Iris
@irismarchal.bsky.social
Associate Editor Reviews @Nature Biotechnology. Views are my own.
Reposted by Iris
How do you detect transgenes in genome-edited crops? We tested several methods and report our findings in 2 back-to-back papers: onlinelibrary.wiley.com/doi/10.1111/...
rdcu.be/eLgUi
rdcu.be/eLgUi
Ensuring effective removal of transgenes before release of genome-edited crops
Nature Biotechnology - Genome editing technology is evolving fast, and many labs worldwide are generating crop plants with improved traits. If transgenes were used to generate the edits, foreign...
rdcu.be
October 16, 2025 at 7:26 AM
How do you detect transgenes in genome-edited crops? We tested several methods and report our findings in 2 back-to-back papers: onlinelibrary.wiley.com/doi/10.1111/...
rdcu.be/eLgUi
rdcu.be/eLgUi
Reposted by Iris
The COP16 decision established a multilateral mechanism for digital sequence information benefit-sharing. DSI researchers assess what has been accomplished so far and identify remaining challenges go.nature.com/4nBE4t8
rdcu.be/eJnid
rdcu.be/eJnid
October 3, 2025 at 8:08 PM
The COP16 decision established a multilateral mechanism for digital sequence information benefit-sharing. DSI researchers assess what has been accomplished so far and identify remaining challenges go.nature.com/4nBE4t8
rdcu.be/eJnid
rdcu.be/eJnid
Reposted by Iris
Redefining druggable targets with artificial intelligence - @wcmenglanderipm.bsky.social @aihealthmit.bsky.social go.nature.com/4fHNMYi
August 20, 2025 at 4:29 PM
Redefining druggable targets with artificial intelligence - @wcmenglanderipm.bsky.social @aihealthmit.bsky.social go.nature.com/4fHNMYi
How can we engineer B cells to treat diseases? Read about the latest developments of this exciting field in this new Review out now in @natbiotech.nature.com www.nature.com/articles/s41...
Engineering B cells to treat and study human disease - Nature Biotechnology
Recent developments in B cell engineering expand our ability to study human disease and drive progress toward new B cell therapies, balancing challenges in clinical implementation with emerging opport...
www.nature.com
August 6, 2025 at 7:55 AM
How can we engineer B cells to treat diseases? Read about the latest developments of this exciting field in this new Review out now in @natbiotech.nature.com www.nature.com/articles/s41...
Reposted by Iris
Can senolytics reverse or slow aging?
Table of companies pursuing this goal.
So far the results are questionable.
@natbiotech.nature.com
www.nature.com/articles/s41...
Table of companies pursuing this goal.
So far the results are questionable.
@natbiotech.nature.com
www.nature.com/articles/s41...
July 6, 2025 at 6:41 PM
Can senolytics reverse or slow aging?
Table of companies pursuing this goal.
So far the results are questionable.
@natbiotech.nature.com
www.nature.com/articles/s41...
Table of companies pursuing this goal.
So far the results are questionable.
@natbiotech.nature.com
www.nature.com/articles/s41...
Gene regulatory networks are crucial for understanding complex gene regulation in plants and could help improve crops for more sustainable and climate-resilient agriculture. Read about it in this Review out now in @natbiotech.nature.com www.nature.com/articles/s41...
Unlocking gene regulatory networks for crop resilience and sustainable agriculture - Nature Biotechnology
Gene regulatory networks are crucial for understanding complex gene regulation in plants and could advance crop improvement for more sustainable and climate-resilient agricultural practices.
www.nature.com
July 2, 2025 at 1:01 PM
Gene regulatory networks are crucial for understanding complex gene regulation in plants and could help improve crops for more sustainable and climate-resilient agriculture. Read about it in this Review out now in @natbiotech.nature.com www.nature.com/articles/s41...
This Review presents a classification system of hybrid engineered biological systems to support researchers in making design choices, out now in @natbiotech.nature.com www.nature.com/articles/s41...
Improving engineered biological systems with electronics and microfluidics - Nature Biotechnology
A classification of hybrid engineered biological systems is presented to support researchers in making design choices that expand their use.
www.nature.com
June 30, 2025 at 7:32 AM
This Review presents a classification system of hybrid engineered biological systems to support researchers in making design choices, out now in @natbiotech.nature.com www.nature.com/articles/s41...
Reposted by Iris
Anatomy of the 23andMe fall and implications for consumer genomics go.nature.com/3Hf6sBE
Anatomy of the 23andMe fall and implications for consumer genomics - Nature Biotechnology
23andMe’s bankruptcy serves as a moment of reflection for the direct-to-consumer (DTC) genomics industry. We analyzed 23andMe financial data and business practices to reveal the factors behind the fal...
go.nature.com
May 29, 2025 at 3:25 PM
Anatomy of the 23andMe fall and implications for consumer genomics go.nature.com/3Hf6sBE
Overcoming key hurdles for the development of next-generation anaerobic cultivation methods could have major impacts on microbial community research and applications. Read how in this new Perspective in @natbiotech.nature.com www.nature.com/articles/s41...
Enabling next-generation anaerobic cultivation through biotechnology to advance functional microbiome research - Nature Biotechnology
Overcoming key hurdles for the development of next-generation anaerobic cultivation methods could have major impacts on microbial community research and applications.
www.nature.com
May 5, 2025 at 1:40 PM
Overcoming key hurdles for the development of next-generation anaerobic cultivation methods could have major impacts on microbial community research and applications. Read how in this new Perspective in @natbiotech.nature.com www.nature.com/articles/s41...
Reposted by Iris
A call for built-in biosecurity safeguards for generative AI tools go.nature.com/3GIpTlR
A call for built-in biosecurity safeguards for generative AI tools - Nature Biotechnology
Nature Biotechnology - A call for built-in biosecurity safeguards for generative AI tools
go.nature.com
April 28, 2025 at 3:21 PM
A call for built-in biosecurity safeguards for generative AI tools go.nature.com/3GIpTlR
Reposted by Iris
Here we share thoughts on next-gen cultivation: rdcu.be/ejPSb. Hope it helps 😄 Was fun to write with great colleagues @lisamaierlab.bsky.social @jselkrig.bsky.social @baerboletta.bsky.social @typaslab.bsky.social @mmmicrobiomelab.bsky.social @leibniz-dsmz.bsky.social @westermannlab.bsky.social
Enabling next-generation anaerobic cultivation through biotechnology to advance functional microbiome research
Nature Biotechnology - Overcoming key hurdles for the development of next-generation anaerobic cultivation methods could have major impacts on microbial community research and applications.
rdcu.be
April 29, 2025 at 11:58 AM
Here we share thoughts on next-gen cultivation: rdcu.be/ejPSb. Hope it helps 😄 Was fun to write with great colleagues @lisamaierlab.bsky.social @jselkrig.bsky.social @baerboletta.bsky.social @typaslab.bsky.social @mmmicrobiomelab.bsky.social @leibniz-dsmz.bsky.social @westermannlab.bsky.social
Reposted by Iris
1/ We need new ways of producing foods and fuels to minimise our impact on our planet. Our new paper now in
@natbiotech.nature.com examines whether microbes hold the key to producing foods and fuels in the future
Open access: rdcu.be/eiIUu
nature.com/articles/s41...
@natbiotech.nature.com examines whether microbes hold the key to producing foods and fuels in the future
Open access: rdcu.be/eiIUu
nature.com/articles/s41...
April 23, 2025 at 12:26 PM
1/ We need new ways of producing foods and fuels to minimise our impact on our planet. Our new paper now in
@natbiotech.nature.com examines whether microbes hold the key to producing foods and fuels in the future
Open access: rdcu.be/eiIUu
nature.com/articles/s41...
@natbiotech.nature.com examines whether microbes hold the key to producing foods and fuels in the future
Open access: rdcu.be/eiIUu
nature.com/articles/s41...
The development of therapeutic cancer vaccines is seeing exciting progress recently. Curious how researchers are dealing with challenges to translate new technologies to the clinic? @natbiotech.nature.com asked experts for an update. www.nature.com/articles/s41...
Cancer vaccines: the experts speak - Nature Biotechnology
The development of therapeutic cancer vaccines has long been a promising yet challenging field of research. While early efforts were impeded by limited efficacy and immune escape, recent advances in i...
www.nature.com
April 17, 2025 at 1:06 PM
The development of therapeutic cancer vaccines is seeing exciting progress recently. Curious how researchers are dealing with challenges to translate new technologies to the clinic? @natbiotech.nature.com asked experts for an update. www.nature.com/articles/s41...
Cell therapies are transforming our ability to treat cancer but are out of reach for many patients. @natbiotech.nature.com asked experts to share their insights into pressing challenges and promising strategies to make these therapies more broadly accessible www.nature.com/articles/s41...
Making cell therapy accessible: challenges and opportunities - Nature Biotechnology
Despite major advances in bringing cancer cell therapies to the clinic, their widespread accessibility remains a substantial challenge. High manufacturing costs, lack of funding and varying regulatory...
www.nature.com
April 16, 2025 at 9:59 AM
Cell therapies are transforming our ability to treat cancer but are out of reach for many patients. @natbiotech.nature.com asked experts to share their insights into pressing challenges and promising strategies to make these therapies more broadly accessible www.nature.com/articles/s41...
Reposted by Iris
A look back at what vaccines have done.
April 14, 2025 at 4:36 PM
A look back at what vaccines have done.
Reposted by Iris
Proud of our new perspective describing the role of mathematical biology for immunotherapy www.nature.com/articles/s41... @natbiotech.nature.com
Virtual cells for predictive immunotherapy - Nature Biotechnology
Synergizing advances in artificial intelligence with mathematical modeling will improve our ability to computationally predict immunotherapy outcomes.
www.nature.com
April 15, 2025 at 2:17 AM
Proud of our new perspective describing the role of mathematical biology for immunotherapy www.nature.com/articles/s41... @natbiotech.nature.com
Reposted by Iris
This month, we've focused on recent developments as well as challenges in cancer immunotherapy, including cancer vaccines, immune checkpoint inhibitors, and CAR-engineered cells. Please read more👇
Spotlight on cancer immunotherapies go.nature.com/3XUTPkM
April 15, 2025 at 6:48 AM
This month, we've focused on recent developments as well as challenges in cancer immunotherapy, including cancer vaccines, immune checkpoint inhibitors, and CAR-engineered cells. Please read more👇
Innate immune cells are promising candidates for cancer immunotherapy and various engineering strategies can be employed to set them up for success. Read about is in this Review in @natbiotech.nature.com and don't forget to check out our full Focus Issue! www.nature.com/articles/s41...
Engineering innate immune cells for cancer immunotherapy - Nature Biotechnology
The unique attributes of innate immune cells position them as attractive candidates for cancer immunotherapy, with engineering strategies to enhance their antitumor potential, offering notable therape...
www.nature.com
April 15, 2025 at 7:47 AM
Innate immune cells are promising candidates for cancer immunotherapy and various engineering strategies can be employed to set them up for success. Read about is in this Review in @natbiotech.nature.com and don't forget to check out our full Focus Issue! www.nature.com/articles/s41...
Reposted by Iris
🔥New Night Science paper!!
Discovery happens when your initial plans fall apart but it requires you to have a particular mindset: it's not extraverted, orderly, neurotic or agreeable that's the most important – discovery requires an OPENNESS to new ideas and unexpected insights.
Discovery happens when your initial plans fall apart but it requires you to have a particular mindset: it's not extraverted, orderly, neurotic or agreeable that's the most important – discovery requires an OPENNESS to new ideas and unexpected insights.
April 2, 2025 at 11:28 AM
🔥New Night Science paper!!
Discovery happens when your initial plans fall apart but it requires you to have a particular mindset: it's not extraverted, orderly, neurotic or agreeable that's the most important – discovery requires an OPENNESS to new ideas and unexpected insights.
Discovery happens when your initial plans fall apart but it requires you to have a particular mindset: it's not extraverted, orderly, neurotic or agreeable that's the most important – discovery requires an OPENNESS to new ideas and unexpected insights.
Reposted by Iris
Shares of US drugmakers fell after reports that @fda.gov top vaccine official, Peter Marks, had been forced to resign, as the Trump administration undertakes an overhaul of federal health agencies #NBTNewsBeat www.reuters.com/business/hea...
Pharma stocks sink after ouster of top FDA vaccine regulator
Shares of U.S. drugmakers fell on Monday after reports that the Food and Drug Administration's top vaccine official, Peter Marks, had been forced to resign, the most high-profile exit at the regulator as the Trump administration undertakes an overhaul of federal health agencies.
www.reuters.com
April 1, 2025 at 4:24 PM
Shares of US drugmakers fell after reports that @fda.gov top vaccine official, Peter Marks, had been forced to resign, as the Trump administration undertakes an overhaul of federal health agencies #NBTNewsBeat www.reuters.com/business/hea...
Check out the state of the field of engineered bacteria for cancer therapy in this Comment in @naturebiotech.bsky.social www.nature.com/articles/s41...
The emerging landscape of engineered bacteria cancer therapies - Nature Biotechnology
Our ability to use engineered bacteria for cancer therapy is rapidly expanding. A survey of preclinical, clinical and commercial efforts provides an overview of the state of the field, revealing trend...
www.nature.com
April 2, 2025 at 8:02 AM
Check out the state of the field of engineered bacteria for cancer therapy in this Comment in @naturebiotech.bsky.social www.nature.com/articles/s41...
Modulating induced proximity at the cell surface is a powerful engineering strategy that can find diverse applications in basic and translational science. Curious to learn about emerging modalities in this space? Read this review out now in @naturebiotech.bsky.social www.nature.com/articles/s41...
Induced proximity at the cell surface - Nature Biotechnology
Technologies to modulate induced proximity at the cell surface advance the manipulation of diverse biological responses.
www.nature.com
March 26, 2025 at 1:54 PM
Modulating induced proximity at the cell surface is a powerful engineering strategy that can find diverse applications in basic and translational science. Curious to learn about emerging modalities in this space? Read this review out now in @naturebiotech.bsky.social www.nature.com/articles/s41...
Nanopore technology might be able to sequence proteins soon! Read about the road ahead in this exciting Perspective rdcu.be/edWPi in @naturebiotech.bsky.social
Toward single-molecule protein sequencing using nanopores
Nature Biotechnology - Maglia and colleagues discuss advances in nanopore technology en route to single-molecule protein sequencing
rdcu.be
March 18, 2025 at 10:18 AM
Nanopore technology might be able to sequence proteins soon! Read about the road ahead in this exciting Perspective rdcu.be/edWPi in @naturebiotech.bsky.social
The program of the CiRT2025 meeting is out: meeting2025.cirt-net.org/program.html. I will be sharing my top 10 tips on publishing with @naturebiotech.bsky.social. See you there?
Program
meeting2025.cirt-net.org
February 10, 2025 at 10:05 AM
The program of the CiRT2025 meeting is out: meeting2025.cirt-net.org/program.html. I will be sharing my top 10 tips on publishing with @naturebiotech.bsky.social. See you there?