Kirk Lohmueller
@klohmueller.bsky.social
Professor at UCLA in Ecology & Evolutionary Biology as well as Human Genetics.
Traffic Ninja. Occasional runner...
https://lohmueller.eeb.ucla.edu
Traffic Ninja. Occasional runner...
https://lohmueller.eeb.ucla.edu
Way to go Ricky & Nandita! It was such a joy to hear about this work developing and now to see it finally out! I remember, Nandita, that you pitched this in your chalk talk during your interview way back when:)
Grateful to share our paper on gene-specific selective sweeps in human gut microbiomes, now out in Nature! It has been a joy to work with @rwolff.bsky.social, whose insights and hard work made this possible.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Gene-specific selective sweeps are pervasive across human gut microbiomes - Nature
Development and application of the integrated linkage disequilibrium score (iLDS) reveals both selective pressures impacting the human gut microbiome and the mechanisms by which gut bacteria adapt to ...
www.nature.com
December 18, 2025 at 3:26 AM
Way to go Ricky & Nandita! It was such a joy to hear about this work developing and now to see it finally out! I remember, Nandita, that you pitched this in your chalk talk during your interview way back when:)
Reposted by Kirk Lohmueller
New research in #GENETICS from @azurita.bsky.social, Christopher Kyriazis, and @klohmueller.bsky.social demonstrates how unmodeled selection on synonymous mutations may affect downstream inferences of the distribution of fitness effects. buff.ly/IDY87W1
December 5, 2025 at 7:02 PM
New research in #GENETICS from @azurita.bsky.social, Christopher Kyriazis, and @klohmueller.bsky.social demonstrates how unmodeled selection on synonymous mutations may affect downstream inferences of the distribution of fitness effects. buff.ly/IDY87W1
Apple pie and page proofs are a good start to the week after a holiday weekend!😀
December 1, 2025 at 3:33 PM
Apple pie and page proofs are a good start to the week after a holiday weekend!😀
Interested in learning more about PhD programs in computational biology and genomics at UCLA? Join our virtual Open House on Monday, Nov 3 at 1:30pm. More info: bioinformatics.ucla.edu/event/gpb-vi... (1/3)
GPB Virtual Open House
bioinformatics.ucla.edu
October 29, 2025 at 7:52 PM
Interested in learning more about PhD programs in computational biology and genomics at UCLA? Join our virtual Open House on Monday, Nov 3 at 1:30pm. More info: bioinformatics.ucla.edu/event/gpb-vi... (1/3)
In the midst of the darkness, I am pleased to announce that UCLA will be hosting the upcoming Southern California Evolutionary Genetics (SCalE) conference on November 1! Registration & abstract submission is here: www.scalemeeting.org/home Deadline is October 13! Hope to see you at UCLA!
Home
The SCalE Meeting is a free, one day regional academic meeting focused on evolutionary genetics and genomics.
This year's SCalE Meeting is hosted by UCLA, sponsored by the Institute for Quantitative ...
www.scalemeeting.org
September 16, 2025 at 4:47 PM
In the midst of the darkness, I am pleased to announce that UCLA will be hosting the upcoming Southern California Evolutionary Genetics (SCalE) conference on November 1! Registration & abstract submission is here: www.scalemeeting.org/home Deadline is October 13! Hope to see you at UCLA!
Reposted by Kirk Lohmueller
Genome-wide associations of fitness components reveal antagonistic pleiotropy and sexual conflict in the Florida Scrub-Jay https://www.biorxiv.org/content/10.1101/2025.09.09.673786v1
September 13, 2025 at 4:32 AM
Genome-wide associations of fitness components reveal antagonistic pleiotropy and sexual conflict in the Florida Scrub-Jay https://www.biorxiv.org/content/10.1101/2025.09.09.673786v1
Reposted by Kirk Lohmueller
Save the date! #PEQG26 June 9-12 2026 in Asilomar, CA. Happens only every 2yrs, but is my favorite conference. Full website coming soon, and registration and abstract submission opens November 14, but I'm allowed to tease that keynotes will be @jnovembre.bsky.social @jennytung.bsky.social and me!
Homepage - Population, Evolutionary, and Quantitative Genetics Conference
Visit our website to learn more.
genetics-gsa.org
September 3, 2025 at 6:51 PM
Save the date! #PEQG26 June 9-12 2026 in Asilomar, CA. Happens only every 2yrs, but is my favorite conference. Full website coming soon, and registration and abstract submission opens November 14, but I'm allowed to tease that keynotes will be @jnovembre.bsky.social @jennytung.bsky.social and me!
Reposted by Kirk Lohmueller
This is a perfect example of how IS science is being destroyed. I hope you write about it somewhere with higher visibility
I have
NIGMS R35, impact score 12
NIHGRI R21, 4th percentile
NHGRI R01, 7th percentile (co-I)
and it seems like none will be funded. 0/3.
PO (who has been very helpful) said "Unfortunately, I do not expect this application will be selected for funding in FY25."
😭
NIGMS R35, impact score 12
NIHGRI R21, 4th percentile
NHGRI R01, 7th percentile (co-I)
and it seems like none will be funded. 0/3.
PO (who has been very helpful) said "Unfortunately, I do not expect this application will be selected for funding in FY25."
😭
August 20, 2025 at 12:01 PM
This is a perfect example of how IS science is being destroyed. I hope you write about it somewhere with higher visibility
Reposted by Kirk Lohmueller
Excited to be heading to St. Louis for #AOS2025! Be on the lookout for talks from our lab!:
- Jenna McCullough (PD) and Jonah Alderson (grad) are up against each other on Wed. morning
- Claire Geiman (grad) will present a poster Wed evening
- Devon DeRaad (PD) will give a talk on Thur afternoon
- Jenna McCullough (PD) and Jonah Alderson (grad) are up against each other on Wed. morning
- Claire Geiman (grad) will present a poster Wed evening
- Devon DeRaad (PD) will give a talk on Thur afternoon
August 11, 2025 at 11:35 PM
Excited to be heading to St. Louis for #AOS2025! Be on the lookout for talks from our lab!:
- Jenna McCullough (PD) and Jonah Alderson (grad) are up against each other on Wed. morning
- Claire Geiman (grad) will present a poster Wed evening
- Devon DeRaad (PD) will give a talk on Thur afternoon
- Jenna McCullough (PD) and Jonah Alderson (grad) are up against each other on Wed. morning
- Claire Geiman (grad) will present a poster Wed evening
- Devon DeRaad (PD) will give a talk on Thur afternoon
Reposted by Kirk Lohmueller
July 23, 2025 at 4:02 AM
Come join us at UCLA!!! We have a growing population genetics community here and Nandita and her lab are outstanding!
I am seeking a postdoc for my group at UCLA. We work at the intersection of population genetics x microbiome (garud.eeb.ucla.edu). If interested, please message me!
Garud Lab
garud.eeb.ucla.edu
July 23, 2025 at 1:46 PM
Come join us at UCLA!!! We have a growing population genetics community here and Nandita and her lab are outstanding!
Reposted by Kirk Lohmueller
Having major FOMO about #SMBE2025 in my hometown… but I’m very proud that my postdoc, Susanna Gutierrez, will be presenting our work on inferring the selection history of adaptive introgression candidates in Peruvians at poster S12-P19. Please visit her during poster session 3 if you're interested!
July 21, 2025 at 6:13 AM
Having major FOMO about #SMBE2025 in my hometown… but I’m very proud that my postdoc, Susanna Gutierrez, will be presenting our work on inferring the selection history of adaptive introgression candidates in Peruvians at poster S12-P19. Please visit her during poster session 3 if you're interested!
Sad to be missing #SMBE2025. But, the lab will be represented with presentations from (all on Wednesday):
Swetha Ramesh (at 11:50 in Symp 17, Noncoding)
Chenlu Di (at 12:05 in Symp 17, Noncoding)
Diana A Gomez (at 15:45 in Symp 19, Con Gen)
Aina Mi Zurita (at 16:40 in Symp 22, Theory Adv)
Swetha Ramesh (at 11:50 in Symp 17, Noncoding)
Chenlu Di (at 12:05 in Symp 17, Noncoding)
Diana A Gomez (at 15:45 in Symp 19, Con Gen)
Aina Mi Zurita (at 16:40 in Symp 22, Theory Adv)
July 21, 2025 at 1:23 AM
Sad to be missing #SMBE2025. But, the lab will be represented with presentations from (all on Wednesday):
Swetha Ramesh (at 11:50 in Symp 17, Noncoding)
Chenlu Di (at 12:05 in Symp 17, Noncoding)
Diana A Gomez (at 15:45 in Symp 19, Con Gen)
Aina Mi Zurita (at 16:40 in Symp 22, Theory Adv)
Swetha Ramesh (at 11:50 in Symp 17, Noncoding)
Chenlu Di (at 12:05 in Symp 17, Noncoding)
Diana A Gomez (at 15:45 in Symp 19, Con Gen)
Aina Mi Zurita (at 16:40 in Symp 22, Theory Adv)
Reposted by Kirk Lohmueller
Schlichta, Peischl & Excoffier reveal how purifying selection on deleterious mutations impacts diversity: while codominant variants create diversity dips, recessive mutations can preserve diversity in bottlenecks through pseudo-overdominance.
🔗 doi.org/10.1093/gbe/evaf107
#genome #evolution
🔗 doi.org/10.1093/gbe/evaf107
#genome #evolution
Evolution of Functional Genomic Diversity During a Bottleneck
Abstract. Most species have been through population bottlenecks and range expansions, and the impact of these events on patterns of diversity has been well
doi.org
June 23, 2025 at 2:40 PM
Schlichta, Peischl & Excoffier reveal how purifying selection on deleterious mutations impacts diversity: while codominant variants create diversity dips, recessive mutations can preserve diversity in bottlenecks through pseudo-overdominance.
🔗 doi.org/10.1093/gbe/evaf107
#genome #evolution
🔗 doi.org/10.1093/gbe/evaf107
#genome #evolution
Quick visit to Heidelberg and Frankfurt to visit family and Bruce Springsteen….this helped refresh my soul in these bizarre and trying times.
June 22, 2025 at 7:48 PM
Quick visit to Heidelberg and Frankfurt to visit family and Bruce Springsteen….this helped refresh my soul in these bizarre and trying times.
Thank you @brucespringsteen.net for (yet again) meeting the moment and speaking up for America in these dangerous times...and giving us some hope in the Promised Land.
May 24, 2025 at 3:45 AM
Thank you @brucespringsteen.net for (yet again) meeting the moment and speaking up for America in these dangerous times...and giving us some hope in the Promised Land.
Reposted by Kirk Lohmueller
Tonight, Bruce Springsteen and The E Street Band opened their Land of Hope & Dreams Tour. Bruce launched this run of shows with three statements about the situation in the United States, with comments preceding his songs Land of Hope and Dreams, House of a Thousand Guitars and My City of Ruins.
Land of Hope and Dreams
YouTube video by Bruce Springsteen
youtu.be
May 14, 2025 at 11:17 PM
Tonight, Bruce Springsteen and The E Street Band opened their Land of Hope & Dreams Tour. Bruce launched this run of shows with three statements about the situation in the United States, with comments preceding his songs Land of Hope and Dreams, House of a Thousand Guitars and My City of Ruins.
Thank you @martamlahr.bsky.social @lquintanamurci.bsky.social @aliceleplongeon.bsky.social @cschlebu.bsky.social for organizing a such a fantastic mtg!!! Lots of great science and fun!😃👏 #HumanEvo25
April 30, 2025 at 4:36 PM
Thank you @martamlahr.bsky.social @lquintanamurci.bsky.social @aliceleplongeon.bsky.social @cschlebu.bsky.social for organizing a such a fantastic mtg!!! Lots of great science and fun!😃👏 #HumanEvo25
Keynote talk from OG Mark Stoneking on the peopling of the Pacific! #HumanEvo25
April 30, 2025 at 11:12 AM
Keynote talk from OG Mark Stoneking on the peopling of the Pacific! #HumanEvo25
Reposted by Kirk Lohmueller
Kirk Lohmueller
DominL uses patterns of archaic ancestry to infer degree of dominance. Provides statistical support for the presence of recessive deleterious mutations in the human genome. Up to 15% of the human genome may carry recessive deleterious mutations! 🧬
#HumanEvo25
DominL uses patterns of archaic ancestry to infer degree of dominance. Provides statistical support for the presence of recessive deleterious mutations in the human genome. Up to 15% of the human genome may carry recessive deleterious mutations! 🧬
#HumanEvo25
April 29, 2025 at 3:08 PM
Kirk Lohmueller
DominL uses patterns of archaic ancestry to infer degree of dominance. Provides statistical support for the presence of recessive deleterious mutations in the human genome. Up to 15% of the human genome may carry recessive deleterious mutations! 🧬
#HumanEvo25
DominL uses patterns of archaic ancestry to infer degree of dominance. Provides statistical support for the presence of recessive deleterious mutations in the human genome. Up to 15% of the human genome may carry recessive deleterious mutations! 🧬
#HumanEvo25
Reposted by Kirk Lohmueller
ML, allele dominance, selection and fitness informing on #Neanderthal introgression by @klohmueller.bsky.social 🥰 🧬!
#HumanEvo25
#HumanEvo25
April 29, 2025 at 3:00 PM
ML, allele dominance, selection and fitness informing on #Neanderthal introgression by @klohmueller.bsky.social 🥰 🧬!
#HumanEvo25
#HumanEvo25
@paleogenomics.bsky.social speaking about the effects of colonization on Mexican genetic variation #HumanEvo25
April 30, 2025 at 8:36 AM
@paleogenomics.bsky.social speaking about the effects of colonization on Mexican genetic variation #HumanEvo25
@amygoldberg.bsky.social telling us about integrating genetic variation and archeology to infer recent processes #HumanEvo25
April 30, 2025 at 8:33 AM
@amygoldberg.bsky.social telling us about integrating genetic variation and archeology to infer recent processes #HumanEvo25
Easter tri-tip! This is going to taste even better after my 7.5 mile run this AM. Trying to find some joy despite everything. Nervous about what this week will bring…
April 21, 2025 at 12:57 AM
Easter tri-tip! This is going to taste even better after my 7.5 mile run this AM. Trying to find some joy despite everything. Nervous about what this week will bring…
Reposted by Kirk Lohmueller
stdpopsim v0.3.0 is out! You can now mix and match your simulations of different demographic histories with published distributions of fitness effects along with gene annotations, and you can even throw in sweeps for good measure. Check out the new manuscript for more info: doi.org/10.1101/2025...
Accessible, realistic genome simulation with selection using stdpopsim
Selection is a fundamental evolutionary force that shapes patterns of genetic variation across species. However, simulations incorporating realistic selection along heterogeneous genomes in complex de...
doi.org
March 24, 2025 at 6:29 PM
stdpopsim v0.3.0 is out! You can now mix and match your simulations of different demographic histories with published distributions of fitness effects along with gene annotations, and you can even throw in sweeps for good measure. Check out the new manuscript for more info: doi.org/10.1101/2025...