Johannes Nemeth
@johannesnemeth.bsky.social
4x father - infectious diseases specialist with scientific interest in tuberculosis, HIV and the host response - book nerd.
Reposted by Johannes Nemeth
Reposted by Johannes Nemeth
From a new @thelancet.com article today entitled "Health care in the USA: money has become the mission" www.thelancet.com/journals/lan...
October 21, 2025 at 10:49 PM
From a new @thelancet.com article today entitled "Health care in the USA: money has become the mission" www.thelancet.com/journals/lan...
Reposted by Johannes Nemeth
Congratulations to new Nobel Laureate and AAI Distinguished Fellow Shimon Sakaguchi, co-winner of the 2025 Nobel Prize in Physiology or Medicine for his foundational discoveries on regulatory T cells and peripheral immune tolerance! Published in The JI in 1995: ow.ly/LGk150X7984.
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
Abstract. Approximately 10% of peripheral CD4+ cells and less than 1% of CD8+ cells in normal unimmunized adult mice express the IL-2 receptor α-chain (CD2
academic.oup.com
October 6, 2025 at 3:26 PM
Congratulations to new Nobel Laureate and AAI Distinguished Fellow Shimon Sakaguchi, co-winner of the 2025 Nobel Prize in Physiology or Medicine for his foundational discoveries on regulatory T cells and peripheral immune tolerance! Published in The JI in 1995: ow.ly/LGk150X7984.
We just published results from the BELIEVE trial—a small, investigator-initiated study testing BCG vaccination in people with treated HIV. academic.oup.com/ofid/advance...
Safety of Bacillus Calmette-Guérin vaccination and impact on HIV-1 latent reservoir size in people with treated HIV-1 Infection
AbstractBackground. Bacillus Calmette-Guérin (BCG) vaccination, used against tuberculosis, is recognized for its immunomodulatory properties, a phenomenon
academic.oup.com
October 1, 2025 at 2:46 PM
We just published results from the BELIEVE trial—a small, investigator-initiated study testing BCG vaccination in people with treated HIV. academic.oup.com/ofid/advance...
Reposted by Johannes Nemeth
I gave my heart and soul to that place. Built entire sections for journalists pushed out of their home countries.
When the writer I hired, Jamal Khashoggi was murdered by Saudi Arabia, they paraded me around as a symbol for press freedom.
I put MY LIFE on the line to defend journalism and WaPo.
When the writer I hired, Jamal Khashoggi was murdered by Saudi Arabia, they paraded me around as a symbol for press freedom.
I put MY LIFE on the line to defend journalism and WaPo.
weird that neither of these articles two main stories decrying censorship mention WaPo's firing of @karenattiah.bsky.social I guess democracy really does die in darkness
September 18, 2025 at 8:30 PM
I gave my heart and soul to that place. Built entire sections for journalists pushed out of their home countries.
When the writer I hired, Jamal Khashoggi was murdered by Saudi Arabia, they paraded me around as a symbol for press freedom.
I put MY LIFE on the line to defend journalism and WaPo.
When the writer I hired, Jamal Khashoggi was murdered by Saudi Arabia, they paraded me around as a symbol for press freedom.
I put MY LIFE on the line to defend journalism and WaPo.
A new modeling study highlights the stakes of recent U.S. funding cuts for TB programs. Without rapid recovery, 26 high-burden countries could see up to 10.7M excess TB cases and 2.2M more deaths by 2030. An urgent call for global reinvestment in TB control.
dx.plos.org/10.1371/jour...
dx.plos.org/10.1371/jour...
A deadly equation: The global toll of US TB funding cuts
The recent withdrawal of U.S. financial support threatens essential TB service delivery, including diagnostics, treatment, TB-HIV co-infection interventions and research initiatives critical to eradic...
dx.plos.org
September 13, 2025 at 7:07 PM
A new modeling study highlights the stakes of recent U.S. funding cuts for TB programs. Without rapid recovery, 26 high-burden countries could see up to 10.7M excess TB cases and 2.2M more deaths by 2030. An urgent call for global reinvestment in TB control.
dx.plos.org/10.1371/jour...
dx.plos.org/10.1371/jour...
What do cancer and tuberculosis have in common?
A shared reliance on c-Myc to suppress immune defenses.
In our latest study, we uncover how Mycobacterium tuberculosis exploits this pathway to persist inside macrophages—even in the presence of IFN-γ. academic.oup.com/jid/advance-...
A shared reliance on c-Myc to suppress immune defenses.
In our latest study, we uncover how Mycobacterium tuberculosis exploits this pathway to persist inside macrophages—even in the presence of IFN-γ. academic.oup.com/jid/advance-...
c-Myc Inhibits Macrophage Antimycobacterial Response in Mycobacterium tuberculosis Infection
c-Myc is an important regulator of macrophage function during Mycobacterium tuberculosis infection. Its inhibition enhances bacterial control, whereas its
academic.oup.com
September 12, 2025 at 6:28 AM
What do cancer and tuberculosis have in common?
A shared reliance on c-Myc to suppress immune defenses.
In our latest study, we uncover how Mycobacterium tuberculosis exploits this pathway to persist inside macrophages—even in the presence of IFN-γ. academic.oup.com/jid/advance-...
A shared reliance on c-Myc to suppress immune defenses.
In our latest study, we uncover how Mycobacterium tuberculosis exploits this pathway to persist inside macrophages—even in the presence of IFN-γ. academic.oup.com/jid/advance-...
Reposted by Johannes Nemeth
We simply cannot allow this to happen
Children deserve better
Children deserve better
August 30, 2025 at 2:12 PM
We simply cannot allow this to happen
Children deserve better
Children deserve better
Can we predict which people with HIV will develop tuberculosis—years before it happens?
In our latest study, we investigated early immune changes that precede active TB, using plasma proteomics and machine learning.
In our latest study, we investigated early immune changes that precede active TB, using plasma proteomics and machine learning.
August 28, 2025 at 12:35 PM
Can we predict which people with HIV will develop tuberculosis—years before it happens?
In our latest study, we investigated early immune changes that precede active TB, using plasma proteomics and machine learning.
In our latest study, we investigated early immune changes that precede active TB, using plasma proteomics and machine learning.
Can a bacterial infection shape how our body responds to a completely different virus? Our new study in PLOS Pathogens explores how Mycobacterium tuberculosis (MTB) co-infection modulates the antibody response to HIV-1. journals.plos.org/plospathogen...
Infection with Mycobacterium tuberculosis alters the antibody response to HIV-1
Author summary Active Mycobacterium tuberculosis (MTB) infection remains a leading cause of death among people with HIV-1 (PWH). However, the majority of PWH infected with MTB do not progress to activ...
journals.plos.org
August 15, 2025 at 11:54 AM
Can a bacterial infection shape how our body responds to a completely different virus? Our new study in PLOS Pathogens explores how Mycobacterium tuberculosis (MTB) co-infection modulates the antibody response to HIV-1. journals.plos.org/plospathogen...
Just read this depressingly accurate piece in the @nyt: How Trump Is Undoing 80 Years of American Greatness www.nytimes.com/2025/08/12/o...
Opinion | How Trump Is Undoing 80 Years of American Greatness
www.nytimes.com
August 12, 2025 at 7:26 PM
Just read this depressingly accurate piece in the @nyt: How Trump Is Undoing 80 Years of American Greatness www.nytimes.com/2025/08/12/o...
Systematic insanity.
Every reputable expert I know considers mRNA vaccine technology to be one of the most revolutionary advances in medicine in our lifetimes. Its inventors won the Nobel Prize in 2023. Shutting it down now is pointless self-harm to humanity.
Release from HHS: HHS will wind down its development of the mRNA vaccine development activities under the Biomedical Advanced Research and Development Authority (BARDA).
August 6, 2025 at 7:35 AM
Systematic insanity.
Excited to share our article in Trends in Microbiology: "Mycobacteria Beyond Disease." This work, rooted in ideas from my postdoc with Alan Aderem, explores how mycobacteria can influence human immunity beyond causing disease.
#Microbiology #Immunology
#Microbiology #Immunology
April 29, 2025 at 5:54 AM
Excited to share our article in Trends in Microbiology: "Mycobacteria Beyond Disease." This work, rooted in ideas from my postdoc with Alan Aderem, explores how mycobacteria can influence human immunity beyond causing disease.
#Microbiology #Immunology
#Microbiology #Immunology
Reposted by Johannes Nemeth
This is another big loss at NIH. He explains why in the thread below.
Our recent conversation about what we should eat
erictopol.substack.com/p/kevin-hall...
Our recent conversation about what we should eat
erictopol.substack.com/p/kevin-hall...
April 16, 2025 at 10:26 PM
This is another big loss at NIH. He explains why in the thread below.
Our recent conversation about what we should eat
erictopol.substack.com/p/kevin-hall...
Our recent conversation about what we should eat
erictopol.substack.com/p/kevin-hall...
New study out in @cidjournal.bsky.social:
“Machine Learning-Based Prediction of Active Tuberculosis in People with HIV Using Clinical Data”
We used routine clinical data at HIV diagnosis to predict who develops active TB—without needing IGRA or TST.
Link: pubmed.ncbi.nlm.nih.gov/40132061/
“Machine Learning-Based Prediction of Active Tuberculosis in People with HIV Using Clinical Data”
We used routine clinical data at HIV diagnosis to predict who develops active TB—without needing IGRA or TST.
Link: pubmed.ncbi.nlm.nih.gov/40132061/
Machine Learning-Based Prediction of Active Tuberculosis in People with HIV using Clinical Data - PubMed
Models based on machine learning offer considerable promise for improving care for PWH, requiring n additional data collection and incurring minimal additional costs while enhancing the identification...
pubmed.ncbi.nlm.nih.gov
March 26, 2025 at 12:43 PM
New study out in @cidjournal.bsky.social:
“Machine Learning-Based Prediction of Active Tuberculosis in People with HIV Using Clinical Data”
We used routine clinical data at HIV diagnosis to predict who develops active TB—without needing IGRA or TST.
Link: pubmed.ncbi.nlm.nih.gov/40132061/
“Machine Learning-Based Prediction of Active Tuberculosis in People with HIV Using Clinical Data”
We used routine clinical data at HIV diagnosis to predict who develops active TB—without needing IGRA or TST.
Link: pubmed.ncbi.nlm.nih.gov/40132061/