Kerstin Ludwig
@kuludwig.bsky.social
Group leader at University of Bonn, studying the genomics of birth defects and infectious diseases.
Congratulations!! Exciting news and super well deserved! 🥳🥳🥳
🏆 Anna Aschenbrenner from DZNE has been awarded the Tobias-Welte Prize by the German Sepsis Society, which recognizes outstanding achievements in sepsis and infection research. The prize honors her innovative work published in Cell.
Read more about the study: www.immunosensation.de/news/scienti...
Read more about the study: www.immunosensation.de/news/scienti...
October 23, 2025 at 11:55 AM
Congratulations!! Exciting news and super well deserved! 🥳🥳🥳
Reposted by Kerstin Ludwig
Woah just discovered this
formatmypaper.com
formatmypaper.com
FormatMyPaper - The End of Manuscript Formatting
Paste your paper, choose your journal, and let our AI handle the tedious rest. Get back to the science.
formatmypaper.com
October 15, 2025 at 4:29 AM
Woah just discovered this
formatmypaper.com
formatmypaper.com
I finally made (it on) my first cover 🤣 🥳!!
Congratulations to @hggadvances.bsky.social, and all my fellow co-editors, for establishing a great genomics journal. And to all authors: if your manuscript still needs a home, consider submitting with us. We would be delighted to handle your paper 🫶 💪.
Congratulations to @hggadvances.bsky.social, and all my fellow co-editors, for establishing a great genomics journal. And to all authors: if your manuscript still needs a home, consider submitting with us. We would be delighted to handle your paper 🫶 💪.
Our October issue is online!
Check out the amazing cover from @comfortandadam.bsky.social to commemorate 5 YEARS of HGG Advances!
www.cell.com/hgg-advances...
Check out the amazing cover from @comfortandadam.bsky.social to commemorate 5 YEARS of HGG Advances!
www.cell.com/hgg-advances...
October 10, 2025 at 6:00 PM
I finally made (it on) my first cover 🤣 🥳!!
Congratulations to @hggadvances.bsky.social, and all my fellow co-editors, for establishing a great genomics journal. And to all authors: if your manuscript still needs a home, consider submitting with us. We would be delighted to handle your paper 🫶 💪.
Congratulations to @hggadvances.bsky.social, and all my fellow co-editors, for establishing a great genomics journal. And to all authors: if your manuscript still needs a home, consider submitting with us. We would be delighted to handle your paper 🫶 💪.
Reposted by Kerstin Ludwig
Very exciting preprint by @axel-schmidt.bsky.social, @kuludwig.bsky.social and team!
Check out Kerstin's thread for overview
Check out Kerstin's thread for overview
🔔Paper alert! Extremely excited to share a preprint from our lab! Spearheaded by @axel-schmidt.bsky.social, a super talented medical & computational geneticist, we studied latent Epstein-Barr virus (EBV) infection at population-scale.
Interested in how this works & what we found? Read along! 👇
Interested in how this works & what we found? Read along! 👇
Host control of latent Epstein-Barr virus infection https://www.medrxiv.org/content/10.1101/2025.07.19.25331823v1
July 24, 2025 at 5:51 AM
Very exciting preprint by @axel-schmidt.bsky.social, @kuludwig.bsky.social and team!
Check out Kerstin's thread for overview
Check out Kerstin's thread for overview
🔔Paper alert! Extremely excited to share a preprint from our lab! Spearheaded by @axel-schmidt.bsky.social, a super talented medical & computational geneticist, we studied latent Epstein-Barr virus (EBV) infection at population-scale.
Interested in how this works & what we found? Read along! 👇
Interested in how this works & what we found? Read along! 👇
Host control of latent Epstein-Barr virus infection https://www.medrxiv.org/content/10.1101/2025.07.19.25331823v1
July 22, 2025 at 4:10 PM
🔔Paper alert! Extremely excited to share a preprint from our lab! Spearheaded by @axel-schmidt.bsky.social, a super talented medical & computational geneticist, we studied latent Epstein-Barr virus (EBV) infection at population-scale.
Interested in how this works & what we found? Read along! 👇
Interested in how this works & what we found? Read along! 👇
Reposted by Kerstin Ludwig
🚨 Most variant screens measure growth or abundance. What do they miss? That variants impact a spectrum of protein and cellular phenotypes. Variant in situ sequencing (VIS-seq) finds what’s missing: image cells 🔬 first, decode later, revealing multi-scale phenotypes for thousands of variants.👇
1/9
1/9
July 7, 2025 at 2:44 AM
🚨 Most variant screens measure growth or abundance. What do they miss? That variants impact a spectrum of protein and cellular phenotypes. Variant in situ sequencing (VIS-seq) finds what’s missing: image cells 🔬 first, decode later, revealing multi-scale phenotypes for thousands of variants.👇
1/9
1/9
Reposted by Kerstin Ludwig
🚀 Thrilled to share our new review on how structural variants reshape 3D genome architecture and cause disease! 🧬🔀
Out now in Nature Reviews Genetics: www.nature.com/articles/s41...
#3D-Genome #StructuralVariants #uksh
Out now in Nature Reviews Genetics: www.nature.com/articles/s41...
#3D-Genome #StructuralVariants #uksh
Structural variants in the 3D genome as drivers of disease - Nature Reviews Genetics
Disruption of the 3D genome caused by structural variation contributes to developmental disorders and cancer. The authors review the causes and molecular and clinical consequences of position effects ...
www.nature.com
July 7, 2025 at 11:12 AM
🚀 Thrilled to share our new review on how structural variants reshape 3D genome architecture and cause disease! 🧬🔀
Out now in Nature Reviews Genetics: www.nature.com/articles/s41...
#3D-Genome #StructuralVariants #uksh
Out now in Nature Reviews Genetics: www.nature.com/articles/s41...
#3D-Genome #StructuralVariants #uksh
So exciting - congratulations!!! 💐🎊👍
We are SO EXCITED to share our story @nature.com:
🧵1/
Maternal obesity reprograms fetal liver macrophages, triggering adult fatty liver disease in the offspring.
This study uncovers how Kupffer cells act as intergenerational messengers in metabolic disease.
👉 Read here: rdcu.be/erD3b
🧵1/
Maternal obesity reprograms fetal liver macrophages, triggering adult fatty liver disease in the offspring.
This study uncovers how Kupffer cells act as intergenerational messengers in metabolic disease.
👉 Read here: rdcu.be/erD3b
Kupffer cell programming by maternal obesity triggers fatty liver disease
Nature - In a mouse model, maternal obesity during pregnancy can lead to fatty liver disease in the offspring, driven by aberrant developmental programming of Kuppfer cells.
rdcu.be
June 18, 2025 at 6:03 PM
So exciting - congratulations!!! 💐🎊👍
Congratulations, this sounds awesome! Looking forward to get this data presented live when you visit us in Bonn forward our Summer School 🎊🤣 @immunosens.bsky.social
How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...
Conservation of regulatory elements with highly diverged sequences across large evolutionary distances
Nature Genetics - Combining functional genomic data from mouse and chicken with a synteny-based strategy identifies positionally conserved cis-regulatory elements in the absence of direct sequence...
rdcu.be
May 27, 2025 at 8:07 PM
Congratulations, this sounds awesome! Looking forward to get this data presented live when you visit us in Bonn forward our Summer School 🎊🤣 @immunosens.bsky.social
Reposted by Kerstin Ludwig
Justified standing ovation for Nobel laureate Katalin Karikó at #ESHG2025
She shared her adventurous scientific life and life lessons like "If you want to do something, you find a way. If not, you find excuses", and reminded us scientists to thank our near and dear because "they suffer a little bit"
She shared her adventurous scientific life and life lessons like "If you want to do something, you find a way. If not, you find excuses", and reminded us scientists to thank our near and dear because "they suffer a little bit"
May 27, 2025 at 12:39 PM
Justified standing ovation for Nobel laureate Katalin Karikó at #ESHG2025
She shared her adventurous scientific life and life lessons like "If you want to do something, you find a way. If not, you find excuses", and reminded us scientists to thank our near and dear because "they suffer a little bit"
She shared her adventurous scientific life and life lessons like "If you want to do something, you find a way. If not, you find excuses", and reminded us scientists to thank our near and dear because "they suffer a little bit"
Congratulations to everyone involved! 🎊💐
We are excellent! What a day - between hugs, applause and a lot of pride. Our rector? Jumping for joy. Our team? Overjoyed. Thank you to everyone who made this historic moment possible! @dependencybonn.de @immunosens.bsky.social @econtribute.bsky.social
© V. Lannert/G. Hübl/Uni Bonn
© V. Lannert/G. Hübl/Uni Bonn
May 23, 2025 at 10:28 AM
Congratulations to everyone involved! 🎊💐
Reposted by Kerstin Ludwig
Hurray! ImmunoSensation will go on! 🥳
The @dfg.de just announced that ImmunoSensation3, focussing on Immune Diversity will be funded!
Let us #celebrate 7 more years of #immunology in #Bonn 🎉
www.immunosensation.de/news/immunos...
The @dfg.de just announced that ImmunoSensation3, focussing on Immune Diversity will be funded!
Let us #celebrate 7 more years of #immunology in #Bonn 🎉
www.immunosensation.de/news/immunos...
Excellence Strategy Funds Bonn Cluster for Immune Research
The Bonn Cluster of Excellence ImmunoSensation will be funded for a further seven years as part of the Excellence Strategy of the German federal and state…
www.immunosensation.de
May 22, 2025 at 3:55 PM
Hurray! ImmunoSensation will go on! 🥳
The @dfg.de just announced that ImmunoSensation3, focussing on Immune Diversity will be funded!
Let us #celebrate 7 more years of #immunology in #Bonn 🎉
www.immunosensation.de/news/immunos...
The @dfg.de just announced that ImmunoSensation3, focussing on Immune Diversity will be funded!
Let us #celebrate 7 more years of #immunology in #Bonn 🎉
www.immunosensation.de/news/immunos...
Reposted by Kerstin Ludwig
🧬 Today! Prof. Rami Abou Jamra (Uni Leipzig) speaks on "Genome sequencing for rare disease diagnostics" at the GHGA lecture series Advances in Data-Driven Biomedicine. Don’t miss it!
📅 May 21 | ⏰ 4PM
🔗 Register: dkfz-de.zoom.us/meeting/regi...
#Genomics #RareDiseases #GHGA
📅 May 21 | ⏰ 4PM
🔗 Register: dkfz-de.zoom.us/meeting/regi...
#Genomics #RareDiseases #GHGA
May 21, 2025 at 9:49 AM
🧬 Today! Prof. Rami Abou Jamra (Uni Leipzig) speaks on "Genome sequencing for rare disease diagnostics" at the GHGA lecture series Advances in Data-Driven Biomedicine. Don’t miss it!
📅 May 21 | ⏰ 4PM
🔗 Register: dkfz-de.zoom.us/meeting/regi...
#Genomics #RareDiseases #GHGA
📅 May 21 | ⏰ 4PM
🔗 Register: dkfz-de.zoom.us/meeting/regi...
#Genomics #RareDiseases #GHGA
Reposted by Kerstin Ludwig
May 21, 2025 at 10:25 AM
Reposted by Kerstin Ludwig
Good morning #VariantEffect25! Kicking things off we have Mafalda Dias, @bennibolo.bsky.social @muffley.bsky.social welcoming us to this 8th annual symposium. We have 250 in-person participants, 60 people online, from 20 countries!
May 21, 2025 at 7:45 AM
Good morning #VariantEffect25! Kicking things off we have Mafalda Dias, @bennibolo.bsky.social @muffley.bsky.social welcoming us to this 8th annual symposium. We have 250 in-person participants, 60 people online, from 20 countries!
Reposted by Kerstin Ludwig
Diving into the 1st session of #VariantEffect25 we have David Adams @davidjadams.bsky.social from the Wellcome Sanger Institute presenting “Decoding Cancer: Clinical and Functional Roles of Nucleotide Variants in Cancer Genes”
May 21, 2025 at 7:51 AM
Diving into the 1st session of #VariantEffect25 we have David Adams @davidjadams.bsky.social from the Wellcome Sanger Institute presenting “Decoding Cancer: Clinical and Functional Roles of Nucleotide Variants in Cancer Genes”
Reposted by Kerstin Ludwig
Can AI-designed binders degrade, aggregate, stain and enrich endogenous proteins in human cells? Check out our new preprint!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Transposon-Display of AI-designed binders enables manipulation of the proteome in human cells
Transposon-Display is a highly scalable screening method that links proteins to their encoding DNA during expression in E. coli via a mutant transposase. Leveraging this system, we identified AI-desig...
www.biorxiv.org
May 16, 2025 at 7:21 PM
Can AI-designed binders degrade, aggregate, stain and enrich endogenous proteins in human cells? Check out our new preprint!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Kerstin Ludwig
📢 new preprint alert: So so excited to share our analysis on the impact of common and rare variants on single-cell gene expression in blood, using WGS and scRNA-seq data from nearly 2,000 individuals and 5.4m cells as part of TenK10K phase 1 🧬 www.medrxiv.org/content/10.1...
🧵👇 (1/n)
🧵👇 (1/n)
March 24, 2025 at 7:47 AM
📢 new preprint alert: So so excited to share our analysis on the impact of common and rare variants on single-cell gene expression in blood, using WGS and scRNA-seq data from nearly 2,000 individuals and 5.4m cells as part of TenK10K phase 1 🧬 www.medrxiv.org/content/10.1...
🧵👇 (1/n)
🧵👇 (1/n)
Reposted by Kerstin Ludwig
My story: I’m a single father and cancer researcher whose wife died of a rare cancer. Science and biomedical research is personal to me. Here is my op-ed in my hometown newspaper. Pls fwd.
www.vindy.com/opinion/edit...
www.vindy.com/opinion/edit...
DOGE ends America’s golden age of biomedical research
Biomedical research impacts all of us. I became curious about how drugs work after my mom was diagnosed with rheumatoid arthritis when I was a small boy. She received “gold shots” as treatment, which ...
www.vindy.com
March 17, 2025 at 9:29 PM
My story: I’m a single father and cancer researcher whose wife died of a rare cancer. Science and biomedical research is personal to me. Here is my op-ed in my hometown newspaper. Pls fwd.
www.vindy.com/opinion/edit...
www.vindy.com/opinion/edit...
Reposted by Kerstin Ludwig
Key reads from last week on human genetics, multiomics, and precision medicine 🧵
1⃣New e/sQTL resource from TOPMed
In 14,324 whole blood & tissue samples the study detects cis- and trans-e/sQTLs and colocalizes them with 10,000 GWAS signals for 164 traits.
🔗 www.medrxiv.org/content/10.1...
1⃣New e/sQTL resource from TOPMed
In 14,324 whole blood & tissue samples the study detects cis- and trans-e/sQTLs and colocalizes them with 10,000 GWAS signals for 164 traits.
🔗 www.medrxiv.org/content/10.1...
February 24, 2025 at 4:09 PM
Key reads from last week on human genetics, multiomics, and precision medicine 🧵
1⃣New e/sQTL resource from TOPMed
In 14,324 whole blood & tissue samples the study detects cis- and trans-e/sQTLs and colocalizes them with 10,000 GWAS signals for 164 traits.
🔗 www.medrxiv.org/content/10.1...
1⃣New e/sQTL resource from TOPMed
In 14,324 whole blood & tissue samples the study detects cis- and trans-e/sQTLs and colocalizes them with 10,000 GWAS signals for 164 traits.
🔗 www.medrxiv.org/content/10.1...
Reposted by Kerstin Ludwig
Modern GWAS can identify 1000s of significant hits but it can be hard to turn this into biological insight. What key cellular functions link genetic variation to disease?
I'm very excited to present our new work combining associations and Perturb-seq to build interpretable causal graphs! A 🧵
I'm very excited to present our new work combining associations and Perturb-seq to build interpretable causal graphs! A 🧵
January 26, 2025 at 12:13 AM
Modern GWAS can identify 1000s of significant hits but it can be hard to turn this into biological insight. What key cellular functions link genetic variation to disease?
I'm very excited to present our new work combining associations and Perturb-seq to build interpretable causal graphs! A 🧵
I'm very excited to present our new work combining associations and Perturb-seq to build interpretable causal graphs! A 🧵
Reposted by Kerstin Ludwig
Decoding cilia signaling and function by the one and only @wachtenlab.bsky.social Thanks for delivering a fantastic #FEBS national lecture at the Norwegian bioscience society winter meeting.
January 25, 2025 at 3:24 PM
Decoding cilia signaling and function by the one and only @wachtenlab.bsky.social Thanks for delivering a fantastic #FEBS national lecture at the Norwegian bioscience society winter meeting.
Reposted by Kerstin Ludwig
Friends and colleagues, I’ve written a book on effective functional genomics study design, which will be available on Amazon in a couple of weeks. Sharing the TOC to spark interest. I hope students and those planning genomics experiments will find it useful! I’ll share updates soon
January 10, 2025 at 3:40 AM
Friends and colleagues, I’ve written a book on effective functional genomics study design, which will be available on Amazon in a couple of weeks. Sharing the TOC to spark interest. I hope students and those planning genomics experiments will find it useful! I’ll share updates soon
Reposted by Kerstin Ludwig
Now available as preprint:
The ENCODE 4 expanded registry of regulatory elements
- 2.35M 🧍 human cCREs
- 927k 🐭 mouse cCREs
www.biorxiv.org/content/10.1...
Led by @moorejille.bsky.social, this preprint summarizes data and analyses generated by hundreds of contributors across ENCODE 4
The ENCODE 4 expanded registry of regulatory elements
- 2.35M 🧍 human cCREs
- 927k 🐭 mouse cCREs
www.biorxiv.org/content/10.1...
Led by @moorejille.bsky.social, this preprint summarizes data and analyses generated by hundreds of contributors across ENCODE 4
January 8, 2025 at 8:35 PM
Now available as preprint:
The ENCODE 4 expanded registry of regulatory elements
- 2.35M 🧍 human cCREs
- 927k 🐭 mouse cCREs
www.biorxiv.org/content/10.1...
Led by @moorejille.bsky.social, this preprint summarizes data and analyses generated by hundreds of contributors across ENCODE 4
The ENCODE 4 expanded registry of regulatory elements
- 2.35M 🧍 human cCREs
- 927k 🐭 mouse cCREs
www.biorxiv.org/content/10.1...
Led by @moorejille.bsky.social, this preprint summarizes data and analyses generated by hundreds of contributors across ENCODE 4
Reposted by Kerstin Ludwig
Happy to share our newest work on #covid19 #hostgenetics ! An analysis of >1000 whole genomes with @kuludwig.bsky.social and Axel Schmidt at University of Bonn and Uniklinik Bonn, the DeCOI consortium and many colleagues from around Germany & beyond. #plospathogens
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
Systematic assessment of COVID-19 host genetics using whole genome sequencing data
Author summary After infection with SARS-CoV-2, symptoms vary widely. On average, individuals who are older, males and those with certain comorbidities tend to be more severely affected by COVID-19. A...
journals.plos.org
January 8, 2025 at 9:50 AM
Happy to share our newest work on #covid19 #hostgenetics ! An analysis of >1000 whole genomes with @kuludwig.bsky.social and Axel Schmidt at University of Bonn and Uniklinik Bonn, the DeCOI consortium and many colleagues from around Germany & beyond. #plospathogens
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...