Thanks! I suggest annotating the axis on the figure next time.

Important stuff, but what is the x-axis here? It’s hard to interpret the graph otherwise.

I would define inflammation to encompass fibroblast activation so the two are intimately linked. Precisely what flavour of inflammation is a different question, and whether it can be detected with our standard histopathological assessment.

True. I feel bad about the volume of steroids some of these kids have.

I know the nephrologists have some evidence to use one-off ritux in nephrotic syndrome so I would be interested to see the effect.

(Hopefully not devastating sepsis.)

The study I want to see is a one-off dose of rituximab as induction then low dose pred + aza vs standard of care.

We give a lot more in kids. Usually 1mg/kg up to a maximum of 40mg/day at induction, then taper weekly as the enzymes improve.