Jerzy Szablowski
@jerzyszablowski.bsky.social
Assistant Professor at Rice Univ. Bioengineering. Developing molecular tools to interact with the brain and treat brain disorders.
Co-founder at Imprint Bio. Inc. NIH New Innovator, Packard Fellow, and DARPA YFA awardee.
www.szablowskilab.org
Co-founder at Imprint Bio. Inc. NIH New Innovator, Packard Fellow, and DARPA YFA awardee.
www.szablowskilab.org
Reposted by Jerzy Szablowski
How can serum marker tests be made more sensitive? The lab of @jerzyszablowski.bsky.social shows that editing markers in vivo to reduce their half-life can provide more sensitive measurement of gene expression dynamics. Read more:
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
December 3, 2025 at 3:59 PM
How can serum marker tests be made more sensitive? The lab of @jerzyszablowski.bsky.social shows that editing markers in vivo to reduce their half-life can provide more sensitive measurement of gene expression dynamics. Read more:
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Addgene now has the NHP-RMAs available - the synthetic serum markers for measuring transgene and Cre-dependent expression, from the preprint (www.biorxiv.org/content/10.1...) with @vincentcostaphd.bsky.social lab.
plasmids for order:
www.addgene.org/browse/artic...
plasmids for order:
www.addgene.org/browse/artic...
Addgene: Synthetic Serum Markers Enable Noninvasive Monitoring of Gene Expression in Primate Brains
www.addgene.org
June 4, 2025 at 4:53 PM
Addgene now has the NHP-RMAs available - the synthetic serum markers for measuring transgene and Cre-dependent expression, from the preprint (www.biorxiv.org/content/10.1...) with @vincentcostaphd.bsky.social lab.
plasmids for order:
www.addgene.org/browse/artic...
plasmids for order:
www.addgene.org/browse/artic...
How can you know if gene delivery in a primate worked Typically through expensive scans or histology. With
@vincentcostaphd.bsky.social
and co-authors we made synthetic markers that monitor gene delivery and Cre-dependent expression with a blood test:
www.biorxiv.org/content/10.1...
@vincentcostaphd.bsky.social
and co-authors we made synthetic markers that monitor gene delivery and Cre-dependent expression with a blood test:
www.biorxiv.org/content/10.1...
June 2, 2025 at 11:45 PM
How can you know if gene delivery in a primate worked Typically through expensive scans or histology. With
@vincentcostaphd.bsky.social
and co-authors we made synthetic markers that monitor gene delivery and Cre-dependent expression with a blood test:
www.biorxiv.org/content/10.1...
@vincentcostaphd.bsky.social
and co-authors we made synthetic markers that monitor gene delivery and Cre-dependent expression with a blood test:
www.biorxiv.org/content/10.1...
What is the next frontier in brain therapy? Small molecules act everywhere; our work targets brain regions with mm precision. Next frontier? Targeting microscale - neuronal connections, ensembles. Here, we test AAV9.retro for noninvasive transduction of neuronal projections. preprint comments
April 26, 2025 at 8:53 PM
What is the next frontier in brain therapy? Small molecules act everywhere; our work targets brain regions with mm precision. Next frontier? Targeting microscale - neuronal connections, ensembles. Here, we test AAV9.retro for noninvasive transduction of neuronal projections. preprint comments
Reposted by Jerzy Szablowski
The MIT McGovern Institute’s story celebrating the 10th birthday of expansion microscopy (ExM). One highlight: ExM is not only easy to do, it’s easy to modify - so lots of people are altering and applying ExM for custom purposes, leading to unexpected innovations: mcgovern.mit.edu/2025/03/03/t...
March 10, 2025 at 12:20 PM
The MIT McGovern Institute’s story celebrating the 10th birthday of expansion microscopy (ExM). One highlight: ExM is not only easy to do, it’s easy to modify - so lots of people are altering and applying ExM for custom purposes, leading to unexpected innovations: mcgovern.mit.edu/2025/03/03/t...
Reposted by Jerzy Szablowski
Posting this image of neurons transfected to secrete proteins that @jerzyszablowski.bsky.social bioengineered to enable noninvasive monitoring of neuronal integrity in NHPs for #fluorescentfriday.
This technology will eventually lead to improved treatments for neurodegenerative disorders.
This technology will eventually lead to improved treatments for neurodegenerative disorders.
March 7, 2025 at 3:19 PM
Posting this image of neurons transfected to secrete proteins that @jerzyszablowski.bsky.social bioengineered to enable noninvasive monitoring of neuronal integrity in NHPs for #fluorescentfriday.
This technology will eventually lead to improved treatments for neurodegenerative disorders.
This technology will eventually lead to improved treatments for neurodegenerative disorders.
We are starting our
@ARIA_research
Precision Neurotechnologies project and have two non-postdoc positions in neuroscience and bioengineering. This funding is independent of US government.
Jobs:
emdz.fa.us2.oraclecloud.com/hcmUI/Candid...
More info:
tinyurl.com/hwsnrwpe
-- please RT --
@ARIA_research
Precision Neurotechnologies project and have two non-postdoc positions in neuroscience and bioengineering. This funding is independent of US government.
Jobs:
emdz.fa.us2.oraclecloud.com/hcmUI/Candid...
More info:
tinyurl.com/hwsnrwpe
-- please RT --
February 17, 2025 at 11:26 PM
We are starting our
@ARIA_research
Precision Neurotechnologies project and have two non-postdoc positions in neuroscience and bioengineering. This funding is independent of US government.
Jobs:
emdz.fa.us2.oraclecloud.com/hcmUI/Candid...
More info:
tinyurl.com/hwsnrwpe
-- please RT --
@ARIA_research
Precision Neurotechnologies project and have two non-postdoc positions in neuroscience and bioengineering. This funding is independent of US government.
Jobs:
emdz.fa.us2.oraclecloud.com/hcmUI/Candid...
More info:
tinyurl.com/hwsnrwpe
-- please RT --
Did you all start sciencing harder recently, or something?
February 6, 2025 at 6:35 PM
Did you all start sciencing harder recently, or something?
Reposted by Jerzy Szablowski
A quick reminder: For every $1 of research funding, NIH generated $2.46 in economic activity. This includes funding jobs in all 50 states. This isn't a red/blue thing: 8.9 jobs per $1M in CA & 12 jobs per $1M in GA. #AcademicSky #PhDSky #MedSky #HealthSky #healthequity #SciComm
bit.ly/40NkIc0
bit.ly/40NkIc0
www.unitedformedicalresearch.org
January 24, 2025 at 8:35 PM
A quick reminder: For every $1 of research funding, NIH generated $2.46 in economic activity. This includes funding jobs in all 50 states. This isn't a red/blue thing: 8.9 jobs per $1M in CA & 12 jobs per $1M in GA. #AcademicSky #PhDSky #MedSky #HealthSky #healthequity #SciComm
bit.ly/40NkIc0
bit.ly/40NkIc0
I am looking forward to working with @LignaniLab_UCL and others on this @ARIA_research neurotechnologies grant. A ~$2.5m contribution to our lab's work that will help us make next generation noninvasive brain therapies for specific brain circuits.
news.rice.edu/news/2025/ri...
news.rice.edu/news/2025/ri...
news.rice.edu
January 21, 2025 at 11:58 PM
I am looking forward to working with @LignaniLab_UCL and others on this @ARIA_research neurotechnologies grant. A ~$2.5m contribution to our lab's work that will help us make next generation noninvasive brain therapies for specific brain circuits.
news.rice.edu/news/2025/ri...
news.rice.edu/news/2025/ri...
Reposted by Jerzy Szablowski
If some calcium enters a dendrite, how far does it diffuse? Rebecca Frank Hayward (who is on the job market!) measured this. www.sciencedirect.com/science/arti...
She combined a blue light-activated Ca++ channel with a red-fluorescent Ca++ sensor. The length constant is about 5 microns.
She combined a blue light-activated Ca++ channel with a red-fluorescent Ca++ sensor. The length constant is about 5 microns.
All-optical mapping of Ca2+ transport and homeostasis in dendrites
Calcium mediates many important signals in dendrites. However, the basic transport properties of calcium in dendrites have been difficult to measure: …
www.sciencedirect.com
December 12, 2024 at 9:02 PM
If some calcium enters a dendrite, how far does it diffuse? Rebecca Frank Hayward (who is on the job market!) measured this. www.sciencedirect.com/science/arti...
She combined a blue light-activated Ca++ channel with a red-fluorescent Ca++ sensor. The length constant is about 5 microns.
She combined a blue light-activated Ca++ channel with a red-fluorescent Ca++ sensor. The length constant is about 5 microns.
Reposted by Jerzy Szablowski
We designed MS2 and PP7 binding coat proteins that are degraded in cells except when bound by their hairpin RNAs.
You can check out our pre-print here: tinyurl.com/27p7hyt9,
and listen to a Google AI-generated podcast on it here: notebooklm.google.com/notebook/d71...
You can check out our pre-print here: tinyurl.com/27p7hyt9,
and listen to a Google AI-generated podcast on it here: notebooklm.google.com/notebook/d71...
November 30, 2024 at 8:48 PM
We designed MS2 and PP7 binding coat proteins that are degraded in cells except when bound by their hairpin RNAs.
You can check out our pre-print here: tinyurl.com/27p7hyt9,
and listen to a Google AI-generated podcast on it here: notebooklm.google.com/notebook/d71...
You can check out our pre-print here: tinyurl.com/27p7hyt9,
and listen to a Google AI-generated podcast on it here: notebooklm.google.com/notebook/d71...
qPCR can measure expression of virtually any gene... in homogenized tissues. Here, we show an "in-vivo qPCR" equivalent, where we measure a sequence-specific transcript with synthetic serum markers and enzyme-based signal amplification.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 12, 2024 at 4:51 PM
qPCR can measure expression of virtually any gene... in homogenized tissues. Here, we show an "in-vivo qPCR" equivalent, where we measure a sequence-specific transcript with synthetic serum markers and enzyme-based signal amplification.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Jerzy Szablowski
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
December 11, 2024 at 4:29 PM
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
Reposted by Jerzy Szablowski
"E11 Bio is excited to share a major step towards brain mapping at 100x lower cost, making whole-brain connectomics at human & mouse scale feasible (🧠→🔬→💻). Critical for curing brain disorders, building human-like AI systems, and even simulating human brains." -CEO Andrew Payne e11.bio/news/roadmap
E11 Bio Roadmap | E11 Bio
e11.bio
December 3, 2024 at 3:41 PM
"E11 Bio is excited to share a major step towards brain mapping at 100x lower cost, making whole-brain connectomics at human & mouse scale feasible (🧠→🔬→💻). Critical for curing brain disorders, building human-like AI systems, and even simulating human brains." -CEO Andrew Payne e11.bio/news/roadmap
Our recent study now out in print at Nature Biotech: Gene expression in the mouse brain is measured with a simple blood draw go.nature.com/48NC0a5
rdcu.be/d1rY1
rdcu.be/d1rY1
Engineered serum markers for non-invasive monitoring of gene expression in the brain - Nature Biotechnology
Gene expression in the mouse brain is measured with a simple blood draw.
go.nature.com
December 9, 2024 at 4:30 PM
Our recent study now out in print at Nature Biotech: Gene expression in the mouse brain is measured with a simple blood draw go.nature.com/48NC0a5
rdcu.be/d1rY1
rdcu.be/d1rY1
Reposted by Jerzy Szablowski
Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..
December 4, 2024 at 4:05 PM
Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..
We have two postdoc positions coming up for early next year in NHP neuroscience with FUS-BBBO and molecular engineering foci. Let me know if you know someone interested!
November 28, 2024 at 4:02 PM
We have two postdoc positions coming up for early next year in NHP neuroscience with FUS-BBBO and molecular engineering foci. Let me know if you know someone interested!
Reposted by Jerzy Szablowski
Excited to share a new review on Magnets for Mechanobiology - teamed up w/ fellow 🧲 enthusiasts from Boston/Madrid/Zurich/Singapore to share how we manipulate cellular microenvironments w/ magnetic fields! Thanks to @danielgmadrid11.bsky.social for bringing us together!
doi.org/10.1002/aisy...
doi.org/10.1002/aisy...
Magnetic Actuation for Mechanomedicine
In this perspective, the emergence of magneto-mechanical actuation systems in biomedical research and mechanomedicine is explored. These materials, ranging from single particles to 3D scaffolds, enab...
doi.org
November 25, 2024 at 2:03 PM
Excited to share a new review on Magnets for Mechanobiology - teamed up w/ fellow 🧲 enthusiasts from Boston/Madrid/Zurich/Singapore to share how we manipulate cellular microenvironments w/ magnetic fields! Thanks to @danielgmadrid11.bsky.social for bringing us together!
doi.org/10.1002/aisy...
doi.org/10.1002/aisy...
We got a summary statement from NIH just 17 days after the study section. Is that a new record?
November 21, 2024 at 7:43 PM
We got a summary statement from NIH just 17 days after the study section. Is that a new record?
I am looking forward to coming back to
@MIT for Neurotech 2024 tomorrow in Bldg 46!
I will talk about noninvasive interfacing with the brain, including new projects with our postdoc Sho Watanabe and collaborators @vincentcostaphd.bsky.social and Rui Chen (UCI).
neurotech.mit.edu
@MIT for Neurotech 2024 tomorrow in Bldg 46!
I will talk about noninvasive interfacing with the brain, including new projects with our postdoc Sho Watanabe and collaborators @vincentcostaphd.bsky.social and Rui Chen (UCI).
neurotech.mit.edu
neurotech.mit.edu
neurotech.mit.edu
November 19, 2024 at 6:16 PM
I am looking forward to coming back to
@MIT for Neurotech 2024 tomorrow in Bldg 46!
I will talk about noninvasive interfacing with the brain, including new projects with our postdoc Sho Watanabe and collaborators @vincentcostaphd.bsky.social and Rui Chen (UCI).
neurotech.mit.edu
@MIT for Neurotech 2024 tomorrow in Bldg 46!
I will talk about noninvasive interfacing with the brain, including new projects with our postdoc Sho Watanabe and collaborators @vincentcostaphd.bsky.social and Rui Chen (UCI).
neurotech.mit.edu
Reposted by Jerzy Szablowski
What happens when you can take videos of acoustic proteins in 3D inside the body? 🧊 You can see things like the flow of CSF in the brain! 🧠
Congrats to Sunho Lee, co-senior author Claire Rabut, and colleagues on "Takoyaki" ultrasound. 🥟 #gasvesicles www.biorxiv.org/content/10.1...
Congrats to Sunho Lee, co-senior author Claire Rabut, and colleagues on "Takoyaki" ultrasound. 🥟 #gasvesicles www.biorxiv.org/content/10.1...
November 18, 2024 at 6:26 PM
What happens when you can take videos of acoustic proteins in 3D inside the body? 🧊 You can see things like the flow of CSF in the brain! 🧠
Congrats to Sunho Lee, co-senior author Claire Rabut, and colleagues on "Takoyaki" ultrasound. 🥟 #gasvesicles www.biorxiv.org/content/10.1...
Congrats to Sunho Lee, co-senior author Claire Rabut, and colleagues on "Takoyaki" ultrasound. 🥟 #gasvesicles www.biorxiv.org/content/10.1...