Juha Hulmi
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juhahulmi.bsky.social
Juha Hulmi
@juhahulmi.bsky.social
120 followers 62 following 36 posts
Professor in Exercise Physiology
Work: https://tinyurl.com/4z884z2p
https://scholar.google.com/citations?hl=en&user=sLZykm8AAAAJ
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juhahulmi.bsky.social
Exogenous hormones in combined hormonal contraceptive users may maintain already suppressed hypothalamic–pituitary–ovarian axis function in the presence of low energy availability in athletes.

@ritutm.bsky.social

onlinelibrary.wiley.com/doi/10.1002/...
Hormone Profiles After Planned Low Energy Availability Exposure in Naturally Menstruating and Hormonal Contraceptive Using Physique Athletes
This observational study investigated the potential influence of hormonal contraceptive (HC) use on selected hormonal biomarkers (estradiol, total testosterone, IGF-1, cortisol, triiodothyronine, an.....
onlinelibrary.wiley.com
November 15, 2025 at 11:40 AM
Reposted by Juha Hulmi
craigagoodman1.bsky.social
Lactylation of mTOR enhances autophagy in skeletal muscle during exercise
www.cell.com/cell-chemica...
Lactylation of mTOR enhances autophagy in skeletal muscle during exercise
Based on an acute exercise model, Yan et al. identify lactate as a positive regulator of autophagy in skeletal muscle. Lactate triggers muscle autophagy via K921 lactylation-dependent inactivation of ...
www.cell.com
November 12, 2025 at 4:33 PM
Reposted by Juha Hulmi
pgreenhaff.bsky.social
Hopefully of interest to scientists and exercise practitioners with and interest in muscle mass and functional gains in human volunteers. doi.org/10.1113/JP28...

@jphysiol.bsky.social
NSAID ingestion augments training‐induced muscle hypertrophy and differentially affects muscle mRNA expression, but not strength gains, in trained men
Abstract figure legend Schematic outlining the impact of NSAID ingestion on resistance exercise training-induced changes in muscle morphology, function and gene networks relative to placebo ingestion...
doi.org
October 27, 2025 at 2:10 PM
Reposted by Juha Hulmi
uniofjyvaskyla.bsky.social
Miksi toiset kehittyvät liikuntaharjoittelussa nopeammin kuin toiset? Miten perimä vaikuttaa tuloksiin? Tule kuulemaan uusinta tutkimusta Jyväskylään 19.–21.11.! Ilmoittaudu normaalihinnalla 31.10. mennessä 👉
www.jyu.fi/fi/uutinen/l...
Liikuntaharjoittelun yksilöllisyys kansainvälisen konferenssin pääteemana Jyväskylässä 19.–21.11.2025
Miksi toiset kehittyvät liikuntaharjoittelussa nopeammin kuin toiset? Miten perimä vaikuttaa harjoittelun tuloksiin? Muun muassa näihin kysymyksiin kuulet vastauksia Jyväskylässä järjestettävässä kansainvälisessä valmennustieteen konferenssissa.
www.jyu.fi
October 28, 2025 at 2:48 PM
Reposted by Juha Hulmi
riikka-k.bsky.social
Our new study together with @juhahulmi.bsky.social shows that:

Mechanical loading induces distinct and shared responses in endothelial and muscle cells and reveals exercise-like molecular profiles
@wrihelsinki.bsky.social

www.biorxiv.org/content/10.1...
Mechanical loading induces distinct and shared responses in endothelial and muscle cells and reveals exercise-like molecular profiles
Skeletal muscles and blood vessels are continuously exposed to mechanical forces, particularly during exercise. We subjected human endothelial and skeletal muscle cells to cyclic mechanical stretch an...
www.biorxiv.org
October 24, 2025 at 10:40 AM
Reposted by Juha Hulmi
hughesdc-muscle.bsky.social
Played a small part in this project, but there some really interesting and cool findings from the Sharples Lab here. Focus on the memory of repeat muscle atrophy in human skeletal muscle 💪
biorxiv-physio.bsky.social bioRxiv Physiology @biorxiv-physio.bsky.social · Oct 16
Repeated Disuse Atrophy Imprints a Molecular Memory in Skeletal Muscle: Transcriptional Resilience in Young Adults and Susceptibility in Aged Muscle https://www.biorxiv.org/content/10.1101/2025.10.16.681134v1
October 18, 2025 at 1:15 AM
Reposted by Juha Hulmi
jphysiol.bsky.social
In this #JournalClub, Igor Longobardi of uspoficial.bsky.social et al. examine the work of Hulmi et al. (2025) and what is next for the ‘muscle memory’ conundrum? ✍️

🔗 Access it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
October 17, 2025 at 11:03 AM
Reposted by Juha Hulmi
smantyselka.bsky.social
I am pleased to share our new research article (in press version) entitled Glycolytic metabolism and biomass production from glucose in human skeletal muscle growth. Link in the comments. 1/3 #myoblue #SkeletalMuscle
October 11, 2025 at 11:18 AM
juhahulmi.bsky.social
New study from our lab! Human muscle cells incorporate glucose into proteins, RNA, and lipids, and anabolic stimulation further increased these processes. Resistance training increased metabolites and enzymes of these processes, e.g., PHGDH, which was shown to be anabolic.
tinyurl.com/2744e22s
Glycolytic metabolism and biomass production from glucose in human skeletal muscle growth | American Journal of Physiology-Cell Physiology | American Physiological Society
Skeletal muscle is the main consumer of glucose after a mixed meal, and resistance exercise further increases muscle glucose uptake. Emerging evidence suggests that glucose uptake in muscles is not on...
tinyurl.com
October 10, 2025 at 5:06 PM
juhahulmi.bsky.social
Elite strength and physique athletes differ in sport-specific muscle size and power. In these athletes, the muscle size contributes to muscle strength. Finally, females have better strength endurance than males, independent of the training background. tinyurl.com/39dfz977
October 7, 2025 at 4:07 AM
juhahulmi.bsky.social
Researchers investigated muscle memory of exercise in mice and the results suggest that skeletal muscle retains a metabolic memory of endurance exercise, which enhances adaptations following retraining:
journals.physiology.org/doi/full/10....
Muscle memory of exercise optimizes mitochondrial metabolism to support skeletal muscle growth | American Journal of Physiology-Cell Physiology | American Physiological Society
Exercise protects against age-related declines in skeletal muscle mass and function while improving overall health. Exercise can also prime long-term muscle health to enhance adaptations upon exercise...
journals.physiology.org
October 2, 2025 at 4:09 AM
juhahulmi.bsky.social
Our findings provide new insight into the metabolomic signature of low energy availability (LEA) and support metabolomics as a tool for early detection of LEA.
physoc.onlinelibrary.wiley.com/doi/10.14814...
Metabolic signature of short‐term low energy availability
Exposure to low energy availability (LEA) can potentially detrimentally affect athletes' health and performance. Timely identification is crucial, yet its detection is often delayed until severe symp...
physoc.onlinelibrary.wiley.com
September 29, 2025 at 10:15 AM
juhahulmi.bsky.social
2 min video of our recent study in J Physiol. physoc.onlinelibrary.wiley.com/doi/10.1113/...

The link below:
September 23, 2025 at 11:34 AM
Reposted by Juha Hulmi
uniofjyvaskyla.bsky.social
Why do some progress faster in resistance training? 💪
How do genetics and physiology shape training responses? 🏋️‍♀️
Join us in Jyväskylä, Finland, Nov 19–21 for the Inter-Individual Variation in Resistance Training Responses Conference.
www.jyu.fi/en/news/indi...
Individual responses to exercise training as the main theme of an international conference in Jyväskylä, November 19–21, 2025
Why do some people progress faster in exercise training than others? How can training responses be predicted, and how does genetics influence the outcomes of training? These questions are addressed at the international coaching science conference.
www.jyu.fi
September 11, 2025 at 9:01 AM
Reposted by Juha Hulmi
craigagoodman1.bsky.social
Combined angiogenic and hypertrophic gene therapy enhances skeletal muscle growth
journals.physiology.org/doi/abs/10.1...
Combined angiogenic and hypertrophic gene therapy enhances skeletal muscle growth | American Journal of Physiology-Cell Physiology | American Physiological Society
Skeletal muscle atrophy in response to pathophysiological stimuli or disuse includes loss of muscle mass and strength. Targeting signaling pathways regulating muscle growth can counteract muscle loss,...
journals.physiology.org
July 8, 2025 at 5:45 PM
Reposted by Juha Hulmi
natrevdiseaseprimers.nature.com
Sarcopenia is accelerated loss of skeletal muscle mass and function commonly, but not exclusively, associated with advancing age. It is observed across many species including humans in whom it can lead to decline in physical function and mobility. https://www.nature.c...
September 6, 2025 at 6:37 AM
juhahulmi.bsky.social
The authors discuss our recent article (link in comments) and its implications. Many questions remain to be elucidated. Muscle memory research is still in its early stages.

physoc.onlinelibrary.wiley.com/doi/10.1113/...
@jphysiol.bsky.social
What is next for the ‘muscle memory’ conundrum? Unresolved questions and future research directions
Click on the article title to read more.
physoc.onlinelibrary.wiley.com
September 6, 2025 at 3:24 AM
Reposted by Juha Hulmi
abigailmackey1.bsky.social
An interesting read:
physoc.onlinelibrary.wiley.com/doi/10.1113/...
The state of mechanistic research in the evidence‐based medicine era: A sandwalk between triangulation and hierarchies
Click on the article title to read more.
physoc.onlinelibrary.wiley.com
September 5, 2025 at 6:28 PM
Reposted by Juha Hulmi
kevinh-phd.bsky.social
I truly enjoyed this discussion with Dr. Mike covering a range of topics on food, nutrition, and metabolism. We also discuss my reasons for leaving NIH and what’s needed to really improve nutrition science.

youtu.be/WBllzAb_vAk?...
“Why I Quit The NIH” | Nutrition Researcher Kevin Hall
YouTube video by Doctor Mike
youtu.be
August 31, 2025 at 4:22 PM
Reposted by Juha Hulmi
juhahulmi.bsky.social
Conference: Inter-individual variation in exercise. Please join! The speakers are e.g.
@mackinprof.bsky.social, @abigailmackey1.bsky.social, M Bamman, T Hornberger, M Roberts, B Schoenfeld, M Perola, G Nader, E Sillanpää, A Hecksteden, W Derave, P Atherton, J Ahtiainen and me.
tinyurl.com/34xzsdss
July 2, 2025 at 6:48 AM
juhahulmi.bsky.social
We showed that varying proximity-to-failure may not enhance short-term RT adaptations, but it allows RT with lower RPE. RIR accuracy was already good at baseline in trained individuals, but further improved by RT, supporting its use to guide training practices. link.springer.com/article/10.1...
Influence of Varying Proximity-to-Failure on Muscular Adaptations and Repetitions-in-Reserve Estimation Accuracy in Resistance-Trained Individuals - Journal of Science in Sport and Exercise
Purpose The effects of varying proximity-to-failure during a resistance training (RT) program remain undetermined. Hence, we explored the influence of varying proximity-to-failure on muscular adaptati...
link.springer.com
August 20, 2025 at 6:54 AM
Reposted by Juha Hulmi
jphysiol.bsky.social
Congratulations to Niclas Rausch, Rebecca L. McIntyre, Fabian Finger & Jens Lund of cbmr.science for winning the #JournalClub 2024 Prize! 📖 🏆

See their winning paper 'Cutting through dogma: a novel tool to dissect lactate biology'⬇️

physoc.onlinelibrary.wiley.com/doi/10.1113/...
August 7, 2025 at 3:02 PM
Reposted by Juha Hulmi
kevinmurachphd.bsky.social
“Muscle memory theory: A critical evaluation” in @JPhysiol led by postdoc Nate Serrano physoc.onlinelibrary.wiley.com/doi/10.1113/...
Muscle memory theory: A critical evaluation
Click on the article title to read more.
physoc.onlinelibrary.wiley.com
August 6, 2025 at 6:35 PM
Reposted by Juha Hulmi
mvfranchi.bsky.social
This was a very cool project to work on!
More to come on this topic from our lab, I hope soon!
jphysiol.bsky.social The Journal of Physiology @jphysiol.bsky.social · Jul 18
Martino V. Franchi et al. observed that previous short-term disuse dictates muscle #geneexpression and #physiological adaptations to subsequent resistance exercise 🧬 🚴‍♂️

📜 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
August 2, 2025 at 6:21 AM
juhahulmi.bsky.social
Early-life exercise even when followed by a detraining extended healthspan in mice. No effects on lifespan.

www.nature.com/articles/s41...
Early-life exercise extends healthspan but not lifespan in mice - Nature Communications
Exercise exerts health benefits, yet the long-term effects of early-life regular exercise on later-life health and lifespan remain poorly understood. Here, the authors show early-life exercise in mice...
www.nature.com
July 29, 2025 at 4:33 AM