can we get to 1000 signatures by 5pm et? (This would really help part 2 of our 5 point action plan...)
✍️ SIGN AND SHARE, DORKS!
#StandUpforScience
#SummerFightforScience
🚨 URGENT RESPONSE CALL 🚨
Trump’s Fool’s Gold Science EO is a dangerous sham.
It gives his appointees the power to dismiss entire bodies of research and punish researchers who fail to fall in line with his agenda.
We’ve launched an open letter.
SIGN & SHARE NOW: actionnetwork.org/petitions/op...
Trump’s Fool’s Gold Science EO is a dangerous sham.
It gives his appointees the power to dismiss entire bodies of research and punish researchers who fail to fall in line with his agenda.
We’ve launched an open letter.
SIGN & SHARE NOW: actionnetwork.org/petitions/op...
Sign The Open Letter to Stand Up For Science Now!
Science is under siege. Trump’s latest Executive Order calls for politically appointed science commissars to evaluate research. Join us in adding your name to our open letter condemning Trump’s escala...
actionnetwork.org
May 26, 2025 at 6:51 PM
👀 Currently at 586 signatures! WOW!
📈 Can we get to 1000 signatures by 5pm et? (This would really help part 2 of our 5 point action plan...)
✍️ SIGN AND SHARE, DORKS!
#StandUpforScience
#SummerFightforScience
📈 Can we get to 1000 signatures by 5pm et? (This would really help part 2 of our 5 point action plan...)
✍️ SIGN AND SHARE, DORKS!
#StandUpforScience
#SummerFightforScience
Reposted by Loïc Ongena
Nature research paper: Deciphering disordered regions controlling mRNA decay in high-throughput
https://go.nature.com/4lG2nGp
https://go.nature.com/4lG2nGp
Deciphering disordered regions controlling mRNA decay in high-throughput - Nature
Using high-throughput functional profiling, how disordered regions control mRNA stability and translation is explored.
go.nature.com
April 27, 2025 at 2:45 PM
Nature research paper: Deciphering disordered regions controlling mRNA decay in high-throughput
https://go.nature.com/4lG2nGp
https://go.nature.com/4lG2nGp
Reposted by Loïc Ongena
The CDC has literally been gutted today.
There’s no need for “April Fools” when reality is a nightmare for every human on this planet.
Thousand of scientists fired.
Entire departments erased.
1/
There’s no need for “April Fools” when reality is a nightmare for every human on this planet.
Thousand of scientists fired.
Entire departments erased.
1/
April 1, 2025 at 4:10 PM
The CDC has literally been gutted today.
There’s no need for “April Fools” when reality is a nightmare for every human on this planet.
Thousand of scientists fired.
Entire departments erased.
1/
There’s no need for “April Fools” when reality is a nightmare for every human on this planet.
Thousand of scientists fired.
Entire departments erased.
1/
Reposted by Loïc Ongena
Nature research paper: irCLIP-RNP and Re-CLIP reveal patterns of dynamic protein assemblies on RNA
https://go.nature.com/42jvUOk
https://go.nature.com/42jvUOk
irCLIP-RNP and Re-CLIP reveal patterns of dynamic protein assemblies on RNA - Nature
EGF-induced recruitment of UPF1 adjacent to HNRNPC induces splicing surveillance of cell proliferation mRNAs.
go.nature.com
March 26, 2025 at 6:34 PM
Nature research paper: irCLIP-RNP and Re-CLIP reveal patterns of dynamic protein assemblies on RNA
https://go.nature.com/42jvUOk
https://go.nature.com/42jvUOk
Reposted by Loïc Ongena
Please repost to get the word out! @nkgarg.bsky.social and I are excited to present a personalized feed for academics! It shows posts about papers from accounts you’re following bsky.app/profile/pape...
March 10, 2025 at 3:12 PM
Please repost to get the word out! @nkgarg.bsky.social and I are excited to present a personalized feed for academics! It shows posts about papers from accounts you’re following bsky.app/profile/pape...
Reposted by Loïc Ongena
ICYMI: New online! Intrinsically disordered regions as facilitators of the transcription factor target search
Intrinsically disordered regions as facilitators of the transcription factor target search
Nature Reviews Genetics, Published online: 21 February 2025; doi:10.1038/s41576-025-00816-3Intrinsically disordered domains (IDRs) are increasingly appreciated as important components of protein function. This Perspective discusses the emerging evidence…
www.nature.com
February 28, 2025 at 2:00 PM
ICYMI: New online! Intrinsically disordered regions as facilitators of the transcription factor target search
Reposted by Loïc Ongena
What is Europe PMC? 🤷♀️
A platform that connects you to global life science publications and preprints from trusted sources. Developed by
@ebi.embl.org it’s your gateway to open science and enhanced research visibility.
Discover your next research tool: www.youtube.com/watch?v=2jyY...
A platform that connects you to global life science publications and preprints from trusted sources. Developed by
@ebi.embl.org it’s your gateway to open science and enhanced research visibility.
Discover your next research tool: www.youtube.com/watch?v=2jyY...
What is Europe PMC
YouTube video by EuropePMC
www.youtube.com
January 31, 2025 at 10:26 AM
What is Europe PMC? 🤷♀️
A platform that connects you to global life science publications and preprints from trusted sources. Developed by
@ebi.embl.org it’s your gateway to open science and enhanced research visibility.
Discover your next research tool: www.youtube.com/watch?v=2jyY...
A platform that connects you to global life science publications and preprints from trusted sources. Developed by
@ebi.embl.org it’s your gateway to open science and enhanced research visibility.
Discover your next research tool: www.youtube.com/watch?v=2jyY...
Reposted by Loïc Ongena
🚨 We are hiring! We are looking for motivated bioinformatician to join our team “Genomics and Development of Childhood Cancers" at Institut Curie, Paris, France.
The interested candidates should apply by sending an email with their CV and motivation letter
The interested candidates should apply by sending an email with their CV and motivation letter
January 8, 2025 at 3:19 PM
🚨 We are hiring! We are looking for motivated bioinformatician to join our team “Genomics and Development of Childhood Cancers" at Institut Curie, Paris, France.
The interested candidates should apply by sending an email with their CV and motivation letter
The interested candidates should apply by sending an email with their CV and motivation letter
Reposted by Loïc Ongena
We are recruiting an enthusiastic engineer to identify isoform-splicing regulation in the developing Drosophila embryo with transcriptomics & genetics in our lively team in @igmm-montpel.bsky.social
Please reshare! #jobOffer #RNA #hox #Drosophila #Nanopore #splicing
emploi.cnrs.fr/Offres/CDD/U...
Please reshare! #jobOffer #RNA #hox #Drosophila #Nanopore #splicing
emploi.cnrs.fr/Offres/CDD/U...
Portail Emploi CNRS - Offre d'emploi - Ingénieur d'études en biologie moléculaire (H/F)
emploi.cnrs.fr
December 9, 2024 at 8:41 PM
We are recruiting an enthusiastic engineer to identify isoform-splicing regulation in the developing Drosophila embryo with transcriptomics & genetics in our lively team in @igmm-montpel.bsky.social
Please reshare! #jobOffer #RNA #hox #Drosophila #Nanopore #splicing
emploi.cnrs.fr/Offres/CDD/U...
Please reshare! #jobOffer #RNA #hox #Drosophila #Nanopore #splicing
emploi.cnrs.fr/Offres/CDD/U...