Kelvin Lau @klausenhauser on 🙅♂️🐘🪡
@klausenhauser.bsky.social
🇨🇦🇭🇰 @EPFL_en protein production + structure facility 🇨🇭| ex @ubc @uwaterloo @unige_en | here for #proteins #structuralbiology #xray #cryoem #plants #mountains #politics #transit #urbanism 🐱🐈 staying for the #hottakes | My views here🧪🧬🌱🔬🏳️🌈
Want @cytiva.bsky.social please make a Gradient Supedex www.sciencedirect.com/science/arti...
Band broadening in pore size gradient size exclusion chromatography columns
Pore size gradient size exclusion chromatography (SEC) columns have been proposed as an alternative to conventional uniform-pore and serially coupled …
www.sciencedirect.com
November 10, 2025 at 7:03 PM
Want @cytiva.bsky.social please make a Gradient Supedex www.sciencedirect.com/science/arti...
Saw this over on LI. Very slick and rasy to use mask generator. No more tinkering around needed like before. mcalbyrne.com/cryomaskr.html
Video: www.linkedin.com/posts/mcalby...
Video: www.linkedin.com/posts/mcalby...
CryomaskR - Matthew Byrne
mcalbyrne.com
November 6, 2025 at 7:22 AM
Saw this over on LI. Very slick and rasy to use mask generator. No more tinkering around needed like before. mcalbyrne.com/cryomaskr.html
Video: www.linkedin.com/posts/mcalby...
Video: www.linkedin.com/posts/mcalby...
Cleaning an office and this is my absolute nightmare circa 2008. Thank goodness most people have moved beyond word files and sequences… but not all 😌
November 5, 2025 at 8:43 AM
Cleaning an office and this is my absolute nightmare circa 2008. Thank goodness most people have moved beyond word files and sequences… but not all 😌
developer.nvidia.com/blog/introdu...
Will this finally be a codon optimizer that works? Still haven’t ever used a magic bullet but I do know not only the codons but the whole sequence play a big role
Will this finally be a codon optimizer that works? Still haven’t ever used a magic bullet but I do know not only the codons but the whole sequence play a big role
Introducing the CodonFM Open Model for RNA Design and Analysis | NVIDIA Technical Blog
Open research is critical for driving innovation, and many breakthroughs in AI and science are achieved through open collaboration. In the field of digital biology research, NVIDIA Clara supports this...
developer.nvidia.com
October 30, 2025 at 7:14 AM
developer.nvidia.com/blog/introdu...
Will this finally be a codon optimizer that works? Still haven’t ever used a magic bullet but I do know not only the codons but the whole sequence play a big role
Will this finally be a codon optimizer that works? Still haven’t ever used a magic bullet but I do know not only the codons but the whole sequence play a big role
Reposted by Kelvin Lau @klausenhauser on 🙅♂️🐘🪡
I am delighted to share this work, led by Miguel Alcantar and done in collaboration with Amgen, on the OrthoRep-driven evolution of computationally designed minibinders. Here, we focus not only on getting high affinity, but also on mapping sequence-affinity landscapes of diverse outcomes.
October 28, 2025 at 7:33 AM
I am delighted to share this work, led by Miguel Alcantar and done in collaboration with Amgen, on the OrthoRep-driven evolution of computationally designed minibinders. Here, we focus not only on getting high affinity, but also on mapping sequence-affinity landscapes of diverse outcomes.
Reposted by Kelvin Lau @klausenhauser on 🙅♂️🐘🪡
We train machine learning models on millions of proteins. But when it comes to making predictions, do we need them to understand all proteins at once? Often, we need an accurate model for the specific protein we are studying or designing. We address this with ProteinTTT arxiv.org/abs/2411.02109 1/🧵
October 23, 2025 at 1:08 PM
We train machine learning models on millions of proteins. But when it comes to making predictions, do we need them to understand all proteins at once? Often, we need an accurate model for the specific protein we are studying or designing. We address this with ProteinTTT arxiv.org/abs/2411.02109 1/🧵
Just did my multiple choice get to know the country 🇨🇭 naturalization test. Now time for some sauna.. wait that’s the wrong country 🇫🇮 .
October 22, 2025 at 1:35 PM
Just did my multiple choice get to know the country 🇨🇭 naturalization test. Now time for some sauna.. wait that’s the wrong country 🇫🇮 .
Reposted by Kelvin Lau @klausenhauser on 🙅♂️🐘🪡
I am fascinated by how viruses evolve - and not just since #SARSCoV2 has shown us at the global stage how consequential virus evolution can be for us.
In my new story in @science.org I got to explore how researchers are probing deeper into the past with old RNA virus genome.
So a 🧪 thread…
In my new story in @science.org I got to explore how researchers are probing deeper into the past with old RNA virus genome.
So a 🧪 thread…
On an Arctic archipelago, frozen soil may preserve a hidden history of viruses
Scientists are hunting for ancient RNA in Svalbard’s permafrost, hoping to shed light on the evolution of viral diseases
www.science.org
October 18, 2025 at 10:02 AM
I am fascinated by how viruses evolve - and not just since #SARSCoV2 has shown us at the global stage how consequential virus evolution can be for us.
In my new story in @science.org I got to explore how researchers are probing deeper into the past with old RNA virus genome.
So a 🧪 thread…
In my new story in @science.org I got to explore how researchers are probing deeper into the past with old RNA virus genome.
So a 🧪 thread…
Reposted by Kelvin Lau @klausenhauser on 🙅♂️🐘🪡
Thrilled to announce our new preprint, “Protein Hunter: Exploiting Structure Hallucination within Diffusion for Protein Design,” in collaboration with @Griffin, @GBhardwaj8 and @sokrypton.org
🧬Code and notebooks will be released by the end of this week.
🎧Golden- Kpop Demon Hunters
🧬Code and notebooks will be released by the end of this week.
🎧Golden- Kpop Demon Hunters
October 13, 2025 at 3:45 PM
Thrilled to announce our new preprint, “Protein Hunter: Exploiting Structure Hallucination within Diffusion for Protein Design,” in collaboration with @Griffin, @GBhardwaj8 and @sokrypton.org
🧬Code and notebooks will be released by the end of this week.
🎧Golden- Kpop Demon Hunters
🧬Code and notebooks will be released by the end of this week.
🎧Golden- Kpop Demon Hunters
Reposted by Kelvin Lau @klausenhauser on 🙅♂️🐘🪡
🚨Our paper is out! 🥳
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...
it all started years ago with a failed experiment
🧵👇 1/9
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...
it all started years ago with a failed experiment
🧵👇 1/9
Hijacking a bacterial ABC transporter for genetic code expansion - Nature
Bacterial ATP-binding cassette (ABC) transporters can be utilized and engineered to transport non-canonical amino acids into Escherichia coli for highly efficient synthesis of proteins with novel func...
www.nature.com
October 16, 2025 at 2:06 PM
🚨Our paper is out! 🥳
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...
it all started years ago with a failed experiment
🧵👇 1/9
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...
it all started years ago with a failed experiment
🧵👇 1/9
Any structural biologists who want some fun? Try building mirror folds. When you’re building them you seriously innately feel like this is “off” but they do exist! When I looked at some of these datasets and deciding which way to turn in Coot it was so offsetting www.biorxiv.org/content/10.1...
October 13, 2025 at 5:05 PM
Any structural biologists who want some fun? Try building mirror folds. When you’re building them you seriously innately feel like this is “off” but they do exist! When I looked at some of these datasets and deciding which way to turn in Coot it was so offsetting www.biorxiv.org/content/10.1...
After the conference comes the weekend :) Strasbourg and Basel + region what a nice combo. Strasbourg Munster or Roche towers? ⛪️🏢
October 12, 2025 at 4:52 PM
After the conference comes the weekend :) Strasbourg and Basel + region what a nice combo. Strasbourg Munster or Roche towers? ⛪️🏢
Finished an exciting 38th Rhine Knee Structural 🧫💎🔬biology meeting lnkd.in/eYse4giF !
See you back in Switzerland in 2026!
See you back in Switzerland in 2026!
October 10, 2025 at 4:42 PM
Finished an exciting 38th Rhine Knee Structural 🧫💎🔬biology meeting lnkd.in/eYse4giF !
See you back in Switzerland in 2026!
See you back in Switzerland in 2026!
Reposted by Kelvin Lau @klausenhauser on 🙅♂️🐘🪡
How do SMC complexes load onto DNA to get ready for loop extrusion?
@roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸♂️🤸♂️🤸♂️.
Check out the new paper: www.cell.com/molecular-ce...
@roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸♂️🤸♂️🤸♂️.
Check out the new paper: www.cell.com/molecular-ce...
October 9, 2025 at 2:43 PM
How do SMC complexes load onto DNA to get ready for loop extrusion?
@roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸♂️🤸♂️🤸♂️.
Check out the new paper: www.cell.com/molecular-ce...
@roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸♂️🤸♂️🤸♂️.
Check out the new paper: www.cell.com/molecular-ce...
Reposted by Kelvin Lau @klausenhauser on 🙅♂️🐘🪡
The latest #AlphaFold DB update is out!
We synchronised with UniProt release 2025_03, predicted protein isoforms across all species, and provide MSAs used to generate each prediction.
Proud of the team at the PDBe for the hard work that went into this. Grateful to play my part in it!
We synchronised with UniProt release 2025_03, predicted protein isoforms across all species, and provide MSAs used to generate each prediction.
Proud of the team at the PDBe for the hard work that went into this. Grateful to play my part in it!
We’re renewing our collaboration with Google DeepMind!
We'll keep developing the AlphaFold Database to support protein science worldwide 🎉
To mark the moment we’ve synchronised the database with UniProtKB release 2025_03.
www.ebi.ac.uk/about/news/t...
🖥️🧬 #AlphaFold
@pdbeurope.bsky.social
We'll keep developing the AlphaFold Database to support protein science worldwide 🎉
To mark the moment we’ve synchronised the database with UniProtKB release 2025_03.
www.ebi.ac.uk/about/news/t...
🖥️🧬 #AlphaFold
@pdbeurope.bsky.social
October 7, 2025 at 2:40 PM
The latest #AlphaFold DB update is out!
We synchronised with UniProt release 2025_03, predicted protein isoforms across all species, and provide MSAs used to generate each prediction.
Proud of the team at the PDBe for the hard work that went into this. Grateful to play my part in it!
We synchronised with UniProt release 2025_03, predicted protein isoforms across all species, and provide MSAs used to generate each prediction.
Proud of the team at the PDBe for the hard work that went into this. Grateful to play my part in it!
Hmmm a library of protein designs all assessed for binding on the same platform. All with sequences, both positive and negative data. Makes for much better comparison than those made via paper claims.
proteinbase.com
proteinbase.com
Proteinbase
The home of protein design data
proteinbase.com
October 6, 2025 at 4:50 PM
Hmmm a library of protein designs all assessed for binding on the same platform. All with sequences, both positive and negative data. Makes for much better comparison than those made via paper claims.
proteinbase.com
proteinbase.com
Reposted by Kelvin Lau @klausenhauser on 🙅♂️🐘🪡
NEW: In 2025, 43% of young American adults regularly get their news from TikTok.
www.pewresearch.org/short-reads/...
www.pewresearch.org/short-reads/...
September 25, 2025 at 4:57 PM
NEW: In 2025, 43% of young American adults regularly get their news from TikTok.
www.pewresearch.org/short-reads/...
www.pewresearch.org/short-reads/...
Reposted by Kelvin Lau @klausenhauser on 🙅♂️🐘🪡
Our latest preprint is now available doi.org/10.1101/2025...! Led by my postdoc, Luqiang Guo @luqiang.bsky.social, we determined a ~2.4 A resolution structure of the hantavirus glycoprotein tetramer on the surface of VLPs. Also determined structures of dimers of tetramers and Fab-bound tetramers.
June 18, 2025 at 2:24 PM
Our latest preprint is now available doi.org/10.1101/2025...! Led by my postdoc, Luqiang Guo @luqiang.bsky.social, we determined a ~2.4 A resolution structure of the hantavirus glycoprotein tetramer on the surface of VLPs. Also determined structures of dimers of tetramers and Fab-bound tetramers.
Reposted by Kelvin Lau @klausenhauser on 🙅♂️🐘🪡
I am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate www.biorxiv.org/content/10.1... #cilia #protistsonsky 🧬🧪
September 23, 2025 at 5:08 PM
I am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate www.biorxiv.org/content/10.1... #cilia #protistsonsky 🧬🧪
Reposted by Kelvin Lau @klausenhauser on 🙅♂️🐘🪡
Be our neighbour !
Be our new colleague! 🎉
The Dept of Molecular and Cellular Biology at the University of Geneva is hiring an Assistant Professor or Associate Professor.
👉 More details here: lnkd.in/e8Z9eAm4
👉 Our department: mocel.unige.ch
Please feel free to share this opportunity with your network.
The Dept of Molecular and Cellular Biology at the University of Geneva is hiring an Assistant Professor or Associate Professor.
👉 More details here: lnkd.in/e8Z9eAm4
👉 Our department: mocel.unige.ch
Please feel free to share this opportunity with your network.
September 24, 2025 at 6:52 AM
Be our neighbour !
Rejected for nationality because I make noise after hours. 😭
September 23, 2025 at 9:07 PM
Rejected for nationality because I make noise after hours. 😭
Long weekend dump. Torn between going to the 🏔️ or my garden. What did I choose?….
September 22, 2025 at 8:16 AM
Long weekend dump. Torn between going to the 🏔️ or my garden. What did I choose?….
Reposted by Kelvin Lau @klausenhauser on 🙅♂️🐘🪡
Heritage Foundation has released an absolutely insane policy proposal to label all trans people as domestic terrorists. It uses completely made up instances of terrorism and made up statistics but facts don't matter to them.
They want us all eradicated.
They want us all eradicated.
September 19, 2025 at 1:19 AM
Heritage Foundation has released an absolutely insane policy proposal to label all trans people as domestic terrorists. It uses completely made up instances of terrorism and made up statistics but facts don't matter to them.
They want us all eradicated.
They want us all eradicated.
anyone can find the preprint? I only found : arcinstitute.org/news/hie-kin...
September 18, 2025 at 8:05 AM
anyone can find the preprint? I only found : arcinstitute.org/news/hie-kin...
Reposted by Kelvin Lau @klausenhauser on 🙅♂️🐘🪡
Many of the most complex and useful functions in biology emerge at the scale of whole genomes.
Today, we share our preprint “Generative design of novel bacteriophages with genome language models”, where we validate the first, functional AI-generated genomes 🧵
Today, we share our preprint “Generative design of novel bacteriophages with genome language models”, where we validate the first, functional AI-generated genomes 🧵
September 17, 2025 at 3:03 PM
Many of the most complex and useful functions in biology emerge at the scale of whole genomes.
Today, we share our preprint “Generative design of novel bacteriophages with genome language models”, where we validate the first, functional AI-generated genomes 🧵
Today, we share our preprint “Generative design of novel bacteriophages with genome language models”, where we validate the first, functional AI-generated genomes 🧵