Peng Jiang Lab@Rutgers
@jianglab.bsky.social
Create hPSC #organoid brain & #chimeric brain to study #neurodevelopment, #aging, #DownSyndrome, #Alzheimers, & #Autism; develop #glial cell replacement therapies. https://cbn.rutgers.edu/peng-jiang-lab/339-peng-jiang-lab
Thrilled to share our new study published in @cp-cellreports.bsky.social, led by Mengmeng Jin, Ziyuan Ma, and Haiwei Zhang. Grateful for a wonderful collaboration with Dr. Steve Goldman, a pioneer in chimeric brain models and a leading expert in glial biology.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Chimeric brain models to study human glial-neuronal and macroglial-microglial interactions
Jin et al. develop chimeric mouse brains containing human microglia, astroglia, oligodendroglia,
and neurons, enabling direct interrogation of human neuron-glia interactions in vivo.
These models reca...
www.cell.com
January 6, 2026 at 7:46 PM
Thrilled to share our new study published in @cp-cellreports.bsky.social, led by Mengmeng Jin, Ziyuan Ma, and Haiwei Zhang. Grateful for a wonderful collaboration with Dr. Steve Goldman, a pioneer in chimeric brain models and a leading expert in glial biology.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Thank you so much for highlighting our work!
New study from Jiang group gives clues to Down syndrome patients' resilience to AD: a DS-linked myeloid mutation (CSF2RB A455D) protects engrafted human microglia against tau by suppressing harmful IFN signaling, boosting phagocytosis, & reducing microglial senescence www.nature.com/articles/s41...
A myeloid trisomy 21-associated gene variant is protective from Alzheimer’s disease - Nature Neuroscience
Engineering human microglia with a Down-syndrome-linked myeloid gene variant resists tau-induced dysfunction and protects neurons in chimeric brains, offering proof of concept for transformative micro...
www.nature.com
November 27, 2025 at 1:57 AM
Thank you so much for highlighting our work!
An idea we started in 2019 is now published in @natneuro.nature.com! Excited to share our new study: rdcu.be/eRvdA
Congrats to Mengmeng Jin and our team! Heartfelt thanks to all collaborators for their support, and to the reviewers for their insightful comments!
Congrats to Mengmeng Jin and our team! Heartfelt thanks to all collaborators for their support, and to the reviewers for their insightful comments!
November 24, 2025 at 2:17 PM
An idea we started in 2019 is now published in @natneuro.nature.com! Excited to share our new study: rdcu.be/eRvdA
Congrats to Mengmeng Jin and our team! Heartfelt thanks to all collaborators for their support, and to the reviewers for their insightful comments!
Congrats to Mengmeng Jin and our team! Heartfelt thanks to all collaborators for their support, and to the reviewers for their insightful comments!
Thrilled to share our review just published in @cp-neuron.bsky.social ! 🎉
Big shoutout to Ava, Mengmeng, and our entire team!
authors.elsevier.com/a/1k-uh3BtfH...
Big shoutout to Ava, Mengmeng, and our entire team!
authors.elsevier.com/a/1k-uh3BtfH...
April 28, 2025 at 4:18 PM
Thrilled to share our review just published in @cp-neuron.bsky.social ! 🎉
Big shoutout to Ava, Mengmeng, and our entire team!
authors.elsevier.com/a/1k-uh3BtfH...
Big shoutout to Ava, Mengmeng, and our entire team!
authors.elsevier.com/a/1k-uh3BtfH...
Reposted by Peng Jiang Lab@Rutgers
Hopefully a little inspiration for our trainees...this was led by an amazing postdoc at UPitt..Dr. Jean Liou
March 7, 2025 at 12:54 AM
Hopefully a little inspiration for our trainees...this was led by an amazing postdoc at UPitt..Dr. Jean Liou
Advancements in 3D models for studying human iPSC-microglia: Insights ... www.sciencedirect.com/science/arti...
Advancements in 3D models for studying human iPSC-microglia: Insights into neurodevelopment and neurological disorders
Microglia are immune cells of the central nervous system, playing a vital role in brain development, homeostasis, and disease. When these cells become…
www.sciencedirect.com
February 8, 2025 at 4:53 PM
Advancements in 3D models for studying human iPSC-microglia: Insights ... www.sciencedirect.com/science/arti...
Reposted by Peng Jiang Lab@Rutgers
Reposted by Peng Jiang Lab@Rutgers
Human longevity and Alzheimer’s disease variants act via microglia and oligodendrocyte gene networks
academic.oup.com/brain/advanc...
academic.oup.com/brain/advanc...
Human longevity and Alzheimer’s disease variants act via microglia and oligodendrocyte gene networks
Graham et al. show that Alzheimer's disease-associated genetic variants are enriched in gene networks expressed by microglia and oligodendrocytes during ag
academic.oup.com
January 13, 2025 at 2:23 PM
Human longevity and Alzheimer’s disease variants act via microglia and oligodendrocyte gene networks
academic.oup.com/brain/advanc...
academic.oup.com/brain/advanc...
