Microglia are immune cells of the central nervous system, playing a vital role in brain development, homeostasis, and disease. When these cells become…

Guiqin Chen, Mengmeng Wang, et al. demonstrate that ApoE3 R136S inhibits AEP-mediated Tau cleavage and neuroinflammation by binding more tightly to Tau, preventing its propagation, and thereby slowing the progression of Alzheimer’s disease in mice.

Graham et al. show that Alzheimer's disease-associated genetic variants are enriched in gene networks expressed by microglia and oligodendrocytes during ag

This article discusses a puzzling issue in brain pathology: why brain-resident microglia are insufficient for protection, and why myeloid cells are needed from the periphery. Several strategies are pr...