Klaus Okkenhaug
@klausokken.bsky.social
Professor of Immunology, Department of Pathology, University of Cambridge.
Research interests: PI3K, immunity, infection, cancer, immunotherapy.
Research interests: PI3K, immunity, infection, cancer, immunotherapy.
These are not a ranking lists we should be topping...
royalsociety.org/-/media/poli...
royalsociety.org/-/media/poli...
October 21, 2025 at 10:23 AM
These are not a ranking lists we should be topping...
royalsociety.org/-/media/poli...
royalsociety.org/-/media/poli...
Reposted by Klaus Okkenhaug
Wonderful to see the seminal discoveries of Shimon Sakaguchi, Mary E. Brunkow & Fred Ramsdell recognised with the Nobel Prize. From Sakaguchi’s discovery of Treg cells to the identification of Foxp3, their research opened a new chapter in immunology, viewed from the prism of dominant tolerance.
October 6, 2025 at 9:56 PM
Wonderful to see the seminal discoveries of Shimon Sakaguchi, Mary E. Brunkow & Fred Ramsdell recognised with the Nobel Prize. From Sakaguchi’s discovery of Treg cells to the identification of Foxp3, their research opened a new chapter in immunology, viewed from the prism of dominant tolerance.
Reposted by Klaus Okkenhaug
A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine
October 6, 2025 at 11:21 AM
A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine
Nobel prize for Tregs!
www.nobelprize.org/prizes/medic...
www.nobelprize.org/prizes/medic...
Nobel Prize in Physiology or Medicine 2025
The Nobel Prize in Physiology or Medicine 2025 was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”
www.nobelprize.org
October 6, 2025 at 10:47 AM
Nobel prize for Tregs!
www.nobelprize.org/prizes/medic...
www.nobelprize.org/prizes/medic...
Great to welcome former PhD student, now Assistant Professor @krishaurum.bsky.social of the DTU back to the Department of Pathology. Excellent presentation on TIL TCRs, peptide-MHC complexes and his recent paper on AI-designed pMHC binders (artificial TCRs).
October 2, 2025 at 4:18 PM
Great to welcome former PhD student, now Assistant Professor @krishaurum.bsky.social of the DTU back to the Department of Pathology. Excellent presentation on TIL TCRs, peptide-MHC complexes and his recent paper on AI-designed pMHC binders (artificial TCRs).
Listen to James Edgar @campathology.bsky.social discuss cosmetic use of exosomes on BBC Radio 4 Inside Health: www.bbc.co.uk/sounds/play/...
(Spoiler alert: he does not approve).
(Spoiler alert: he does not approve).
Inside Health - Exosomes: Is cosmetics' biggest trend a health risk? - BBC Sounds
James finds out why there are fears over new skincare products, plus physio goes digital.
www.bbc.co.uk
July 29, 2025 at 11:42 AM
Listen to James Edgar @campathology.bsky.social discuss cosmetic use of exosomes on BBC Radio 4 Inside Health: www.bbc.co.uk/sounds/play/...
(Spoiler alert: he does not approve).
(Spoiler alert: he does not approve).
Amazing new paper from @krishaurum.bsky.social and colleagues, designing novel pMHC-binders (synthetic TCRs) in silico: www.science.org/doi/10.1126/...
De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells
The recognition of intracellular antigens by CD8+ T cells through T cell receptors (TCRs) is central for adaptive immunity against infections and cancer. However, the identification of TCRs from patie...
www.science.org
July 28, 2025 at 7:41 AM
Amazing new paper from @krishaurum.bsky.social and colleagues, designing novel pMHC-binders (synthetic TCRs) in silico: www.science.org/doi/10.1126/...
Reposted by Klaus Okkenhaug
We're recruiting a postdoc to join my lab at @oncology.ox.ac.uk & @oxcio.bsky.social to understand immune regulation in cancer and develop new approaches for cancer prevention and metastasis.
Deadline: 11 August 2025
my.corehr.com/pls/uoxrecru...
Lab info: www.oncology.ox.ac.uk/team/jie-yang
Deadline: 11 August 2025
my.corehr.com/pls/uoxrecru...
Lab info: www.oncology.ox.ac.uk/team/jie-yang
Job Details
my.corehr.com
July 18, 2025 at 10:19 AM
We're recruiting a postdoc to join my lab at @oncology.ox.ac.uk & @oxcio.bsky.social to understand immune regulation in cancer and develop new approaches for cancer prevention and metastasis.
Deadline: 11 August 2025
my.corehr.com/pls/uoxrecru...
Lab info: www.oncology.ox.ac.uk/team/jie-yang
Deadline: 11 August 2025
my.corehr.com/pls/uoxrecru...
Lab info: www.oncology.ox.ac.uk/team/jie-yang
Reposted by Klaus Okkenhaug
I've been incredibly lucky to be supported by the @erc.europa.eu with a Start, Consolidator and now Advanced grant! Each of these awards enabled 'blue skies' research into the immune system, as well as resulting in direct translational impact on patients and via commercialisation. 🥰
📣 Good news: 281 top researchers have just won ERC Advanced Grants!
The new funding, worth nearly €721 million, is part of the 🇪🇺 EU’s #HorizonEurope programme.
Find out more 👉 europa.eu/!JYKxkD
#ERCAdG #FrontierResearch @ec.europa.eu
The new funding, worth nearly €721 million, is part of the 🇪🇺 EU’s #HorizonEurope programme.
Find out more 👉 europa.eu/!JYKxkD
#ERCAdG #FrontierResearch @ec.europa.eu
June 17, 2025 at 10:18 AM
I've been incredibly lucky to be supported by the @erc.europa.eu with a Start, Consolidator and now Advanced grant! Each of these awards enabled 'blue skies' research into the immune system, as well as resulting in direct translational impact on patients and via commercialisation. 🥰
Reposted by Klaus Okkenhaug
I am delighted to see that Len Stephens, my colleague and PI3K pioneer, has been awarded the 2026 Biochemical Society Morton Lecture for outstanding contributions to lipid biochemistry! www.babraham.ac.uk/news/2025/04...
Dr Len Stephens awarded the Morton Lecture | Babraham Institute
www.babraham.ac.uk
April 8, 2025 at 8:51 AM
I am delighted to see that Len Stephens, my colleague and PI3K pioneer, has been awarded the 2026 Biochemical Society Morton Lecture for outstanding contributions to lipid biochemistry! www.babraham.ac.uk/news/2025/04...
Reposted by Klaus Okkenhaug
New research article from the lab led by the amazing @amydashwood.bsky.social !
In collaboration with @vib-switch-lab.bsky.social @cbdresearch.bsky.social we engineered variants of #IL2 designed for therapeutic use. 1/11
www.sciencedirect.com/science/arti...
In collaboration with @vib-switch-lab.bsky.social @cbdresearch.bsky.social we engineered variants of #IL2 designed for therapeutic use. 1/11
www.sciencedirect.com/science/arti...
Directed disruption of IL2 aggregation and receptor binding sites produces designer biologics with enhanced specificity and improved production capacity
The pleotropic nature of interleukin-2 (IL2) has allowed it to be used as both a pro-inflammatory and anti-inflammatory therapeutic agent, through pro…
www.sciencedirect.com
March 18, 2025 at 3:02 PM
New research article from the lab led by the amazing @amydashwood.bsky.social !
In collaboration with @vib-switch-lab.bsky.social @cbdresearch.bsky.social we engineered variants of #IL2 designed for therapeutic use. 1/11
www.sciencedirect.com/science/arti...
In collaboration with @vib-switch-lab.bsky.social @cbdresearch.bsky.social we engineered variants of #IL2 designed for therapeutic use. 1/11
www.sciencedirect.com/science/arti...
Reposted by Klaus Okkenhaug
Last few days to apply for this:
There is a Postdoc job available in my lab to study fundamental mechanisms of antiviral immunity, specifically in the context of viral nucleic acid sensing. Please take a look here and contact me if interested:
#immunosky #virology 🧪
www.jobs.cam.ac.uk/job/50254/
#immunosky #virology 🧪
www.jobs.cam.ac.uk/job/50254/
Research Assistant / Research Associate (Fixed Term) - Job Opportunities - University of Cambridge
Research Assistant / Research Associate (Fixed Term) in the Department of Pathology at the University of Cambridge.
www.jobs.cam.ac.uk
March 7, 2025 at 1:33 PM
Last few days to apply for this:
Reposted by Klaus Okkenhaug
Thrilled to share new work led by @jieyang437.bsky.social in the lab published today in @Nature. We find that Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. @Cambridge_Uni @CRUKCamCentre rdcu.be/eci1U
March 5, 2025 at 6:56 PM
Thrilled to share new work led by @jieyang437.bsky.social in the lab published today in @Nature. We find that Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. @Cambridge_Uni @CRUKCamCentre rdcu.be/eci1U
Brilliant new paper from Jie Yang @jieyang437.bsky.social and Rahul Roychoudhuri @roychoudhurilab.bsky.social linking aspirin to immune-mediated prevention of cancer metastasis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity - Nature
Inhibition of cyclooxygenase 1 releases T cells from immunosuppression by platelet-derived thromboxane A2, thereby enhancing the immune response against metastasis.
www.nature.com
March 5, 2025 at 4:58 PM
Brilliant new paper from Jie Yang @jieyang437.bsky.social and Rahul Roychoudhuri @roychoudhurilab.bsky.social linking aspirin to immune-mediated prevention of cancer metastasis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Klaus Okkenhaug
📢 Calling all Signallers! Join us for this celebratory smorgasbord of signalling research on 1-2 May with sessions on #proteostasis, #PI3K, #autophagy, #redox biology and #nuclear signalling. 🧪
Latest Institute research with special guests ⤵️
www.eventbrite.co.uk/e/cellular-s...
Latest Institute research with special guests ⤵️
www.eventbrite.co.uk/e/cellular-s...
Cellular signals for health & disease
A symposium marking the contributions of Len Stephens and Phillip Hawkins
www.eventbrite.co.uk
February 12, 2025 at 12:48 PM
📢 Calling all Signallers! Join us for this celebratory smorgasbord of signalling research on 1-2 May with sessions on #proteostasis, #PI3K, #autophagy, #redox biology and #nuclear signalling. 🧪
Latest Institute research with special guests ⤵️
www.eventbrite.co.uk/e/cellular-s...
Latest Institute research with special guests ⤵️
www.eventbrite.co.uk/e/cellular-s...
Reposted by Klaus Okkenhaug
📢 New position! We are recruiting an Associate Professor / Professor of Infection and/or Immunity to join our innovative research community!
Find out more about the position and apply: https://buff.ly/40m1udb
Find out more about the position and apply: https://buff.ly/40m1udb
January 9, 2025 at 12:30 PM
📢 New position! We are recruiting an Associate Professor / Professor of Infection and/or Immunity to join our innovative research community!
Find out more about the position and apply: https://buff.ly/40m1udb
Find out more about the position and apply: https://buff.ly/40m1udb
Many congratulations to Prof Ashley Moffett on this honour!
This is in recognition of her long and impactful research on the genetics and immunology of maternal and foetal health, especially as related to pre-eclampsia and and the role of NK cells in the development and function of the placenta.
This is in recognition of her long and impactful research on the genetics and immunology of maternal and foetal health, especially as related to pre-eclampsia and and the role of NK cells in the development and function of the placenta.
Our very own Professor Ashley Moffett of Reproductive Immunology was awarded the prestigious CMP for Women’s Reproductive Health. The foremost international authority on the immunology of human reproduction, her work has helped explain high rates of pre-eclampsia and maternal mortality in Africa.
January 7, 2025 at 12:46 PM
Many congratulations to Prof Ashley Moffett on this honour!
This is in recognition of her long and impactful research on the genetics and immunology of maternal and foetal health, especially as related to pre-eclampsia and and the role of NK cells in the development and function of the placenta.
This is in recognition of her long and impactful research on the genetics and immunology of maternal and foetal health, especially as related to pre-eclampsia and and the role of NK cells in the development and function of the placenta.
Reposted by Klaus Okkenhaug
A very rare position for an immunology professorship at Cambridge. Something to think about!
www.jobs.cam.ac.uk/job/49381/
www.jobs.cam.ac.uk/job/49381/
Associate Professor/Professor of Infection and/or Immunity - Job Opportunities - University of Cambridge
Associate Professor/Professor of Infection and/or Immunity in the Department of Pathology at the University of Cambridge.
www.jobs.cam.ac.uk
December 13, 2024 at 9:53 AM
A very rare position for an immunology professorship at Cambridge. Something to think about!
www.jobs.cam.ac.uk/job/49381/
www.jobs.cam.ac.uk/job/49381/
Reposted by Klaus Okkenhaug
A starter pack for PhD students and Postdocs in Immunology to connect 🔽
Drop a 🧬 and I'll add you to the list.
Let's build the upcoming immuno community!
#ImmunoSky 🧪
go.bsky.app/RABVXY4
Drop a 🧬 and I'll add you to the list.
Let's build the upcoming immuno community!
#ImmunoSky 🧪
go.bsky.app/RABVXY4
December 4, 2024 at 7:14 AM
A starter pack for PhD students and Postdocs in Immunology to connect 🔽
Drop a 🧬 and I'll add you to the list.
Let's build the upcoming immuno community!
#ImmunoSky 🧪
go.bsky.app/RABVXY4
Drop a 🧬 and I'll add you to the list.
Let's build the upcoming immuno community!
#ImmunoSky 🧪
go.bsky.app/RABVXY4
Professorship in Immunity and Infection at the University of Cambridge:
www.jobs.cam.ac.uk/job/49381/
Check out the cross-departmental infection and immunity theme for the grand challenges we want to address:
www.bio.cam.ac.uk/research/inf...
Application deadline: Jan 26th, 2025.
www.jobs.cam.ac.uk/job/49381/
Check out the cross-departmental infection and immunity theme for the grand challenges we want to address:
www.bio.cam.ac.uk/research/inf...
Application deadline: Jan 26th, 2025.
Associate Professor/Professor of Infection and/or Immunity - Job Opportunities - University of Cambridge
Associate Professor/Professor of Infection and/or Immunity in the Department of Pathology at the University of Cambridge.
www.jobs.cam.ac.uk
November 29, 2024 at 4:57 PM
Professorship in Immunity and Infection at the University of Cambridge:
www.jobs.cam.ac.uk/job/49381/
Check out the cross-departmental infection and immunity theme for the grand challenges we want to address:
www.bio.cam.ac.uk/research/inf...
Application deadline: Jan 26th, 2025.
www.jobs.cam.ac.uk/job/49381/
Check out the cross-departmental infection and immunity theme for the grand challenges we want to address:
www.bio.cam.ac.uk/research/inf...
Application deadline: Jan 26th, 2025.
"The FDA has approved Genentech’s inavolisib (Itovebi) in combination with the CDK4/6 inhibitor palbociclib and the oestrogen-receptor antagonist fulvestrant for endocrine-resistant, PIK3CA-mutated, hormone receptor-positive, HER2-negative breast cancer." #PI3K
www.nature.com/articles/d41...
www.nature.com/articles/d41...
FDA approves PI3Kα inhibitor that does double duty as a degrader
Discover the world’s best science and medicine | Nature.com
www.nature.com
November 28, 2024 at 8:40 AM
"The FDA has approved Genentech’s inavolisib (Itovebi) in combination with the CDK4/6 inhibitor palbociclib and the oestrogen-receptor antagonist fulvestrant for endocrine-resistant, PIK3CA-mutated, hormone receptor-positive, HER2-negative breast cancer." #PI3K
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Our latest paper reveals an intriguing and essential role for the class III #PI3K VPS34 in Treg homeostasis and function. Selective deletion of VPS34 in Treg led to a scurfy-like phenotype, suggesting an essential role for VPS34 in Treg-suppression.
doi.org/10.3389/fimm...
#immunosky
doi.org/10.3389/fimm...
#immunosky
November 27, 2024 at 10:38 AM
Our latest paper reveals an intriguing and essential role for the class III #PI3K VPS34 in Treg homeostasis and function. Selective deletion of VPS34 in Treg led to a scurfy-like phenotype, suggesting an essential role for VPS34 in Treg-suppression.
doi.org/10.3389/fimm...
#immunosky
doi.org/10.3389/fimm...
#immunosky
Reposted by Klaus Okkenhaug
The freshly cooked video summarizing the Art project developed in the frame of our PIPgen MSCA DN: “PIPgenerating ART: Where Art meet Science “. A collaborative activitys between our students and the Cambridge School of Visual Performing Arts.
www.youtube.com/watch?v=tQxA...
www.youtube.com/watch?v=tQxA...
PIPgenerating ART: Where Art meet Science
YouTube video by PIPgen
www.youtube.com
November 23, 2024 at 6:46 PM
The freshly cooked video summarizing the Art project developed in the frame of our PIPgen MSCA DN: “PIPgenerating ART: Where Art meet Science “. A collaborative activitys between our students and the Cambridge School of Visual Performing Arts.
www.youtube.com/watch?v=tQxA...
www.youtube.com/watch?v=tQxA...
Reposted by Klaus Okkenhaug
Both #Cancer #Research starter packs are now completely full!
~300 researchers, oncologists, students, postdocs, patient advocates, and organizations supporting cancer research 🧪🔬⚕️
I hope you'll find these useful to build our community here
Pack 1: go.bsky.app/FEoaJMc
Pack 2: go.bsky.app/6EcjWNA
~300 researchers, oncologists, students, postdocs, patient advocates, and organizations supporting cancer research 🧪🔬⚕️
I hope you'll find these useful to build our community here
Pack 1: go.bsky.app/FEoaJMc
Pack 2: go.bsky.app/6EcjWNA
November 23, 2024 at 1:27 PM
Both #Cancer #Research starter packs are now completely full!
~300 researchers, oncologists, students, postdocs, patient advocates, and organizations supporting cancer research 🧪🔬⚕️
I hope you'll find these useful to build our community here
Pack 1: go.bsky.app/FEoaJMc
Pack 2: go.bsky.app/6EcjWNA
~300 researchers, oncologists, students, postdocs, patient advocates, and organizations supporting cancer research 🧪🔬⚕️
I hope you'll find these useful to build our community here
Pack 1: go.bsky.app/FEoaJMc
Pack 2: go.bsky.app/6EcjWNA