Karthick Natarajan
@karthicknatarajan.bsky.social
Postdoctoral at NYU Langone. Working on TDP-43, Retrotransposons and Neurodegeneration
Reposted by Karthick Natarajan
Preprint: CD200R1 loss in CNS-associated macrophages triggers T cell-driven neurodegeneration in Parkinson’s disease
www.researchsquare.com/article/rs-7...
www.researchsquare.com/article/rs-7...
August 12, 2025 at 7:03 PM
Preprint: CD200R1 loss in CNS-associated macrophages triggers T cell-driven neurodegeneration in Parkinson’s disease
www.researchsquare.com/article/rs-7...
www.researchsquare.com/article/rs-7...
Reposted by Karthick Natarajan
A recent study showed that newborns have high levels of p-tau, a biomarker for #Alzheimer disease.
Understanding how infants clear the protein could help prevent aggregation, which leads to #neurodegeneration in adults.
Understanding how infants clear the protein could help prevent aggregation, which leads to #neurodegeneration in adults.
Clues to Alzheimer Disease in the Newborn Brain
This Medical News article discusses a new finding that healthy infants have high blood levels of the protein p-tau217, a key biomarker for Alzheimer disease.
jamanetwork.com
August 16, 2025 at 4:06 AM
A recent study showed that newborns have high levels of p-tau, a biomarker for #Alzheimer disease.
Understanding how infants clear the protein could help prevent aggregation, which leads to #neurodegeneration in adults.
Understanding how infants clear the protein could help prevent aggregation, which leads to #neurodegeneration in adults.
Reposted by Karthick Natarajan
Hypoxia ameliorates neurodegeneration and movement disorder in a mouse model of Parkinson’s disease
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Hypoxia ameliorates neurodegeneration and movement disorder in a mouse model of Parkinson’s disease - Nature Neuroscience
Parkinson’s disease (PD) involves toxic protein buildup and energy failure in neurons. Continuously breathing low-oxygen air protected mice from PD-like neuronal loss and reversed symptoms, even after...
www.nature.com
August 21, 2025 at 4:22 PM
Hypoxia ameliorates neurodegeneration and movement disorder in a mouse model of Parkinson’s disease
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Karthick Natarajan
Happy to share an exciting study from Yihong Ye’s lab at NIH, with a minor contribution from our lab: ceroid lipofuscinosis-4 (CLN4)-linked DNAJC5 mutations cause lysosomal damage as a driver of neurodegeneration in iPSC-derived neurons. CHIP safeguards lysosomes via microautophagy 👉 rdcu.be/eChof
CHIP protects lysosomes from CLN4 mutant-induced membrane damage
Nature Cell Biology - Lee et al. use an aggregation-prone CLN4 mutant that causes lysosomal damage in neurons and show that in non-neurons, the ubiquitin ligase CHIP prevents CLN4-dependent...
rdcu.be
August 25, 2025 at 1:23 PM
Happy to share an exciting study from Yihong Ye’s lab at NIH, with a minor contribution from our lab: ceroid lipofuscinosis-4 (CLN4)-linked DNAJC5 mutations cause lysosomal damage as a driver of neurodegeneration in iPSC-derived neurons. CHIP safeguards lysosomes via microautophagy 👉 rdcu.be/eChof
Maverick.
The end of the genetic paradigm of cancer
Genome sequencing results and single-cell transcriptomics continue to produce findings that challenge the idea that cancer is purely a ‘genetic disease’. This Essay delves into cancer omics data that ...
journals.plos.org
March 20, 2025 at 12:16 AM
Maverick.
