Dr. Jake P. Mann
@jakepmann.bsky.social
I am excited to have arrived in Helsinki for @espghansociety.bsky.social Annual Meeting.
I’ll be presenting some more of our biliary atresia data and recording a very exciting in-person version of the ESPGHAN podcast.
I’ll be presenting some more of our biliary atresia data and recording a very exciting in-person version of the ESPGHAN podcast.
May 13, 2025 at 8:34 PM
I am excited to have arrived in Helsinki for @espghansociety.bsky.social Annual Meeting.
I’ll be presenting some more of our biliary atresia data and recording a very exciting in-person version of the ESPGHAN podcast.
I’ll be presenting some more of our biliary atresia data and recording a very exciting in-person version of the ESPGHAN podcast.
Here's a preprint of our work where we found that most genes which cause monogenic, severe liver disease also affect the onset and/or severity of liver-related traits in adults.
[Not yet peer reviewed.]
doi.org/10.1101/2025...
[Not yet peer reviewed.]
doi.org/10.1101/2025...
Genes that cause severe liver disease in children also influence risk and severity of common liver conditions in adults
Background and aims Rare, pathogenic variants in multiple genes can cause severe liver disease, requiring transplantation in childhood, but it is unclear whether common variants in the same genes conf...
doi.org
May 13, 2025 at 7:18 AM
Here's a preprint of our work where we found that most genes which cause monogenic, severe liver disease also affect the onset and/or severity of liver-related traits in adults.
[Not yet peer reviewed.]
doi.org/10.1101/2025...
[Not yet peer reviewed.]
doi.org/10.1101/2025...
Thanks! I suggest annotating the axis on the figure next time.
May 13, 2025 at 7:18 AM
Thanks! I suggest annotating the axis on the figure next time.
Important stuff, but what is the x-axis here? It’s hard to interpret the graph otherwise.
May 12, 2025 at 11:00 AM
Important stuff, but what is the x-axis here? It’s hard to interpret the graph otherwise.
I’m at @easlnews.bsky.social Congress in Amsterdam this week and sharing some of our biliary atresia data tomorrow
May 7, 2025 at 10:21 AM
I’m at @easlnews.bsky.social Congress in Amsterdam this week and sharing some of our biliary atresia data tomorrow
Reposted by Dr. Jake P. Mann
The Finisher: Jasmin Paris and the Barkley Marathons. A wonderful film about wonderful people, and an incredibly inspiring Jasmin.
The Finisher: Jasmin Paris and the Barkley Marathons (Full Documentary)
In 2024, Jasmin Paris made history by becoming the first woman to finish the Barkley Marathons, widely known as one of the hardest races in the world and a d...
www.youtube.com
April 21, 2025 at 8:43 AM
The Finisher: Jasmin Paris and the Barkley Marathons. A wonderful film about wonderful people, and an incredibly inspiring Jasmin.
Reposted by Dr. Jake P. Mann
Here we are in Spanish talking liver health. #WorldLiverDay
Hoy, #DíaMundialDelHígado, hablamos de la enfermedad hepática crónica más frecuente del mundo y cómo prevenirla.
¡Ciencia #EnMenosDeUnMinuto para que ganes un quesito verde en el Trivial Pursuit!
Puedes ver más de esta serie en nuestro #TikTok: 🟠https://bit.ly/ISGlobal_TikTok
¡Ciencia #EnMenosDeUnMinuto para que ganes un quesito verde en el Trivial Pursuit!
Puedes ver más de esta serie en nuestro #TikTok: 🟠https://bit.ly/ISGlobal_TikTok
April 19, 2025 at 4:47 PM
Here we are in Spanish talking liver health. #WorldLiverDay
I would define inflammation to encompass fibroblast activation so the two are intimately linked. Precisely what flavour of inflammation is a different question, and whether it can be detected with our standard histopathological assessment.
April 20, 2025 at 2:00 PM
I would define inflammation to encompass fibroblast activation so the two are intimately linked. Precisely what flavour of inflammation is a different question, and whether it can be detected with our standard histopathological assessment.
Reposted by Dr. Jake P. Mann
Paediatric Liver Transplantation: A new perspective💡
How common is graft fibrosis in young recipients - and what does it mean long term?💭
Join Dr Steffen Hartleif on the latest #ESPGHAN podcast as he explores future strategies in immunosuppression.🔍
Listen now🎧 ow.ly/LWkE50Vlk1T
How common is graft fibrosis in young recipients - and what does it mean long term?💭
Join Dr Steffen Hartleif on the latest #ESPGHAN podcast as he explores future strategies in immunosuppression.🔍
Listen now🎧 ow.ly/LWkE50Vlk1T
April 20, 2025 at 8:30 AM
Paediatric Liver Transplantation: A new perspective💡
How common is graft fibrosis in young recipients - and what does it mean long term?💭
Join Dr Steffen Hartleif on the latest #ESPGHAN podcast as he explores future strategies in immunosuppression.🔍
Listen now🎧 ow.ly/LWkE50Vlk1T
How common is graft fibrosis in young recipients - and what does it mean long term?💭
Join Dr Steffen Hartleif on the latest #ESPGHAN podcast as he explores future strategies in immunosuppression.🔍
Listen now🎧 ow.ly/LWkE50Vlk1T
I remember seeing this work presented last year and it’s stunning.
Why do some patients remain healthy while others develop severe liver complications despite having the exact same genetic mutation in Alpha-1 Antitrypsin Deficiency?
Proud of being part of this project - Deep Visual Proteomics at single cell level
👉in @nature.com
www.nature.com/articles/s41...
Proud of being part of this project - Deep Visual Proteomics at single cell level
👉in @nature.com
www.nature.com/articles/s41...
April 16, 2025 at 7:38 PM
I remember seeing this work presented last year and it’s stunning.
2nd run of Visium HD complete 🫡
April 10, 2025 at 5:48 PM
2nd run of Visium HD complete 🫡
Reposted by Dr. Jake P. Mann
Love this ...
April 10, 2025 at 2:18 PM
Love this ...
The downside of being totally focused on functional experiments for my fellowship application is that I have become a '40 unread emails' person
April 9, 2025 at 9:53 AM
The downside of being totally focused on functional experiments for my fellowship application is that I have become a '40 unread emails' person
And here I am thinking that my multicolour immunofluorescence is pretty
ESA/Webb (@esa.int) images (Feb 28, 2025)
Explore NGC 2283, a barred spiral galaxy, revealing vibrant star formation and the remnants of supernova SN 2023AXU captured by #JamesWebb.
esawebb.org/images/potm2502a/
Explore NGC 2283, a barred spiral galaxy, revealing vibrant star formation and the remnants of supernova SN 2023AXU captured by #JamesWebb.
esawebb.org/images/potm2502a/
April 3, 2025 at 10:10 PM
And here I am thinking that my multicolour immunofluorescence is pretty
The real question is ‘will I ever find a paper that Alex (Knisley) thinks is free of major flaws?’
New #ESPGHAN podcast!🚀
Dr Jake Mann explores:
🔬Lactobacillus reuteri & Gastroenteritis – Do high-dose probiotics reduce diarrhoea duration?
📊Early Sugar Exposure – Could early sugar restriction lower diabetes & hypertension risk?
Tune in now!🎧ow.ly/MfcW50Vrwvk
Dr Jake Mann explores:
🔬Lactobacillus reuteri & Gastroenteritis – Do high-dose probiotics reduce diarrhoea duration?
📊Early Sugar Exposure – Could early sugar restriction lower diabetes & hypertension risk?
Tune in now!🎧ow.ly/MfcW50Vrwvk
April 1, 2025 at 6:35 PM
The real question is ‘will I ever find a paper that Alex (Knisley) thinks is free of major flaws?’
I’m back up in Edinburgh this week learning new spatial techniques and using some very rare paediatric samples.
All round quite exciting.
All round quite exciting.
March 27, 2025 at 7:02 AM
I’m back up in Edinburgh this week learning new spatial techniques and using some very rare paediatric samples.
All round quite exciting.
All round quite exciting.
I _think_ we needed to dilute our samples a bit more
March 4, 2025 at 5:19 PM
I _think_ we needed to dilute our samples a bit more
Reposted by Dr. Jake P. Mann
Anyone interested in working with me at Institute of Metabolic Science - Metabolic Research Laboratories, University of Cambridge, on how AMGEN's new obesity drug MariTide works? I have a 3 year postdoc position available! Deadline March 31st! please share www.jobs.cam.ac.uk/job/50529/
Research Associate (Fixed Term) - Job Opportunities - University of Cambridge
Research Associate (Fixed Term) in the Department of Clinical Biochemistry at the University of Cambridge.
www.jobs.cam.ac.uk
March 3, 2025 at 3:51 PM
Anyone interested in working with me at Institute of Metabolic Science - Metabolic Research Laboratories, University of Cambridge, on how AMGEN's new obesity drug MariTide works? I have a 3 year postdoc position available! Deadline March 31st! please share www.jobs.cam.ac.uk/job/50529/
True. I feel bad about the volume of steroids some of these kids have.
I know the nephrologists have some evidence to use one-off ritux in nephrotic syndrome so I would be interested to see the effect.
(Hopefully not devastating sepsis.)
I know the nephrologists have some evidence to use one-off ritux in nephrotic syndrome so I would be interested to see the effect.
(Hopefully not devastating sepsis.)
March 2, 2025 at 5:43 PM
True. I feel bad about the volume of steroids some of these kids have.
I know the nephrologists have some evidence to use one-off ritux in nephrotic syndrome so I would be interested to see the effect.
(Hopefully not devastating sepsis.)
I know the nephrologists have some evidence to use one-off ritux in nephrotic syndrome so I would be interested to see the effect.
(Hopefully not devastating sepsis.)
The study I want to see is a one-off dose of rituximab as induction then low dose pred + aza vs standard of care.
We give a lot more in kids. Usually 1mg/kg up to a maximum of 40mg/day at induction, then taper weekly as the enzymes improve.
We give a lot more in kids. Usually 1mg/kg up to a maximum of 40mg/day at induction, then taper weekly as the enzymes improve.
March 2, 2025 at 5:12 PM
The study I want to see is a one-off dose of rituximab as induction then low dose pred + aza vs standard of care.
We give a lot more in kids. Usually 1mg/kg up to a maximum of 40mg/day at induction, then taper weekly as the enzymes improve.
We give a lot more in kids. Usually 1mg/kg up to a maximum of 40mg/day at induction, then taper weekly as the enzymes improve.
I know I'm biased, but I'd say this is a particularly good one.
Keep sending me your feedback and requests!
Keep sending me your feedback and requests!
New #ESPGHAN Podcast!🔊
Join Dr Jake Mann for the JPGN Journal Club as he explores:
📌ALT trends in adolescents & MASLD risk
📌The gut microbiome’s link to lipids & neurodevelopment in malnourished children
Don’t miss these expert insights!🌟Listen now🎧 ow.ly/WfWu50V1azM
Join Dr Jake Mann for the JPGN Journal Club as he explores:
📌ALT trends in adolescents & MASLD risk
📌The gut microbiome’s link to lipids & neurodevelopment in malnourished children
Don’t miss these expert insights!🌟Listen now🎧 ow.ly/WfWu50V1azM
March 1, 2025 at 4:58 PM
I know I'm biased, but I'd say this is a particularly good one.
Keep sending me your feedback and requests!
Keep sending me your feedback and requests!
The CRUK Clinical PhD Programme at @unibirmingham.bsky.social is open for applications. This is an amazing opportunity.
If you're interested in applying, then I have project around the immunology of hepatocellular carcinoma (and also some HCC GWAS hits to follow-up) so get in touch!
If you're interested in applying, then I have project around the immunology of hepatocellular carcinoma (and also some HCC GWAS hits to follow-up) so get in touch!
Cancer Research UK Clinical PhDs at the University of Birmingham
A prestigious Cancer Research UK-funded doctoral training programme offering fully funded non-clinical and clinical PhD fellowships based at the CRUK Birmingham Cancer Centre.
www.birmingham.ac.uk
February 27, 2025 at 8:36 AM
The CRUK Clinical PhD Programme at @unibirmingham.bsky.social is open for applications. This is an amazing opportunity.
If you're interested in applying, then I have project around the immunology of hepatocellular carcinoma (and also some HCC GWAS hits to follow-up) so get in touch!
If you're interested in applying, then I have project around the immunology of hepatocellular carcinoma (and also some HCC GWAS hits to follow-up) so get in touch!
Reposted by Dr. Jake P. Mann
Nature research paper: Human-correlated genetic models identify precision therapy for liver cancer
https://go.nature.com/41qNkbs
https://go.nature.com/41qNkbs
Human-correlated genetic models identify precision therapy for liver cancer - Nature
As proof of principle, an analysis using a suite of human-aligned immunocompetent mouse models of hepatocellular carcinoma identifies a promising therapeutic candidate, cladribine, which acts in a highly effective subtype-specific manner in combination with standard-of-care therapy.
go.nature.com
February 25, 2025 at 8:45 AM
Nature research paper: Human-correlated genetic models identify precision therapy for liver cancer
https://go.nature.com/41qNkbs
https://go.nature.com/41qNkbs