Tim Doulton
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kentkidneydoc.bsky.social
Tim Doulton
@kentkidneydoc.bsky.social
Consultant kidney/BP doc East Kent | Co-lead KSS RDN for kidney disorders research | #NephSky | ❤️ NHS, 🎸, 🚴🏻 🌊 👨‍🍳 | Recent convert to open water 🏊🏻‍♂️| Hate inequality | Views my own
Pinned
www.ukkidney.org/about-us/new...

@ukkidney.org Guidance on managing blood pressure in CYP and adults on dialysis 👏🏻
New Guidance on Managing Blood Pressure
A new UKKA guideline has been published on managing blood pressure in dialysis patients The UK Kidney Association (UKKA) has published a new
www.ukkidney.org
@ukkidney.org guidelines for managing blood pressure in adults and CYP on dialysis is now published in BMC Nephrology 👏🏻

@profdg.bsky.social @hswapnil.medsky.social

Find it here: link.springer.com/article/10.1...
Management of blood pressure in adults, children and young people on dialysis: UK kidney association clinical practice guideline - BMC Nephrology
People with end stage kidney disease receiving dialysis have a very risk of cardiovascular disease and mortality. Hypertension is a modifiable risk factor for cardiovascular disease and mortality, affecting around 90% of dialysis patients. Conversely, intradialytic hypotension in haemodialysis patients is associated with debilitating symptoms as well as the risk of cardiovascular disease and mortality. Blood pressure management in dialysis patients involves accurate measurement of blood pressure, setting a target blood pressure, adequate fluid volume management, lifestyle changes, modification of dialysis and dialysate, and the use of medication with proven efficacy in these patients. However, globally there is no published contemporary clinical practice guideline to assist health care professionals to manage blood pressure in dialysis patients. This is mainly because of a dearth of good quality evidence to inform guideline recommendations. Here, we present a comprehensive guideline to manage blood pressure in dialysis patients based on a thorough systematic review of literature. The guideline development committee comprised a multidisciplinary group of nephrology healthcare professionals and a patient. The evidence underpinning the guidance is often of moderate to low quality, influencing the strength of the recommendations. Therefore, the committee have come up with a list of research recommendations with a view to informing future guidelines. It is envisaged that this guideline will improve the care and outcomes of dialysis patients in the UK and elsewhere.
link.springer.com
September 30, 2025 at 10:59 AM
With Nye Bevan in Cardiff today
September 13, 2025 at 5:34 PM
Reposted by Tim Doulton
Proud to have worked with colleagues and friends around the world on #ACHIEVE. We're disappointed spiro didn't prevent CV death/heart failure hospitalizations, but we've shown it's possible to do publicly funded large RCTs of repurposed meds in ESKD. More to do!
www.sciencedirect.com/science/arti...
Spironolactone versus placebo in patients undergoing maintenance dialysis (ACHIEVE): an international, parallel-group, randomised controlled trial
Patients undergoing maintenance dialysis for kidney failure are at substantial risk of cardiovascular morbidity and mortality. We aimed to establish i…
www.sciencedirect.com
August 15, 2025 at 2:57 AM
www.theguardian.com/business/202...

From someone who has been PI on multiple clinical trials in people with kidney disease this is deeply concerning …

@rthonwesstreeting.bsky.social
Britain is ‘a terrible place’ to sell medicines, says drug firm executive
Sanofi’s market access chief urges ministers to come up with a roadmap to raise spending on new treatments
www.theguardian.com
September 12, 2025 at 10:52 AM
Unlike Radiohead it doesn’t look like the Smiths will be touring again anytime soon 😢

www.theguardian.com/music/2025/s...
Morrissey puts his business interests in the Smiths up for sale ‘to any interested party’
Musician says he has ‘no choice’ after being ‘burnt out by any and all connections’ to his former bandmates
www.theguardian.com
September 4, 2025 at 8:04 AM
bihs.org.uk/news/21/prof...

Graham was my boss and MD supervisor at St George’s, University of London.

He started me on a journey that continues to this day. Our East Kent Hypertension Clinic is part of Graham’s legacy.

A giant in nephrology and CV medicine 🙏🏻
Professor Graham A MacGregor (1941-2025)
bihs.org.uk
September 3, 2025 at 7:30 AM
18km continuous ascent to Col de la Colombière with my mate Bryan over the summer 🥵
August 23, 2025 at 9:46 PM
Aleppo by Jenny Saville
August 18, 2025 at 3:41 PM
Poole Harbour
July 8, 2025 at 9:17 PM
Nephrology community take note 👇 #nephsky @bmj.com

Risks of assuming homogenous effects of ancillary treatment in heterogenous healthcare systems in global RCTs

www.bmj.com/content/389/...
Rethinking approaches to analysis of global randomised controlled trials
Choice of statistical models and data integrity are vital A BMJ investigation by Doshi (doi:10.1136/bmj.r1201)1raises concerns about the integrity of two randomised trials with surrogate endpoints th...
www.bmj.com
July 5, 2025 at 10:54 AM
Getting Away With It All
James
#IOW2025
❤️
June 23, 2025 at 9:02 AM
@ukkidney.org #UKKW25 Prof David Wheeler and one of my fave slides reminding us how nephrologists weren’t so good at RCTs 🤣 but how times have changed … 1/2
June 11, 2025 at 11:01 AM
Reposted by Tim Doulton
💪 PD lets patients manage care at home, maintaining hope as they wait.

👥 We honor recipients, donors, and all who navigate this path with strength. PD supports this journey.

#WorldTransplantDay #PeritonealDialysis #TransplantDay
June 6, 2025 at 6:10 AM
Reposted by Tim Doulton
🌱 Today is #TransplantDay, celebrating organ donors' life-saving gift. At ISPD, we emphasize the journey before that crucial call.

🫘 #PeritonealDialysis (PD) is more than a treatment; it's a vital bridge offering freedom and quality of life for those awaiting a transplant.

#WorldTransplantDay
June 6, 2025 at 6:10 AM
Reposted by Tim Doulton
Most comprehensive clinical practice guideline on the management of hypertension in dialysis patients - first-of-its-kind globally - based on extensive systematic literature review
✨New first-of-its-kind guideline on managing blood pressure in adults, children & young people on dialysis.

The important guidance covers BP targets, treatment & lifestyle approaches to improve care.

📰News story: ow.ly/VjO650ViYlz

Full Guideline: ow.ly/tocb50ViYly
April 2, 2025 at 8:59 PM
Reposted by Tim Doulton
How about the siRNA (hot off the press from yesterday's @jama.com )

Zilebesiran summary evidence

@drjmluther.bsky.social at @hypertensioncanada.bsky.social #CHC25
May 29, 2025 at 2:55 PM
Thanks @ukkidney.org for my 🎁 … I’ve always hankered after a sprung-loaded self-retracting lanyard (such a thing must have a specific name 🤣)
May 29, 2025 at 6:29 AM
This *headline* is misleading @jama.com

RH = BP uncontrolled on 3 agents inc a diuretic. KARDIA-2 participants had BP uncontrolled on MONOTHERAPY - including submaximal amlodipine!

When combined with an ARB dSBP was -4.5 mmHg so only moderately additive to existing RAASi

#nephjc
May 28, 2025 at 9:37 PM
Reposted by Tim Doulton
“Science has no passport, no gender, no ethnicity, no political party.”

EC President Ursula von der Leyen, announcing a €500M initiative to attract top global talent.

In a fractured world, science remains a unifying force – rooted in diversity, driven by curiosity, and shared by all humanity.
May 6, 2025 at 11:26 AM
Reposted by Tim Doulton
Remarkable conduct from the GMC.

The Leng Review is currently investigating whether PAs are safe seeing patients.

Yet here's the GMC steaming ahead will rolling out 1000s more PAs, in the face of fierce opposition from doctors with major safety concerns.

www.theguardian.com/education/20...
GMC approves 36 courses to teach more than 1,000 NHS physician associates
New accreditation for PAs and anaesthesia associates is ‘important milestone’ for patient assurance, regulator says
www.theguardian.com
April 30, 2025 at 6:17 AM
It is a legitimate question to ask @wesstreeting.bsky.social @skinnock.bsky.social: what actual actions are @teamlabouruk.bsky.social going to take to address the inhumanity of corridor care which persists in my Trust (SE England) today on a sunny April morning?

www.theguardian.com/commentisfre...
My mum died in A&E last month – and the place was like a war zone | Zoe Williams
Amid the debate about trans people on hospital wards we have lost sight of dignity, respect and the horrifying reality of a health service in meltdown, writes Zoe Williams
www.theguardian.com
April 29, 2025 at 1:06 PM
Reposted by Tim Doulton
Aaand it’s official, we have a new antihypertensive class!!!! 🎉🍾🎊

I like this RCT design in particular because it was open to both uncontrolled not-yet-resistant AND resistant hypertensive patients, opening to door to prescribe it as an earlier line agent

www.nejm.org/doi/full/10....
Lorundrostat Efficacy and Safety in Patients with Uncontrolled Hypertension | NEJM
Aldosterone dysregulation contributes to hypertension. Lorundrostat is an aldosterone synthase inhibitor, but data on its efficacy and safety in patients with hypertension are limited. In this mult...
www.nejm.org
April 23, 2025 at 10:38 PM
😂🤣
April 3, 2025 at 3:59 PM
Reposted by Tim Doulton
I'd completely forgotten that the 2026 World Cup is being held jointly between the US, Mexico and Canada. Christ what a mess. www.theguardian.com/football/202...
The 2026 World Cup, heralded as a uniter, is facing divisive road blocks
And on-again, off-again trade war and threats from the US toward both of its co-hosts leave fans and teams in a tough position
www.theguardian.com
March 28, 2025 at 6:06 AM