Peng Jiang Lab@Rutgers
@jianglab.bsky.social
Create hPSC #organoid brain & #chimeric brain to study #neurodevelopment, #aging, #DownSyndrome, #Alzheimers, & #Autism; develop #glial cell replacement therapies. https://cbn.rutgers.edu/peng-jiang-lab/339-peng-jiang-lab
We also discuss technical challenges and share ideas to improve current models—making them more effective and broadly applicable.
We’re excited about the growing potential of chimeric brain models, and hope this piece sparks new ideas, collaborations, and progress in the field!
We’re excited about the growing potential of chimeric brain models, and hope this piece sparks new ideas, collaborations, and progress in the field!
April 28, 2025 at 4:18 PM
We also discuss technical challenges and share ideas to improve current models—making them more effective and broadly applicable.
We’re excited about the growing potential of chimeric brain models, and hope this piece sparks new ideas, collaborations, and progress in the field!
We’re excited about the growing potential of chimeric brain models, and hope this piece sparks new ideas, collaborations, and progress in the field!
• Enable glial replacement strategies: studying interactions between diseased human glia and newly engrafted replacement human glia
• Study In vivo reprogramming of glia to neurons
• Combine with single-cell and functional assays to deepen the understanding of the human brain
• Study In vivo reprogramming of glia to neurons
• Combine with single-cell and functional assays to deepen the understanding of the human brain
April 28, 2025 at 4:18 PM
• Enable glial replacement strategies: studying interactions between diseased human glia and newly engrafted replacement human glia
• Study In vivo reprogramming of glia to neurons
• Combine with single-cell and functional assays to deepen the understanding of the human brain
• Study In vivo reprogramming of glia to neurons
• Combine with single-cell and functional assays to deepen the understanding of the human brain
• Reveal human-specific brain development & aging processes
• Uncover mechanisms of neurodevelopmental (e.g., autism) and neurodegenerative (e.g., Alzheimer’s) disorders
• Uncover mechanisms of neurodevelopmental (e.g., autism) and neurodegenerative (e.g., Alzheimer’s) disorders
April 28, 2025 at 4:18 PM
• Reveal human-specific brain development & aging processes
• Uncover mechanisms of neurodevelopmental (e.g., autism) and neurodegenerative (e.g., Alzheimer’s) disorders
• Uncover mechanisms of neurodevelopmental (e.g., autism) and neurodegenerative (e.g., Alzheimer’s) disorders
In this review, we center around one key idea: unlock.
How can chimeric brain models unlock the mysteries of human brain development, aging, and disease?
We discussed how these chimeric models can: 👇
How can chimeric brain models unlock the mysteries of human brain development, aging, and disease?
We discussed how these chimeric models can: 👇
April 28, 2025 at 4:18 PM
In this review, we center around one key idea: unlock.
How can chimeric brain models unlock the mysteries of human brain development, aging, and disease?
We discussed how these chimeric models can: 👇
How can chimeric brain models unlock the mysteries of human brain development, aging, and disease?
We discussed how these chimeric models can: 👇
Recently, with strong support from the team, we rebuilt it from scratch—and @cp-neuron.bsky.social gave it a home!
Big thanks to the reviewers for their thoughtful and constructive feedback!
Big thanks to the reviewers for their thoughtful and constructive feedback!
April 28, 2025 at 4:18 PM
Recently, with strong support from the team, we rebuilt it from scratch—and @cp-neuron.bsky.social gave it a home!
Big thanks to the reviewers for their thoughtful and constructive feedback!
Big thanks to the reviewers for their thoughtful and constructive feedback!
This review was actually written once before (the section on methodological considerations for creating chimeric models is shown in the image below), but it didn’t make it to publication at the time.
April 28, 2025 at 4:18 PM
This review was actually written once before (the section on methodological considerations for creating chimeric models is shown in the image below), but it didn’t make it to publication at the time.
Since starting my lab, we’ve made chimeric brain models a core focus. Our team published studies on the human microglia chimeric brain model and applied chimeric models to investigate disease mechanisms.
April 28, 2025 at 4:18 PM
Since starting my lab, we’ve made chimeric brain models a core focus. Our team published studies on the human microglia chimeric brain model and applied chimeric models to investigate disease mechanisms.
I was inspired by Dr. Suchun Zhang’s work on differentiating human PSCs + transplanting them into mice, and Dr. Steven Goldman’s work on human oligodendroglia taking over mouse brains.
We discussed the idea of chimeric models in our 2014 Nat Commun paper 👇
We discussed the idea of chimeric models in our 2014 Nat Commun paper 👇
April 28, 2025 at 4:18 PM
I was inspired by Dr. Suchun Zhang’s work on differentiating human PSCs + transplanting them into mice, and Dr. Steven Goldman’s work on human oligodendroglia taking over mouse brains.
We discussed the idea of chimeric models in our 2014 Nat Commun paper 👇
We discussed the idea of chimeric models in our 2014 Nat Commun paper 👇
The idea for this review has been a long time in the making.
Back during my postdoc, I often discussed “no brainer” mice (mice lacking cortical structures) with my mentor Dr. Wenbin Deng, which sparked my curiosity about human cell engraftment in the mouse brain.
Back during my postdoc, I often discussed “no brainer” mice (mice lacking cortical structures) with my mentor Dr. Wenbin Deng, which sparked my curiosity about human cell engraftment in the mouse brain.
April 28, 2025 at 4:18 PM
The idea for this review has been a long time in the making.
Back during my postdoc, I often discussed “no brainer” mice (mice lacking cortical structures) with my mentor Dr. Wenbin Deng, which sparked my curiosity about human cell engraftment in the mouse brain.
Back during my postdoc, I often discussed “no brainer” mice (mice lacking cortical structures) with my mentor Dr. Wenbin Deng, which sparked my curiosity about human cell engraftment in the mouse brain.