Jason C.L. Tong
@jasontongdphil.bsky.social
DPhil student in the Radcliffe Department of Medicine, @ox.ac.uk
Reposted by Jason C.L. Tong
Our latest assessment of 3 widely used GLP-1R antisera independently with @daveyboyhod Some are useful, others not fit for purpose. Use of non-validated antisera sows confusion in the field and creates problems that are difficult to later rectify www.cell.com/cell-metabol...
Reassessment of antibody-based detection of the murine T cell GLP-1 receptor
Glucagon-like peptide 1 receptor (GLP-1R) agonists exhibit anti-inflammatory actions,
yet the importance of direct immune cell GLP-1R signaling remains uncertain. Although
T cells respond to GLP-1, lo...
www.cell.com
September 2, 2025 at 2:48 PM
Our latest assessment of 3 widely used GLP-1R antisera independently with @daveyboyhod Some are useful, others not fit for purpose. Use of non-validated antisera sows confusion in the field and creates problems that are difficult to later rectify www.cell.com/cell-metabol...
So grateful to have worked on this project with such a talented team across multiple labs – we got to do lots of very beautiful and exciting imaging!
August 21, 2025 at 11:10 AM
So grateful to have worked on this project with such a talented team across multiple labs – we got to do lots of very beautiful and exciting imaging!
Reposted by Jason C.L. Tong
Reposted by Jason C.L. Tong
This is a *pretty amazing* paper--really fascinating implications for those who wish the field would finally begin to look into #cellbio
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...
Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication
Tong et al. utilize advanced imaging approaches to reveal that beta cells located
next to alpha cells are specially adapted as glucagon sensors by virtue of their high
expression levels of GLP1R. Thes...
www.cell.com
July 18, 2025 at 8:34 PM
This is a *pretty amazing* paper--really fascinating implications for those who wish the field would finally begin to look into #cellbio
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...
Reposted by Jason C.L. Tong
Tong et al. show that beta cells adjacent to alpha cells are equipped as glucagon sensors by virtue of glucagon-like peptide-1 receptor enrichment and disproportionately contribute to alpha cell regulation of beta cell function. 🧪
#PancSky
www.cell.com/cell-metabol...
#PancSky
www.cell.com/cell-metabol...
Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication
Tong et al. utilize advanced imaging approaches to reveal that beta cells located
next to alpha cells are specially adapted as glucagon sensors by virtue of their high
expression levels of GLP1R. Thes...
www.cell.com
July 15, 2025 at 9:14 AM
Tong et al. show that beta cells adjacent to alpha cells are equipped as glucagon sensors by virtue of glucagon-like peptide-1 receptor enrichment and disproportionately contribute to alpha cell regulation of beta cell function. 🧪
#PancSky
www.cell.com/cell-metabol...
#PancSky
www.cell.com/cell-metabol...
Reposted by Jason C.L. Tong
A regulated pathway through which glucagon modulates insulin release via alpha to beta cell communication and control of GLP-1R internalization and beta cell Ca2+ responses to high glucose @cp-cellmetabolism.bsky.social @daveyboyhod.bsky.social #islets www.cell.com/cell-metabol...
Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication
Tong et al. utilize advanced imaging approaches to reveal that beta cells located
next to alpha cells are specially adapted as glucagon sensors by virtue of their high
expression levels of GLP1R. Thes...
www.cell.com
July 15, 2025 at 9:43 PM
A regulated pathway through which glucagon modulates insulin release via alpha to beta cell communication and control of GLP-1R internalization and beta cell Ca2+ responses to high glucose @cp-cellmetabolism.bsky.social @daveyboyhod.bsky.social #islets www.cell.com/cell-metabol...
Reposted by Jason C.L. Tong
Pretty elegant study showing how glucagon can activate GLP1 receptors in beta cells in a paracrine fashion, especially if an alpha cell borders a beta cell, which then helps with insulin release.
Online now: Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication
Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication
Tong et al. utilize advanced imaging approaches to reveal that beta cells located next to alpha cells are specially adapted as glucagon sensors by virtue of their high expression levels of GLP1R. These beta cells respond first to rising glucose, triggering robust responses across the pancreatic islet.
dlvr.it
July 14, 2025 at 5:05 PM
Pretty elegant study showing how glucagon can activate GLP1 receptors in beta cells in a paracrine fashion, especially if an alpha cell borders a beta cell, which then helps with insulin release.
Reposted by Jason C.L. Tong
Online now: Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication
Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication
Tong et al. utilize advanced imaging approaches to reveal that beta cells located next to alpha cells are specially adapted as glucagon sensors by virtue of their high expression levels of GLP1R. These beta cells respond first to rising glucose, triggering robust responses across the pancreatic islet.
dlvr.it
July 14, 2025 at 3:43 PM
Online now: Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication
Thrilled to have won the Poster Prize at @rdmoxford.bsky.social Day 2025! Thanks to all that have made the work possible, especially my supervisor Prof. David Hodson, the judges for listening to my presentation, and to everyone who came along and asked insightful questions and gave great feedback!
March 17, 2025 at 11:08 PM
Thrilled to have won the Poster Prize at @rdmoxford.bsky.social Day 2025! Thanks to all that have made the work possible, especially my supervisor Prof. David Hodson, the judges for listening to my presentation, and to everyone who came along and asked insightful questions and gave great feedback!