Peng Jiang Lab@Rutgers
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jianglab.bsky.social
Peng Jiang Lab@Rutgers
@jianglab.bsky.social
Create hPSC #organoid brain & #chimeric brain to study #neurodevelopment, #aging, #DownSyndrome, #Alzheimers, & #Autism; develop #glial cell replacement therapies. https://cbn.rutgers.edu/peng-jiang-lab/339-peng-jiang-lab
This review was actually written once before (the section on methodological considerations for creating chimeric models is shown in the image below), but it didn’t make it to publication at the time.
April 28, 2025 at 4:18 PM
I was inspired by Dr. Suchun Zhang’s work on differentiating human PSCs + transplanting them into mice, and Dr. Steven Goldman’s work on human oligodendroglia taking over mouse brains.

We discussed the idea of chimeric models in our 2014 Nat Commun paper 👇
April 28, 2025 at 4:18 PM
Thrilled to share our review just published in @cp-neuron.bsky.social ! 🎉
Big shoutout to Ava, Mengmeng, and our entire team!
authors.elsevier.com/a/1k-uh3BtfH...
April 28, 2025 at 4:18 PM