Sakari Mäntyselkä
@smantyselka.bsky.social
PhD candidate in Exercise Physiology. MSc in Cell and Molecular Biology. Interested in metabolism, regulation of muscle size, and bioanalytics (e.g. metabolomics).
Orcid: https://orcid.org/0000-0002-2313-0735
Orcid: https://orcid.org/0000-0002-2313-0735
Our new preprint suggest that in vitro mechanical cyclic stretching alone induces many similar molecular responses as exercise in vivo.
Our new study together with @juhahulmi.bsky.social shows that:
Mechanical loading induces distinct and shared responses in endothelial and muscle cells and reveals exercise-like molecular profiles
@wrihelsinki.bsky.social
www.biorxiv.org/content/10.1...
Mechanical loading induces distinct and shared responses in endothelial and muscle cells and reveals exercise-like molecular profiles
@wrihelsinki.bsky.social
www.biorxiv.org/content/10.1...
Mechanical loading induces distinct and shared responses in endothelial and muscle cells and reveals exercise-like molecular profiles
Skeletal muscles and blood vessels are continuously exposed to mechanical forces, particularly during exercise. We subjected human endothelial and skeletal muscle cells to cyclic mechanical stretch an...
www.biorxiv.org
October 24, 2025 at 11:49 AM
Our new preprint suggest that in vitro mechanical cyclic stretching alone induces many similar molecular responses as exercise in vivo.
I am pleased to share our new research article (in press version) entitled Glycolytic metabolism and biomass production from glucose in human skeletal muscle growth. Link in the comments. 1/3 #myoblue #SkeletalMuscle
October 11, 2025 at 11:18 AM
I am pleased to share our new research article (in press version) entitled Glycolytic metabolism and biomass production from glucose in human skeletal muscle growth. Link in the comments. 1/3 #myoblue #SkeletalMuscle
Reposted by Sakari Mäntyselkä
Why do some progress faster in resistance training? 💪
How do genetics and physiology shape training responses? 🏋️♀️
Join us in Jyväskylä, Finland, Nov 19–21 for the Inter-Individual Variation in Resistance Training Responses Conference.
www.jyu.fi/en/news/indi...
How do genetics and physiology shape training responses? 🏋️♀️
Join us in Jyväskylä, Finland, Nov 19–21 for the Inter-Individual Variation in Resistance Training Responses Conference.
www.jyu.fi/en/news/indi...
Individual responses to exercise training as the main theme of an international conference in Jyväskylä, November 19–21, 2025
Why do some people progress faster in exercise training than others? How can training responses be predicted, and how does genetics influence the outcomes of training? These questions are addressed at the international coaching science conference.
www.jyu.fi
September 11, 2025 at 9:01 AM
Why do some progress faster in resistance training? 💪
How do genetics and physiology shape training responses? 🏋️♀️
Join us in Jyväskylä, Finland, Nov 19–21 for the Inter-Individual Variation in Resistance Training Responses Conference.
www.jyu.fi/en/news/indi...
How do genetics and physiology shape training responses? 🏋️♀️
Join us in Jyväskylä, Finland, Nov 19–21 for the Inter-Individual Variation in Resistance Training Responses Conference.
www.jyu.fi/en/news/indi...
I assume that today will be a great talk!
Erik Richter is an exercise physiology legend and will give the 18th HyperMet talk on interaction of exercise and insulin on glucose uptake. tomorrow, Thursday, 28.08.2025 15-16 h Munich time. The Zoom-link is here:
tum-conf.zoom-x.de/j/6920502369...
Password: 702487
tum-conf.zoom-x.de/j/6920502369...
Password: 702487
August 28, 2025 at 6:48 AM
I assume that today will be a great talk!
Reposted by Sakari Mäntyselkä
One major, unsolved problem is all those unknown signals in MS metabolomics data. To predict what they are, Mike Skinneder has developed DeeMet. He will give the 17th HyperMet talk next Thursday at 15 h Munich time. Join here (please RT): tum-conf.zoom-x.de/j/6392132327...
August 16, 2025 at 7:39 AM
One major, unsolved problem is all those unknown signals in MS metabolomics data. To predict what they are, Mike Skinneder has developed DeeMet. He will give the 17th HyperMet talk next Thursday at 15 h Munich time. Join here (please RT): tum-conf.zoom-x.de/j/6392132327...
Reposted by Sakari Mäntyselkä
Really looking forward to Lykke Sylow given the 16th HyperMet talk this Thursday 15 h. Whe will talk about the effect of hypertrophy stimulation on fat mass and glucose homeostasis (recent preprint). Please RT and join here: tum-conf.zoom-x.de/j/6903199711...
August 11, 2025 at 8:13 AM
Really looking forward to Lykke Sylow given the 16th HyperMet talk this Thursday 15 h. Whe will talk about the effect of hypertrophy stimulation on fat mass and glucose homeostasis (recent preprint). Please RT and join here: tum-conf.zoom-x.de/j/6903199711...
Our pre-print is now available 🤓
www.biorxiv.org/content/10.1...
Check how differently muscle cells and endothelial cells respond to mechanical loading from our latest study. Great work by @erikniemi.bsky.social @smantyselka.bsky.social and collaboration with @juhahulmi.bsky.social. Supported by @wrihelsinki.bsky.social
Check how differently muscle cells and endothelial cells respond to mechanical loading from our latest study. Great work by @erikniemi.bsky.social @smantyselka.bsky.social and collaboration with @juhahulmi.bsky.social. Supported by @wrihelsinki.bsky.social
Mechanical loading reveals cell type-specific responses and role of PHGDH in endothelial cell growth
Skeletal muscle and blood vessels are constantly subjected to mechanical forces, especially during exercise. We subjected human endothelial cells (ECs) and muscle cells (MCs) to cyclic mechanical stre...
www.biorxiv.org
July 3, 2025 at 7:37 PM
Our pre-print is now available 🤓
Reposted by Sakari Mäntyselkä
Conference: Inter-individual variation in exercise. Please join! The speakers are e.g.
@mackinprof.bsky.social, @abigailmackey1.bsky.social, M Bamman, T Hornberger, M Roberts, B Schoenfeld, M Perola, G Nader, E Sillanpää, A Hecksteden, W Derave, P Atherton, J Ahtiainen and me.
tinyurl.com/34xzsdss
@mackinprof.bsky.social, @abigailmackey1.bsky.social, M Bamman, T Hornberger, M Roberts, B Schoenfeld, M Perola, G Nader, E Sillanpää, A Hecksteden, W Derave, P Atherton, J Ahtiainen and me.
tinyurl.com/34xzsdss
July 2, 2025 at 6:48 AM
Conference: Inter-individual variation in exercise. Please join! The speakers are e.g.
@mackinprof.bsky.social, @abigailmackey1.bsky.social, M Bamman, T Hornberger, M Roberts, B Schoenfeld, M Perola, G Nader, E Sillanpää, A Hecksteden, W Derave, P Atherton, J Ahtiainen and me.
tinyurl.com/34xzsdss
@mackinprof.bsky.social, @abigailmackey1.bsky.social, M Bamman, T Hornberger, M Roberts, B Schoenfeld, M Perola, G Nader, E Sillanpää, A Hecksteden, W Derave, P Atherton, J Ahtiainen and me.
tinyurl.com/34xzsdss
Effects of Skeletal Muscle Hypertrophy on Fat Mass and Glucose Homeostasis in Humans and Animals: A Narrative Review with Systematic Literature Search
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Effects of Skeletal Muscle Hypertrophy on Fat Mass and Glucose Homeostasis in Humans and Animals: A Narrative Review with Systematic Literature Search - Sports Medicine
Overweight, obesity, and type 2 diabetes mellitus are metabolic health problems and diseases that affect billions of people worldwide. Studies in animals and humans suggest that stimulating global mus...
link.springer.com
June 28, 2025 at 2:24 PM
A comparison of human skeletal muscle cell maturation in 2D versus 3D culture: A quantitative proteomic study. #myoblue
physoc.onlinelibrary.wiley.com/doi/10.14814...
physoc.onlinelibrary.wiley.com/doi/10.14814...
physoc.onlinelibrary.wiley.com
June 27, 2025 at 6:56 AM
A comparison of human skeletal muscle cell maturation in 2D versus 3D culture: A quantitative proteomic study. #myoblue
physoc.onlinelibrary.wiley.com/doi/10.14814...
physoc.onlinelibrary.wiley.com/doi/10.14814...
Reposted by Sakari Mäntyselkä
The commonly used antibiotic streptomycin reduces protein synthesis and differentiation in cultured C2C12 myotubes
physoc.onlinelibrary.wiley.com/doi/10.14814...
physoc.onlinelibrary.wiley.com/doi/10.14814...
The commonly used antibiotic streptomycin reduces protein synthesis and differentiation in cultured C2C12 myotubes
The antibiotic streptomycin is an integral part of cell culture medium. Because streptomycin inhibits bacterial protein synthesis, streptomycin might also have off-target effects on muscle cell funct...
physoc.onlinelibrary.wiley.com
June 17, 2025 at 5:58 PM
The commonly used antibiotic streptomycin reduces protein synthesis and differentiation in cultured C2C12 myotubes
physoc.onlinelibrary.wiley.com/doi/10.14814...
physoc.onlinelibrary.wiley.com/doi/10.14814...
Very interesting study! Congratulations!
A tour de force! Mouse, worm, and human data all telling the same story. Amazing! “microRNA-1 Regulates Metabolic Flexibility by Programming Adult Skeletal Muscle Pyruvate Metabolism” www.sciencedirect.com/science/arti...
microRNA-1 Regulates Metabolic Flexibility by Programming Adult Skeletal Muscle Pyruvate Metabolism
Metabolic flexibility refers to the ability of a tissue to adjust cellular fuel choice in response to conditional changes in metabolic demand and acti…
www.sciencedirect.com
June 10, 2025 at 3:26 PM
Very interesting study! Congratulations!
Reposted by Sakari Mäntyselkä
This review highlights the molecular mechanisms that regulate glucose utilization in skeletal muscle, the primary site of glucose storage and oxidation.
Erik A. Richter, et al.
doi.org/10.1152/phys...
#GlucoseMetabolism #InsulinSensitization
Erik A. Richter, et al.
doi.org/10.1152/phys...
#GlucoseMetabolism #InsulinSensitization
June 3, 2025 at 12:00 PM
This review highlights the molecular mechanisms that regulate glucose utilization in skeletal muscle, the primary site of glucose storage and oxidation.
Erik A. Richter, et al.
doi.org/10.1152/phys...
#GlucoseMetabolism #InsulinSensitization
Erik A. Richter, et al.
doi.org/10.1152/phys...
#GlucoseMetabolism #InsulinSensitization
Reposted by Sakari Mäntyselkä
Muscle needs to make serine from glucose to protect the fibers from mitochondrial disease. Read our story, a tour de force of Anastasiia Marmyleva and Christopher Jackson @SWAN @STEMM Helsinki University www.cell.com/cell-reports...
De novo serine biosynthesis is protective in mitochondrial disease
Jackson et al. show that serine becomes an essential amino acid in mitochondrial muscle
disease, delaying disease progression. Blocking local biosynthesis of serine challenges
cellular phospholipid ho...
www.cell.com
May 16, 2025 at 3:00 PM
Muscle needs to make serine from glucose to protect the fibers from mitochondrial disease. Read our story, a tour de force of Anastasiia Marmyleva and Christopher Jackson @SWAN @STEMM Helsinki University www.cell.com/cell-reports...
I look forward to the results of the human clinical trial in the future! Very interesting research area! clinicaltrials.gov/study/NCT056...
May 15, 2025 at 7:24 AM
I look forward to the results of the human clinical trial in the future! Very interesting research area! clinicaltrials.gov/study/NCT056...
Reposted by Sakari Mäntyselkä
Considerations of working with human primary muscle cells - happy to have contributed to this important topic. Thank you Tom Francis and Steve Harridge for inviting me and Casper Soendenbroe to join you!
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Insights into human muscle biology from human primary skeletal muscle cell culture - Journal of Muscle Research and Cell Motility
This review arises from the symposium held in honour of Prof Jenny Morgan at UCL in 2024 and the authors would like to acknowledge the outstanding contribution that Prof Morgan has made to the field o...
link.springer.com
May 13, 2025 at 12:32 PM
Considerations of working with human primary muscle cells - happy to have contributed to this important topic. Thank you Tom Francis and Steve Harridge for inviting me and Casper Soendenbroe to join you!
link.springer.com/article/10.1...
link.springer.com/article/10.1...
I can fully recommend Juha Hulmi! I am a final year PhD student in Juha's group.
Happy to host potential candidates. Please DM or email (juha.hulmi@jyu.fi) me if you are or know someone interested.
Choose Science. Choose Europe.
A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.
With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.
Apply by 10 September → europa.eu/!fBTMgF
A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.
With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.
Apply by 10 September → europa.eu/!fBTMgF
May 14, 2025 at 11:21 AM
I can fully recommend Juha Hulmi! I am a final year PhD student in Juha's group.
Reposted by Sakari Mäntyselkä
🧵5 Top Free Alternatives to BioRender for Scientific Illustrations!
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These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.
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May 13, 2025 at 7:55 PM
🧵5 Top Free Alternatives to BioRender for Scientific Illustrations!
These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.
Save and share the post!
These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.
Save and share the post!
Reposted by Sakari Mäntyselkä
Excited to share this! We found that muscles "remember" at the proteome level that they have been training. We also report quite reproducible proteome response to resistance training.
physoc.onlinelibrary.wiley.com/doi/full/10....
@jphysiol.bsky.social @varjosal.bsky.social
physoc.onlinelibrary.wiley.com/doi/full/10....
@jphysiol.bsky.social @varjosal.bsky.social
April 5, 2025 at 5:09 AM
Excited to share this! We found that muscles "remember" at the proteome level that they have been training. We also report quite reproducible proteome response to resistance training.
physoc.onlinelibrary.wiley.com/doi/full/10....
@jphysiol.bsky.social @varjosal.bsky.social
physoc.onlinelibrary.wiley.com/doi/full/10....
@jphysiol.bsky.social @varjosal.bsky.social
Reposted by Sakari Mäntyselkä
Scientists, academics, researchers: We’re excited to share that @altmetric.com is now tracking mentions of your research on Bluesky! 🧪
There are already many articles for which there is more attention on Bluesky than on other comparable micro-blogging sites, meaning the academic community and the general public have clearly adopted Bluesky as one of its core places to disseminate and discuss new research.
A Place of Joy.
A Place of Joy.
December 3, 2024 at 2:10 PM
Scientists, academics, researchers: We’re excited to share that @altmetric.com is now tracking mentions of your research on Bluesky! 🧪
Great study by my PhD supervisor Juha Hulmi and my colleague PhD student Eeli Halonen and their team and collaborators like @varjosal.bsky.social et al!
"Human skeletal muscle possesses both reversible proteomic signatures and a retained proteomic memory..." #myoblue
www.biorxiv.org/content/10.1...
"Human skeletal muscle possesses both reversible proteomic signatures and a retained proteomic memory..." #myoblue
www.biorxiv.org/content/10.1...
Human skeletal muscle possesses both reversible proteomic signatures and a retained proteomic memory after repeated resistance training
Investigating repeated resistance training separated by a training break enables exploration of the potential for a proteomic memory of skeletal muscle growth. Our aim was to examine skeletal muscle p...
www.biorxiv.org
November 22, 2024 at 4:47 PM
Great study by my PhD supervisor Juha Hulmi and my colleague PhD student Eeli Halonen and their team and collaborators like @varjosal.bsky.social et al!
"Human skeletal muscle possesses both reversible proteomic signatures and a retained proteomic memory..." #myoblue
www.biorxiv.org/content/10.1...
"Human skeletal muscle possesses both reversible proteomic signatures and a retained proteomic memory..." #myoblue
www.biorxiv.org/content/10.1...
Very interesting and great study by Horberger Lab and their collaborators! "Identification of a Resistance Exercise-Specific Signaling Pathway that Drives Skeletal Muscle Growth" www.researchsquare.com/article/rs-4... #myoblue
Identification of a Resistance Exercise-Specific Signaling Pathway that Drives Skeletal Muscle Growth
A human model of unilateral endurance versus resistance exercise, in conjunction with deep phosphoproteomic analyses, was used to identify exercise mode-specific phosphorylation events. Among the outc...
www.researchsquare.com
November 22, 2024 at 4:39 PM
Very interesting and great study by Horberger Lab and their collaborators! "Identification of a Resistance Exercise-Specific Signaling Pathway that Drives Skeletal Muscle Growth" www.researchsquare.com/article/rs-4... #myoblue